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Home >> Signaling Pathways

Signaling Pathways

The antibody-drug conjugate (ADC), a humanized or human monoclonal antibody conjugated with highly cytotoxic small molecules (payloads) through chemical linkers, is a novel therapeutic format and has great potential to make a paradigm shift in cancer chemotherapy. The three components of the ADC together give rise to a powerful oncolytic agent capable of delivering normally intolerable cytotoxins directly to cancer cells, which then internalize and release the cell-destroying drugs. At present, two ADCs, Adcetris and Kadcyla, have received regulatory approval with >40 others in clinical development.

ADCs are administered intravenously in order to prevent the mAb from being destroyed by gastric acids and proteolytic enzymes. The mAb component of the ADC enables it to circulate in the bloodstream until it finds and binds to tumor-specific cell surface antigens present on target cancer cells. Linker chemistry is an important determinant of the safety, specificity, potency and activity of ADCs. Linkers are designed to be stable in the blood stream (to conform to the increased circulation time of mAbs) and labile at the cancer site to allow rapid release of the cytotoxic drug. First generation ADCs made use of early cytotoxins such as the anthracycline, doxorubicin or the anti-metabolite/antifolate agent, methotrexate. Current cytotoxins have far greater potency and can be divided into three main groups: auristatins, maytansines and calicheamicins.

The development of site-specific conjugation methodologies for constructing homogeneous ADCs is an especially promising path to improving ADC design, which will open the way for novel cancer therapeutics.

References:

[1] Tsuchikama K, et al. Protein Cell. 2016 Oct 14. DOI:10.1007/s13238-016-0323-0.

[2] Peters C, et al. Biosci Rep. 2015 Jun 12;35(4). pii: e00225. doi: 10.1042/BSR20150089.

Targets for  Signaling Pathways

Products for  Signaling Pathways

  1. Cat.No. Product Name Information
  2. GC71925 10-Hydroxyaloin A 10-10-Hydroxyaloin A is potent SARS-CoV-2 inhibitor. 10-Hydroxyaloin A Chemical Structure
  3. GC52398 10-oxo-12(Z)-Octadecenoic Acid ethyl ester

    10-keto-12Z-Octadecenoic Acid ethyl ester, 10-oxo-12-cis-Octadecenoic Acid ethyl ester

     An ester form of 10-oxo-12(Z)-octadecenoic acid 10-oxo-12(Z)-Octadecenoic Acid ethyl ester Chemical Structure
  4. GC52428 10-oxo-12(Z)-Octadecenoic Acid-d5

    10-keto-12Z-Octadecenoic Acid-d5, 10-oxo-12-cis-Octadecenoic Acid-d5

     An internal standard for the quantification of 10-oxo-12(Z)-octadecenoic acid 10-oxo-12(Z)-Octadecenoic Acid-d5 Chemical Structure
  5. GC13863 10Panx

    10Panx

     A peptide inhibitor of PANX1 10Panx Chemical Structure
  6. GC52423 10Panx (trifluoroacetate salt)

    10Panx1, WRQAAFVDSY

     A peptide inhibitor of PANX1 10Panx (trifluoroacetate salt) Chemical Structure
  7. GC68204 11-Azidoundecanoic acid 11-Azidoundecanoic acid Chemical Structure
  8. GC66224 11-Maleimidoundecanoic acid 11-Maleimidoundecanoic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. 11-Maleimidoundecanoic acid Chemical Structure
  9. GC73480 113-N16B 113-N16B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs). 113-N16B Chemical Structure
  10. GC52343 113-O12B An ionizable cationic lipidoid 113-O12B Chemical Structure
  11. GC92076 119-23 119-23 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. 119-23 Chemical Structure
  12. GC91213 12β-Hydroxyisocholic Acid

    A bile acid

     12β-Hydroxyisocholic Acid Chemical Structure
  13. GN10444 12-O-tetradecanoyl phorbol-13-acetate

    PMA; TPA; Phorbol myristate acetate

    A PKC activator

     12-O-tetradecanoyl phorbol-13-acetate Chemical Structure
  14. GC90652 12-oxo-9(Z)-Dodecenoic Acid

