Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

Home >> Signaling Pathways >> Angiogenesis

Angiogenesis

Products for  Angiogenesis

  1. Cat.No. Product Name Information
  2. GC19251 MK-8617 MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2. MK-8617 Chemical Structure
  3. GC13004 ML161

    ML161

     Reversible inhibitor of PAR1-mediated platelet activation ML161 Chemical Structure
  4. GC19449 ML221

    ML221 is a potent apelin (APJ) functional antagonist

     ML221 Chemical Structure
  5. GC18608 MMP-2/MMP-9 Inhibitor II

    Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor II

     MMP-2/MMP-9 inhibitor II is a dual inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 17 and 30 nM, respectively). MMP-2/MMP-9 Inhibitor II Chemical Structure
  6. GC18616 MMP-8 Inhibitor I

    Matrix Metalloproteinase-8 Inhibitor I

     MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM. MMP-8 Inhibitor I Chemical Structure
  7. GC10048 MNS

    3,4Methylenedioxyβnitrostyrene, NSC 10120, NSC 105303, NSC 170724, Syk Inhibitor III

     Inhibitor of Src/Syk tyrosine kinases MNS Chemical Structure
  8. GC10046 Molidustat (BAY85-3934)

    Molidustat

     Molidustat (BAY85-3934) (BAY 85-3934) is a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with mean IC50 values of 480 nM for PHD1, 280 nM for PHD2, and 450 nM for PHD3. Molidustat (BAY85-3934) Chemical Structure
  9. GC36661 MT-802 MT-802 is a potent BTK degrader based on Cereblon ligand, with a DC50 of 1 nM. MT-802 Chemical Structure
  10. GC49686 N-desmethyl Regorafenib N-oxide An active metabolite of regorafenib N-desmethyl Regorafenib N-oxide Chemical Structure
  11. GC62255 N-piperidine Ibrutinib hydrochloride N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620. SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM. N-piperidine Ibrutinib hydrochloride Chemical Structure
  12. GC44290 NAADP (sodium salt)

    Nicotinic acid adenine dinucleotide phosphate

    Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization.

     NAADP (sodium salt) Chemical Structure
  13. GC61109 Natalizumab Natalizumab is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab Chemical Structure
  14. GC44358 Nebivolol O-β-D-Glucuronide Nebivolol O-β-D-glucuronide is an active metabolite of the β1-adrenergic receptor antagonist nebivolol. Nebivolol O-β-D-Glucuronide Chemical Structure
  15. GC91360 NM-3 NM-3 is a synthetic isocoumarin and an inhibitor of angiogenesis. NM-3 Chemical Structure
  16. GC73434 NRX-0492 NRX-0492 is an orally active and potent degrader of BTK. NRX-0492 Chemical Structure
  17. GC44465 NSC 12

    NSC 172285

     NSC 12 is an extracellular trap for fibroblast growth factor 2 (FGF2) that binds FGF2 (Kd = 51 μM) and interferes with its interaction with FGFR1, without affecting the ability of FGF2 to bind heparin or heparin sulfate proteoglycans (HSPGs). NSC 12 Chemical Structure
  18. GC44475 NVP-BEZ235 (hydrochloride)

    Dactolisib

     NVP-BEZ235 is a potent dual inhibitor of phosphatidylinositol 3-kinase (PI3K) and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies. NVP-BEZ235 (hydrochloride) Chemical Structure
  19. GC69600 NX-2127

    NX-2127 is an orally effective BTK inhibitor that can induce the degradation of mutated BTKC481S in cells. NX-2127 inhibits the proliferation of TMD8 cells with the BTKC481S mutation more effectively than Ibrutinib. NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3), corresponding to concentrations of 25 nM and 54 nM, respectively. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T cells.

     NX-2127 Chemical Structure
  20. GC49349 O-Desethyl Sildenafil A metabolite of sildenafil O-Desethyl Sildenafil Chemical Structure
  21. GC16107 Obtustatin An integrin α1β1 inhibitor Obtustatin Chemical Structure
  22. GC74342 Obtustatin triacetate Obtustatin triacetate is a 41-residue non-RGD disintegrin. Obtustatin triacetate Chemical Structure
  23. GC17358 Octyl-α-ketoglutarate

    α-KG octyl ester

     prolyl hydroxylases (PHD) activator Octyl-α-ketoglutarate Chemical Structure
  24. GC15199 OGT 2115 Heparanase inhibitor OGT 2115 Chemical Structure
  25. GC12821 Oltipraz

    NSC 347901, RP 35972

     Nrf2 activator;An antischistosomal agent Oltipraz Chemical Structure
  26. GC13219 ONO-4059

    GS-4059 analog

     ONO-4059 is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor. ONO-4059 Chemical Structure
  27. GC69630 Orbofiban acetate

    Orbofiban acetate is an orally active platelet membrane glycoprotein IIb/IIIa antagonist that inhibits platelet aggregation.

