VDA
VDAs (vascular disrupting agents) target established tumor vasculature and lead to blood vessels shutdown and selective tumor necrosis.
Products for VDA
- Cat.No. Product Name Information
- GC10235 Plinabulin (NPI-2358) Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells. Plinabulin (NPI-2358) binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells.