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Home >> Signaling Pathways

Signaling Pathways

The antibody-drug conjugate (ADC), a humanized or human monoclonal antibody conjugated with highly cytotoxic small molecules (payloads) through chemical linkers, is a novel therapeutic format and has great potential to make a paradigm shift in cancer chemotherapy. The three components of the ADC together give rise to a powerful oncolytic agent capable of delivering normally intolerable cytotoxins directly to cancer cells, which then internalize and release the cell-destroying drugs. At present, two ADCs, Adcetris and Kadcyla, have received regulatory approval with >40 others in clinical development.

ADCs are administered intravenously in order to prevent the mAb from being destroyed by gastric acids and proteolytic enzymes. The mAb component of the ADC enables it to circulate in the bloodstream until it finds and binds to tumor-specific cell surface antigens present on target cancer cells. Linker chemistry is an important determinant of the safety, specificity, potency and activity of ADCs. Linkers are designed to be stable in the blood stream (to conform to the increased circulation time of mAbs) and labile at the cancer site to allow rapid release of the cytotoxic drug. First generation ADCs made use of early cytotoxins such as the anthracycline, doxorubicin or the anti-metabolite/antifolate agent, methotrexate. Current cytotoxins have far greater potency and can be divided into three main groups: auristatins, maytansines and calicheamicins.

The development of site-specific conjugation methodologies for constructing homogeneous ADCs is an especially promising path to improving ADC design, which will open the way for novel cancer therapeutics.

References:

[1] Tsuchikama K, et al. Protein Cell. 2016 Oct 14. DOI:10.1007/s13238-016-0323-0.

[2] Peters C, et al. Biosci Rep. 2015 Jun 12;35(4). pii: e00225. doi: 10.1042/BSR20150089.

Targets for  Signaling Pathways

Products for  Signaling Pathways

  1. Cat.No. Product Name Information
  2. GC73510 (S)-SKBG-1 (S)-SKBG-1 is an inactive and covalent NONO ligand, used for assay control. (S)-SKBG-1 Chemical Structure
  3. GC73683 (S)-STX-478 (S)-STX-478 is the S-enantiomer of STX-478. (S)-STX-478 Chemical Structure
  4. GC72828 (S)-Subasumstat

    (S)-TAK-981

     (S)-Subasumstat is the isomer of Subasumstat , and can be used as an experimental control. (S)-Subasumstat Chemical Structure
  5. GC66064 (S)-Thalidomide

    (S)-(-)-Thalidomide

     (S)-Thalidomide ((S)-(-)-Thalidomide) is the S-enantiomer of Thalidomide. (S)-Thalidomide has immunomodulatory, anti-inflammatory, antiangiogenic and pro-apoptotic effects. (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN) . (S)-Thalidomide Chemical Structure
  6. GC73435 (S)-TNG260 (S)-TNG260 is an isomer of TNG260. (S)-TNG260 Chemical Structure
  7. GC69977 (S)-Veliflapon

    (S)-BAY X 1005; (S)-DG-031

    (S)-Veliflapon ((S)-BAY X 1005) is an orally active leukotriene biosynthesis and 5-lipoxygenase activating protein (FLAP) inhibitor. It inhibits the formation of leukotriene B4 (LTB4) in rat, mouse, and human white blood cells with IC50 values of 0.026 μM, 0.039 μM, and 0.22 μM respectively. (S)-Veliflapon exhibits enantioselectivity in human whole blood.

     (S)-Veliflapon Chemical Structure
  8. GC69979 (S)-VQW-765

    (S)-AQW-051

    (S)-VQW-765 ((S)-AQW-051) is a partial agonist of the α7 nicotinic acetylcholine receptor (nAChR) with oral activity, selectivity and efficacy. It has potential applications in cognitive impairments associated with neurological diseases such as Alzheimer's disease or schizophrenia.