     Orbofiban acetate Chemical Structure
  28. GC41625 Oroxylin A

    6-Methoxybaicalein

    Oroxylin A is a flavonoid that has been found in S.

     Oroxylin A Chemical Structure
  29. GC36821 OSU-T315 OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner. OSU-T315 causes cell death through apoptosis and autophagy. OSU-T315 Chemical Structure
  30. GC11951 PAR 4 (1-6)

    GYPGQV

    PAR4 agonist

     PAR 4 (1-6) Chemical Structure
  31. GC62101 PAR-2-IN-1 PAR-2-IN-1 is a protease-activated receptor-2 (PAR2) signaling pathway inhibitor with anti-inflammatory and anticancer effects. PAR-2-IN-1 Chemical Structure
  32. GA23350 PAR-3 (1-6) amide (human) PAR-3 (1-6) amide (human) is a proteinase-activated receptor (PAR-3) agonist peptide. PAR-3 (1-6) amide (human) Chemical Structure
  33. GC33599 PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA))

    PAR-4-AP TFA; AY-NH2 TFA

     PAR-4 agonist peptide, amide TFA (PAR-4-AP (TFA)) is a synthetic peptide primarily used to activate protease-activated receptor 4 (PAR-4) . PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)) Chemical Structure
  34. GC15817 PAR-4 Agonist Peptide, amide (AY-NH2)

    PAR-4-AP; AY-NH2

     PAR-4 Agonist Peptide, amide(AY-NH2) (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist. PAR-4 Agonist Peptide, amide (AY-NH2) Chemical Structure
  35. GC38134 Parmodulin 2 Reversible inhibitor of PAR1mediated platelet activation Parmodulin 2 Chemical Structure
  36. GC69663 Parstatin(mouse) TFA

    Parstatin (mouse) TFA is a peptide agonist of the PAR-1 thrombin receptor with cell-penetrating properties and an effective inhibitor of angiogenesis.

     Parstatin(mouse) TFA Chemical Structure
  37. GC40085 Pazopanib-d6 Pazopanib-d6 is intended for use as an internal standard for the quantification of pazopanib by GC- or LC-MS. Pazopanib-d6 Chemical Structure
  38. GC36861 PCI 29732 A multi-kinase inhibitor PCI 29732 Chemical Structure
  39. GC13812 PCI-32765 (Ibrutinib)

    Imbruvica, PCI 32765

     PCI-32765 (Ibrutinib) is an irreversible selective inhibitor of Bruton s tyrosine kinase (BTK) that selectively targets its kinase domain and modulates BTK downstream signaling by reducing its phosphorylating capacity with IC50 of 0.5 nM in cell-free assays. PCI-32765 (Ibrutinib) Chemical Structure
  40. GC12921 PCI-32765 Racemate PCI-32765 Racemate (PCI-32765 Racemate) is the racemate of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with IC50 value of 0.5 nM. PCI-32765 Racemate Chemical Structure
  41. GC30155 PCI-33380 PCI-33380 is an irreversible and selective Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe). PCI-33380 Chemical Structure
  42. GC44584 PD 168368 PD 168368 is a competitive antagonist of neuromedin B (NMB) receptors (Kis = 15-45 nM for rat and human receptors expressed in various cell lines). PD 168368 Chemical Structure
  43. GC34709 PF-06250112 PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively. PF-06250112 Chemical Structure
  44. GC62515 Pirtobrutinib

    LOXO-305, LY3527727

     Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM. Pirtobrutinib Chemical Structure
  45. GC10235 Plinabulin (NPI-2358)

    NPI-2358

     Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells. Plinabulin (NPI-2358) binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells. Plinabulin (NPI-2358) Chemical Structure
  46. GC67708 PLN-1474 PLN-1474 Chemical Structure
  47. GC47965 Pomalidomide-d5 An internal standard for the quantification of pomalidomide Pomalidomide-d5 Chemical Structure
  48. GC47966 PPACK (trifluoroacetate salt)

    Pebac, DPhenylalanylprolylarginyl Chloromethyl Ketone

     An antithrombin peptide PPACK (trifluoroacetate salt) Chemical Structure
  49. GC31339 PRN1008

    PRN1008

     PRN1008 (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton's Tyrosine Kinase (BTK), with an IC50 of 1.3 nM. PRN1008 Chemical Structure
  50. GC47980 Propionyl-L-carnitine-d3 (chloride)

    C3:0 Carnitine-d3, CAR 3:0-d3, L-Carnitine propionyl ester-d3, Levocarnitine propionate-d3, L-Propionylcarnitine-d3

    An internal standard for the quantification of propionyl-L-carnitine

     Propionyl-L-carnitine-d3 (chloride) Chemical Structure
  51. GC69768 Protease-Activated Receptor-1, PAR-1 Agonist

    Protease-Activated Receptor-1, PAR-1 Agonist is a selective peptide that activates Protease-Activated Receptor-1 (PAR-1), which corresponds to the PAR1 ligand and selectively mimics the action of thrombin through this receptor.

     Protease-Activated Receptor-1, PAR-1 Agonist Chemical Structure
  52. GC62469 Protease-Activated Receptor-1, PAR-1 Agonist TFA Protease-Activated Receptor-1, PAR-1 Agonist TFA is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist TFA corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor. Protease-Activated Receptor-1, PAR-1 Agonist TFA Chemical Structure
  53. GC61456 Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is a proteinase-activated receptor (PAR-3) agonist peptide. Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA Chemical Structure
  54. GC33429 Protease-Activated Receptor-4 Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4). Protease-Activated Receptor-4 Chemical Structure
  55. GC49873 Protectin D1 methyl ester

    Neuroprotectin D1 methyl ester, NPD1 methyl ester, PD1 methyl ester

     An esterified form of protectin D1 Protectin D1 methyl ester Chemical Structure
  56. GC32680 PT-2385 PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM. PT-2385 Chemical Structure
  57. GC37034 PT2977

    PT2977; MK-6482

     PT2977 (PT2977) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. PT2977, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC). PT2977 Chemical Structure
  58. GC60311 PTUPB PTUPB is a novel dual COX-2 and sEH inhibitor with IC50 values of 1.26 nM and 0.9 μM, respectively. PTUPB Chemical Structure
  59. GC15594 PX 12

    IV-2

     An irreversible inhibitor of thioredoxin-1 PX 12 Chemical Structure
  60. GC11031 PX-478 2HCl

    PX-478 is a selective inhibitor that suppresses constitutive and hypoxia-induced HIF-1α levels.

     PX-478 2HCl Chemical Structure
  61. GC37048 QL47 QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses. QL47 Chemical Structure
  62. GC49221 QLT0267 An ILK inhibitor QLT0267 Chemical Structure
  63. GC44800 Quininib A CysLT1 and CysLT2 receptor antagonist Quininib Chemical Structure
  64. GC37066 Rac-PT2399 A potent and specific HIF-2α inhibitor Rac-PT2399 Chemical Structure
  65. GC40213 Regorafenib-13C-d3 Regorafenib-13C-d3 is intended for use as an internal standard for the quantification of regorafenib by GC- or LC-MS. Regorafenib-13C-d3 Chemical Structure
  66. GC38375 Remibrutinib Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. Remibrutinib Chemical Structure
  67. GC10184 RGD (Arg-Gly-Asp) Peptides RGD (Arg-Gly-Asp) Peptides is a tripeptide that can bind to integrins, effectively induce cell adhesion, locate a specific cell line and produce a specific cellular response. RGD (Arg-Gly-Asp) Peptides Chemical Structure
  68. GC37524 RGD peptide (GRGDNP) TFA RGD peptide (GRGDNP) TFA Chemical Structure
  69. GC34402 RGD Trifluoroacetate RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins. RGD Trifluoroacetate Chemical Structure
  70. GC16385 RGDS peptide

    Fibronectin Inhibitor, HArgGlyAspSerOH

     RGDS peptide is an integrin binding sequence that inhibits integrin receptor function. RGDS peptide Chemical Structure
  71. GC45798 Rhein-13C4