    A metabolite of linoleic acid and linolenic acid

     12-oxo-9(Z)-Dodecenoic Acid Chemical Structure
  15. GC71326 12R-LOX-IN-2 12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX). 12R-LOX-IN-2 Chemical Structure
  16. GC91073 13(Z)-Docosenoic Acid (sodium salt)

    A 22-carbon monounsaturated fatty acid

     13(Z)-Docosenoic Acid (sodium salt) Chemical Structure
  17. GC68488 15-Azido-pentadecanoic acid

    Azido Palmitic Acid

    15-Azido-pentadecanoic acid is a chemical reagent containing an azide group. Azido Palmitic Acid can be used to identify and characterize post-translational palmitoylated proteins using a simple and robust two-step labeling and detection technique.

     15-Azido-pentadecanoic acid Chemical Structure
  18. GC65988 16-Azidohexadecanoic acid 16-Azidohexadecanoic acid, a synthetic fatty acid, can be used as a modification marker for nucleotides and a molecular probe for fatty acid metabolism. 16-Azidohexadecanoic acid Chemical Structure
  19. GC17557 17 alpha-propionate

    CB-03-01

     A peripherally selective androgen receptor antagonist 17 alpha-propionate Chemical Structure
  20. GC68493 17α-Hydroxyprogesterone-d8

    17-Hydroxyprogesterone-d8; 17-OHP-d8

    17α-Hydroxyprogesterone-d8 is the deuterated form of 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-OHP) is an endogenous progestogen that serves as a chemical intermediate in the biosynthesis of other steroid hormones, including glucocorticoids, androgens, and estrogens.

     17α-Hydroxyprogesterone-d8 Chemical Structure
  21. GC91109 17β-Estradiol 3-O-Sulfate (sodium salt)

    An inactive metabolite of 17β-estradiol

     17β-Estradiol 3-O-Sulfate (sodium salt) Chemical Structure
  22. GC90945 17β-Estradiol-2,4,16,16-d4 3-sulfate (sodium salt)

    An internal standard for the quantification of 17β-estradiol-3-sulfate

     17β-Estradiol-2,4,16,16-d4 3-sulfate (sodium salt) Chemical Structure
  23. GC65870 17β-Estradiol-3-β-D-glucuronide-d3 sodium 17β-Estradiol-3-β-D-glucuronide-d3 sodium is the deuterium labeled 17β-Estradiol-3-β-D-glucuronide. 17β-Estradiol-3-β-D-glucuronide-d3 sodium Chemical Structure
  24. GC68494 17β-HSD1-IN-1

    17β-HSD1-IN-1 (Compound 1) is a highly selective inhibitor of 17β-HSD1, with IC50 values of 5.6 and 3155 nM for inhibition of 17β-HSD1 and 17β-HSD2, respectively. It can be used for research on non-small cell lung cancer (NSCLC).

     17β-HSD1-IN-1 Chemical Structure
  25. GC71338 17β-HSD10-IN-1 17β-HSD10-IN-1 (compound 9) is an orally active inhibitor of 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) with blood-brain permeability. 17β-HSD10-IN-1 Chemical Structure
  26. GC11720 17-AAG (KOS953)

    BMS 722782, CP 127374, KOS 953, NSC 330507, Tanespimycin

     17-AAG(Geldanamycin), a natural benzoquinone ansamycin antibiotic, is the first established inhibitor of Hsp90. 17-AAG (KOS953) Chemical Structure
  27. GC17210 17-AAG Hydrochloride

    Tanespimycin Hydrochloride;NSC 330507 Hydrochloride;CP 127374 Hydrochloride;17AAG Hydrochloride;17 AAG Hydrochloride

