PtdIns-(3,4,5)-P3 (1-stearoyl, 2-arachidonoyl) (sodium salt) (Synonyms: PI(3,4,5)P3, PI(P-18:0/20:4), PIP33,4,5(18:0/20:4), Phosphatidylinositol3,4,5triphosphate C18 (sodium salt)) |
| Catalog No.GC44751 |
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids.
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Sample solution is provided at 25 µL, 10mM.
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The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and Akts are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific PLC. Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see also references and .
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