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Home >> Signaling Pathways

Signaling Pathways

The antibody-drug conjugate (ADC), a humanized or human monoclonal antibody conjugated with highly cytotoxic small molecules (payloads) through chemical linkers, is a novel therapeutic format and has great potential to make a paradigm shift in cancer chemotherapy. The three components of the ADC together give rise to a powerful oncolytic agent capable of delivering normally intolerable cytotoxins directly to cancer cells, which then internalize and release the cell-destroying drugs. At present, two ADCs, Adcetris and Kadcyla, have received regulatory approval with >40 others in clinical development.

ADCs are administered intravenously in order to prevent the mAb from being destroyed by gastric acids and proteolytic enzymes. The mAb component of the ADC enables it to circulate in the bloodstream until it finds and binds to tumor-specific cell surface antigens present on target cancer cells. Linker chemistry is an important determinant of the safety, specificity, potency and activity of ADCs. Linkers are designed to be stable in the blood stream (to conform to the increased circulation time of mAbs) and labile at the cancer site to allow rapid release of the cytotoxic drug. First generation ADCs made use of early cytotoxins such as the anthracycline, doxorubicin or the anti-metabolite/antifolate agent, methotrexate. Current cytotoxins have far greater potency and can be divided into three main groups: auristatins, maytansines and calicheamicins.

The development of site-specific conjugation methodologies for constructing homogeneous ADCs is an especially promising path to improving ADC design, which will open the way for novel cancer therapeutics.

References:

[1] Tsuchikama K, et al. Protein Cell. 2016 Oct 14. DOI:10.1007/s13238-016-0323-0.

[2] Peters C, et al. Biosci Rep. 2015 Jun 12;35(4). pii: e00225. doi: 10.1042/BSR20150089.

Targets for  Signaling Pathways

Products for  Signaling Pathways

  1. Cat.No. Product Name Information
  2. GC66692 (+)-Biotin-SLC (+)-Biotin-SLC is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. (+)-Biotin-SLC Chemical Structure
  3. GN10605 (+)-Catechin hydrate (+)-Catechin hydrate Chemical Structure
  4. GC63999 (+)-Coclaurine hydrochloride (+)-Coclaurine ((+)-(R)-Coclaurine) hydrochloride, benzyltetrahydroisoquinoline alkaloid isolated from a variety of plant sources. (+)-Coclaurine hydrochloride Chemical Structure
  5. GN10654 (+)-Corynoline (+)-Corynoline Chemical Structure
  6. GC61765 (+)-Isomenthone (+)-Isomenthone is an isomenthone isolated from Ziziphora clinopodioides Lam. (+)-Isomenthone Chemical Structure
  7. GC64207 (+)-JNJ-A07 (+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+)-JNJ-A07 Chemical Structure
  8. GC61595 (+)-JQ-1-aldehyde (+)-JQ-1-aldehyde is the aldehyde form of (+)-JQ1. (+)-JQ-1-aldehyde can be uesd as a precursor to synthesize PROTACs, which targets BET bromodomains. (+)-JQ-1-aldehyde Chemical Structure
  9. GC61647 (+)-Longifolene (+)-Longifolene is a sesquiterpenoid and a metabolite in rabbits. (+)-Longifolene Chemical Structure
  10. GC67931 (+)-Medioresinol (+)-Medioresinol Chemical Structure
  11. GC16616 (+)-MK 801 (+)-MK 801 Chemical Structure
  12. GC68210 (+)-Norfenfluramine (+)-Norfenfluramine Chemical Structure
  13. GC63969 (+)-Schisandrin B (+)-Schisandrin B is an enantiomer of Schisandrin B. (+)-Schisandrin B Chemical Structure
  14. GC48783 (+)-Sorokinianin A phytotoxic fungal metabolite (+)-Sorokinianin Chemical Structure
  15. GC69720 (+)SHIN2

    (+)SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor, and its in vivo target can be traced using 13C-serine. (+)SHIN2 increases the survival rate of mice with primary acute T-cell lymphoblastic leukemia (T-ALL) driven by Notch1 and has a synergistic effect with Methotrexate.