     Hsp90 inhibitor,geldanamycin analogue 17-AAG Hydrochloride Chemical Structure
  28. GC68426 17a-Hydroxypregnenolone-d3 17a-Hydroxypregnenolone-d3 Chemical Structure
  29. GC71042 18β-Glycyrrhetyl-3-O-sulfate 18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)) is a potent type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) inhibitor with an IC50 of 0.10 µM using rat kidney microsome. 18β-Glycyrrhetyl-3-O-sulfate Chemical Structure
  30. GC71169 18-Azido-stearic acid 18-Azido-stearic acid is a click chemistry reagent containing an azide group. 18-Azido-stearic acid Chemical Structure
  31. GC91773 18-hydroxy Oleoyl Leucine-d7 18-hydroxy Oleoyl leucine-d7 is intended for use as an internal standard for the quantification of 18-hydroxy oleoyl leucine by GC- or LC-MS. 18-hydroxy Oleoyl Leucine-d7 Chemical Structure
  32. GC15623 1alpha, 25-Dihydroxy VD2-D6 1alpha, 25-Dihydroxy VD2-D6 Chemical Structure
  33. GC72952 1E7-03 1E7-03, a low MW tetradroquinoline derivative targeting protein phosphatase-1, can inhibit HIV-1 transcription. 1E7-03 Chemical Structure
  34. GC90584 1H,1H,2H,2H-Perfluorodecanesulfonic Acid

    A polyfluoroalkyl substance

     1H,1H,2H,2H-Perfluorodecanesulfonic Acid Chemical Structure
  35. GC90585 1H,1H,2H,2H-Perfluorohexanesulfonic Acid

    A polyfluoroalkyl substance

     1H,1H,2H,2H-Perfluorohexanesulfonic Acid Chemical Structure
  36. GC52216 1H,1H,2H,2H-Perfluorooctanesulfonic Acid

    6:2 Fluorotelomer Sulfonate, 6:2 Fluorotelomer Sulfonic Acid, 6:2 FTS, 6:2 FTSA

     A polyfluoroalkyl substance 1H,1H,2H,2H-Perfluorooctanesulfonic Acid Chemical Structure
  37. GC90815 2',3'-cyclic NADP+ (sodium salt)

    A substrate for CNP

     2',3'-cyclic NADP+ (sodium salt) Chemical Structure
  38. GC66890 2',3'-Dideoxy-5-iodocytidine 2',3'-Dideoxy-5-iodocytidine is used for gene sequencing can be used as an antibiotic. 2',3'-Dideoxy-5-iodocytidine is particular effective against Mycobacterium. 2',3'-Dideoxy-5-iodocytidine Chemical Structure
  39. GC52501 2',3'-Dideoxyadenosine 5'-triphosphate (lithium salt)

    ddATP

     An inhibitor of reverse transcriptases and DNA polymerases 2',3'-Dideoxyadenosine 5'-triphosphate (lithium salt) Chemical Structure
  40. GC90803 2',3'-Dideoxyadenosine-5'-O-triphosphate (sodium salt)

    A reverse transcriptase inhibitor and an active metabolite of ddA and ddI

     2',3'-Dideoxyadenosine-5'-O-triphosphate (sodium salt) Chemical Structure
  41. GC71982 2',4'-Dihydroxy-6'-Methoxyacetophenone 2',4'-Dihydroxy-6'-Methoxyacetophenone is a phenolic acetophenone from Artemisia annua. 2',4'-Dihydroxy-6'-Methoxyacetophenone Chemical Structure
  42. GC67628 2',7'-Dichlorofluorescein 2',7'-Dichlorofluorescein acts as a fluorescent probe (Ex=496 nm and Em=525 nm) for reactive oxygen species (ROS) measurement. 2',7'-Dichlorofluorescein Chemical Structure
  43. GC90813 2'-deoxy NAD+ (sodium salt)

    A TRPM2 agonist

     2'-deoxy NAD+ (sodium salt) Chemical Structure
  44. GC67627 2'-Deoxy-5'-O-DMT-2'-fluorouridine 2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5'-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity. 2'-Deoxy-5'-O-DMT-2'-fluorouridine Chemical Structure
  45. GC67328 2'-Deoxy-L-adenosine 2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV). 2'-Deoxy-L-adenosine Chemical Structure
  46. GC73523 2'-Deoxy-N3-methylcytidine hydriodide 2’-Deoxy-N3-metlcytidine driodide is a purine nucleoside analog. 2'-Deoxy-N3-methylcytidine hydriodide Chemical Structure
  47. GC74092 2'-Deoxyguanosine-13C10

