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Home >> Signaling Pathways

Signaling Pathways

The antibody-drug conjugate (ADC), a humanized or human monoclonal antibody conjugated with highly cytotoxic small molecules (payloads) through chemical linkers, is a novel therapeutic format and has great potential to make a paradigm shift in cancer chemotherapy. The three components of the ADC together give rise to a powerful oncolytic agent capable of delivering normally intolerable cytotoxins directly to cancer cells, which then internalize and release the cell-destroying drugs. At present, two ADCs, Adcetris and Kadcyla, have received regulatory approval with >40 others in clinical development.

ADCs are administered intravenously in order to prevent the mAb from being destroyed by gastric acids and proteolytic enzymes. The mAb component of the ADC enables it to circulate in the bloodstream until it finds and binds to tumor-specific cell surface antigens present on target cancer cells. Linker chemistry is an important determinant of the safety, specificity, potency and activity of ADCs. Linkers are designed to be stable in the blood stream (to conform to the increased circulation time of mAbs) and labile at the cancer site to allow rapid release of the cytotoxic drug. First generation ADCs made use of early cytotoxins such as the anthracycline, doxorubicin or the anti-metabolite/antifolate agent, methotrexate. Current cytotoxins have far greater potency and can be divided into three main groups: auristatins, maytansines and calicheamicins.

The development of site-specific conjugation methodologies for constructing homogeneous ADCs is an especially promising path to improving ADC design, which will open the way for novel cancer therapeutics.

References:

[1] Tsuchikama K, et al. Protein Cell. 2016 Oct 14. DOI:10.1007/s13238-016-0323-0.

[2] Peters C, et al. Biosci Rep. 2015 Jun 12;35(4). pii: e00225. doi: 10.1042/BSR20150089.

Targets for  Signaling Pathways

Products for  Signaling Pathways

  1. Cat.No. Product Name Information
  2. GC73402 (16R)-Epothilone D

    (16R)-KOS 862

     (16R)-Epothilone D is the isomer of Epothilone D , and can be used as an experimental control. (16R)-Epothilone D Chemical Structure
  3. GC72769 (1R)-AZD-1480 (1R)-AZD-1480 is the (1R) chiral isomer of AZD-1480, an ATP competitive JAK1 and JAK2 inhibitor. (1R)-AZD-1480 Chemical Structure
  4. GC72832 (1R)-IDH889 (1R)-IDH889 is the isomer of IDH889 , and can be used as an experimental control. (1R)-IDH889 Chemical Structure
  5. GC70232 (1R,2R)-Calhex 231 hydrochloride (1R,2R)-Calhex 231 hydrochloride is the isomer of Calhex 231 hydrochloride , and can be used as an experimental control. (1R,2R)-Calhex 231 hydrochloride Chemical Structure
  6. GC70081 (1R,2R)-U-50488 hydrochloride

    (1R,2R)-U-50488 hydrochloride is the absolute configuration of (±)-U-50488 hydrochloride. (±)-U-50488 hydrochloride is a κ opioid receptor agonist.

     (1R,2R)-U-50488 hydrochloride Chemical Structure
  7. GC67880 (1R,2S)-Xeruborbactam disodium

    (1R,2S)-QPX7728 disodium

     (1R,2S)-Xeruborbactam disodium Chemical Structure
  8. GC73081 (1R,3S)-Compound E (1R,3S)-Compound E is the isomer of Compound E , and can be used as an experimental control. (1R,3S)-Compound E Chemical Structure
  9. GC73057 (1R,9R)-Exatecan mesylate

    (1R,9R)-DX8951f

     (1R,9R)-Exatecan mesylate((1R,9R)-DX8951f) is an isomer of Exatecan mesylate. (1R,9R)-Exatecan mesylate Chemical Structure
  10. GC70349 (1S)-CCR2 antagonist 1 (1S)-CCR2 antagonist 1 is a left-handed chiral body of CCR2 antagonist 1 . (1S)-CCR2 antagonist 1 Chemical Structure
  11. GC73042 (1S,2S)-ML-SI3

    (+)-trans-ML-SI3

     (1S,2S)-ML-SI3 is a trans-isomer of ML-SI3 that targets all three isoforms of TRPML. (1S,2S)-ML-SI3 Chemical Structure
  12. GC65885 (1S,3R)-GNE-502 (1S,3R)-GNE-502 (compound 179) is a potent ERα degrader with an EC50 value of 13 nM against ERα in MCF7 HCS. (1S,3R)-GNE-502 can be used to research cancer related with estrogen receptor. (1S,3R)-GNE-502 Chemical Structure
  13. GC73056 (1S,9R)-Exatecan mesylate

    (1S,9R)-DX8951f

     (1S,9R)-Exatecan mesylate ((1S,9R)-DX8951f) is an isomer of Exatecan mesylate. (1S,9R)-Exatecan mesylate Chemical Structure
  14. GC68525 (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid

    (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid is a saponin that can be isolated from Rubus ellipticus var. obcordatus. It inhibits α-Glucosidase with an IC50 of 1.68 mM.

     (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid Chemical Structure
  15. GC65777 (2-Pyridyldithio)-PEG2-Boc (2-Pyridyldithio)-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. (2-Pyridyldithio)-PEG2-Boc Chemical Structure
  16. GC65623 (2-pyridyldithio)-PEG4 acid (2-pyridyldithio)-PEG4 acid is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (2-pyridyldithio)-PEG4 acid Chemical Structure
  17. GC65703 (2-Pyridyldithio)-PEG4-alcohol (2-Pyridyldithio)-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. (2-Pyridyldithio)-PEG4-alcohol Chemical Structure
  18. GC11717 (24S)-MC 976 (24S)-MC 976 Chemical Structure
  19. GC68509 (25R)-12α-Hydroxyspirost-4-en-3-one

    (25R)-12α-Hydroxyspirost-4-en-3-one is a secondary metabolite produced by Nocardia globerula from Hecogenin.

     (25R)-12α-Hydroxyspirost-4-en-3-one Chemical Structure
  20. GC70234 (2R)-Octyl-α-hydroxyglutarate sodium (2R)-Octyl-α-hydroxyglutarate (sodium) is the sodium salt form of (2R)-Octyl-α-hydroxyglutarate. (2R)-Octyl-α-hydroxyglutarate sodium Chemical Structure
  21. GC70210 (2R)-SR59230A (2R)-SR59230A is the isomer of SR59230A , and can be used as an experimental control. (2R)-SR59230A Chemical Structure
  22. GC73089 (2R)-Vildagliptin

    (2R)-LAF237; (2R)-NVP-LAF 237

     (2R)-Vildagliptin is the isomer of Vildagliptin , and can be used as an experimental control. (2R)-Vildagliptin Chemical Structure
  23. GC73162 (2R,2R)-PF-07258669 (2R,2R)-PF-07258669 is a MC4R (melanocortin 4 receptor) antagonist. (2R,2R)-PF-07258669 Chemical Structure
  24. GC70784 (2R,3R)-Firazorexton (2R,3R)-Firazorexton ((2R,3R)-TAK-994 free base) is an isomer of Firazorexton . (2R,3R)-Firazorexton Chemical Structure
  25. GC73067 (2R,3R)-GSK973 (2R,3R)-GSK973 is an isomer of GSK973. (2R,3R)-GSK973 Chemical Structure
  26. GC68522 (2R,3S)-Brassinazole

    Brassinazole (0.5, 1, 5 μM) significantly caused morphological abnormalities in seedlings similar to BR-deficient mutants. Brassinazole resulted in dwarfism and altered leaf morphology, such as the typical downward curling and dark green appearance seen in Arabidopsis BR-deficient mutants. However, treatment with 10 nM BR reversed the dwarfism.

     (2R,3S)-Brassinazole Chemical Structure
  27. GC70605 (2R,4S)-Hydroxy Itraconazole-d5 (2R,4S)-Hydroxy Itraconazole-d5 is the deuterium labeled (2R,4S)-Hydroxy Itraconazole. (2R,4S)-Hydroxy Itraconazole-d5 Chemical Structure
  28. GC68524 (2S)-N3-IsoSer (DCHA)

    "(2S)-N3-IsoSer DCHA" is a click chemistry reagent, which is a chiral α-hydroxy acid containing azide."