     (+)SHIN2 Chemical Structure
  16. GC49502 (-)-β-Sesquiphellandrene A sesquiterpene with antiviral and anticancer activities (-)-β-Sesquiphellandrene Chemical Structure
  17. GC61646 (-)-Camphoric acid (-)-Camphoric acid Chemical Structure
  18. GC48635 (-)-Cryptopleurine An alkaloid with diverse biological activities (-)-Cryptopleurine Chemical Structure
  19. GC63940 (-)-Denudatin B (-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B Chemical Structure
  20. GC14049 (-)-Epigallocatechin gallate (EGCG) (-)-Epigallocatechin Gallate sulfate (EGCG) is a major polyphenol in green tea that inhibits cell proliferation and induces apoptosis. In addition, it inhibits the activity of glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) .. (-)-Epigallocatechin gallate (EGCG) Chemical Structure
  21. GC63570 (-)-Hydroxycitric acid lactone (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone Chemical Structure
  22. GC13822 (-)-JQ1 A selective inhibitor of BET bromodomains (-)-JQ1 Chemical Structure
  23. GN10445 (-)-pareruptorin A (-)-pareruptorin A Chemical Structure
  24. GC48551 (-)-Physostigmine (salicylate) An alkaloid and cholinergic agent (-)-Physostigmine (salicylate) Chemical Structure
  25. GC62728 (1E)-CFI-400437 dihydrochloride (1E)-CFI-400437 dihydrochloride is a potent PLK4 (IC50= 0.6 nM) inhibitor and selective against other members of the PLK family (>10 μM). (1E)-CFI-400437 dihydrochloride inhibits Aurora A, Aurora B, KDR and FLT-3 with IC50s of 0.37, 0.21, 0.48, and 0.18 μM, respectively. Antiproliferative activity. (1E)-CFI-400437 dihydrochloride Chemical Structure
  26. GC62729 (1R)-α-Pinene (1R)-α-Pinene is a volatile monoterpene with antimicrobial activities. (1R)-α-Pinene Chemical Structure
  27. GC65363 (1R)-Tenofovir amibufenamide (1R)-Tenofovir amibufenamide ((1R)-HS-10234) is the isomer of Tenofovir amibufenamide, is an orally active antiviral agent. (1R)-Tenofovir amibufenamide Chemical Structure
  28. GC64062 (1R,2R)-ML-SI3

    (1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 (IC50 values of 1.6 and 2.3 μM) and a weak inhibitor (IC50 12.5 μM) of TRPML3.

     (1R,2R)-ML-SI3 Chemical Structure
  29. GC70081 (1R,2R)-U-50488 hydrochloride

    (1R,2R)-U-50488 hydrochloride is the absolute configuration of (±)-U-50488 hydrochloride. (±)-U-50488 hydrochloride is a κ opioid receptor agonist.

     (1R,2R)-U-50488 hydrochloride Chemical Structure
  30. GC67880 (1R,2S)-Xeruborbactam disodium (1R,2S)-Xeruborbactam disodium Chemical Structure
  31. GC62730 (1S)-Calcitriol (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). (1S)-Calcitriol Chemical Structure
  32. GC65547 (1S,2R)-Alicapistat (1S,2R)-Alicapistat ((1S,2R)-ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD). (1S,2R)-Alicapistat Chemical Structure
  33. GC62193 (1S,2S)-Bortezomib (1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans. (1S,2S)-Bortezomib Chemical Structure
  34. GC65885 (1S,3R)-GNE-502 (1S,3R)-GNE-502 (compound 179) is a potent ERα degrader with an EC50 value of 13 nM against ERα in MCF7 HCS. (1S,3R)-GNE-502 can be used to research cancer related with estrogen receptor. (1S,3R)-GNE-502 Chemical Structure
  35. GC68525 (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid

    (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid is a saponin that can be isolated from Rubus ellipticus var. obcordatus. It inhibits α-Glucosidase with an IC50 of 1.68 mM.

     (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid Chemical Structure
  36. GC63900 (2-pyridyldithio)-PEG1-hydrazine (2-pyridyldithio)-PEG1-hydrazine is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (2-pyridyldithio)-PEG1-hydrazine Chemical Structure
  37. GC65777 (2-Pyridyldithio)-PEG2-Boc (2-Pyridyldithio)-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. (2-Pyridyldithio)-PEG2-Boc Chemical Structure
  38. GC65623 (2-pyridyldithio)-PEG4 acid (2-pyridyldithio)-PEG4 acid is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (2-pyridyldithio)-PEG4 acid Chemical Structure
  39. GC65703 (2-Pyridyldithio)-PEG4-alcohol (2-Pyridyldithio)-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. (2-Pyridyldithio)-PEG4-alcohol Chemical Structure
  40. GC65337 (2-Pyridyldithio)-PEG4-propargyl (2-Pyridyldithio)-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. (2-Pyridyldithio)-PEG4-propargyl Chemical Structure
  41. GC11717 (24S)-MC 976 (24S)-MC 976 Chemical Structure
  42. GC68509 (25R)-12α-Hydroxyspirost-4-en-3-one

    (25R)-12α-Hydroxyspirost-4-en-3-one is a secondary metabolite produced by Nocardia globerula from Hecogenin.