     (S)-VQW-765 Chemical Structure
  9. GC72758 (S,R)-S63845 (S,R)-S63845 is the isomer of S63845 , and can be used as an experimental control. (S,R)-S63845 Chemical Structure
  10. GC65883 (S,R)-WT IDH1 Inhibitor 2

    GSK321

     (S,R)-WT IDH1 Inhibitor 2 (GSK321) is a potent, selective mutant IDH1 inhibitor with IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. (S,R)-WT IDH1 Inhibitor 2 induces decrease in intracellular 2-HG, abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. (S,R)-WT IDH1 Inhibitor 2 can be used for research of acute myeloid leukemia (AML) and other cancers. (S,R)-WT IDH1 Inhibitor 2 Chemical Structure
  11. GC73839 (S,R,R)-VBY-825 (S, R, R)-VBY-825 is the isomer of VBY-825 , and can be used as an experimental control. (S,R,R)-VBY-825 Chemical Structure
  12. GC69944 (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA

    (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is a synthetic E3 ligase ligand-linker conjugate containing the (S,R,S)-AHPC ligand, which can be used in PROTAC research.

     (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA Chemical Structure
  13. GC69945 (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA

    "(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA" is a synthetic E3 ligase ligand-linker conjugate, which includes a ligand based on (S,R,S)-AHPC and a three-unit PEG linker."

     (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA Chemical Structure
  14. GC69946 (S,R,S)-AHPC-amido-C7-acid

    (S,R,S)-AHPC-amido-C7-acid contains a VHL ligand for recruiting E3 ubiquitin ligases and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used for designing PROTACs.

     (S,R,S)-AHPC-amido-C7-acid Chemical Structure
  15. GC69947 (S,R,S)-AHPC-C10-NHBoc

    (S,R,S)-AHPC-C10-NHBoc is a synthetic E3 ligase ligand-linker conjugate, containing a VHL ligand based on (S,R,S)-AHPC and one linker. It can be used to synthesize targeted PROTACs for BET.

     (S,R,S)-AHPC-C10-NHBoc Chemical Structure
  16. GC68352 (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine Chemical Structure
  17. GC69743 (S,R,S)-AHPC-C4-NH2 hydrochloride

    VH032-C4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 28

    (S,R,S)-AHPC-C4-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate, containing a VHL ligand based on (S,R,S)-AHPC and one linker. It is used for the synthesis of targeted PROTACs for EED.

     (S,R,S)-AHPC-C4-NH2 hydrochloride Chemical Structure
  18. GC69948 (S,R,S)-AHPC-CO-C9-acid

    VH032-NH-CO-C9-acid

    "(S,R,S)-AHPC-CO-C9-acid" is a ligand-linker complex of E3 ligase, which can be attached to the ligand of a protein to form a PROTAC."

     (S,R,S)-AHPC-CO-C9-acid Chemical Structure
  19. GC69949 (S,R,S)-AHPC-isobutyl acetate-methanesulfonothioate-Me-C10-NH2 TFA

    (Please note that this is a chemical name and may not have a direct translation into English) (Please also note that the use of chemicals should only be done by trained professionals in appropriate settings with proper safety measures.) (Please consult with a professional chemist for accurate information regarding this compound.) The (S,R,S)-AHPC-isobutyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is part of PROTAC BRD4 Degrader-12.

     (S,R,S)-AHPC-isobutyl acetate-methanesulfonothioate-Me-C10-NH2 TFA Chemical Structure
  20. GC67831 (S,R,S)-AHPC-Me-C10-Br (S,R,S)-AHPC-Me-C10-Br Chemical Structure
  21. GC67729 (S,R,S)-AHPC-Me-C6-NH2 (S,R,S)-AHPC-Me-C6-NH2 Chemical Structure
  22. GC66630 (S,R,S)-AHPC-PEG2-acid (S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. (S,R,S)-AHPC-PEG2-acid Chemical Structure
  23. GC73083 (S,S)-BMS-984923 (S,S)-BMS-984923 is a less active (S,S)-enantiomer of BMS-984923. (S,S)-BMS-984923 Chemical Structure
  24. GC73104 (S,S)-CPI-1612 (S,S)-CPI-1612 is the isomer of CPI-1612 , and can be used as an experimental control. (S,S)-CPI-1612 Chemical Structure
  25. GC67672 (S,S)-GNE 5729 (S,S)-GNE 5729 Chemical Structure
  26. GC67682 (S,S)-GSK321 (S,S)-GSK321 Chemical Structure
  27. GC73095 (S,S,R)-AHPC-C6-NH2 hydrochloride (S,S,R)-AHPC-C6-NH2 drochloride is the drochloride salt form of (S,S,R)-AHPC-C6-NH2. (S,S,R)-AHPC-C6-NH2 hydrochloride Chemical Structure
  28. GC74175 (S,S,R,S,R)-Boc-Dap-NE (S,S,R,S,R)-Boc-Dap-NE is an isomer of the dipeptide Boc-Dap-NE. (S,S,R,S,R)-Boc-Dap-NE Chemical Structure
  29. GC72938 (S,S,S)-AHPC-Boc

