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(-)-PX20606 trans isomer ((-)-PX-102 trans isomer)

Catalog No.GC31386

(-)-PX20606 trans isomer ((-)-PX-102 trans isomer) is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.

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(-)-PX20606 trans isomer ((-)-PX-102 trans isomer) Chemical Structure

Cas No.: 1268244-88-7

Size Price Stock Qty
10mM (in 1mL DMSO)
$1,543.00
In stock
1mg
$321.00
In stock
2mg
$506.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(-)-PX20606 trans isomer is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.

[1]. Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53.

Chemical Properties

Cas No. 1268244-88-7 SDF
Canonical SMILES ClC1=C(C2=NOC(C3CC3)=C2COC4=CC=C([C@@H]5C[C@H]5C6=CC=C(C(O)=O)C=C6)C(Cl)=C4)C(Cl)=CC=C1.[(-)].[Rotation]
Formula C29H22Cl3NO4 M.Wt 554.85
Solubility Ethanol : ≥ 50 mg/mL (90.11 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.8023 mL 9.0114 mL 18.0229 mL
5 mM 0.3605 mL 1.8023 mL 3.6046 mL
10 mM 0.1802 mL 0.9011 mL 1.8023 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for (-)-PX20606 trans isomer ((-)-PX-102 trans isomer)

Average Rating: 5 ★★★★★ (Based on Reviews and 31 reference(s) in Google Scholar.)

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