     (2S)-N3-IsoSer (DCHA) Chemical Structure
  29. GC68523 (2S,3R)-Brassinazole

    (2S,3R)-Brassinazole is an isomer of brassinazole, which is a compound that inhibits the biosynthesis of brassinosteroids (BR), a class of plant steroids, by acting on the oxidation process from 6-oxo-campestanol to teasterone. (2S,3R)-Brassinazole may be the most active form of brassinazole.

     (2S,3R)-Brassinazole Chemical Structure
  30. GC72621 (2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine (2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine is the isomer of 7-Deaza-2'-deoxy-7-iodoadenosine , and can be used as an experimental control. (2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine Chemical Structure
  31. GC72663 (3E,8Z,11Z)-3,8,11-Tetradecatrienyl acetate (3E,8Z,11Z)-3,8,11-Tetradecatrienyl acetate is a sex pheromone capable of attracting male South American tomato pinworms (Scrobipalpuloides absoluta), which can be isolated from the tomato pest. (3E,8Z,11Z)-3,8,11-Tetradecatrienyl acetate Chemical Structure
  32. GC73117 (3R,10R,14aS)-AZD4625 (3R,10R,14aS)-AZD4625 is the isomer of AZD4625 , and can be used as an experimental control. (3R,10R,14aS)-AZD4625 Chemical Structure
  33. GC72813 (3R,5R,6S)-Atogepant

    (3R,5R,6S)-MK-8031; (3R,5R,6S)-AGN-241689

     (3R,5R,6S)-Atogepant ((3R,5R,6S)-MK-8031) is the enantiomer of Atogepant. (3R,5R,6S)-Atogepant Chemical Structure
  34. GC73214 (3S,4R)-GNE-6893 (3S,4R)-GNE-6893 is a potent and orally active HPK1 inhibitor. (3S,4R)-GNE-6893 Chemical Structure
  35. GC74160 (3S,4S)-Tivantinib

    (3S,4S)-ARQ 197; ARQ 198

     (3S,4S)-Tivantinib is a potent and highly selective inhibitor of the receptor tyrosine kinase c-MET. (3S,4S)-Tivantinib Chemical Structure
  36. GC68317 (3S,5R)-Fluvastatin-d6 sodium

    (3S,5R)-XU 62-320 D6

     (3S,5R)-Fluvastatin-d6 sodium Chemical Structure
  37. GC72936 (3S,5S,6R)-Navtemadlin

    (3S,5S,6R)-AMG 232; (3S,5S,6R)-KRT-232

     (3S,5S,6R)-Navtemadlin is the isomer of Navtemadlin , and can be used as an experimental control. (3S,5S,6R)-Navtemadlin Chemical Structure
  38. GC73101 (4S)-PROTAC SOS1 degrader-1 diTFA (4S)-PROTAC SOS1 degrader-1 (diTFA) is a potent PROTAC SOS1 degrader. (4S)-PROTAC SOS1 degrader-1 diTFA Chemical Structure
  39. GC68574 (6R)-ML753286

    (6R)-ML753286 is an isomer of ML753286. ML753286 is an orally active and selective inhibitor of BCRP (breast cancer resistance protein), with an IC50 of 0.6 μM. ML753286 has high permeability and low to moderate clearance in rodent and human liver S9 fractions, and plasma stability across different species.

     (6R)-ML753286 Chemical Structure
  40. GC72962 (7R)-SBP-0636457

    (7R)-SBI-0636457; (7R)-SB1-0636457

     (7R)-SBP-0636457 is the isomer of SBP-0636457 , and can be used as an experimental control. (7R)-SBP-0636457 Chemical Structure
  41. GC73955 (7S)-BAY-593 (7S)-BAY-593 is the S-enantiomer of BAY-593. (7S)-BAY-593 Chemical Structure
  42. GC73534 (9R,12aR)-AZD4747 (9R, 12aR)-AZD4747 is a diastereomer of AZD4747. (9R,12aR)-AZD4747 Chemical Structure
  43. GC68652 (Aminooxy)acetamide-Val-Cit-PAB-MMAE

    (Aminooxy)acetamide-Val-Cit-PAB-MMAE (MMAE 5) is an intermediate used in the synthesis and preparation of drug-conjugates for ADCs. It forms a MMAE polyamide conjugate by forming an oxime bond with a polyamide. The MMAE polyamide conjugate can then be linked to Trastuzumab to create an ADC.