    Deoxyguanosine-13C10; Guanine deoxyriboside-13C10

     2'-Deoxyguanosine-13C10 (Deoxyguanosine-13C10; Guanine deoxyriboside-13C10) is 13C-labeled 2'-Deoxyguanosine. 2'-Deoxyguanosine-13C10 Chemical Structure
  48. GC71729 2'-Deoxyguanosine-13C10,15N5 monohydrate 2'-Deoxyguanosine-13C10,15N5 (monohydrate) is the 13C and 15N labeled 2'-Deoxyguanosine monohydrate. 2'-Deoxyguanosine-13C10,15N5 monohydrate Chemical Structure
  49. GC70730 2'-Ethyl Simvastatin 2'-Ethyl Simvastatin (compound 6) is a Mevinolin analog, with HMG-CoA reductase inhibition. 2'-Ethyl Simvastatin Chemical Structure
  50. GC25010 2'-Hydroxy-2-methoxychalcone 2'-Hydroxy-2-methoxychalcone is a chemical. 2'-Hydroxy-2-methoxychalcone Chemical Structure
  51. GC66651 2'-O,4'-C-Methyleneadenosine

    LNA-A

     2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog. 2'-O,4'-C-Methyleneadenosine Chemical Structure
  52. GC66654 2'-O,4'-C-Methylenecytidine

    LNA-C(Bz)

     2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands. 2'-O,4'-C-Methylenecytidine Chemical Structure
  53. GC66655 2'-O,4'-C-Methyleneguanosine

    LNA-G

     2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand. 2'-O,4'-C-Methyleneguanosine Chemical Structure
  54. GC68521 2'-O-MB-cAMP sodium

    2'-O-Monobutyryl cyclic AMP sodium

    2'-O-MB-cAMP (2'-O-Monobutyryl cyclic AM) sodium is an active precursor of Cyclic AMP.

     2'-O-MB-cAMP sodium Chemical Structure
  55. GC52183 2'-O-Methyl-5-methyluridine

    2'-O-Methylribothymidine, 2'-O-Methylthymidine

     2'-O-Methyl-5-methyluridine Chemical Structure
  56. GC66713 2'-O-MOE-5-Me-C(Bz) 2'-O-MOE-5-Me-C (Bz) is a nucleotide for the stereoselective synthesis of nucleoside alkyl phosphonates. 2'-O-MOE-5-Me-C(Bz) Chemical Structure
  57. GC66657 2'-O-MOE-5-Me-rC 2'-O-MOE-5-Me-rC is an active compound. 2'-O-MOE-5-Me-rC can be used for oligonucleotide synthesis. 2'-O-MOE-5-Me-rC Chemical Structure
  58. GC66091 2'-O-MOE-5-Me-rU 2'-O-MOE-5-Me-rU is an active compound. 2'-O-MOE-5-Me-rU can be used for oligonucleotide synthesis. 2'-O-MOE-5-Me-rU Chemical Structure
  59. GC66656 2'-O-MOE-rC 2'-O-MOE-rC is a 2'-O-MOE modified nucleoside. 2'-O-MOE-rC can be used for synthesis of DNA. 2'-O-MOE-rC Chemical Structure
  60. GC66652 2'-O-MOE-U 2'-O-MOE-U is a phosphoramidite, can be used for oligonucleotide synthesis. 2'-O-MOE-U Chemical Structure
  61. GC70652 2'MeO6MF 2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors. 2'MeO6MF Chemical Structure
  62. GC67384 2′-Deoxy-β-L-uridine 2'-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5'-triphosphates with the viral DNA polymerase. 2′-Deoxy-β-L-uridine Chemical Structure
  63. GC90517 2,2'-Bisnaloxone

    A potential impurity in commercial preparations of naloxone

     2,2'-Bisnaloxone Chemical Structure
  64. GC90941 2,3,4,6,7,8-Hexachlorodibenzofuran

    A dioxin-like polychlorinated dibenzofuran

     2,3,4,6,7,8-Hexachlorodibenzofuran Chemical Structure
  65. GC66487 2,3,4,6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide 2,3,4,6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. 2,3,4,6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide Chemical Structure
  66. GC90944 2,3,4,7,8-Pentachlorodibenzofuran

    A dioxin-like polychlorinated dibenzofuran

     2,3,4,7,8-Pentachlorodibenzofuran Chemical Structure
  67. GC90818 2,3,7,8-Tetrachlorodibenzo-p-dioxin

