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Home >> Signaling Pathways

Signaling Pathways

The antibody-drug conjugate (ADC), a humanized or human monoclonal antibody conjugated with highly cytotoxic small molecules (payloads) through chemical linkers, is a novel therapeutic format and has great potential to make a paradigm shift in cancer chemotherapy. The three components of the ADC together give rise to a powerful oncolytic agent capable of delivering normally intolerable cytotoxins directly to cancer cells, which then internalize and release the cell-destroying drugs. At present, two ADCs, Adcetris and Kadcyla, have received regulatory approval with >40 others in clinical development.

ADCs are administered intravenously in order to prevent the mAb from being destroyed by gastric acids and proteolytic enzymes. The mAb component of the ADC enables it to circulate in the bloodstream until it finds and binds to tumor-specific cell surface antigens present on target cancer cells. Linker chemistry is an important determinant of the safety, specificity, potency and activity of ADCs. Linkers are designed to be stable in the blood stream (to conform to the increased circulation time of mAbs) and labile at the cancer site to allow rapid release of the cytotoxic drug. First generation ADCs made use of early cytotoxins such as the anthracycline, doxorubicin or the anti-metabolite/antifolate agent, methotrexate. Current cytotoxins have far greater potency and can be divided into three main groups: auristatins, maytansines and calicheamicins.

The development of site-specific conjugation methodologies for constructing homogeneous ADCs is an especially promising path to improving ADC design, which will open the way for novel cancer therapeutics.

References:

[1] Tsuchikama K, et al. Protein Cell. 2016 Oct 14. DOI:10.1007/s13238-016-0323-0.

[2] Peters C, et al. Biosci Rep. 2015 Jun 12;35(4). pii: e00225. doi: 10.1042/BSR20150089.

Targets for  Signaling Pathways

Products for  Signaling Pathways

  1. Cat.No. Product Name Information
  2. GC65045 (S)-MRTX-1719 (S)-MRTX-1719 (example 16-7) is the S-enantiomer of MRTX-1719. (S)-MRTX-1719 is a PRMT5/MTA complex inhibitor, with an IC50 of 7070 nM. (S)-MRTX-1719 Chemical Structure
  3. GC68476 (S)-Nicardipine (S)-Nicardipine Chemical Structure
  4. GC49179 (S)-O-Desmethyl Naproxen A metabolite of (S)-naproxen (S)-O-Desmethyl Naproxen Chemical Structure
  5. GC62450 (S)-PI3Kα-IN-4 (S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S)-PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S)-PI3Kα-IN-4 can be used for the research of cancer. (S)-PI3Kα-IN-4 Chemical Structure
  6. GC69941 (S)-Renzapride

    (S)-Renzapride ((S)-BRL 24924) is an isomer of Renzapride. Renzapride is a 5-HT4 receptor agonist with a Ki value of 115 nM. It also acts as an antagonist for the 5HT2b and 5HT3 receptors. Renzapride can be used in research on constipation-predominant irritable bowel syndrome (C-IBS).

     (S)-Renzapride Chemical Structure
  7. GC63797 (S)-Sunvozertinib (S)-Sunvozertinib ((S)-DZD9008), the S-enantiomer of Sunvozertinib, shows inhibitory activity against EGFR exon 20 NPH and ASV insertions, EGFR L858R/T790M mutation and Her2 exon20 YVMA insertion (IC50=51.2 nM, 51.9 nM, 1 nM, and 21.2 nM, respectively). (S)-Sunvozertinib also inhibits BTK. (S)-Sunvozertinib Chemical Structure
  8. GC66064 (S)-Thalidomide (S)-Thalidomide ((S)-(-)-Thalidomide) is the S-enantiomer of Thalidomide. (S)-Thalidomide has immunomodulatory, anti-inflammatory, antiangiogenic and pro-apoptotic effects. (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN) . (S)-Thalidomide Chemical Structure
  9. GC69977 (S)-Veliflapon

    (S)-Veliflapon ((S)-BAY X 1005) is an orally active leukotriene biosynthesis and 5-lipoxygenase activating protein (FLAP) inhibitor. It inhibits the formation of leukotriene B4 (LTB4) in rat, mouse, and human white blood cells with IC50 values of 0.026 μM, 0.039 μM, and 0.22 μM respectively. (S)-Veliflapon exhibits enantioselectivity in human whole blood.

     (S)-Veliflapon Chemical Structure
  10. GC69979 (S)-VQW-765

    (S)-VQW-765 ((S)-AQW-051) is a partial agonist of the α7 nicotinic acetylcholine receptor (nAChR) with oral activity, selectivity and efficacy. It has potential applications in cognitive impairments associated with neurological diseases such as Alzheimer's disease or schizophrenia.

     (S)-VQW-765 Chemical Structure
  11. GC65883 (S,R)-WT IDH1 Inhibitor 2 (S,R)-WT IDH1 Inhibitor 2 (GSK321) is a potent, selective mutant IDH1 inhibitor with IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. (S,R)-WT IDH1 Inhibitor 2 induces decrease in intracellular 2-HG, abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. (S,R)-WT IDH1 Inhibitor 2 can be used for research of acute myeloid leukemia (AML) and other cancers. (S,R)-WT IDH1 Inhibitor 2 Chemical Structure
  12. GC62283 (S,R,S)-AHPC (S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells. (S,R,S)-AHPC Chemical Structure
  13. GC69944 (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA

    (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is a synthetic E3 ligase ligand-linker conjugate containing the (S,R,S)-AHPC ligand, which can be used in PROTAC research.

     (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA Chemical Structure
  14. GC69945 (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA

    "(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA" is a synthetic E3 ligase ligand-linker conjugate, which includes a ligand based on (S,R,S)-AHPC and a three-unit PEG linker."

     (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA Chemical Structure
  15. GC62148 (S,R,S)-AHPC-amido-C5-acid (S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133. (S,R,S)-AHPC-amido-C5-acid Chemical Structure
  16. GC69946 (S,R,S)-AHPC-amido-C7-acid

    (S,R,S)-AHPC-amido-C7-acid contains a VHL ligand for recruiting E3 ubiquitin ligases and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used for designing PROTACs.

     (S,R,S)-AHPC-amido-C7-acid Chemical Structure
  17. GC62684 (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a E3 ligase ligand-linker conjugate that contains on one end a VHL ligand. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is used in PROTAC technology. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH Chemical Structure
  18. GC69947 (S,R,S)-AHPC-C10-NHBoc

    (S,R,S)-AHPC-C10-NHBoc is a synthetic E3 ligase ligand-linker conjugate, containing a VHL ligand based on (S,R,S)-AHPC and one linker. It can be used to synthesize targeted PROTACs for BET.

     (S,R,S)-AHPC-C10-NHBoc Chemical Structure
  19. GC68352 (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine Chemical Structure
  20. GC69743 (S,R,S)-AHPC-C4-NH2 hydrochloride

    (S,R,S)-AHPC-C4-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate, containing a VHL ligand based on (S,R,S)-AHPC and one linker. It is used for the synthesis of targeted PROTACs for EED.

     (S,R,S)-AHPC-C4-NH2 hydrochloride Chemical Structure
  21. GC65133 (S,R,S)-AHPC-C5-COOH (S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized?E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases. (S,R,S)-AHPC-C5-COOH Chemical Structure
  22. GC69948 (S,R,S)-AHPC-CO-C9-acid

    "(S,R,S)-AHPC-CO-C9-acid" is a ligand-linker complex of E3 ligase, which can be attached to the ligand of a protein to form a PROTAC."

     (S,R,S)-AHPC-CO-C9-acid Chemical Structure
  23. GC69949 (S,R,S)-AHPC-isobutyl acetate-methanesulfonothioate-Me-C10-NH2 TFA

    (Please note that this is a chemical name and may not have a direct translation into English) (Please also note that the use of chemicals should only be done by trained professionals in appropriate settings with proper safety measures.) (Please consult with a professional chemist for accurate information regarding this compound.) The (S,R,S)-AHPC-isobutyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is part of PROTAC BRD4 Degrader-12.