    (S,S,S)-VH032-Boc

     (S,S,S)-AHPC-Boc is the isomer of (S,R,S)-AHPC-Boc , and can be used as an experimental control. (S,S,S)-AHPC-Boc Chemical Structure
  30. GC74174 (S,S,S,S,R)-Boc-Dap-NE (S,S,S,S,R)-Boc-Dap-NE is the inactive isomer of Boc-Dap-NE , and can be used as an experimental control. (S,S,S,S,R)-Boc-Dap-NE Chemical Structure
  31. GC67761 (Z)-10-Hydroxynortriptyline-d3 (Z)-10-Hydroxynortriptyline-d3 Chemical Structure
  32. GC73208 (Z)-JQ1-TCO JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 , an inhibitor of BET. (Z)-JQ1-TCO Chemical Structure
  33. GC72798 (Z)-ONO 1301

    (Z)-ONO-AP 500-02

     (Z)-ONO 1301 is the isomer of ONO 1301 , and can be used as an experimental control. (Z)-ONO 1301 Chemical Structure
  34. GC26181 (±)-Catechin

    rel-Cianidanol; rel-Catechuic acid

    (±) - Catechin (rel Xianidanol) is the racemate of Catechin.

     (±)-Catechin Chemical Structure
  35. GC11965 (±)-Huperzine A

    Hup A, (-)-Selagine

     A neuroprotective AChE inhibitor (±)-Huperzine A Chemical Structure
  36. GC20027 (±)5(6)-DiHET MaxSpec® Standard

    (±)5,6-DiHETrE

    5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET by epoxide hydrolases.

     (±)5(6)-DiHET MaxSpec® Standard Chemical Structure
  37. GC26151 (−)-Apomorphine (hydrochloride hydrate)

    5,6,6aR,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol, monohydrochloride, hydrate

     (-)-Apomorphine (hydrochloride hydrate) acts as a potent dopamine receptor agonist with a broad spectrum on all D1- and D2-like receptors (D1, D2S, D2L, D3, D4, D5). (−)-Apomorphine (hydrochloride hydrate) Chemical Structure
  38. GC26094 (−)-Apomorphine (hydrochloride)

    NSC 11442

     (−)-Apomorphine (hydrochloride) Chemical Structure
  39. GC74183 1'-epi Gemcitabine hydrochloride

    1'-epi LY 188011 hydrochloride

     1'-epi Gemcitabine drochloride is the isomer of Gemcitabine drochloride , and can be used as an experimental control. 1'-epi Gemcitabine hydrochloride Chemical Structure
  40. GC65729 1,1,1-Trifluoroethyl-PEG2-azide 1,1,1-Trifluoroethyl-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG2-azide Chemical Structure
  41. GC65715 1,1,1-Trifluoroethyl-PEG2-propargyl 1,1,1-Trifluoroethyl-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG2-propargyl Chemical Structure
  42. GC66567 1,1,1-Trifluoroethyl-PEG4-alcohol 1,1,1-Trifluoroethyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG4-alcohol Chemical Structure
  43. GC67011 1,1,1-Trifluoroethyl-PEG4-amine 111-Trifluoroethyl-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG4-amine Chemical Structure
  44. GC67295 1,1,1-Trifluoroethyl-PEG4-aminooxy 1,1,1-Trifluoroethyl-PEG4-aminooxy is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG4-aminooxy Chemical Structure
  45. GC67595 1,1,1-Trifluoroethyl-PEG4-azide 111-Trifluoroethyl-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG4-azide Chemical Structure
  46. GC66971 1,1,1-Trifluoroethyl-PEG4-propargyl 1,1,1-Trifluoroethyl-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG4-propargyl Chemical Structure
  47. GC65718 1,1,1-Trifluoroethyl-PEG4-Tos 1,1,1-Trifluoroethyl-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG4-Tos Chemical Structure
  48. GC67833 1,1,3-Tribromoacetone 1,1,3-Tribromoacetone Chemical Structure
  49. GC71868 1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid 1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid is a Triterpenoid that isolated from the plant of Agrimonia Pilosa with antimalarial and antidiabetic activities. 1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid Chemical Structure
  50. GC17055 1,2,3,4,5,6-Hexabromocyclohexane

    Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation.