     (25R)-12α-Hydroxyspirost-4-en-3-one Chemical Structure
  43. GC62731 (2R,3R)-Butane-2,3-diol (2R,3R)-Butane-2,3-diol is an endogenous metabolite. (2R,3R)-Butane-2,3-diol Chemical Structure
  44. GC68522 (2R,3S)-Brassinazole

    Brassinazole (0.5, 1, 5 μM) significantly caused morphological abnormalities in seedlings similar to BR-deficient mutants. Brassinazole resulted in dwarfism and altered leaf morphology, such as the typical downward curling and dark green appearance seen in Arabidopsis BR-deficient mutants. However, treatment with 10 nM BR reversed the dwarfism.

     (2R,3S)-Brassinazole Chemical Structure
  45. GC62130 (2R,5S)-Ritlecitinib (2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective JAK3 inhibitor (IC50=144.8 nM) extracted from patent US20150158864A1, example 68. (2R,5S)-Ritlecitinib Chemical Structure
  46. GC68524 (2S)-N3-IsoSer (DCHA)

    "(2S)-N3-IsoSer DCHA" is a click chemistry reagent, which is a chiral α-hydroxy acid containing azide."

     (2S)-N3-IsoSer (DCHA) Chemical Structure
  47. GC68523 (2S,3R)-Brassinazole

    (2S,3R)-Brassinazole is an isomer of brassinazole, which is a compound that inhibits the biosynthesis of brassinosteroids (BR), a class of plant steroids, by acting on the oxidation process from 6-oxo-campestanol to teasterone. (2S,3R)-Brassinazole may be the most active form of brassinazole.

