RBPJ Inhibitor-1 (RIN1) |
| Catalog No.GC25838 |
RBPJ Inhibitor-1 (RIN1) is a potent inhibitor of the transcription factor RBPJ that disrupts the interaction between NOTCH and RBPJ.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2682114-39-0
Sample solution is provided at 25 µL, 10mM.
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RBPJ Inhibitor-1 (RIN1) is a potent inhibitor of the transcription factor RBPJ that disrupts the interaction between NOTCH and RBPJ.
RBPJ Inhibitor-1 (RIN1) blocks the functional interaction of RBPJ with SHARP, a scaffold protein that forms a transcriptional repressor complex with RBPJ in the absence of NOTCH signaling. Consistent with disruption of NOTCH signaling, RIN1 inhibits the proliferation of hematologic cancer cell lines and promotes skeletal muscle differentiation from C2C12 myoblasts.[1]
[1] Cecilia Hurtado, et al. Sci Rep. 2019 Jul 25;9(1):10811.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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