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Home >> Signaling Pathways >> Angiogenesis >> VDA

VDA

VDAs (vascular disrupting agents) target established tumor vasculature and lead to blood vessels shutdown and selective tumor necrosis.

Products for VDA

Cat.No. Product Name Information
GC10235 Plinabulin (NPI-2358)

NPI-2358
Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells. Plinabulin (NPI-2358) binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells.