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ADC Linker

Antibody-drug conjugates (ADCs) consist of a desirable monoclonal antibody, an active cytotoxic drug and an appropriate linker. An appropriate linker between the antibody and the cytotoxic drug provides a specific bridge, and thus helps the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately releases the cytotoxic drug at tumor sites. In addition to conjugation, the linkers maintain ADCs’ stability during the preparation and storage stages of the ADCs and during the systemic circulation period.

The ADCs currently undergoing clinical evaluation contain linkers are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell. Noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule, which will retain the linker and the amino acid by which it was attached to the antibody.

The selection of linker is target dependent, based on the knowledge of the internalization and degradation of the antibody-target antigen complex, and a preclinical in vitro and in vivo activity comparison of conjugates. Moreover, the choice of a linker is also influenced by which cytotoxin is used, as each molecule has different chemical constraints, and frequently the drug structure lends itself to a specific linker.

Targets for  ADC Linker

Products for  ADC Linker

  1. Cat.No. Product Name Information
  2. GC38459 Propargyl-C2-NHS ester Propargyl-C2-NHS ester is a nonclaevable linker for antibody-drug-conjugation (ADC). Propargyl-C2-NHS ester  Chemical Structure
  3. GC66846 Propargyl-C8-amido-PEG2-NHS ester Propargyl-C8-amido-PEG2-NHS ester is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-C8-amido-PEG2-NHS ester  Chemical Structure
  4. GC38075 Propargyl-O-C1-amido-PEG2-C2-NHS ester Propargyl-O-C1-amido-PEG2-C2-NHS ester is a nonclaevable 2-unit PEG linker for antibody-drug-conjugation (ADC). Propargyl-O-C1-amido-PEG2-C2-NHS ester  Chemical Structure
  5. GC38020 Propargyl-O-C1-amido-PEG4-C2-NHS ester Propargyl-O-C1-amido-PEG4-C2-NHS ester is a nonclaevable 4-unit PEG linker for antibody-drug-conjugation (ADC). Propargyl-O-C1-amido-PEG4-C2-NHS ester  Chemical Structure
  6. GC64251 Propargyl-PEG1-NHS ester Propargyl-PEG1-NHS ester is a nonclaevable 1-unit PEG linker for antibody-drug-conjugation (ADC). Propargyl-PEG1-NHS ester  Chemical Structure
  7. GC66761 Propargyl-PEG1-SS-alcohol Propargyl-PEG1-SS-alcohol is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG1-SS-alcohol  Chemical Structure
  8. GC66633 Propargyl-PEG1-SS-PEG1-acid Propargyl-PEG1-SS-PEG1-acid is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG1-SS-PEG1-acid  Chemical Structure
  9. GC67130 Propargyl-PEG1-SS-PEG1-C2-Boc Propargyl-PEG1-SS-PEG1-C2-Boc is a Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG1-SS-PEG1-C2-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG1-SS-PEG1-C2-Boc  Chemical Structure
  10. GC67582 Propargyl-PEG1-SS-PEG1-PFP ester Propargyl-PEG1-SS-PEG1-PFP ester is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG1-SS-PEG1-PFP ester  Chemical Structure
  11. GC66938 Propargyl-PEG1-SS-PEG1-propargyl Propargyl-PEG1-SS-PEG1-propargyl is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG1-SS-PEG1-propargyl  Chemical Structure
  12. GC61551 Propargyl-PEG2-acid Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG2-acid  Chemical Structure
  13. GC61207 Propargyl-PEG2-amine Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG2-amine  Chemical Structure
  14. GC65807 Propargyl-PEG2-NHBoc Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG2-NHBoc  Chemical Structure
  15. GC65485 Propargyl-PEG3-acid Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. Propargyl-PEG3-acid  Chemical Structure
  16. GC66729 Propargyl-PEG3-NHS ester Propargyl-PEG3-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG3-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG3-NHS ester  Chemical Structure
  17. GC62245 Propargyl-PEG4-Br Propargyl-PEG4-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Br is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG4-Br  Chemical Structure
  18. GC65836 Propargyl-PEG4-CH2CH2-Boc Propargyl-PEG4-CH2CH2-Boc is a non-cleavable ADC linker that can be used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG4-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-CH2CH2-Boc  Chemical Structure
  19. GC67451 Propargyl-PEG4-thiol Propargyl-PEG4-thiol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-thiol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG4-thiol  Chemical Structure
  20. GC64151 Propargyl-PEG5-acid Propargyl-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-acid can used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG5-acid  Chemical Structure
  21. GC64322 Propargyl-PEG5-amine Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-amine  Chemical Structure
  22. GC63835 Propargyl-PEG5-NHS ester Propargyl-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-NHS ester  Chemical Structure
  23. GC65653 Propargyl-PEG6-acid Propargyl-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG6-acid  Chemical Structure
  24. GC66611 Propargyl-PEG6-NHS ester Propargyl-PEG6-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG6-NHS ester  Chemical Structure
  25. GC65809 Propargyl-PEG7-acid Propargyl-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG7-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG7-acid  Chemical Structure
  26. GC67156 Propargyl-PEG7-NHS ester Propargyl-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG7-NHS ester  Chemical Structure
  27. GC66303 Propargyl-PEG8-acid Propargyl-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The ADCs can be used in bacterial infections caused by Gram-negative bacteria. Propargyl-PEG8-acid  Chemical Structure
  28. GC67153 Propargyl-PEG8-bromide Propargyl-PEG8-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-bromide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG8-bromide  Chemical Structure
  29. GC66709 Propargyl-PEG8-NH2 Propargyl-PEG8-NH2 (compound 3b) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-NH2 is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG8-NH2  Chemical Structure
  30. GC66707 Propargyl-PEG8-NHS ester Propargyl-PEG8-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG8-NHS ester  Chemical Structure
  31. GC67320 Propargyl-PEG9-bromide Propargyl-PEG9-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG9-bromide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG9-bromide  Chemical Structure
  32. GC66218 Propargyl-Tos Propargyl-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-Tos  Chemical Structure
  33. GC69783 Py-MAA-Val-Cit-PAB-MMAE

