Prion Protein (106-126) (trifluoroacetate salt) (Synonyms: PrP) |
| Catalog No.GC44682 |
Prion Protein (106-126) is a peptide fragment of the cellular prion protein PrPc.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Prion Protein (106-126) is a peptide fragment of the cellular prion protein PrPc. It forms fibrils that are organized into β-strands, a behavior characteristic of amyloids. It is toxic to primary rat hippocampal neurons at a concentration of 80 μM following incubation for 10 days and induces DNA fragmentation and apoptosis. Prion Protein (106-126) (25 μM) activates ERK1 and 2, p38, and JNK1 and 2 kinases, induces apoptosis, increases NADPH oxidase-dependent production of reactive oxygen species (ROS), and decreases glutathione (GSH) levels in 1C115-HT serotonergic and 1C11NE noradrenergic differentiated neuronal cells. It forms channels in lipid bilayer membranes that are freely permeable to calcium, sodium, potassium, lithium, rubidium, cesium, and chloride ions at a concentration of 20 μM, and channel formation is significantly enhanced by aging and low pH. In vivo, intraocular injection of prion protein (106-126) (1 mM) increases the number of terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL) positive nuclei in mice 4 days post injection.
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