Pimprinine (Synonyms: NSC 80793)

Pimprinine is an alkaloid originally isolated from Streptomyces that has diverse biological activities, including anticonvulsant, antiplatelet, and antimicrobial properties. It inhibits deamination of serotonin by monoamine oxidase (MAO; IC50 = 48 μM). Pimprinine (80 mg/kg) increases the minimum and maximum electroshock seizure thresholds in mice. In a mouse model of tremorine-induced tremors, it increases the latency to tremor onset, as well as reduces the intensity and duration of tremors and the analgesic activity of tremorine when administered at a dose of 80 mg/kg. Pimprinine inhibits aggregation of rabbit platelets induced by arachidonic acid or collagen (IC50s = 3 and 25 μg/ml, respectively) and arachidonic acid-induced thromboxane A2 (TXA2) synthesis in rabbit platelets in vitro (IC50 = 6 μg/ml). It also inhibits the growth of M. tuberculosis, P. varioti, C. albicans, and S. lutea in vitro (MICs = 25, 1, 1.5, and 2.5 μg/ml, respectively).

References:
[1].Takeuchi, T., Ogawa, K., Iinuma, H., et al. Monoamine oxidase inhibitors isolated from fermented broths J. Antibiot. (Tokyo) 26(3), 162-167 (1973).
[2].Naik, S.R., Harindran, J., and Varde, A.B. Pimprinine, an extracellular alkaloid produced by Streptomyces CDRIL-312: Fermentation, isolation and pharmacological activity J. Biotechnol. 88(1), 1-10 (2001).
[3].Umehara, K., Yoshida, K., Okamoto, M., et al. Studies on new antiplatelet agents, WS-30581 A and B J. Antibiot. (Tokyo) 37(10), 1153-1160 (1984).
[4].Intaraudom, C., Rachtawee, P., Suvannakad, R., et al. Antimalarial and antituberculosis substances from Streptomyces sp. BCC26924 Tetrahedron 67(39), 7593-7597 (2011).