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Pimethixene maleate

Catalog No.GC65296

Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent.

Products are for research use only. Not for human use. We do not sell to patients.

Pimethixene maleate Chemical Structure

Cas No.: 13187-06-9

Size Price Stock Qty
10mM (in 1mL DMSO)
$34.60
In stock
10mg
$31.50
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Protocol

5-HT1AReceptor

7.63(pKi)

5-HT2AReceptor

10.22(pKi)

5-HT2BReceptor

10.44(pKi)

5-HT2CReceptor

8.42(pKi)

D2receptor

8.19(pKi)

DD4.4receptor

7.54(pKi)

M1receptor

8.61(pKi)

M2receptor

9.38(pKi)

Background

Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent.Pimethixene maleate is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively[1].

[1]. Schmitz B, et al. BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80.

Chemical Properties

Cas No. 13187-06-9 SDF Download SDF
Formula C23H23NO4S M.Wt 409.5
Solubility DMSO : 100 mg/mL (244.20 mM; Need ultrasonic) Storage 4°C, away from moisture
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.442 mL 12.21 mL 24.42 mL
5 mM 0.4884 mL 2.442 mL 4.884 mL
10 mM 0.2442 mL 1.221 mL 2.442 mL
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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