     (S,R,S)-AHPC-isobutyl acetate-methanesulfonothioate-Me-C10-NH2 TFA Chemical Structure
  24. GC67831 (S,R,S)-AHPC-Me-C10-Br (S,R,S)-AHPC-Me-C10-Br Chemical Structure
  25. GC64371 (S,R,S)-AHPC-Me-C10-NH2 (S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432. (S,R,S)-AHPC-Me-C10-NH2 Chemical Structure
  26. GC63494 (S,R,S)-AHPC-Me-C5-COOH (S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216. (S,R,S)-AHPC-Me-C5-COOH Chemical Structure
  27. GC67729 (S,R,S)-AHPC-Me-C6-NH2 (S,R,S)-AHPC-Me-C6-NH2 Chemical Structure
  28. GC63561 (S,R,S)-AHPC-Me-C7 ester (S,R,S)-AHPC-Me-C7 ester is a E3 ligase ligand-linker conjugate used to synthesise BCL-XL PROTAC degraders. (S,R,S)-AHPC-Me-C7 ester Chemical Structure
  29. GC62585 (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 can be used in PROTAC BRD4 Degrader-5 and PROTAC BRD4 Degrader-5-CO-PEG3-N3. (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 Chemical Structure
  30. GC62183 (S,R,S)-AHPC-O-Ph-PEG1-NH2 (S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1. PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02. (S,R,S)-AHPC-O-Ph-PEG1-NH2 Chemical Structure
  31. GC66630 (S,R,S)-AHPC-PEG2-acid (S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. (S,R,S)-AHPC-PEG2-acid Chemical Structure
  32. GC61774 (S,R,S)-AHPC-PEG5-Boc (S,R,S)-AHPC-PEG5-Boc is a E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for Cdc20 degrader CP5V. (S,R,S)-AHPC-PEG5-Boc Chemical Structure
  33. GC67672 (S,S)-GNE 5729 (S,S)-GNE 5729 Chemical Structure
  34. GC67682 (S,S)-GSK321 (S,S)-GSK321 Chemical Structure
  35. GC64535 (S,S)-TAPI-1 (S,S)-TAPI-1 is an isomer of TAPI-1. (S,S)-TAPI-1 Chemical Structure
  36. GC67761 (Z)-10-Hydroxynortriptyline-d3 (Z)-10-Hydroxynortriptyline-d3 Chemical Structure
  37. GC62291 (Z)-Orantinib (Z)-Orantinib ((Z)-SU6668) is a potent, selective, orally active and ATP competitive inhibitor of Flk‐1/KDR, PDGFRβ, and FGFR1, with IC50s of 2.1, 0.008, and 1.2 ?M, respectively. (Z)-Orantinib is a potent antiangiogenic and antitumor agent that induces regression of established tumors. (Z)-Orantinib Chemical Structure
  38. GC11965 (±)-Huperzine A A neuroprotective AChE inhibitor (±)-Huperzine A Chemical Structure
  39. GC14252 (–)-Stepholidine A dopamine receptor antagonist and 5-HT1A partial agonist (–)-Stepholidine Chemical Structure
  40. GC63946 0990CL 0990CL is a?specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi. 0990CL Chemical Structure
  41. GC62761 1α-Hydroxy-3-epi-vitamin D3 1α-Hydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone (PTH) secretion. 1α-Hydroxy-3-epi-vitamin D3 Chemical Structure
  42. GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog 1(R)-(Trifluoromethyl)oleyl alcohol Chemical Structure
  43. GC65171 1,1′,1′′,1′′′-[1,4-Piperazinediylbis(2,1-ethanediylnitrilo)]tetrakis[2-dodecanol] 1,1′,1′′,1′′′-[1,4-Piperazinediylbis(2,1-ethanediylnitrilo)]tetrakis[2-dodecanol] is a lipid/lipidoid used in preparation of lipid-based or lipidoid nanoparticles. 1,1′,1′′,1′′′-[1,4-Piperazinediylbis(2,1-ethanediylnitrilo)]tetrakis[2-dodecanol] Chemical Structure
  44. GC49768 1,1’-Ethylidene-bis-(L-tryptophan) A potential impurity found in commercial preparations of L-tryptophan 1,1’-Ethylidene-bis-(L-tryptophan) Chemical Structure
  45. GC65729 1,1,1-Trifluoroethyl-PEG2-azide 1,1,1-Trifluoroethyl-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG2-azide Chemical Structure
  46. GC65715 1,1,1-Trifluoroethyl-PEG2-propargyl 1,1,1-Trifluoroethyl-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG2-propargyl Chemical Structure
  47. GC66567 1,1,1-Trifluoroethyl-PEG4-alcohol 1,1,1-Trifluoroethyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG4-alcohol Chemical Structure
  48. GC67011 1,1,1-Trifluoroethyl-PEG4-amine 111-Trifluoroethyl-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG4-amine Chemical Structure
  49. GC67295 1,1,1-Trifluoroethyl-PEG4-aminooxy 1,1,1-Trifluoroethyl-PEG4-aminooxy is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG4-aminooxy Chemical Structure
  50. GC67595 1,1,1-Trifluoroethyl-PEG4-azide 111-Trifluoroethyl-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG4-azide Chemical Structure
  51. GC66971 1,1,1-Trifluoroethyl-PEG4-propargyl 1,1,1-Trifluoroethyl-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG4-propargyl Chemical Structure
  52. GC65718 1,1,1-Trifluoroethyl-PEG4-Tos 1,1,1-Trifluoroethyl-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG4-Tos Chemical Structure
  53. GC67833 1,1,3-Tribromoacetone 1,1,3-Tribromoacetone Chemical Structure
  54. GC17055 1,2,3,4,5,6-Hexabromocyclohexane 1,2,3,4,5,6-六溴环己烷（1,2,3,4,5,6-Hexabromocyclohexane）直接抑制JAK2激酶结构域内的口袋，抑制自身磷酸化。 1,2,3,4,5,6-Hexabromocyclohexane Chemical Structure
  55. GC61719 1,2,3,4-Tetramethylbenzene 1,2,3,4-Tetramethylbenzene consists of a benzene ring with four methyl groups (-CH3) as a substituent. 1,2,3,4-Tetramethylbenzene Chemical Structure
  56. GC61729 1,2,3-Trimethoxybenzene 1,2,3-Trimethoxybenzene is a member of the class of compounds known as anisoles. 1,2,3-Trimethoxybenzene Chemical Structure
  57. GC61898 1,2,4-Trihydroxybenzene 1,2,4-Trihydroxybenzene (Hydroxyhydroquinone), a by-product of coffee bean roasting, increases intracellular Ca2+ concentration in rat thymic lymphocytes. 1,2,4-Trihydroxybenzene Chemical Structure
  58. GC66452 1,2-Bis(3-(trifluoromethyl)phenyl)diselane 1,2-Bis(3-(trifluoromethyl)phenyl)diselane is an active compound and can be used for research. 1,2-Bis(3-(trifluoromethyl)phenyl)diselane Chemical Structure
  59. GC68484 1,2-O-Isopropylidene-5-O-p-toluoyl-a-D-xylofuranose

    1,2-O-Isopropylidene-5-O-p-toluoyl-a-D-xylofuranose is a purine nucleoside analogue. Purine nucleoside analogues have broad anti-tumor activity and target malignant tumors in the inert lymphatic system. The anticancer mechanism in this process depends on inhibiting DNA synthesis, inducing apoptosis (cell death), etc.

     1,2-O-Isopropylidene-5-O-p-toluoyl-a-D-xylofuranose Chemical Structure
  60. GC61731 1,3,5-Triisopropylbenzene 1,3,5-Triisopropylbenzene acts as a fuel and fuel additive. 1,3,5-Triisopropylbenzene Chemical Structure
  61. GC61399 1,3,6,8-Tetrahydroxynaphthalene 1,3,6,8-Tetrahydroxynaphthalene (T4HN) is an indispensable precursor to DHN (1,8-Dihydroxynaphthalene) melanin and is an unique symmetrical compound of polyketide origin. 1,3,6,8-Tetrahydroxynaphthalene Chemical Structure
  62. GC49220 1,3-Benzodioxole-5,6-diamine (hydrochloride) A fluorescent derivatization reagent 1,3-Benzodioxole-5,6-diamine (hydrochloride) Chemical Structure
  63. GC66949 1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane 1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane Chemical Structure
  64. GC67054 1,3-Bis-aminooxy propane 1,3-Bis-aminooxy propane is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. 1,3-Bis-aminooxy propane Chemical Structure
  65. GC62352 1,3-Butanediol 1,3-Butanediol, an ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol Chemical Structure
  66. GC19661 1,3-Dihydroxyacetone 1,3-Dihydroxyacetone (DHA), the main active ingredient in sunless tanning skin-care preparations and an important precursor for the synthesis of various fine chemicals, is produced on an industrial scale by microbial fermentation of glycerol over Gluconobacter oxydans. 1,3-Dihydroxyacetone Chemical Structure
  67. GC61827 1,3-Dimethylpyrazole 1,3-Dimethylpyrazole is a bioactive compound isolated from Moso Bamboo Root. 1,3-Dimethylpyrazole Chemical Structure
  68. GC67985 1,3-Oxazolidine-2-thione 1,3-Oxazolidine-2-thione Chemical Structure
  69. GC61709 1,3-Propanediol 1,3-Propanediol is produced in nature by the fermentation of glycerol in microorganism. 1,3-Propanediol Chemical Structure
  70. GC68134 1,3-Propanesultam 1,3-Propanesultam Chemical Structure
  71. GC64247 1,4,7-Triazonane 1,4,7-Triazonane (1,4,7-Triazacyclononane), an intermediate in the synthesis of 1,4,7-trifunctionalized derivatives, is a possible reagent for compleximetric titrations with high cation-binding selectivity. 1,4,7-Triazonane Chemical Structure
  72. GC19528 1,4-Benzoquinone A toxic metabolite of benzene 1,4-Benzoquinone Chemical Structure
  73. GC62755 1,4-D-Gulonolactone 1,4-D-Gulonolactone is an endogenous metabolite. 1,4-D-Gulonolactone Chemical Structure
  74. GC68486 1,4-Diaminobutane-d8 dihydrochloride

    1,4-Diaminobutane-d8 (dihydrochloride) is the deuterated form of 1,4-Diaminobutane dihydrochloride. 1,4-Diaminobutane (Putrescine) dihydrochloride is an endogenous metabolite that can serve as an indicator of pollution caused by Cr(III) or Cr(VI) stress in higher plants such as barley and rapeseed.

