Porcupine-IN-1 (Synonyms: PORCN-IN-1) |
| Catalog No.GC19299 |
Porcupine-IN-1 is potent porcupine inhibitor with an IC50 of 0.5±0.2 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2036044-77-4
Sample solution is provided at 25 µL, 10mM.
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Porcupine-IN-1 is potent porcupine inhibitor with an IC50 of 0.5±0.2 nM.
Porcupine is an enzyme that catalyses the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Porcupine-IN-1 is as potent as the clinical compound LGK974 in a cell based STF reporter gene assay. Porcupine-IN-1 potently inhibits the secretion of Wnt3A, therefore is confirmed to be a porcupine inhibitor[1].
Porcupine-IN-1 demonstrates moderate clearance under the treatment of human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg). It exhibits high clearance when treated with mouse microsomes (109 mL/min/kg)[1].
References:
[1]. Xu Z, et al. Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the 'reversed' amide scaffold.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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