     (2S,3R)-Brassinazole Chemical Structure
  48. GC64260 (2S,5S)-Censavudine (2S,5S)-Censavudine ((2S,5S)-OBP-601) is the (2S,5S)-enantiomer of Censavudine. (2S,5S)-Censavudine Chemical Structure
  49. GC63524 (32-Carbonyl)-RMC-5552 (32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2). (32-Carbonyl)-RMC-5552 Chemical Structure
  50. GC49690 (3R,5R)-Rosuvastatin (calcium salt) A potential impurity found in bulk preparations of rosuvastatin (3R,5R)-Rosuvastatin (calcium salt) Chemical Structure
  51. GC68317 (3S,5R)-Fluvastatin-d6 sodium (3S,5R)-Fluvastatin-d6 sodium Chemical Structure
  52. GC65358 (4-NH2)-Exatecan (4-NH2)-Exatecan, a topoisomerase inhibitor derivative extracted from patent US20200306243A1, compound A. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs). (4-NH2)-Exatecan Chemical Structure
  53. GC62710 (5α)-Stigmastane-3,6-dione (5α)-Stigmastane-3,6-dione is a naturally occurring sterol that could be isolated from fruits of Ailanthus altissima Swingle. (5α)-Stigmastane-3,6-dione Chemical Structure
  54. GC63685 (6R,7S)-Cefminox sodium heptahydrate (6R,7S)-Cefminox sodium heptahydrate is an isomer of Cefminox sodium heptahydrate. (6R,7S)-Cefminox sodium heptahydrate Chemical Structure
  55. GC49519 (6S)-5,6,7,8-tetrahydro-L-Biopterin (sulfate) A diastereomer of (6R)-5,6,7,8-tetrahydro-L-biopterin (6S)-5,6,7,8-tetrahydro-L-Biopterin (sulfate) Chemical Structure
  56. GC52100 (Arg)9 (trifluoroacetate salt) A cationic cell-penetrating peptide (Arg)9 (trifluoroacetate salt) Chemical Structure
  57. GC52442 (D)-PPA 1 (trifluoroacetate salt) An inhibitor of the PD-1-PD-L1 protein-protein interaction (D)-PPA 1 (trifluoroacetate salt) Chemical Structure
  58. GC15373 (E)-2-Decenoic acid An unsaturated fatty acid found in royal jelly (E)-2-Decenoic acid Chemical Structure
  59. GC66255 (E)-3,4,5-Trimethoxycinnamic acid (E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy. (E)-3,4,5-Trimethoxycinnamic acid Chemical Structure
  60. GC65239 (E)-3,4-(Methylenedioxy)cinnamic acid (E)-3,4-(Methylenedioxy)cinnamic acid is a cinnamic acid derivative obtained from the stem bark of Brombya platynema. (E)-3,4-(Methylenedioxy)cinnamic acid Chemical Structure
  61. GC61668 (E)-3,4-Dimethoxycinnamic acid (E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. (E)-3,4-Dimethoxycinnamic acid Chemical Structure
  62. GC49003 (E)-Ajoene A disulfide with diverse biological activities (E)-Ajoene Chemical Structure
  63. GC62122 (E)-Akt inhibitor-IV (E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor, with potent cytotoxic. (E)-Akt inhibitor-IV Chemical Structure
  64. GC62733 (E)-Coniferin (E)-Coniferin is the isomer of Coniferin. (E)-Coniferin Chemical Structure
  65. GC66371 (E)-Ferulic acid-d3 (E)-Ferulic acid-d3 ((E)-Coniferic acid-d3) is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. (E)-Ferulic acid-d3 Chemical Structure
  66. GC61437 (E)-Methyl 4-coumarate (E)-Methyl 4-coumarate (Methyl 4-hydroxycinnamate), found in several plants, such as green onion (Allium cepa) or noni (Morinda citrifolia L. (E)-Methyl 4-coumarate Chemical Structure
  67. GC62734 (E)-Oct-2-enoic acid (E)-Oct-2-enoic acid is an endogenous metabolite. (E)-Oct-2-enoic acid Chemical Structure
  68. GC63903 (E)-Osmundacetone (E)-Osmundacetone is the isomer of Osmundacetone. (E)-Osmundacetone Chemical Structure
  69. GC67663 (E)-TCO-PEG4-NHS ester (E)-TCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. (E)-TCO-PEG4-NHS ester Chemical Structure
  70. GC49189 (E/Z)-4-hydroxy Tamoxifen-d5 An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen (E/Z)-4-hydroxy Tamoxifen-d5 Chemical Structure
  71. GC61807 (E/Z)-AG490 (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3. (E/Z)-AG490 Chemical Structure
  72. GC25000 (E/Z)-BCI (E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells. (E/Z)-BCI Chemical Structure
  73. GC62407 (E/Z)-Eltrombopag 13C (E/Z)-Eltrombopag 13C ((E/Z)-SB-497115 13C4) is a mixture complex of E-Eltrombopag and Z-Eltrombopag, with 13C labeled. (E/Z)-Eltrombopag 13C Chemical Structure
  74. GC62735 (E/Z)-GO289 (E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function. (E/Z)-GO289 Chemical Structure
  75. GC62736 (E/Z)-GSK-3β inhibitor 1 (E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. (E/Z)-GSK-3β inhibitor 1 Chemical Structure
  76. GC61564 (E/Z)-IT-603 (E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). (E/Z)-IT-603 Chemical Structure
  77. GC62560 (E/Z)-Sivopixant (E/Z)-Sivopixant ((E/Z)-S-600918) is a potent P2X3 receptor antagonist with an IC50 of 4 nM. (E/Z)-Sivopixant Chemical Structure
  78. GC67476 (E/Z)-Sulindac sulfide (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM). (E/Z)-Sulindac sulfide selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease. (E/Z)-Sulindac sulfide Chemical Structure
  79. GC64657 (E/Z)-ZINC09659342 (E/Z)-ZINC09659342 is an inhibitor of Lbc-RhoA interaction. (E/Z)-ZINC09659342 Chemical Structure
  80. GC64429 (E/Z)-Zotiraciclib citrate (E/Z)-Zotiraciclib citrate is a potent CDK2, JAK2, and FLT3 inhibitor. (E/Z)-Zotiraciclib citrate Chemical Structure
  81. GC63864 (E/Z)-Zotiraciclib hydrochloride (E/Z)-Zotiraciclib ((E/Z)-TG02) hydrochloride is a potent CDK2, JAK2, and FLT3 inhibitor. (E/Z)-Zotiraciclib hydrochloride Chemical Structure
  82. GA11210 (H-Cys-OH)2 (H-Cys-OH)2 Chemical Structure
  83. GN10783 (R) Ginsenoside Rh2 (R) Ginsenoside Rh2 Chemical Structure
  84. GC69834 (R)-(+)-Dimethindene maleate

    (R)-(+)-Dimethindene maleate is an orally active H1-receptor blocker with anti-histamine properties in pigs.

