Home>>Analytical Standards>>Ranolazine-d5

Ranolazine-d5 (Synonyms: CVT 303-d5; RS 43285-003-d5)

Catalog No.GC40235

Ranolazine-d5 is intended for use as an internal standard for the quantification of ranolazine by GC- or LC-MS.

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Ranolazine-d5 Chemical Structure

Cas No.: 1092804-87-9

Size Price Stock Qty
500μg
$307.00
In stock
1mg
$582.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Ranolazine-d5 is intended for use as an internal standard for the quantification of ranolazine by GC- or LC-MS. Ranolazine is a piperazine derivative with cardioprotective activity. It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively). Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively). In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits. Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide , connective tissue growth factor (CTGF), brain natriuretic peptide , and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin .

Chemical Properties

Cas No. 1092804-87-9 SDF
Synonyms CVT 303-d5; RS 43285-003-d5
Canonical SMILES OC(C([2H])([2H])OC1=C(OC)C=CC=C1)([2H])C([2H])([2H])N2CCN(CC(NC3=C(C)C=CC=C3C)=O)CC2
Formula C24H28D5N3O4 M.Wt 432.6
Solubility Dichloromethane: Soluble,Methanol: Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.3116 mL 11.558 mL 23.116 mL
5 mM 0.4623 mL 2.3116 mL 4.6232 mL
10 mM 0.2312 mL 1.1558 mL 2.3116 mL
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