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Pixantrone-d8 (maleate)

Catalog No.GC52455

An internal standard for the quantification of pixantrone

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Pixantrone-d8 (maleate) Chemical Structure

Size Price Stock Qty
1 mg
$424.00
In stock
5 mg
$1,484.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Pixantrone-d8 is intended for use as an internal standard for the quantification of pixantrone by GC- or LC-MS. Pixantrone is a DNA topoisomerase II inhibitor.1 It induces SV40 DNA cleavage in the presence of mouse topoisomerase II and induces DNA single-strand breaks in NCI H187 cells in a concentration-dependent manner. Pixantrone is cytotoxic to L1210 leukemia cells as well as doxorubicin-sensitive and -resistant LoVo colon adenocarcinoma cells (IC50 = 0.01, 0.24, and 7.2 µg/ml, respectively).2 It decreases disease severity in a rat model of myasthenia gravis induced by immunization with the T. californica acetylcholine receptor (AChR) when administered at a dose of 8.12 mg/kg once per week for six weeks.3 Formulations containing pixantrone have been used in the treatment of non-Hodgkin B cell lymphoma.

1.De Isabella, P., Palumbo, M., Sissi, C., et al.Topoisomerase II DNA cleavage stimulation, DNA binding activity, cytotoxicity, and physico-chemical properties of 2-aza- and 2-aza-oxide-anthracenedione derivativesMol. Pharmacol.48(1)30-38(1995) 2.Krapcho, A.P., Petry, M.E., Getahun, Z., et al.6,9-Bis[(aminoalkyl)amino]benzo[g]isoquinoline-5,10-diones. A novel class of chromophore-modified antitumor anthracene-9,10-diones: Synthesis and antitumor evaluationsJ. Med. Chem.37(6)828-837(1994) 3.Marolda, R., Ruocco, C., Cordiglieri, C., et al.Differential targeting of immune-cells by Pixantrone in experimental myasthenia gravisJ. Neuroimmunol.258(1-2)(2013)

Chemical Properties

Cas No. SDF Download SDF
Canonical SMILES NC([2H])([2H])C([2H])([2H])NC1=C2C(C(C(C=CN=C3)=C3C2=O)=O)=C(NC([2H])([2H])C([2H])([2H])N)C=C1.OC(/C=C\C(O)=O)=O.OC(/C=C\C(O)=O)=O
Formula C17H11D8N5O2 ? 2C4H4O4 M.Wt 565.6
Solubility DMSO: soluble,Methanol: soluble,Water: soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.768 mL 8.8402 mL 17.6803 mL
5 mM 0.3536 mL 1.768 mL 3.5361 mL
10 mM 0.1768 mL 0.884 mL 1.768 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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