    A toxicant and an agonist of AhR

     2,3,7,8-Tetrachlorodibenzo-p-dioxin Chemical Structure
  68. GC90819 2,3,7,8-Tetrachlorodibenzofuran

    A polychlorinated dibenzofuran and dioxin

     2,3,7,8-Tetrachlorodibenzofuran Chemical Structure
  69. GC12258 2,3-DCPE hydrochloride 2,3-DCPE hydrochloride Chemical Structure
  70. GC67743 2,3-Dihydroxyquinoxaline 2,3-Dihydroxyquinoxaline Chemical Structure
  71. GC90081 2,3-dinor-8-iso Prostaglandin F1α

    An active metabolite of arachidonic acid and 8-iso PGF2α

     2,3-dinor-8-iso Prostaglandin F1α Chemical Structure
  72. GC70354 2,3-Diphosphoglyceric acid pentasodium 2,3-Diphosphoglyceric acid (2,3-DPG) pentasodium is an intermediate of the glycolytic pathway. 2,3-Diphosphoglyceric acid pentasodium Chemical Structure
  73. GC25006 2,4'-Dihydroxybenzophenone 2,4'-Dihydroxybenzophenone (DHBP) is an organic compound used for the synthesis of pharmaceutical agents. 2,4'-Dihydroxybenzophenone Chemical Structure
  74. GC68044 2,4,6-Trihydroxybenzaldehyde 2,4,6-Trihydroxybenzaldehyde Chemical Structure
  75. GC68452 2,4,6-Triiodophenol 2,4,6-Triiodophenol Chemical Structure
  76. GC71530 2,4-D-13C6 2,4-D-13C6 is the 13C-labeled 2,4-D. 2,4-D-13C6 Chemical Structure
  77. GC68234 2,4-Difluorobenzaldehyde 2,4-Difluorobenzaldehyde Chemical Structure
  78. GC71311 2,4-Difluorophenylethynylcobalamin 2,4-Difluorophenylethynylcobalamin is a potential B12 antivitamin via binding to human B12 -processing enzyme CblC with high affinity (KD=130 nm). 2,4-Difluorophenylethynylcobalamin Chemical Structure
  79. GC68132 2,6-Dichloroquinone-4-chloroimide 2,6-Dichloroquinone-4-chloroimide Chemical Structure
  80. GC66679 2,6-Dimethyl-L-tyrosine

    Dmt

     2,6-Dimethyl-L-tyrosine (Dmt) is a tyrosine derivative that enhances receptor affinity, functional bioactivity and in vivo analgesia of opioid peptides. 2,6-Dimethyl-L-tyrosine Chemical Structure
  81. GC91055 2,6-Xylidine-d6 (hydrochloride)

    An Analytical Reference Standard

     2,6-Xylidine-d6 (hydrochloride) Chemical Structure
  82. GC71909 2,7"-Phloroglucinol-6,6'-bieckol 2,7"-Phloroglucinol-6,6'-bieckol is an orally active dual α-amylase/α-glucosidase inhibitor with IC50 values of 6.94 μM and 23.35 μM respectively. 2,7"-Phloroglucinol-6,6'-bieckol Chemical Structure
  83. GC68512 2,7-Dichlorodihydrofluorescein

    DCFH2

    2,7-Dichlorodihydrofluorescein (DCFH2) is a non-fluorescent probe. 2,7-Dichlorodihydrofluorescein produces highly fluorescent 2',7'-dichlorofluorescein (DCF), which can be used for measuring reactive oxygen species.

     2,7-Dichlorodihydrofluorescein Chemical Structure
  84. GC66721 2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride 2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride Chemical Structure
  85. GC68504 2-(2-Methylbenzamido)acetic acid-d7

    2-(2-Methylbenzamido)acetic acid-d7 is the deuterated form of 2-(2-Methylbenzamido)acetic acid. 2-(2-Methylbenzamido)acetic acid is a metabolite that can be detected in urine.