     1,2,3,4,5,6-Hexabromocyclohexane Chemical Structure
  51. GC90942 1,2,3,4,6,7,8,9-Octachlorodibenzofuran

    A dioxin-like polychlorinated dibenzofuran

     1,2,3,4,6,7,8,9-Octachlorodibenzofuran Chemical Structure
  52. GC90936 1,2,3,4,6,7,8-Heptachlorodibenzofuran

    A dioxin-like polychlorinated dibenzofuran

     1,2,3,4,6,7,8-Heptachlorodibenzofuran Chemical Structure
  53. GC90937 1,2,3,4,7,8,9-Heptachlorodibenzofuran

    A dioxin-like polychlorinated dibenzofuran

     1,2,3,4,7,8,9-Heptachlorodibenzofuran Chemical Structure
  54. GC90938 1,2,3,4,7,8-Hexachlorodibenzofuran

    A dioxin-like polychlorinated dibenzofuran

     1,2,3,4,7,8-Hexachlorodibenzofuran Chemical Structure
  55. GC71736 1,2,3,4-Tetrahydrobenzo[h]quinolin-3-ol 1,2,3,4-Tetrahydrobenzo[h]quinolin-3-ol is a biological material or organic compound that can be used in life science research. 1,2,3,4-Tetrahydrobenzo[h]quinolin-3-ol Chemical Structure
  56. GC90934 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin

    A polychlorinated dibenzodioxin

     1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin Chemical Structure
  57. GC90939 1,2,3,6,7,8-Hexachlorodibenzofuran

    A dioxin-like polychlorinated dibenzofuran

     1,2,3,6,7,8-Hexachlorodibenzofuran Chemical Structure
  58. GC90940 1,2,3,7,8,9-Hexachlorodibenzofuran

    A dioxin-like polychlorinated dibenzofuran

     1,2,3,7,8,9-Hexachlorodibenzofuran Chemical Structure
  59. GC90943 1,2,3,7,8-Pentachlorodibenzofuran

    A dioxin-like polychlorinated dibenzofuran

     1,2,3,7,8-Pentachlorodibenzofuran Chemical Structure
  60. GC92074 1,2,3-Trioleoyl Glycerol-d5

    Glyceryl Trioleate-d5; TG(18:1/18:1/18:1)-d5; Triolein-d5

     1,2,3-Trioleoyl glycerol-d5 is intended for use as an internal standard for the quantification of 1,2,3-trioleoyl glycerol by GC- or LC-MS. 1,2,3-Trioleoyl Glycerol-d5 Chemical Structure
  61. GC66452 1,2-Bis(3-(trifluoromethyl)phenyl)diselane 1,2-Bis(3-(trifluoromethyl)phenyl)diselane is an active compound and can be used for research. 1,2-Bis(3-(trifluoromethyl)phenyl)diselane Chemical Structure
  62. GC90744 1,2-Dioleoyl-3(R)-trimethylammoniumpropane (chloride)

    A cationic lipid

     1,2-Dioleoyl-3(R)-trimethylammoniumpropane (chloride) Chemical Structure
  63. GC90745 1,2-Dioleoyl-3(S)-trimethylammoniumpropane (chloride)

    A cationic lipid

     1,2-Dioleoyl-3(S)-trimethylammoniumpropane (chloride) Chemical Structure
  64. GC68484 1,2-O-Isopropylidene-5-O-p-toluoyl-a-D-xylofuranose

    1,2-O-Isopropylidene-5-O-p-toluoyl-a-D-xylofuranose is a purine nucleoside analogue. Purine nucleoside analogues have broad anti-tumor activity and target malignant tumors in the inert lymphatic system. The anticancer mechanism in this process depends on inhibiting DNA synthesis, inducing apoptosis (cell death), etc.