    Rheic Acid-13C4

    An internal standard for the quantification of rhein

     Rhein-13C4 Chemical Structure
  72. GC37541 Risuteganib Risuteganib Chemical Structure
  73. GC17991 RLLFT-NH2 Protease-activated receptor agonist RLLFT-NH2 Chemical Structure
  74. GC11230 RN486 Btk inhibitor,potent and selective RN486 Chemical Structure
  75. GC62397 RO0270608 RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. RO0270608 Chemical Structure
  76. GC72461 Rovelizumab Rovelizumab is a humanized monoclonal leukointegrin antibody. Rovelizumab Chemical Structure
  77. GC73373 RSH-7 RSH-7 is a potent BTK and FLT3 inhibitor with IC50s of 47, 12 nM, respectively. RSH-7 Chemical Structure
  78. GC14795 RWJ 50271 LFA-1/sICAM interaction inhibitor RWJ 50271 Chemical Structure
  79. GC61777 RWJ-56110 dihydrochloride RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride Chemical Structure
  80. GC14143 SB273005

    An αvβ3 antagonist

     SB273005 Chemical Structure
  81. GC10291 SCH 79797 dihydrochloride PAR1 receptor antagonist SCH 79797 dihydrochloride Chemical Structure
  82. GC63540 SCH79797 SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 Chemical Structure
  83. GC64571 Sibrafiban

    RO 48-3657

     Sibrafiban (RO 48-3657) is the orally active, nonpeptide, double-prodrug of Ro 44-3888 and a selective glycoprotein IIb/IIIa receptor antagonist. Sibrafiban Chemical Structure
  84. GC49713 SIKVAV (acetate)

    Hexapeptide-10, Ser-Ile-Lys-Val-Ala-Val

     A laminin α1-derived peptide SIKVAV (acetate) Chemical Structure
  85. GC49358 Sildenafil Chlorosulfonyl

    CMP

     An intermediate in the synthesis of sildenafil Sildenafil Chlorosulfonyl Chemical Structure
  86. GC48078 Sildenafil-d3 An internal standard for the quantification of sildenafil Sildenafil-d3 Chemical Structure
  87. GC62614 SJF620 hydrochloride SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN. SJF620 hydrochloride Chemical Structure
  88. GC14540 SLIGKV-NH2 SLIGKV-NH2 (SLIGKV-NH2) is a highly potent protease-activated receptor-2 (PAR2) activating peptide. SLIGKV-NH2 Chemical Structure
  89. GC17514 SLIGRL-NH2

    Protease-Activated Receptor-2 Activating Peptide

     PAR2 activator SLIGRL-NH2 Chemical Structure
  90. GC37672 Spebrutinib besylate

    AVL-292 benzenesulfonate; CC-292 besylate

     Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a potent inhibitor of Btk kinase activity (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s) in biochemical assays. Spebrutinib besylate Chemical Structure
  91. GC40963 Spirolaxine Spirolaxine is a long-chain phthalide produced by the fungus S. Spirolaxine Chemical Structure
  92. GC31993 SR121566A SR121566A is a novel non-peptide Glycoprotein IIb/IIIa (GP IIb-IIIa) antagonist, which can inhibit ADP-, arachidonic acid- and collagen-induced human platelet aggregation with IC50s of 46±7.5, 56±6 and 42±3 nM, respectively. SR121566A Chemical Structure
  93. GC44956 Streptochlorin

    SF 2583A

     Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. Streptochlorin Chemical Structure
  94. GC45688 STX140

    2-Methoxyestradiol-bis-sulphamate

     An estrogen sulfamate STX140 Chemical Structure
  95. GC44966 Sucrose octasulfate (potassium salt)

    SOS, Sucrosofate potassium

     Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. Sucrose octasulfate (potassium salt) Chemical Structure
  96. GC74395 Synstatin (92-119)

    SSTN92-119

     Synstatin (92-119) is an anti-tumor agent that inhibits angiogenesis and cancer cell invasion. Synstatin (92-119) Chemical Structure
  97. GC32876 SYP-5 A HIF-1 inhibitor SYP-5 Chemical Structure
  98. GC48122 Tafluprost (free acid)-d4

    AFP-172-d4

     A neuropeptide with diverse biological activities Tafluprost (free acid)-d4 Chemical Structure
  99. GC48123 Tafluprost-d4

    AFP-168-d4

     A neuropeptide with diverse biological activities Tafluprost-d4 Chemical Structure
  100. GC64120 TAK-020 TAK-020 is a covalent Btk inhibitor, which becomes the clinical candidate. TAK-020 Chemical Structure
  101. GC12037 TC-I 15 α2β1 integrin inhibitor TC-I 15 Chemical Structure

Items 201 to 300 of 343 total

per page
  2. 1
  3. 2
  4. 3
  5. 4

Set Descending Direction