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Propionyl-L-carnitine-d3 (chloride) (Synonyms: C3:0 Carnitine-d3, CAR 3:0-d3, L-Carnitine propionyl ester-d3, Levocarnitine propionate-d3, L-Propionylcarnitine-d3)

Catalog No.GC47980

An internal standard for the quantification of propionyl-L-carnitine

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Propionyl-L-carnitine-d3 (chloride) Chemical Structure

Cas No.: 1334532-19-2

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1mg
$157.00
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5 mg
$623.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Propionyl-L-carnitine-d3 is intended for use as an internal standard for the quantification of propionyl-L-carnitine by GC- or LC-MS. Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids.1 Propionyl-L-carnitine increases the basal release of prostaglandin E2 and 6-keto Prostaglandin F in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 in non-contaminated cells.1 It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal.2 Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.3

1.Garrelds, I.M., Elliott, G.R., Pruimboom, W.M., et al.Effects of carnitine and its congeners on eicosanoid discharge from rat cells: Implications for release of TNFαMediators of Inflammation2(7)S57-S62(1993) 2.Stasi, M.A., Scioli, M.G., Arcuri, G., et al.Propionyl-L-carnitine improves postischemic blood flow recovery and arteriogenetic revascularization and reduces endothelial NADPH-oxidase 4-mediated superoxide productionArterioscler. Thromb. Vasc. Biol.30(3)426-435(2010) 3.Ferrari, R., Ceconi, C., Cargnoni, A., et al.The effect of propionyl-L-carnitine on the ischemic and reperfused intact myocardium and on their derived mitochondriaCardiovasc. Drugs Ther.5 (Suppl 1)57-65(1991)

Chemical Properties

Cas No. 1334532-19-2 SDF
Synonyms C3:0 Carnitine-d3, CAR 3:0-d3, L-Carnitine propionyl ester-d3, Levocarnitine propionate-d3, L-Propionylcarnitine-d3
Canonical SMILES C[N+](C)(C([2H])([2H])[2H])C[C@@H](CC(O)=O)OC(CC)=O.[Cl-]
Formula C10H17D3NO4.Cl M.Wt 256.7
Solubility DMF: 15 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 10 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.8956 mL 19.478 mL 38.956 mL
5 mM 0.7791 mL 3.8956 mL 7.7912 mL
10 mM 0.3896 mL 1.9478 mL 3.8956 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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