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ADC Linker

Antibody-drug conjugates (ADCs) consist of a desirable monoclonal antibody, an active cytotoxic drug and an appropriate linker. An appropriate linker between the antibody and the cytotoxic drug provides a specific bridge, and thus helps the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately releases the cytotoxic drug at tumor sites. In addition to conjugation, the linkers maintain ADCs’ stability during the preparation and storage stages of the ADCs and during the systemic circulation period.

The ADCs currently undergoing clinical evaluation contain linkers are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell. Noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule, which will retain the linker and the amino acid by which it was attached to the antibody.

The selection of linker is target dependent, based on the knowledge of the internalization and degradation of the antibody-target antigen complex, and a preclinical in vitro and in vivo activity comparison of conjugates. Moreover, the choice of a linker is also influenced by which cytotoxin is used, as each molecule has different chemical constraints, and frequently the drug structure lends itself to a specific linker.

Targets for  ADC Linker

Products for  ADC Linker

  1. Cat.No. Product Name Information
  2. GC67414 Biotin-PEG1-azide Biotin-PEG1-azide is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Biotin-PEG1-azide  Chemical Structure
  3. GC65237 Biotin-PEG1-NH2 Biotin-PEG1-NH2 is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Biotin-PEG1-NH2  Chemical Structure
  4. GC62656 Biotin-PEG3-SS-azide Biotin-PEG3-SS-azide is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Biotin-PEG3-SS-azide  Chemical Structure
  5. GC67267 Biotin-PEG4-Dde-TAMRA-PEG3-Azide Biotin-PEG4-Dde-TAMRA-PEG3-Azide is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Biotin-PEG4-Dde-TAMRA-PEG3-Azide  Chemical Structure
  6. GC66749 Biotin-PEG4-PFP ester Biotin-PEG4-PFP ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Biotin-PEG4-PFP ester  Chemical Structure
  7. GC67198 Biotin-sar-oh Biotin-sar-oh is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Biotin-sar-oh  Chemical Structure
  8. GC66964 Bis-(PEG6-acid)-SS Bis-(PEG6-acid)-SS is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-(PEG6-acid)-SS  Chemical Structure
  9. GC65858 Bis-?PEG4-?NHS ester Bis-​PEG4-​NHS ester is a nonclaevable 4-unit PEG linker for antibody-drug-conjugation (ADC). Bis-?PEG4-?NHS ester  Chemical Structure
  10. GC38338 Bis-PEG1-NHS ester Bis-PEG1-NHS ester is a nonclaevable 1-unit PEG linker for antibody-drug-conjugation (ADC). Bis-PEG1-NHS ester  Chemical Structure
  11. GC67181 Bis-PEG1-PFP ester Bis-PEG1-PFP ester is a non-cleavable (1 unit PEG) ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-PEG1-PFP ester  Chemical Structure
  12. GC67317 Bis-PEG17-NHS ester Bis-PEG17-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG17-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-PEG17-NHS ester  Chemical Structure
  13. GC60083 Bis-PEG2-NHS ester Bis-PEG2-NHS ester is a nonclaevable 2-unit PEG linker for antibody-drug-conjugation (ADC). Bis-PEG2-NHS ester  Chemical Structure
  14. GC65859 Bis-PEG3-NHS ester Bis-PEG3-NHS ester is a nonclaevable 3-unit PEG linker for antibody-drug-conjugation (ADC). Bis-PEG3-NHS ester  Chemical Structure
  15. GC65652 Bis-PEG5-NHS ester Bis-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-PEG5-NHS ester  Chemical Structure
  16. GC39521 Bis-PEG6-NHS ester Bis-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-PEG6-NHS ester  Chemical Structure
  17. GC63834 Bis-PEG7-NHS ester Bis-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-PEG7-NHS ester  Chemical Structure
  18. GC63847 Bis-PEG9-NHS ester Bis-PEG9-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG9-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-PEG9-NHS ester  Chemical Structure
  19. GC66906 Bis-SS-C3-NHS ester Bis-SS-C3-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-SS-C3-NHS ester  Chemical Structure