     1,4-Diaminobutane-d8 dihydrochloride Chemical Structure
  75. GC19683 1,4-Dichlorobenzene 1,4-Dichlorobenzene is used as an intermediate product in the manufacture of pigments, pesticides and disinfectants. 1,4-Dichlorobenzene Chemical Structure
  76. GC61949 1,4-DPCA ethyl ester 1,4-DPCA ethyl ester is the ethyl ester of 1,4-DPCA and can inhibit factor inhibiting HIF (FIH). 1,4-DPCA ethyl ester Chemical Structure
  77. GC19717 1,6-anhydroglucose 1,6-anhydroglucose (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature. 1,6-anhydroglucose Chemical Structure
  78. GC67200 1,6-Bis(mesyloxy)hexane 16-Bismesyloxyhexane is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1,6-Bis(mesyloxy)hexane Chemical Structure
  79. GC65551 1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine 1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside. 1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine Chemical Structure
  80. GC49537 1-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1,2-ethanediol A sterically hindered para-alkylphenol 1-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1,2-ethanediol Chemical Structure
  81. GC49346 1-(3-Chlorophenyl)biguanide (hydrochloride) A 5-HT3 receptor agonist 1-(3-Chlorophenyl)biguanide (hydrochloride) Chemical Structure
  82. GC49294 1-(4-Chlorobenzhydryl)piperazine An inactive metabolite of meclizine and chlorcyclizine 1-(4-Chlorobenzhydryl)piperazine Chemical Structure
  83. GC52356 1-1(Z)-Hexadecenyl-2-Arachidonoyl-sn-glycero-3-PC A plasmalogen 1-1(Z)-Hexadecenyl-2-Arachidonoyl-sn-glycero-3-PC Chemical Structure
  84. GC64404 1-Aminopropan-2-ol 1-Aminopropan-2-ol is a microbial metabolism of amino alcohol metabolism via propionaldehyde and acetaldehyde in a species of Pseudomonas. 1-Aminopropan-2-ol Chemical Structure
  85. GC64176 1-Boc-azetidine-3-carboxylic acid 1-Boc-azetidine-3-carboxylic acid is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACsup 1-Boc-azetidine-3-carboxylic acid Chemical Structure
  86. GC64159 1-Boc-azetidine-3-yl-methanol 1-Boc-azetidine-3-yl-methanol is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-yl-methanol is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs 1-Boc-azetidine-3-yl-methanol Chemical Structure
  87. GC65223 1-Bromo-6-chlorohexane 1-Bromo-6-chlorohexane is a PROTAC linker can be used in the synthesis of PROTACs. 1-Bromo-6-chlorohexane Chemical Structure
  88. GC49861 1-Carboxycyclohexaneacetic Acid A potential impurity in commercial preparations of gabapentin 1-Carboxycyclohexaneacetic Acid Chemical Structure
  89. GC64145 1-Cbz-3-Hydroxyazetidine 1-Cbz-3-Hydroxyazetidine is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-3-Hydroxyazetidine is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs. 1-Cbz-3-Hydroxyazetidine Chemical Structure
  90. GC64047 1-Cbz-azetidine-3-carboxylic acid 1-Cbz-azetidine-3-carboxylic acid is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs 1-Cbz-azetidine-3-carboxylic acid Chemical Structure
  91. GN10317 1-Deoxynojirimycin 1-Deoxynojirimycin Chemical Structure
  92. GC52186 1-Docosahexaenoyl-2-hydroxy-sn-glycero-3-PC 1-Docosahexaenoyl-2-hydroxy-sn-glycero-3-PC Chemical Structure
  93. GC62760 1-Dodecylimidazole 1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity. 1-Dodecylimidazole Chemical Structure
  94. GC61690 1-Eicosanol 1-Eicosanol is a natural compound with antioxidant activity isolated from Hypericum carinatum. 1-Eicosanol Chemical Structure
  95. GC49470 1-Ethyl-1-nitrosourea (hydrate) A DNA alkylating agent 1-Ethyl-1-nitrosourea (hydrate) Chemical Structure
  96. GC67844 1-Fluoronaphthalene 1-Fluoronaphthalene Chemical Structure
  97. GC62754 1-Furfurylpyrrole 1-Furfurylpyrrole has been identified as a potential contributor of flavor and aroma to popcorn. 1-Furfurylpyrrole Chemical Structure
  98. GC61642 1-Heptadecanol 1-Heptadecanol is a long-chain primary alcohol with antibacterial activity from Solena amplexicaulis leaves. 1-Heptadecanol Chemical Structure
  99. GC68495 1-Hexadecanol-d4

    1-Hexadecanol-d4 is the deuterated form of 1-hexadecanol. 1-Hexadecanol is a fatty alcohol, which is a hydrophobic substrate.

     1-Hexadecanol-d4 Chemical Structure
  100. GC68496 1-Hexadecanol-d5

    1-Hexadecanol-d5 is the deuterated form of 1-hexadecanol. 1-Hexadecanol is a fatty alcohol, which is a hydrophobic substrate.

     1-Hexadecanol-d5 Chemical Structure
  101. GC61723 1-Hexanol 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties. 1-Hexanol Chemical Structure

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