(R)-HTS-3 |
| Catalog No.GC52290 |
An inhibitor of LPCAT3
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2771208-83-2
Sample solution is provided at 25 µL, 10mM.
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(R)-HTS-3 is an inhibitor of lysophosphatidylcholine acyltransferase 3 (LPCAT3; IC50 = 0.09 µM), an enzyme involved in the synthesis of C20:4-containing phospholipids.1 It reduces the incorporation of arachidonic acid-d8 into phospholipids when used at concentrations of 1, 3, and 10 µM. (R)-HTS-3 (10 µM) reduces RSL3-induced ferroptosis in HT-1080 and 786-O cancer cells.
1.Reed, A., Ichu, T.-A., Milosevich, N., et al.LPCAT3 inhibitors remodel the polyunsaturated phospholipid content of human cells and protect from ferroptosisACS Chem. Biol.17(6)1607-1618(2022)
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