     (R)-(+)-Dimethindene maleate Chemical Structure
  85. GC49167 (R)-(+)-Trityl glycidyl ether A synthetic precursor (R)-(+)-Trityl glycidyl ether Chemical Structure
  86. GC61425 (R)-(-)-1,2-Propanediol (R)-(-)-1,2-Propanediol is a (R)-enantiomer of 1,2-Propanediol that produced from glucose in Escherichia coli expressing NADH-linked glycerol dehydrogenase genes. (R)-(-)-1,2-Propanediol Chemical Structure
  87. GC61694 (R)-(-)-2-Butanol (R)-(-)-2-Butanol is released by the females of the white grub beetle, Dasylepida ishigakiensis, to attract males. (R)-(-)-2-Butanol Chemical Structure
  88. GC69823 (R)-(-)-Ibuprofen-d3

    (R)-(-)-Ibuprofen-d3 is the deuterated form of (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, which has no effect on COX and can inhibit NF-κB activation. (R)-(-)-Ibuprofen has anti-inflammatory properties and can be used in pain relief research.

     (R)-(-)-Ibuprofen-d3 Chemical Structure
  89. GC63791 (R)-(-)-JQ1 Enantiomer (R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect. (R)-(-)-JQ1 Enantiomer Chemical Structure
  90. GC62737 (R)-(-)-O-Desmethyl Venlafaxine D6 (R)-(-)-O-Desmethyl Venlafaxine D6 Chemical Structure
  91. GC61759 (R)-3-Hydroxybutanoic acid sodium (R)-3-Hydroxybutanoic acid sodium ((R)-3-Hydroxybutyric acid) is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium Chemical Structure
  92. GC65610 (R)-5-Hydroxy-1,7-diphenyl-3-heptanone (R)-5-Hydroxy-1,7-diphenyl-3-heptanone is a diarylheptanoid that can be found in Alpinia officinarum. (R)-5-Hydroxy-1,7-diphenyl-3-heptanone Chemical Structure
  93. GC69793 (R)-5-O-Benzoyl-1,2-di-O-isopropylidene-alpha-D-xylofuranose

    (R)-5-O-Benzoyl-1,2-di-O-isopropylidene-alpha-D-xylofuranose is a purine nucleoside analogue. Purine nucleoside analogues have broad anti-tumor activity and target inert lymphoid malignancies. The anticancer mechanism in this process depends on inhibiting DNA synthesis, inducing apoptosis (cell death), etc.

     (R)-5-O-Benzoyl-1,2-di-O-isopropylidene-alpha-D-xylofuranose Chemical Structure
  94. GC66904 (R)-8-Azido-2-(Fmoc-amino)octanoic acid (R)-8-Azido-2-(Fmoc-amino)octanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (R)-8-Azido-2-(Fmoc-amino)octanoic acid Chemical Structure
  95. GC67688 (R)-Asundexian (R)-Asundexian Chemical Structure
  96. GC25001 (R)-Avanafil R-Avanafil is a strong competitive inhibitor of phosphodiesterase 5 (PDE5) with a demonstrated in vitro IC 50 of 5.2 nM. (R)-Avanafil Chemical Structure
  97. GC64091 (R)-Azetidine-2-carboxylic acid (R)-Azetidine-2-carboxylic acid is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). (R)-Azetidine-2-carboxylic acid is also a alkyl chain-based PROTAC linker?that can be (R)-Azetidine-2-carboxylic acid Chemical Structure
  98. GC63781 (R)-BAY-899 (R)-BAY-899 is the R-enantiomer of BAY-899. (R)-BAY-899 Chemical Structure
  99. GC63906 (R)-BDP9066 (R)-BDP9066 is a potent inhibitor of myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK). (R)-BDP9066 blocks cancer cell invasion. (R)-BDP9066 has the potential for the research of proliferative diseases, such as cancer. (R)-BDP9066 Chemical Structure
  100. GC61491 (R)-Bicalutamide (R)-Bicalutamide is the (R)-enantiomer of Bicalutamide. (R)-Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R)-Bicalutamide is widely used for the research of prostate cancer. (R)-Bicalutamide Chemical Structure
  101. GC69805 (R)-Casopitant

    (R)-Casopitant ((R)-GW679769) is an isomer of Casopitant. Casopitant is an NK(1) receptor antagonist that can be used in the research of chemotherapy-induced nausea and vomiting.

     (R)-Casopitant Chemical Structure

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