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Prostaglandin F2α methyl ester (Synonyms: PGF2α methyl ester)

Catalog No.GC18370

Prostaglandin F2α methyl ester (PGF2α methyl ester) is an analog of PGF2α in which the C-1 carboxyl group has been esterified as the methyl ester.

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Prostaglandin F2α methyl ester Chemical Structure

Cas No.: 33854-16-9

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500μg
$44.00
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1mg
$83.00
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5mg
$342.00
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10mg
$602.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Prostaglandin F2α methyl ester (PGF2α methyl ester) is an analog of PGF2α in which the C-1 carboxyl group has been esterified as the methyl ester. PGF2α methyl ester was one of the first PG esters shown to have ocular hypotensive activity. This compound continues to be a standard by which other ocular hypotensive PG prodrugs are evaluated. The methyl ester is about 4-5 times more potent than the free acid, PGF2α. This difference is attributed to improved corneal penetration, and a depot effect of prolonged retention of the ester form of the compound in ocular tissue. A 2.5 ug dose of PGF2α-OMe applied to the eyes of cats results in a 6-8 mm Hg reduction in IOP.

Chemical Properties

Cas No. 33854-16-9 SDF
Synonyms PGF2α methyl ester
Chemical Name 9α,11α,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid, methyl ester
Canonical SMILES CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(OC)=O
Formula C21H36O5 M.Wt 368.5
Solubility DMF: 35 mg/ml,DMSO: 35 mg/ml,Ethanol: 50 mg/ml,Ethanol:PBS (pH 7.2) (1:4): 0.4 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.7137 mL 13.5685 mL 27.137 mL
5 mM 0.5427 mL 2.7137 mL 5.4274 mL
10 mM 0.2714 mL 1.3569 mL 2.7137 mL
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