     1,2-O-Isopropylidene-5-O-p-toluoyl-a-D-xylofuranose Chemical Structure
  65. GC66949 1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane 1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane Chemical Structure
  66. GC67054 1,3-Bis-aminooxy propane 1,3-Bis-aminooxy propane is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. 1,3-Bis-aminooxy propane Chemical Structure
  67. GC67985 1,3-Oxazolidine-2-thione 1,3-Oxazolidine-2-thione Chemical Structure
  68. GC68134 1,3-Propanesultam

    1,1-Dioxoisothiazolidine

     1,3-Propanesultam Chemical Structure
  69. GC68486 1,4-Diaminobutane-d8 dihydrochloride 1,4-Diaminobutane-d8 dihydrochloride is the deuterium-substituted 1,4-Diaminobutane dihydrochloride, which is more stable and largely as tracer for quantitation during the drug development process. 1,4-Diaminobutane-d8 dihydrochloride Chemical Structure
  70. GC67200 1,6-Bis(mesyloxy)hexane 16-Bismesyloxyhexane is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1,6-Bis(mesyloxy)hexane Chemical Structure
  71. GC71928 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one is a potent nucleocapsid (N) protein inhibitor can be isolated from Curcuma kwangsiensis. 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one Chemical Structure
  72. GC70586 1,7-Dimethyluric acid-d3 1,7-Dimethyluric acid-d3 is the deuterium labeled 1,7-Dimethyluric acid. 1,7-Dimethyluric acid-d3 Chemical Structure
  73. GC71294 1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine 1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine is a thymidine analog. 1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine Chemical Structure
  74. GC52356 1-1(Z)-Hexadecenyl-2-Arachidonoyl-sn-glycero-3-PC

    1-1(Z)-Hexadecenyl-2-Arachidonoyl-sn-glycero-3-Phosphocholine, 1-1(Z)-Hexadecenyl-2-Arachidonoyl-sn-glycero-3-Phosphatidylcholine, 16:0p/20:4-PC, PC(P-16:0/20:4), C16(plasm)-20:4-PC, PlgPC 16:0/20:4

     A plasmalogen 1-1(Z)-Hexadecenyl-2-Arachidonoyl-sn-glycero-3-PC Chemical Structure
  75. GC90952 1-Aminoguanosine-3',5'-monophosphate (sodium salt)

    A substrate for cGMP-dependent protein kinase

     1-Aminoguanosine-3',5'-monophosphate (sodium salt) Chemical Structure
  76. GN10317 1-Deoxynojirimycin

    BAY-h-5955, D-1-Deoxynojirimycin, 1-DNJ, 1-dNM, Moranoline

     1-Deoxynojirimycin Chemical Structure
  77. GC74704 1-Ethenylpyrene

    1-Vinylpyrene

     1-Ethenylpyrene (1-Vinylpyrene) is an anti-chemical carcinogen that inhibits the formation of skin tumors initiated by either DMBA or Benzo[a]pyrene. 1-Ethenylpyrene Chemical Structure
  78. GC67844 1-Fluoronaphthalene 1-Fluoronaphthalene Chemical Structure
  79. GC26199 1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine 1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine Chemical Structure
  80. GC68495 1-Hexadecanol-d4

    1-Hexadecanol-d4 is the deuterated form of 1-hexadecanol. 1-Hexadecanol is a fatty alcohol, which is a hydrophobic substrate.

     1-Hexadecanol-d4 Chemical Structure
  81. GC68496 1-Hexadecanol-d5

    1-Hexadecanol-d5 is the deuterated form of 1-hexadecanol. 1-Hexadecanol is a fatty alcohol, which is a hydrophobic substrate.

     1-Hexadecanol-d5 Chemical Structure
  82. GC72552 1-Hydroxypyrene-d9 1-Hydroxypyrene-d9 is the deuterium labeled 1-Hydroxypyrene. 1-Hydroxypyrene-d9 Chemical Structure
  83. GC25004 1-Iodoadamantane

    Adamantyl iodide

     1-Iodoadamantane (Adamantyl iodide) is a chemical. 1-Iodoadamantane Chemical Structure
  84. GC66557 1-Isothiocyanato-PEG3-azide 1-Isothiocyanato-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1-Isothiocyanato-PEG3-azide Chemical Structure
  85. GC65697 1-Isothiocyanato-PEG4-alcohol 1-Isothiocyanato-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1-Isothiocyanato-PEG4-alcohol Chemical Structure
  86. GC90774 1-Linoleoyl Lysophosphatidic Acid (sodium salt)