     2-(2-Methylbenzamido)acetic acid-d7 Chemical Structure
  86. GC66678 2-(3-Trifluoromethylphenyl)glycine hydrochloride 2-(3-Trifluoromethylphenyl)glycine hydrochloride is a precursor of substituted 2-acetamido-5-aryl-l, 2,4-triazolones. Substituted 2-acetamido-5-aryl-l, 2,4-triazolones are dual V1a/V2 receptor antagonists and can be used in cardiovascular disease research. 2-(3-Trifluoromethylphenyl)glycine hydrochloride Chemical Structure
  87. GC67619 2-(4-Biphenylyl)-5-phenyl-1,3,4-oxadiazole 2-(4-Biphenylyl)-5-phenyl-1,3,4-oxadiazole is a laser dyes with high photoluminescence (PL) quantum efficiency. 2-(4-Biphenylyl)-5-phenyl-1,3,4-oxadiazole Chemical Structure
  88. GC68093 2-(4-Chlorophenoxy)ethanol 2-(4-Chlorophenoxy)ethanol Chemical Structure
  89. GC66595 2-(Azido-PEG2-amido)-1,3-propandiol 2-(Azido-PEG2-amido)-13-propandiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 2-(Azido-PEG2-amido)-1,3-propandiol Chemical Structure
  90. GC66746 2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane 2-Azido-PEG3-amido-13-biscarboxylethoxypropane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane Chemical Structure
  91. GC66548 2-(Azido-PEG3-amido)-1,3-bis(NHS ester) 2-(Azido-PEG3-amido)-1,3-bis(NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 2-(Azido-PEG3-amido)-1,3-bis(NHS ester) Chemical Structure
  92. GC67303 2-(Biotin-amido)-1,3-bis-(C1-PEG1-acid) 2-(Biotin-amido)-13-bis(carboxylethoxy)propane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 2-(Biotin-amido)-1,3-bis-(C1-PEG1-acid) Chemical Structure
  93. GC90442 2-(Chloromethyl)-3-(2-methylphenyl)quinazolin-4(3H)-one

    An Analytical Reference Standard

     2-(Chloromethyl)-3-(2-methylphenyl)quinazolin-4(3H)-one Chemical Structure
  94. GC91650 2-(Morpholin-4-yl)ethane-1-sulfonamide

    4-Morpholineethanesulfonamide

     2-(Morpholin-4-yl)ethane-1-sulfonamide is a byproduct in the synthesis of diazo compounds. 2-(Morpholin-4-yl)ethane-1-sulfonamide Chemical Structure
  95. GC66326 2-(Naphthalen-1-yl)-5-phenyloxazole

    α-NPO

     2-(Naphthalen-1-yl)-5-phenyloxazole (α-NPO) is an organic fluorescent dye. 2-(Naphthalen-1-yl)-5-phenyloxazole has a nitrogen atom in its structure that can interfere with the nitrogen content from the amination step. 2-(Naphthalen-1-yl)-5-phenyloxazole Chemical Structure
  96. GC25008 2-Acetamidofluorene

    2-AAF, 2-Acetaminofluorene, N-2-Fluorenylacetamide, N-Acetyl-2-aminofluorene

     2-Acetamidofluorene Chemical Structure
  97. GC67087 2-Amino-1,3-bis(carboxylethoxy)propane 2-Amino-13-bis(carboxylethoxy)propane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 2-Amino-1,3-bis(carboxylethoxy)propane Chemical Structure
  98. GC74106 2-Amino-1,3-bis(carboxylethoxy)propane hydrochloride 2-Amino-1,3-bis(carboxylethoxy)propane drochloride is a non-protein amino acid, sulfamic acid. 2-Amino-1,3-bis(carboxylethoxy)propane hydrochloride Chemical Structure
  99. GC66717 2-Amino-2-(p-tolyl)acetic acid 2-Amino-2-(p-tolyl)acetic acid is used for optimizing azide skeleton, and is the intermediate in the synthesis of 1,3, 4-thiadiazole compounds. 1,3,4-thiadiazole compounds exhibit potential anti-cancer activity, and inhibit glutaminase (GLSI). 2-Amino-2-(p-tolyl)acetic acid Chemical Structure
  100. GC68195 2-Amino-5-methylthiophene-3-carbonitrile 2-Amino-5-methylthiophene-3-carbonitrile Chemical Structure
  101. GC73817 2-APQC 2-APQC is a SIRT3 activator with the Kd value of 2.756 μM. 2-APQC Chemical Structure

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