Protectin D1 (Synonyms: Neuroprotectin D1, NPD1, PD1) |
| Catalog No.GC40981 |
Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 660430-03-5
Sample solution is provided at 25 µL, 10mM.
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Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phagocytosis of apoptotic polymorphonuclear leukocytes (PMNs) by macrophages in a non-phlogistic manner and is generated in vitro during macrophage-apoptotic interactions. It enhances phagocytosis in mice after 24 hours, but not at the initiation or peak of inflammation. It also decreases PMN infiltration in a zymosan-induced mouse model of inflammation when administered at a dose of 300 ng per animal. Protectin D1 (200 µg, i.v.) inhibits increases in neutrophil counts in bronchoalveolar fluid (BALF) and lung myeloperoxidase activity in a mouse model of pulmonary injury and inflammation induced by intratracheal LPS instillation. It also decreases pulmonary edema and promotes neutrophil apoptosis in BALF.
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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