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(R)-CR8

Catalog No.GC41716

(R)-CR8 Chemical Structure

An inhibitor of cyclindependent kinases

Size Price Stock Qty
1mg
$85.00
In stock
10mg
$296.00
In stock
50mg
$847.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Background

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-CR8 is a second-generation analog of (R)-roscovitine that inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T with IC50 values of 0.09, 0.072, 0.041, 0.11, and 0.18 μM, respectively. (R)-CR8 has 2- to 4-fold improved potency for the inhibition of CDKs over (R)-roscovitine and can inhibit the proliferation of various cancer cell lines with ~40-fold more potency than (R)-roscovitine (IC50s ~ 0.39 versus 27.8 μM, respectively). (R)-CR8 also inhibits casein kinase 1 (CK1δ/ε) with an IC50 value of 0.40 μM and inhibits GSK3α/β with an IC50 value of 12 μM.

Chemical Properties

Cas No. 294646-77-8 SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES CC(C)N(C=N1)C2=C1C(NCC3=CC=C(C4=NC=CC=C4)C=C3)=NC(N[C@H](CC)CO)=N2
Formula C24H29N7O M.Wt 431.5
Solubility DMSO: Soluble,Ethanol: Soluble Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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