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Pomalidomide-d5

Catalog No.GC47965

An internal standard for the quantification of pomalidomide

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Pomalidomide-d5 Chemical Structure

Cas No.: 1377838-49-7

Size Price Stock Qty
500 μg
$512.00
In stock
1 mg
$973.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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Background

Pomalidomide-d5 is intended for use as an internal standard for the quantification of pomalidomide by GC- or LC-MS. Pomalidomide is an analog of thalidomide that inhibits the E3 ligase protein cereblon (CRBN) with an IC50 value of approximately 3 µM for the human recombinant CRBN-DNA damage binding protein-1 (CRBN-DDB1) complex.1 It inhibits autoubiquitination of CRBN in HEK293T cells expressing CRBN but not those expressing a thalidomide-binding defective CRBN mutation. It inhibits proliferation of U266 myeloma cells when used at concentrations ranging from 0.1 to 10 µM. Pomalidomide also has antiangiogenic and immunomodulatory effects against myeloma cells, modulating cell adhesion, decreasing production of key pro-survival cytokines, including TNF-α, and triggering the activation of caspase-8.2,3 Pomalidomide (3 mg/kg per day), in combination with dexamethasone, reduces tumor growth in a H929 R10-1 lenalidomide-resistant mouse xenograft model.4 Formulations containing pomalidomide have been used in the treatment of multiple myeloma.

1.Lopez-Girona, A., Mendy, D., Miller, K., et al.Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomideLeukemia26(11)2326-2335(2012) 2.Zhu, Y.X., Kortuem, K.M., and Stewart, A.K.Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myelomaLeukemia and Lymphoma54(4)683-687(2013) 3.Latif, T., Chauhan, N., Khan, R., et al.Thalidomide and its analogues in the treatment of multiple myelomaExp.Hermatol.Oncol.1(1)27(2012) 4.Rychak, E., Mendy, D., Shi, T., et al.Pomalidomide in combination with dexamethasone results in synergistic anti-tumour responses in pre-clinical models of lenalidomide-resistant multiple myelomaBr. J. Haematol.172(6)889-901(2016)

Chemical Properties

Cas No. 1377838-49-7 SDF
Canonical SMILES NC1=C2C(C(N(C3([2H])C(NC(C([2H])([2H])C3([2H])[2H])=O)=O)C2=O)=O)=CC=C1
Formula C13H6D5N3O4 M.Wt 278.3
Solubility DMF: 10 mg/ml,DMSO: 15 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.5932 mL 17.9662 mL 35.9324 mL
5 mM 0.7186 mL 3.5932 mL 7.1865 mL
10 mM 0.3593 mL 1.7966 mL 3.5932 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 12 reference(s) in Google Scholar.)

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