Home>>PKSI-527
PKSI-527 Catalog No.GC44659

Size Price Stock Qty
5mg
$129.00
In stock
25mg
$540.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 128837-71-8 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES NC[C@@H]1CC[C@@H](C(N[C@@H](CC2=CC=CC=C2)C(NC3=CC=C(CC(O)=O)C=C3)=O)=O)CC1.Cl
Formula C25H31N3O4•HCl M.Wt 474
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times. In vivo, PKSI-527 (300 mg/kg per day) reduces hyperplasia, pannus formation, and infiltration of inflammatory cells in the tarsal joint of mice with collagen-induced arthritis.