     (Aminooxy)acetamide-Val-Cit-PAB-MMAE Chemical Structure
  44. GC52442 (D)-PPA 1 (trifluoroacetate salt)

    DPPA-1, NYSKPTDRQYHF

     An inhibitor of the PD-1-PD-L1 protein-protein interaction (D)-PPA 1 (trifluoroacetate salt) Chemical Structure
  45. GC69009 (D)-PPA 1 TFA

    (D)-PPA 1 TFA is an anti-hydrolysis D-peptide antagonist. It is an effective PD-1/PD-L1 inhibitor with an affinity of 0.51 μM for binding to PD-1, and it works both in vitro and in vivo.

     (D)-PPA 1 TFA Chemical Structure
  46. GC15373 (E)-2-Decenoic acid

    trans-2-Decylenic Acid

     An unsaturated fatty acid found in royal jelly (E)-2-Decenoic acid Chemical Structure
  47. GC66255 (E)-3,4,5-Trimethoxycinnamic acid

    TMCA

     (E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy. (E)-3,4,5-Trimethoxycinnamic acid Chemical Structure
  48. GC72618 (E)-3,4-Dimethoxychalcone (E)-3,4-Dimethoxychalcone is an isoform of 3,4-Dimethoxychalcone , a potential antimicrobial and antioxidant agent. (E)-3,4-Dimethoxychalcone Chemical Structure
  49. GC70220 (E)-Crotylbarbital (E)-Crotylbarbital is the isomer of Crotylbarbital. (E)-Crotylbarbital Chemical Structure
  50. GC66371 (E)-Ferulic acid-d3

    (E)-Coniferic acid-d3

     (E)-Ferulic acid-d3 ((E)-Coniferic acid-d3) is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. (E)-Ferulic acid-d3 Chemical Structure
  51. GC91418 (E)-KPT-330

    KTP-330; trans Selinexor

     (E)-KPT-330 is a metabolite of the exportin 1 (XPO1/CRM1) inhibitor selinexor. (E)-KPT-330 Chemical Structure
  52. GC67663 (E)-TCO-PEG4-NHS ester (E)-TCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. (E)-TCO-PEG4-NHS ester Chemical Structure
  53. GC72591 (E,E)-RGFP966 (E,E)-RGFP966 is a selective and CNS permeable HDAC3 inhibitor that can be used for the research of Huntington’s disease. (E,E)-RGFP966 Chemical Structure
  54. GC25000 (E/Z)-BCI

    BCI, NSC 150117

     (E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells. (E/Z)-BCI Chemical Structure
  55. GC91543 (E/Z)-Droloxifene

    3-Hydroxytamoxifen

     (E/Z)-Droloxifene is a mixture of (E)-droloxifene, a selective estrogen receptor modulator (SERM), and (Z)-droloxifene. (E/Z)-Droloxifene Chemical Structure
  56. GC72756 (E/Z)-Necrosulfonamide (E/Z)-Necrosulfonamide is a racemic compound of Necrosulfonamide. (E/Z)-Necrosulfonamide Chemical Structure
  57. GC67476 (E/Z)-Sulindac sulfide (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM). (E/Z)-Sulindac sulfide selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease. (E/Z)-Sulindac sulfide Chemical Structure
  58. GC72216 (Gly14)-Humanin (human) (acetate) (Gly14)-Humanin (human) (14-Glycine-Humanin (human)) acetate is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) (acetate) Chemical Structure
  59. GA11210 (H-Cys-OH)2

    (-)-Cystine, NSC 13203

     (H-Cys-OH)2 Chemical Structure
  60. GC72210 (Leu31,Pro34)-Peptide YY (human) (TFA) (Leu31,Pro34)-Peptide YY (human) (TFA) is the TFA form of (Leu31,Pro34)-Peptide YY (human) . (Leu31,Pro34)-Peptide YY (human) (TFA) Chemical Structure
  61. GC72235 (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin acetate (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin is a potent vasopressin V1 receptor (VP V1R) antagonist. (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin acetate Chemical Structure
  62. GC72195 (Pro3) GIP, human TFA (Pro3) GIP, human TFA is an efficacious, stable and specifichuman GIP receptor (hGIPR)full agonist. (Pro3) GIP, human TFA Chemical Structure
  63. GN10783 (R) Ginsenoside Rh2 (R) Ginsenoside Rh2 Chemical Structure
  64. GC74692 (R)-(+)-Aminoglutethimide

    d-Aminoglutethimide

     (R)-(+)-Aminoglutethimide is a potent and orally active aromatase inhibitor. (R)-(+)-Aminoglutethimide Chemical Structure
  65. GC69834 (R)-(+)-Dimethindene maleate

    (R)-(+)-Dimethindene maleate is an orally active H1-receptor blocker with anti-histamine properties in pigs.

