Home>>PROTAC RIPK degrader-6
PROTAC RIPK degrader-6 Catalog No.GC61215

Size Price Stock Qty
10mM*1 mL in DMSO
$770.00
In stock
5mg
$538.00
In stock
10mg
$788.00
In stock
25mg
$1,437.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 2089205-64-9 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=S(C(C(OCCOCCOCCOCCOCC(NC1=C(CN(C2C(NC(CC2)=O)=O)C3=O)C3=CC=C1)=O)=C4)=CC(C4=NC=C5)=C5NC6=CC(N=CS7)=C7C=C6)(C(C)(C)C)=O
Formula C43H48N6O11S2 M.Wt 889
Solubility DMSO: 100 mg/mL (112.49 mM) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder[1].

PROTACs is useful for the targeted degradation of proteins and other polypeptides which on the one end binds to the cereblon and on the other end to the target protein (RIP2 kinase). By bringing the target protein in close proximity to the E3-Ligase, these compounds form a ternary complex leading to polyubiquitination of the target protein inducing its degradation[1].

[1]. John David Harlin, et al. Compounds for the modulation of rip2 kinase activity. WO2017046036A1.