PKSI-527 |
| Catalog No.GC44659 |
PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 128837-71-8
Sample solution is provided at 25 µL, 10mM.
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PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times. In vivo, PKSI-527 (300 mg/kg per day) reduces hyperplasia, pannus formation, and infiltration of inflammatory cells in the tarsal joint of mice with collagen-induced arthritis.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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