Home>>Signaling Pathways>> Ubiquitination/ Proteasome>> Autophagy>>(-)-PX20606 trans isomer ((-)-PX-102 trans isomer)
(-)-PX20606 trans isomer ((-)-PX-102 trans isomer) Catalog No.GC31386

Size Price Stock Qty
10mM*1mLinDMSO
$1,543.00
In stock
1mg
$321.00
In stock
2mg
$506.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 1268244-88-7 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES ClC1=C(C2=NOC(C3CC3)=C2COC4=CC=C([C@@H]5C[C@H]5C6=CC=C(C(O)=O)C=C6)C(Cl)=C4)C(Cl)=CC=C1.[(-)].[Rotation]
Formula C29H22Cl3NO4 M.Wt 554.85
Solubility Ethanol : ≥ 50 mg/mL (90.11 mM) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

(-)-PX20606 trans isomer is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.

[1]. Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53.