    A glycerophospholipid

     1-Linoleoyl Lysophosphatidic Acid (sodium salt) Chemical Structure
  87. GC72838 1-Methyladenosine-d3 hydrochloride 1-Metladenosine-d3 drochloride is the drochloride salt form of deuterium labeled 1-Metladenosine. 1-Methyladenosine-d3 hydrochloride Chemical Structure
  88. GC92019 1-Octadecyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)

    LPA O-18:0; O-18:0 LPA; 1-Octadecyl-2-hydroxy-sn-glycero-3-PA; 1-Octadecyl LPA; 1-Octadecyl Lysophosphatidic Acid; 1-Oleyl LPA; 1-Oleyl Lysophosphatidic Acid; PA(O-18:0/0:0); 1-Stearyl-2-hydroxy-sn-glycero-3-PA

     1-Octadecyl-2-hydroxy-sn-glycero-3-phosphate (1-Octadecyl LPA) is a LPA analog containing stearyl alcohol at the sn-1 position. 1-Octadecyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt) Chemical Structure
  89. GC74657 1-Octanol-d17

    Octanol-d17

     1-Octanol-d17 is the deuterium labeled 1-Octanol. 1-Octanol-d17 Chemical Structure
  90. GC92061 1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC

    1-Hexadecanoyl-2-13(S)-HODE-sn-glycero-3-Phosphocholine; 13(S)-Hydroxyoctadecadienoic Acid-PLPC; 1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-Phosphocholine; 1-Palmitoyl-2-(13-hydroxy-cis-9,trans-11-octadecadienoyl)-L-3-phosphatidylcholine

     1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC is an oxidized phospholipid that contains palmitic acid and 13(S)-HODE at the sn-1 and sn-2 positions, respectively. 1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC Chemical Structure
  91. GC68501 1-Palmitoyl-2-oleoyl-sn-glycerol

    1-Palmitoyl-2-oleoyl-sn-glycerol is an endogenous metabolite and a major diacylglycerol in hypoxia-inducible factor (HIF)-1.

     1-Palmitoyl-2-oleoyl-sn-glycerol Chemical Structure
  92. GC90829 1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-PC

    A phospholipid-porphyrin conjugate

     1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-PC Chemical Structure
  93. GC90811 1-Palmitoyl-d9-2-Arachidonoyl-sn-glycero-3-PC

    An internal standard for the quantification of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-PC

     1-Palmitoyl-d9-2-Arachidonoyl-sn-glycero-3-PC Chemical Structure
  94. GC68502 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine

    1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine can be chosen as a model volatile compound for studying the molecular species of oxidized phosphatidylcholines. This method was applied to actual food samples, namely soybean lecithin.

     1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine Chemical Structure
  95. GC25003 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B hydrochloride (1:1)

    Anidulafungin Nucleus

     1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]-Echinocandin B Hydrochloride (Anidulafungin Nucleus) is used in the commercialization and late-stage development of a semisynthetic antifungal anidulafungin/D-fructose. 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B hydrochloride (1:1) Chemical Structure
  96. GC91585 10α-hydroxy Naltrexone 10α-hydroxy Naltrexone is a derivative of the opioid antagonist naltrexone. 10α-hydroxy Naltrexone Chemical Structure
  97. GC90363 10(11)-Cl-BBQ

    A mixture that acts as an AhR agonist

     10(11)-Cl-BBQ Chemical Structure
  98. GC66057 10,11-Dihydrocarbamazepine 10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy. 10,11-Dihydrocarbamazepine Chemical Structure
  99. GC91581 10-(Phosphonooxy)-1-decanole

    10-Hydroxydecyl dihydrogen phosphate,HDP

     10-(Phosphonooxy)-1-decanole is a hydrolytic degradation product of 10-methacryloyloxydecyl dihydrogen phosphate-N-methylacryloyl glycine (MDP-NMGly) dental primers. 10-(Phosphonooxy)-1-decanole Chemical Structure
  100. GC91226 10-Chloroestra-1,4-diene-3,17-dione

    A sterone ERα agonist

     10-Chloroestra-1,4-diene-3,17-dione Chemical Structure
  101. GC12954 10-DAB (10-Deacetylbaccatin)

    NSC 251677

     An inhibitor of microtubule assembly 10-DAB (10-Deacetylbaccatin) Chemical Structure

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