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Ralfinamide mesylate Catalog No.GC13283

Sodium channel blocker

Size Price Stock Qty
10mg
$83.00
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50mg
$334.00
Ship Within 7 Days

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 202825-45-4 SDF
Chemical Name (S)-2-((4-((2-fluorobenzyl)oxy)benzyl)amino)propanamide methanesulfonate
Canonical SMILES OS(=O)(C)=O.FC1=CC=CC=C1COC2=CC=C(C=C2)CN[C@H](C(N)=O)C
Formula C17H19FN2O2.CH3SO3H M.Wt 398.45
Solubility <9.96mg/ml in H2O; <39.84mg/ml in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na+ channel blocker derived from α-aminoamide, with function of suppressing pain[1][2].

Ralfinamide (30 mg/kg, 60 mg/kg; p.o.; twice daily; 42 days) treated with Ralfinamide (80 mg/kg; p.o.; twice daily; 7 days) preoperatively suppresses neuropathic pain[1].

References:
[1]. Zhang SH, et al. Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain. 2008 Oct 15;139(2):293-305.
[2]. Liang X, et al. Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain. Eur J Pharmacol. 2018 Mar 15;823:27-34.