Home>>Signaling Pathways>> Others>> Environmental Toxicology>>Ranitidine S-oxide

Ranitidine S-oxide

Catalog No.GC52054

Ranitidine S-oxide is the metabolite of Ranitidine.

Products are for research use only. Not for human use. We do not sell to patients.

Ranitidine S-oxide Chemical Structure

Cas No.: 73851-70-4

Size Price Stock Qty
1 mg
$36.00
In stock
5 mg
$170.00
In stock
10 mg
$269.00
In stock
25 mg
$537.00
In stock

Tel:(909) 407-4943 Email: sales@glpbio.com

Customer Reviews

Based on customer reviews.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

View current batch:

Background

Ranitidine S-oxide is a metabolite of the histamine H2 receptor antagonist ranitidine .1 It is formed via S-oxidation of ranitidine by flavin-containing monooxygenase 3 (FMO3) and FMO5.2 Ranitidine S-oxide is acutely cytotoxic to the aquatic species B. calyciflorus and C. dubia (LC50s = 4.51 and 7.85 mg/L, respectively), and it inhibits the reproduction of B. calyciflorus and C. dubia with chronic exposure (EC50s = 0.83 and 0.51 mg/L, respectively).3 It is mutagenic to S. typhimurium and genotoxic to E. coli when used at concentrations ranging from 0.312 to 0.625 µg/ml and 0.312 to 5 µg/ml, respectively.

1.Smith, M.S., Oxford, J., and Evans, M.B.Improved method for the separation of ranitidine and its metabolites based on supercritical fluid chromatographyJ. Chromatogr. A.683(2)(1994) 2.Chung, W.-G., Park, C.-S., Roh, H.-K., et al.Oxidation of ranitidine by isozymes of flavin-containing monooxygenase and cytochrome P450Jpn. J. Pharmacol.84(2)213-220(2000) 3.Isidori, M., Parrella, A., Pistillo, P., et al.Effects of ranitidine and its photoderivatives in the aquatic environmentEnviron. Int.35(5)821-825(2009)

Chemical Properties

Cas No. 73851-70-4 SDF Download SDF
Canonical SMILES O=S(CC1=CC=C(CN(C)C)O1)CCN/C(NC)=C/[N+]([O-])=O
Formula C13H22N4O4S M.Wt 330.4
Solubility DMSO: soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.0266 mL 15.1332 mL 30.2663 mL
5 mM 0.6053 mL 3.0266 mL 6.0533 mL
10 mM 0.3027 mL 1.5133 mL 3.0266 mL
  • Molarity Calculator

  • Dilution Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

Calculate

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for Ranitidine S-oxide

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for Ranitidine S-oxide

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.