ADC Linker
Antibody-drug conjugates (ADCs) consist of a desirable monoclonal antibody, an active cytotoxic drug and an appropriate linker. An appropriate linker between the antibody and the cytotoxic drug provides a specific bridge, and thus helps the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately releases the cytotoxic drug at tumor sites. In addition to conjugation, the linkers maintain ADCs’ stability during the preparation and storage stages of the ADCs and during the systemic circulation period.
The ADCs currently undergoing clinical evaluation contain linkers are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell. Noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule, which will retain the linker and the amino acid by which it was attached to the antibody.
The selection of linker is target dependent, based on the knowledge of the internalization and degradation of the antibody-target antigen complex, and a preclinical in vitro and in vivo activity comparison of conjugates. Moreover, the choice of a linker is also influenced by which cytotoxin is used, as each molecule has different chemical constraints, and frequently the drug structure lends itself to a specific linker.
Targets for ADC Linker
Products for ADC Linker
- Cat.No. Product Name Information
- GC67414 Biotin-PEG1-azide Biotin-PEG1-azide is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC65237 Biotin-PEG1-NH2 Biotin-PEG1-NH2 is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC62656 Biotin-PEG3-SS-azide Biotin-PEG3-SS-azide is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67267 Biotin-PEG4-Dde-TAMRA-PEG3-Azide Biotin-PEG4-Dde-TAMRA-PEG3-Azide is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66749 Biotin-PEG4-PFP ester Biotin-PEG4-PFP ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67198 Biotin-sar-oh Biotin-sar-oh is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66964 Bis-(PEG6-acid)-SS Bis-(PEG6-acid)-SS is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC65858 Bis-?PEG4-?NHS ester Bis-PEG4-NHS ester is a nonclaevable 4-unit PEG linker for antibody-drug-conjugation (ADC).
- GC38338 Bis-PEG1-NHS ester Bis-PEG1-NHS ester is a nonclaevable 1-unit PEG linker for antibody-drug-conjugation (ADC).
- GC67181 Bis-PEG1-PFP ester Bis-PEG1-PFP ester is a non-cleavable (1 unit PEG) ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67317 Bis-PEG17-NHS ester Bis-PEG17-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG17-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC60083 Bis-PEG2-NHS ester Bis-PEG2-NHS ester is a nonclaevable 2-unit PEG linker for antibody-drug-conjugation (ADC).
- GC65859 Bis-PEG3-NHS ester Bis-PEG3-NHS ester is a nonclaevable 3-unit PEG linker for antibody-drug-conjugation (ADC).
- GC65652 Bis-PEG5-NHS ester Bis-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC39521 Bis-PEG6-NHS ester Bis-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC63834 Bis-PEG7-NHS ester Bis-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC63847 Bis-PEG9-NHS ester Bis-PEG9-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG9-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66906 Bis-SS-C3-NHS ester Bis-SS-C3-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC64023 Bis-sulfone-PEG3-Azide Bis-sulfone-PEG3-Azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67539 Bis-Tos-(2-hydroxyethyl disulfide) Bis-Tos-(2-hydroxyethyl disulfide) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66046 bisSP1 bisSP1 is an antibody drug conjugates linker.
- GC38739 BMPS BMPS is a nonclaevable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC62535 BnO-PEG6-OH BnO-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66116 Boc-aminooxy-amide-PEG4-propargyl Boc-aminooxy-amide-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66762 Boc-aminooxy-ethyl-SS-propanol Boc-aminooxy-ethyl-SS-propanol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66754 Boc-Aminooxy-PEG2-bromide Boc-Aminooxy-PEG2-bromide is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66213 Boc-C14-COOH Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
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GC63924
Boc-C16-COOH
Boc-C16-COOH is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs
- GC67000 Boc-Cystamine Boc-Cystamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC60651 Boc-Dap-NE Boc-Dap-NE, a dipeptide, is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC65003 Boc-Gly-Gly-Phe-Gly-OH Boc-Gly-Gly-Phe-Gly-OH, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).
- GC35539 Boc-Gly-Gly-Phe-Gly-OH TFA Boc-Gly-Gly-Phe-Gly-OH TFA, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).
- GC38234 Boc-NH-C6-Br Boc-NH-C6-Br is a non-cleavable linker used for antibody-drug conjugates (ADC).
- GC63995 Boc-NH-ethyl-SS-propionic acid Boc-NH-ethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66179 Boc-NH-PEG1-CH2CH2COOH Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs.
- GC60655 Boc-NH-PEG4-CH2CH2COOH Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Boc-NH-PEG4-CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC).
- GC60656 Boc-NH-PEG4-CH2CH2NH2 Boc-NH-PEG4-CH2CH2NH2 a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-NH-PEG4-CH2CH2NH2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- GC64316 Boc-NH-PEG4-CH2COOH Boc-NH-PEG4-CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG4-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- GC39200 Boc-NH-PEG6-CH2CH2COOH Boc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- GC67188 Boc-Phe-(Alloc)Lys-PAB-PNP Boc-Phe-(Alloc)Lys-PAB-PNP is a used as a cleavable linker for antibody-drug conjugates (ADC).
- GC64198 Boc-trans-D-Hyp-OMe Boc-trans-D-Hyp-OMe is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). Boc-trans-D-Hyp-OMe is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs.
- GC66690 Boc-Val-Ala-PAB-PNP Boc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC39596 Boc-Val-Cit-OH Boc-Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC63992 Boc-Val-Cit-PAB Boc-Val-Cit-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC62705 Boc-Val-Cit-PAB-PNP Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC60658 Boc-Val-Dil-Dap-OH Boc-Val-Dil-Dap-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC60664 Br-PEG4-C2-Boc Br-PEG4-C2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC63609 Bromo-PEG2-C2-azide Bromo-PEG2-C2-azide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bromo-PEG2-C2-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- GC66946 BS2G Crosslinker disodium BS2G Crosslinker (disodium) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67489 BS3 Crosslinker BS3 Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC62879 BS3 Crosslinker disodium BS3 Crosslinker disodium is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38040 Cbz-Phe-(Alloc)Lys-PAB-PNP Cbz-Phe-(Alloc)Lys-PAB-PNP is an cleavable linker for antibody-drug conjugates (ADC) design.
- GC64093 cis-4-Hydroxy-D-proline hydrochloride cis-4-Hydroxy-D-proline hydrochloride is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs.
- GC64155 cis-4-Hydroxy-L-proline hydrochloride cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based?PROTAC linker?that can be used in the synthesis of PROTACs.
- GC62899 CL2A CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker.
- GC66216 D-Proline, 4-hydroxy-, methyl ester hydrochloride D-Proline, 4-hydroxy-, methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). D-Proline, 4-hydroxy-, methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2
- GC39242 DBCO-acid DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester, and drug-linker conjugates DBCO-PEG-MMAE.
- GC63331 DBCO-amine DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC63315 DBCO-C3-Acid DBCO-C3-Acid is a Click Chemistry intermediate used in the synthesis of antibody-drug conjugate (ADC) linker.
- GC61874 DBCO-C6-acid DBCO-C6-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-C6-acid can be used in the synthesis of carmaphycin analogues.
- GC60741 DBCO-CONH-S-S-NHS ester DBCO-CONH-S-S-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC62325 DBCO-Maleimide DBCO-Maleimide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67325 DBCO-NHCO-PEG4-acid DBCO-Amide-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-Amide-PEG5-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67172 DBCO-NHCO-PEG4-amine DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB-MMAE and DBCO-TRX-MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively).
- GC66312 DBCO-NHCO-PEG4-NH-Boc DBCO-NHCO-PEG4-NH-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-NH-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66614 DBCO-NHCO-PEG4-NHS ester DBCO-NHCO-PEG4-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67987 DBCO-NHCO-S-S-NHS ester
- GC39241 DBCO-NHS ester DBCO-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC35814 DBCO-NHS ester 2 DBCO-NHS ester is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester is a derivative of Dibenzylcyclooctyne (DBCO) used in copper-free click chemistry.
- GC66815 DBCO-NHS ester 3 DBCO-NHS ester 3 (Compound 12) is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 3 is a derivative of Dibenzylcyclooctyne (DBCO) obtained by activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC).
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GC60122
DBCO-PEG3-SS-NHS ester
DBCO-PEG3-SS-NHS ester is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC60743 DBCO-PEG4-acetic-Val-Cit-PAB DBCO-PEG4-acetic-Val-Cit-PAB is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC39605 DBCO-PEG4-amine DBCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker).
- GC67529 DBCO-PEG4-DBCO DBCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC61480 DBCO-PEG4-Maleimide DBCO-PEG4-Maleimide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66196 DBCO-PEG5-NHS ester DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66851 DBCO-Sulfo-Link-biotin DBCO-Sulfo-Link-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67161 DBCO-Sulfo-NHS ester sodium DBCO-Sulfo-NHS ester sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66848 Dimethylamine-SPDB Dimethylamine-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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GC43479
Disuccinimidyl Glutarate
Disuccinimidyl Glutarate is an insoluble bisfunctional N-hydroxysuccinimide (NHS ester) crosslinking agent that is commonly used to pair radiolabelled ligands to cell surface receptors
- GC43480 Disuccinimidyl Suberate Disuccinimidyl Suberate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC63498 DM21 DM21 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38773 DMAC-PDB DMAC-PDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC64199 Docosanedioic acid Docosanedioic acid is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs.
- GC61798 DOTA-NHS-ester DOTA-NHS-ester is a linker for affibody molecules and is applied in small animals PET, SPECT, and CT. DOTA-NHS-ester can be used to label radiotherapeutic agents or imaging probes for the detection of tumors.
- GC18378 DSP DSP is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs).
- GC67488 DTSSP Crosslinker DTSSP Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC65996 EC1167 hydrochloride EC1167 hydrochloride is the linker for EC1169. EC1169 is prostate-specific membrane antigen targeting-tubulysin conjugate. EC1169 hydrochloride has the potential to treat recurrent metastatic, castration-resistant prostate cancer (MCRPC).
- GC66214 Eicosanedioic acid Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis
- GC62468 endo-BCN-PEG4-Val-Cit-PAB-MMAE endo-BCN-PEG4-Val-Cit-PAB-MMAE is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC64049 Ethyl azetidine-3-carboxylate hydrochloride Ethyl azetidine-3-carboxylate hydrochloride is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). Ethyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs
- GC67638 Fluorescein-DBCO Fluorescein-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC60848 Fmoc-3VVD-OH Fmoc-3VVD-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GA21498 Fmoc-AEEAc-OH Fmoc-AEEAc-OH (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-AEEAc-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- GC60849 Fmoc-Ala-Ala-Asn(Trt)-OH Fmoc-Ala-Ala-Asn(Trt)-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38633 Fmoc-Ala-Ala-Asn-PABC-PNP Fmoc-Ala-Ala-Asn-PABC-PNP is a peptide cleavable ADC linker.
- GC61603 Fmoc-aminooxy-PEG2-NH2 Fmoc-aminooxy-PEG2-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC39229 Fmoc-Asp-NH2 Fmoc-Asp-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GA21545 Fmoc-Asp-NH₂
- GC64197 Fmoc-azetidine-3-carboxylic acid Fmoc-azetidine-3-carboxylic acid is a cleavable ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs.