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Procaine (hydrochloride) (Synonyms: Novocaine)

Catalog No.GC44685

Procaine (hydrochloride) is an analytical reference standard categorized as a local anesthetic that is used as an adulterant.

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Procaine (hydrochloride) Chemical Structure

Cas No.: 1951/5/8

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1mg
$41.00
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5mg
$103.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Procaine hydrochloride is a local anesthetic drug of the amino ester group.Target: OthersProcaine hydrochloride is a local anesthetic of the ester type that has a slow onset and a short duration of action.Procaine (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM [1]. Procaine is a DNA-demethylating agent that produces a 40% reduction in 5-methylcytosine DNA content as determined by high-performance capillary electrophoresis or total DNA enzyme digestion. Procaine can also demethylate densely hypermethylated CpG islands. Procaine also has growth-inhibitory effects in these cancer cells, causing mitotic arrest [2]. Procaine functions as an excitant of limbic system cells, and that procaine alters synaptic transmission in some, but not all, output pathways from the amygdale [3].

References:
[1]. Fan, P. and F.F. Weight, Procaine impairs the function of 5-HT3 receptor-ion channel complex in rat sensory ganglion neurons. Neuropharmacology, 1994. 33(12): p. 1573-9.
[2]. Villar-Garea, A., et al., Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res, 2003. 63(16): p. 4984-9.
[3]. Adamec, R.E. and C. Stark-Adamec, The effects of procaine HCl on population cellular and evoked response activity within the limbic system of the cat. Evidence for differential excitatory action of procaine in a variety of limbic circuits. Prog Neuropsychopharmacol Biol Psychiatry, 1987. 11(4): p. 345-64.

Chemical Properties

Cas No. 1951/5/8 SDF
Synonyms Novocaine
Canonical SMILES NC1=CC=C(C(OCCN(CC)CC)=O)C=C1.Cl
Formula C13H20N2O2•HCl M.Wt 272.8
Solubility DMF: 20 mg/ml,DMSO: 14 mg/ml,Ethanol: 16 mg/ml,PBS (pH 7.2): 10 mg/ml Storage 4°C, protect from light ,unstable in solution, ready to use.
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.6657 mL 18.3284 mL 36.6569 mL
5 mM 0.7331 mL 3.6657 mL 7.3314 mL
10 mM 0.3666 mL 1.8328 mL 3.6657 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 31 reference(s) in Google Scholar.)

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