  20. GC64023 Bis-sulfone-PEG3-Azide Bis-sulfone-PEG3-Azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-sulfone-PEG3-Azide  Chemical Structure
  21. GC67539 Bis-Tos-(2-hydroxyethyl disulfide) Bis-Tos-(2-hydroxyethyl disulfide) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-Tos-(2-hydroxyethyl disulfide)  Chemical Structure
  22. GC66046 bisSP1 bisSP1 is an antibody drug conjugates linker. bisSP1  Chemical Structure
  23. GC38739 BMPS BMPS is a nonclaevable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). BMPS  Chemical Structure
  24. GC62535 BnO-PEG6-OH BnO-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). BnO-PEG6-OH  Chemical Structure
  25. GC66116 Boc-aminooxy-amide-PEG4-propargyl Boc-aminooxy-amide-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-aminooxy-amide-PEG4-propargyl  Chemical Structure
  26. GC66762 Boc-aminooxy-ethyl-SS-propanol Boc-aminooxy-ethyl-SS-propanol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-aminooxy-ethyl-SS-propanol  Chemical Structure
  27. GC66754 Boc-Aminooxy-PEG2-bromide Boc-Aminooxy-PEG2-bromide is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Aminooxy-PEG2-bromide  Chemical Structure
  28. GC66213 Boc-C14-COOH Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-C14-COOH  Chemical Structure
  29. GC63924 Boc-C16-COOH Boc-C16-COOH is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs Boc-C16-COOH  Chemical Structure
  30. GC67000 Boc-Cystamine Boc-Cystamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Cystamine  Chemical Structure
  31. GC60651 Boc-Dap-NE Boc-Dap-NE, a dipeptide, is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Dap-NE  Chemical Structure
  32. GC65003 Boc-Gly-Gly-Phe-Gly-OH Boc-Gly-Gly-Phe-Gly-OH, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC). Boc-Gly-Gly-Phe-Gly-OH  Chemical Structure
  33. GC35539 Boc-Gly-Gly-Phe-Gly-OH TFA Boc-Gly-Gly-Phe-Gly-OH TFA, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC). Boc-Gly-Gly-Phe-Gly-OH TFA  Chemical Structure
  34. GC38234 Boc-NH-C6-Br Boc-NH-C6-Br is a non-cleavable linker used for antibody-drug conjugates (ADC). Boc-NH-C6-Br  Chemical Structure
  35. GC63995 Boc-NH-ethyl-SS-propionic acid Boc-NH-ethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-NH-ethyl-SS-propionic acid  Chemical Structure
  36. GC66179 Boc-NH-PEG1-CH2CH2COOH Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs. Boc-NH-PEG1-CH2CH2COOH  Chemical Structure
  37. GC60655 Boc-NH-PEG4-CH2CH2COOH Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Boc-NH-PEG4-CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG4-CH2CH2COOH  Chemical Structure
  38. GC60656 Boc-NH-PEG4-CH2CH2NH2 Boc-NH-PEG4-CH2CH2NH2 a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-NH-PEG4-CH2CH2NH2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG4-CH2CH2NH2  Chemical Structure
  39. GC64316 Boc-NH-PEG4-CH2COOH Boc-NH-PEG4-CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG4-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG4-CH2COOH  Chemical Structure
  40. GC39200 Boc-NH-PEG6-CH2CH2COOH Boc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG6-CH2CH2COOH  Chemical Structure
  41. GC67188 Boc-Phe-(Alloc)Lys-PAB-PNP Boc-Phe-(Alloc)Lys-PAB-PNP is a used as a cleavable linker for antibody-drug conjugates (ADC). Boc-Phe-(Alloc)Lys-PAB-PNP  Chemical Structure
  42. GC64198 Boc-trans-D-Hyp-OMe Boc-trans-D-Hyp-OMe is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). Boc-trans-D-Hyp-OMe is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs. Boc-trans-D-Hyp-OMe  Chemical Structure
  43. GC66690 Boc-Val-Ala-PAB-PNP Boc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Val-Ala-PAB-PNP  Chemical Structure
  44. GC39596 Boc-Val-Cit-OH Boc-Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Val-Cit-OH  Chemical Structure
  45. GC63992 Boc-Val-Cit-PAB Boc-Val-Cit-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Val-Cit-PAB  Chemical Structure
  46. GC62705 Boc-Val-Cit-PAB-PNP Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Val-Cit-PAB-PNP  Chemical Structure
  47. GC60658 Boc-Val-Dil-Dap-OH Boc-Val-Dil-Dap-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Val-Dil-Dap-OH  Chemical Structure
  48. GC60664 Br-PEG4-C2-Boc Br-PEG4-C2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Br-PEG4-C2-Boc  Chemical Structure
  49. GC63609 Bromo-PEG2-C2-azide Bromo-PEG2-C2-azide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bromo-PEG2-C2-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG2-C2-azide  Chemical Structure
  50. GC66946 BS2G Crosslinker disodium BS2G Crosslinker (disodium) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). BS2G Crosslinker disodium  Chemical Structure
  51. GC67489 BS3 Crosslinker BS3 Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). BS3 Crosslinker  Chemical Structure
  52. GC62879 BS3 Crosslinker disodium BS3 Crosslinker disodium is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). BS3 Crosslinker disodium  Chemical Structure
  53. GC38040 Cbz-Phe-(Alloc)Lys-PAB-PNP Cbz-Phe-(Alloc)Lys-PAB-PNP is an cleavable linker for antibody-drug conjugates (ADC) design. Cbz-Phe-(Alloc)Lys-PAB-PNP  Chemical Structure
  54. GC64093 cis-4-Hydroxy-D-proline hydrochloride cis-4-Hydroxy-D-proline hydrochloride is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs. cis-4-Hydroxy-D-proline hydrochloride  Chemical Structure
  55. GC64155 cis-4-Hydroxy-L-proline hydrochloride cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based?PROTAC linker?that can be used in the synthesis of PROTACs. cis-4-Hydroxy-L-proline hydrochloride  Chemical Structure
  56. GC62899 CL2A CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A  Chemical Structure
  57. GC66216 D-Proline, 4-hydroxy-, methyl ester hydrochloride D-Proline, 4-hydroxy-, methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). D-Proline, 4-hydroxy-, methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2 D-Proline, 4-hydroxy-, methyl ester hydrochloride  Chemical Structure
  58. GC39242 DBCO-acid DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester, and drug-linker conjugates DBCO-PEG-MMAE. DBCO-acid  Chemical Structure
  59. GC63331 DBCO-amine DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-amine  Chemical Structure
  60. GC63315 DBCO-C3-Acid DBCO-C3-Acid is a Click Chemistry intermediate used in the synthesis of antibody-drug conjugate (ADC) linker. DBCO-C3-Acid  Chemical Structure
  61. GC61874 DBCO-C6-acid DBCO-C6-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-C6-acid can be used in the synthesis of carmaphycin analogues. DBCO-C6-acid  Chemical Structure
  62. GC60741 DBCO-CONH-S-S-NHS ester DBCO-CONH-S-S-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-CONH-S-S-NHS ester  Chemical Structure
  63. GC62325 DBCO-Maleimide DBCO-Maleimide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-Maleimide  Chemical Structure
  64. GC67325 DBCO-NHCO-PEG4-acid DBCO-Amide-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-Amide-PEG5-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-NHCO-PEG4-acid  Chemical Structure
  65. GC67172 DBCO-NHCO-PEG4-amine DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB-MMAE and DBCO-TRX-MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively). DBCO-NHCO-PEG4-amine  Chemical Structure
  66. GC66312 DBCO-NHCO-PEG4-NH-Boc DBCO-NHCO-PEG4-NH-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-NH-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-NHCO-PEG4-NH-Boc  Chemical Structure
  67. GC66614 DBCO-NHCO-PEG4-NHS ester DBCO-NHCO-PEG4-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-NHCO-PEG4-NHS ester  Chemical Structure
  68. GC67987 DBCO-NHCO-S-S-NHS ester DBCO-NHCO-S-S-NHS ester  Chemical Structure
  69. GC39241 DBCO-NHS ester DBCO-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-NHS ester  Chemical Structure
  70. GC35814 DBCO-NHS ester 2 DBCO-NHS ester is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester is a derivative of Dibenzylcyclooctyne (DBCO) used in copper-free click chemistry. DBCO-NHS ester 2  Chemical Structure
  71. GC66815 DBCO-NHS ester 3 DBCO-NHS ester 3 (Compound 12) is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 3 is a derivative of Dibenzylcyclooctyne (DBCO) obtained by activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC). DBCO-NHS ester 3  Chemical Structure
  72. GC60122 DBCO-PEG3-SS-NHS ester

    DBCO-PEG3-SS-NHS ester is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

    DBCO-PEG3-SS-NHS ester  Chemical Structure
  73. GC60743 DBCO-PEG4-acetic-Val-Cit-PAB DBCO-PEG4-acetic-Val-Cit-PAB is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-acetic-Val-Cit-PAB  Chemical Structure
  74. GC39605 DBCO-PEG4-amine DBCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker). DBCO-PEG4-amine  Chemical Structure
  75. GC67529 DBCO-PEG4-DBCO DBCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-DBCO  Chemical Structure
  76. GC61480 DBCO-PEG4-Maleimide DBCO-PEG4-Maleimide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-Maleimide  Chemical Structure
  77. GC66196 DBCO-PEG5-NHS ester DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG5-NHS ester  Chemical Structure
  78. GC66851 DBCO-Sulfo-Link-biotin DBCO-Sulfo-Link-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-Sulfo-Link-biotin  Chemical Structure
  79. GC67161 DBCO-Sulfo-NHS ester sodium DBCO-Sulfo-NHS ester sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-Sulfo-NHS ester sodium  Chemical Structure
  80. GC66848 Dimethylamine-SPDB Dimethylamine-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Dimethylamine-SPDB  Chemical Structure
  81. GC43479 Disuccinimidyl Glutarate

    Disuccinimidyl Glutarate is an insoluble bisfunctional N-hydroxysuccinimide (NHS ester) crosslinking agent that is commonly used to pair radiolabelled ligands to cell surface receptors

    Disuccinimidyl Glutarate  Chemical Structure
  82. GC43480 Disuccinimidyl Suberate Disuccinimidyl Suberate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Disuccinimidyl Suberate  Chemical Structure
  83. GC63498 DM21 DM21 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DM21  Chemical Structure
  84. GC38773 DMAC-PDB DMAC-PDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DMAC-PDB  Chemical Structure
  85. GC64199 Docosanedioic acid Docosanedioic acid is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs. Docosanedioic acid  Chemical Structure
  86. GC61798 DOTA-NHS-ester DOTA-NHS-ester is a linker for affibody molecules and is applied in small animals PET, SPECT, and CT. DOTA-NHS-ester can be used to label radiotherapeutic agents or imaging probes for the detection of tumors. DOTA-NHS-ester  Chemical Structure
  87. GC18378 DSP DSP is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs). DSP  Chemical Structure
  88. GC67488 DTSSP Crosslinker DTSSP Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DTSSP Crosslinker  Chemical Structure
  89. GC65996 EC1167 hydrochloride EC1167 hydrochloride is the linker for EC1169. EC1169 is prostate-specific membrane antigen targeting-tubulysin conjugate. EC1169 hydrochloride has the potential to treat recurrent metastatic, castration-resistant prostate cancer (MCRPC). EC1167 hydrochloride  Chemical Structure
  90. GC66214 Eicosanedioic acid Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis Eicosanedioic acid  Chemical Structure
  91. GC62468 endo-BCN-PEG4-Val-Cit-PAB-MMAE endo-BCN-PEG4-Val-Cit-PAB-MMAE is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). endo-BCN-PEG4-Val-Cit-PAB-MMAE  Chemical Structure
  92. GC64049 Ethyl azetidine-3-carboxylate hydrochloride Ethyl azetidine-3-carboxylate hydrochloride is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). Ethyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs Ethyl azetidine-3-carboxylate hydrochloride  Chemical Structure
  93. GC67638 Fluorescein-DBCO Fluorescein-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fluorescein-DBCO  Chemical Structure
  94. GC60848 Fmoc-3VVD-OH Fmoc-3VVD-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-3VVD-OH  Chemical Structure
  95. GA21498 Fmoc-AEEAc-OH Fmoc-AEEAc-OH (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-AEEAc-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Fmoc-AEEAc-OH  Chemical Structure
  96. GC60849 Fmoc-Ala-Ala-Asn(Trt)-OH Fmoc-Ala-Ala-Asn(Trt)-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Ala-Ala-Asn(Trt)-OH  Chemical Structure
  97. GC38633 Fmoc-Ala-Ala-Asn-PABC-PNP Fmoc-Ala-Ala-Asn-PABC-PNP is a peptide cleavable ADC linker. Fmoc-Ala-Ala-Asn-PABC-PNP  Chemical Structure
  98. GC61603 Fmoc-aminooxy-PEG2-NH2 Fmoc-aminooxy-PEG2-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-aminooxy-PEG2-NH2  Chemical Structure
  99. GC39229 Fmoc-Asp-NH2 Fmoc-Asp-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Asp-NH2  Chemical Structure
  100. GA21545 Fmoc-Asp-NH₂ Fmoc-Asp-NH₂  Chemical Structure
  101. GC64197 Fmoc-azetidine-3-carboxylic acid Fmoc-azetidine-3-carboxylic acid is a cleavable ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs. Fmoc-azetidine-3-carboxylic acid  Chemical Structure

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