     (R)-(+)-Dimethindene maleate Chemical Structure
  66. GC74261 (R)-(+)-O-Demethylbuchenavianine (R)-(+)-O-Demetlbuchenavianine is an inhibitor for Cyclin-dependent kinases (CDK). (R)-(+)-O-Demethylbuchenavianine Chemical Structure
  67. GC69823 (R)-(-)-Ibuprofen-d3

    (R)-Ibuprofen-d3

    (R)-(-)-Ibuprofen-d3 is the deuterated form of (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, which has no effect on COX and can inhibit NF-κB activation. (R)-(-)-Ibuprofen has anti-inflammatory properties and can be used in pain relief research.

     (R)-(-)-Ibuprofen-d3 Chemical Structure
  68. GC91185 (R)-(-)-Metalaxyl-d6

    An internal standard for the quantification of (R)-(−)-metalaxyl

     (R)-(-)-Metalaxyl-d6 Chemical Structure
  69. GC91359 (R)-(4-Bromophenyl)(phenyl)methanamine (R)-(4-Bromophenyl)(phenyl)methanamine is a synthetic intermediate. (R)-(4-Bromophenyl)(phenyl)methanamine Chemical Structure
  70. GC91125 (R)-2-(3-(2-Ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic Acid

    An intermediate in the synthesis of ervogastat

     (R)-2-(3-(2-Ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic Acid Chemical Structure
  71. GC71626 (R)-3-Hydroxybutanoic acid-13C2 sodium (R)-3-Hydroxybutanoic acid-13C2 (sodium) is the 13C labeled (R)-3-Hydroxybutanoic acid (sodium) . (R)-3-Hydroxybutanoic acid-13C2 sodium Chemical Structure
  72. GC69793 (R)-5-O-Benzoyl-1,2-di-O-isopropylidene-alpha-D-xylofuranose

    (R)-5-O-Benzoyl-1,2-di-O-isopropylidene-alpha-D-xylofuranose is a purine nucleoside analogue. Purine nucleoside analogues have broad anti-tumor activity and target inert lymphoid malignancies. The anticancer mechanism in this process depends on inhibiting DNA synthesis, inducing apoptosis (cell death), etc.

     (R)-5-O-Benzoyl-1,2-di-O-isopropylidene-alpha-D-xylofuranose Chemical Structure
  73. GC66904 (R)-8-Azido-2-(Fmoc-amino)octanoic acid (R)-8-Azido-2-(Fmoc-amino)octanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (R)-8-Azido-2-(Fmoc-amino)octanoic acid Chemical Structure
  74. GC91906 (R)-AS-1 (R)-AS-1 is a positive allosteric modulator of excitatory amino acid transporter 2 (EAAT2; EC50 = 11 nM in a glutamate uptake assay). (R)-AS-1 Chemical Structure
  75. GC67688 (R)-Asundexian

    (R)-BAY-2433334

     (R)-Asundexian Chemical Structure
  76. GC25001 (R)-Avanafil R-Avanafil is a strong competitive inhibitor of phosphodiesterase 5 (PDE5) with a demonstrated in vitro IC 50 of 5.2 nM. (R)-Avanafil Chemical Structure
  77. GC73037 (R)-Benpyrine (R)-Benpyrine is the isomer of Benpyrine , and can be used as an experimental control. (R)-Benpyrine Chemical Structure
  78. GC72968 (R)-BI-2852 (R)-BI-2852 is the isomer of BI-2852 , and can be used as an experimental control. (R)-BI-2852 Chemical Structure
  79. GC73749 (R)-Birabresib

    (R)-OTX-015; (R)-MK-8628

     (R)-Birabresib is the isomer of Birabresib , and can be used as an experimental control. (R)-Birabresib Chemical Structure
  80. GC69805 (R)-Casopitant

    (R)-GW679769

    (R)-Casopitant ((R)-GW679769) is an isomer of Casopitant. Casopitant is an NK(1) receptor antagonist that can be used in the research of chemotherapy-induced nausea and vomiting.

     (R)-Casopitant Chemical Structure
  81. GC14729 (R)-Crizotinib

    PF 2341066

     A c-MET and ALK receptor tyrosine kinase inhibitor (R)-Crizotinib Chemical Structure
  82. GC73545 (R)-DZD1516 (R)-DZD1516 is the R enantiomer of DZD1516. (R)-DZD1516 Chemical Structure
  83. GC69812 (R)-Elexacaftor

    (R)-VX-445

    (R)-Elexacaftor is the enantiomer of Elexacaftor (Compound 1) and comes from Compound 37 in patent WO2018107100A1. It is a corrector of cystic fibrosis transmembrane conductance regulator (CFTR), with an EC50 value of 0.29 uM for CFTR dF508.

     (R)-Elexacaftor Chemical Structure
  84. GC67857 (R)-Elsubrutinib

    (R)-ABBV-105

     (R)-Elsubrutinib Chemical Structure
  85. GC74127 (R)-Exatecan Intermediate 1 (R)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1. (R)-Exatecan Intermediate 1 Chemical Structure
  86. GC70240 (R)-Fasiglifam (R)-Fasiglifam is the isomer of Fasiglifam , and can be used as an experimental control. (R)-Fasiglifam Chemical Structure
  87. GC73116 (R)-FT709 (R)-FT709 is an active compound. (R)-FT709 Chemical Structure
  88. GC70492 (R)-GDC-0927 (R)-GDC-0927 ((R)-SRN-927) is a (R)-enantiomer of GDC-0927 . (R)-GDC-0927 Chemical Structure
  89. GC73737 (R)-GSK866 (R)-GSK866 is the (R)-enantiomer of GSK866. (R)-GSK866 Chemical Structure
  90. GC70906 (R)-HH2853 (R)-HH2853 is a mutant EZH2 inhibitor with an IC50 of <100 nM for EZH2-Y641F. (R)-HH2853 Chemical Structure
  91. GC52290 (R)-HTS-3 An inhibitor of LPCAT3 (R)-HTS-3 Chemical Structure
  92. GC70609 (R)-IDO/TDO-IN-1 (R)-IDO/TDO-IN-1 (compound 25) is an indoleamine-2,3-dioxygenase (IDO) inhibitor, with good pharmacokinetic properties. (R)-IDO/TDO-IN-1 Chemical Structure
  93. GC72833 (R)-INCB054329 (R)-INCB054329 is the isomer of INCB054329 , and can be used as an experimental control. (R)-INCB054329 Chemical Structure
  94. GC67864 (R)-Irsenontrine

    (R)-E2027

     (R)-Irsenontrine Chemical Structure
  95. GC70322 (R)-L 888607 (R)-L 888607 is the isomer of L 888607 , and can be used as an experimental control. (R)-L 888607 Chemical Structure
  96. GC66419 (R)-Lercanidipine-d3 hydrochloride (R)-lercanidipine D3 (hydrochloride) is a deuterium labeled (R)-Lercanidipine hydrochloride. (R)-Lercanidipine D3 (hydrochloride), the R-enantiomer of Lercanidipine, is a calcium channel blocker. (R)-Lercanidipine-d3 hydrochloride Chemical Structure
  97. GC73528 (R)-M3913

    (R)-M3913(compound C-155) is a enantiomer of M3913.

     (R)-M3913 Chemical Structure
  98. GC71217 (R)-mchm5U (R)-mchm5U is a diastereomer of (S)-mchm5U . (R)-mchm5U Chemical Structure
  99. GC70839 (R)-Merimepodib (R)-Merimepodib is the isomer of Merimepodib , and can be used as an experimental control. (R)-Merimepodib Chemical Structure
  100. GC67937 (R)-Mirtazapine

    (R)-Org3770; (R)-6-Azamianserin

     (R)-Mirtazapine Chemical Structure
  101. GC70870 (R)-MK-5046 (R)-MK-5046 is the isomer of MK-5046 , and can be used as an experimental control. (R)-MK-5046 Chemical Structure

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