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Purified Ganglioside Mixture (bovine) (ammonium salt)

Catalog No.GC52484

A mixture of purified bovine gangliosides

Products are for research use only. Not for human use. We do not sell to patients.

Purified Ganglioside Mixture (bovine) (ammonium salt) Chemical Structure

Size Price Stock Qty
1 mg
$46.00
In stock
5 mg
$160.00
In stock
10 mg
$272.00
In stock
25 mg
$452.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Gangliosides are glycosphingolipids found in all vertebrate cells with particularly high levels found in the central nervous system.1,2 Gangliosides in the brain typically contain a saturated stearic acid as the fatty acyl chain, which is located in the outer leaflet of the plasma membrane with the ceramide chain, and a glycan group that faces outward and mediates cell-cell interactions. Gangliosides pack densely with cholesterol to form lipid microdomains that modulate both intra- and inter-cell signaling events. More than 180 gangliosides have been identified that differ based on the position and number of sialic acid residues. The expression of various gangliosides varies during development indicating specialized roles at distinct stages. Deficiencies in the synthesis or breakdown of gangliosides are associated with seizure and neurodegenerative disorders, respectively. They also regulate receptor function by direct association and receptor trafficking. Gangliosides have been implicated in tumorigenesis because they can modulate cell surface events including proliferation, migration, and adhesion.3 's Purified Ganglioside Mixture contains ganglioside molecular species with primarily C18:0 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1065]

1.Yu, R.K., Tsai, Y.T., Ariga, T., et al.Structures, biosynthesis, and functions of gangliosides-an overviewJ. Oleo. Sci.60(10)537-544(2011) 2.Schnaar, R.L.Gangliosides of the vertebrate nervous systemJ. Mol. Biol.428(16)3325-3336(2016) 3.Seyfried, T.N., and Mukherjee, P.Ganglioside GM3 is antiangiogenic in malignant brain cancerJ. Oncol.961243(2010)

Chemical Properties

Cas No. SDF Download SDF
Formula M.Wt 0
Solubility Chloroform:Methanol:Water (2:1:0.1): Soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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