    Py-MAA-Val-Cit-PAB-MMAE (AAJ8D6-PY-Val-Cit-MMAE) is an ADC linker used to synthesize Zapadcine-3a (ADC). Zapadcine-3a has broad-spectrum anti-tumor activity. It targets TRAILR2 and is engulfed by tumor cell lysosomes, releasing small molecule compounds to specifically kill TRAILR2-positive tumors. Zapadcine-3a efficiently eliminates tumor cells and cures tumors.

    Py-MAA-Val-Cit-PAB-MMAE  Chemical Structure
  34. GC61257 S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) and refers to the Alkyl-Chain composition. S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is the linker portions of the molecules employed for mAb attachment purposes. S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate  Chemical Structure
  35. GC66171 SIA Crosslinker SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). SIA Crosslinker  Chemical Structure
  36. GC38695 SMCC SMCC is a protein crosslinker. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses. SMCC  Chemical Structure
  37. GC39441 SMPT SMPT is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). SMPT  Chemical Structure
  38. GC38549 SNPB SNPB is a cleavable linker that is used for making antibody-drug conjugate (ADC). SNPB  Chemical Structure
  39. GC66834 SNPB-sulfo-Me SNPB-sulfo-Me is a cleavable linker that is used for making antibody-drug conjugate (ADC). SNPB-sulfo-Me  Chemical Structure
  40. GC30150 SPDB SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs). SPDB  Chemical Structure
  41. GC38017 SPDB-sulfo SPDB-sulfo is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs) . SPDB-sulfo  Chemical Structure
  42. GC38342 SPDH SPDH is a cleavable ADC linker used for diagnosis and treatment of cancer or B cell proliferative diseas. SPDH  Chemical Structure
  43. GC38598 SPDMB SPDMB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs). SPDMB  Chemical Structure
  44. GC38334 SPDMV SPDMV is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs). SPDMV  Chemical Structure
  45. GC38019 SPDMV-sulfo SPDMV-sulfo is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs). SPDMV-sulfo  Chemical Structure
  46. GC30018 SPDP (SPDP Crosslinker) SPDP (SPDP Crosslinker) (SPDP (SPDP Crosslinker) Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs). SPDP (SPDP Crosslinker)  Chemical Structure
  47. GC38336 SPDV SPDV is a cleavable ADC linker used for diagnosis and treatment of cancer or B cell proliferative diseas. SPDV  Chemical Structure
  48. GC69936 Spermine(N3BBB)

    Spermine (N3BBB) is a click chemistry reagent containing an azide group, which can be used for various biochemical research purposes.

    Spermine(N3BBB)  Chemical Structure
  49. GC38333 SPP SPP is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate. SPP  Chemical Structure
  50. GC38239 Succinic anhydride Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide. Succinic anhydride  Chemical Structure
  51. GC64609 Sulfo-LC-SPDP Sulfo-LC-SPDP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker. Sulfo-LC-SPDP  Chemical Structure
  52. GC66617 Sulfo-SIAB Sulfo-SIAB is a nonclaevable monovalent bilinker. Sulfo-SIAB  Chemical Structure
  53. GC67483 Sulfo-SIAB sodium Sulfo-SIAB sodium is a nonclaevable monovalent bilinker. Sulfo-SIAB sodium  Chemical Structure
  54. GC30045 Sulfo-SMCC sodium Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively. Sulfo-SMCC sodium  Chemical Structure
  55. GC67187 Sulfo-SMPB sodium Sulfo-SMPB sodium is a non-cleavable, heterobifunctional chemical cross-linking reagent which contains N-hydroxysuccinimide (NHS) ester and maleimide groups, allowing covalent conjugation of amine- and sulfhydryl-containing molecules. Sulfo-SMPB sodium  Chemical Structure
  56. GC66618 Sulfo-SNPB Sulfo-SNPB is a cleavable linker that is used for making antibody-drug conjugate (ADC). Sulfo-SNPB  Chemical Structure
  57. GC39447 sulfo-SPDB sulfo-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). sulfo-SPDB  Chemical Structure
  58. GC66540 Sulfo-SPDP-C6-NHS sodium Sulfo-SPDP-C6-NHS sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Sulfo-SPDP-C6-NHS sodium  Chemical Structure
  59. GC38603 Sulfo-SPP Sulfo-SPP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker. Sulfo-SPP  Chemical Structure
  60. GC64164 tans-4-Hydroxy-D-proline hydrochloride tans-4-Hydroxy-D-proline hydrochloride is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PR tans-4-Hydroxy-D-proline hydrochloride  Chemical Structure
  61. GC64180 tans-4-Hydroxy-D-proline methyl ester hydrochloride tans-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs. tans-4-Hydroxy-D-proline methyl ester hydrochloride  Chemical Structure
  62. GC67491 TCO-PEG12-NHS ester TCO-PEG12-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG12-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). TCO-PEG12-NHS ester  Chemical Structure
  63. GC66850 TCO-PEG4-DBCO TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). TCO-PEG4-DBCO  Chemical Structure
  64. GC67602 TCO-PEG4-NHS ester TCO-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). TCO-PEG4-NHS ester  Chemical Structure
  65. GC69999 TCO-SS-amine

    TCO-SS-amine is a cleavable ADC linker that can be used to synthesize antibody-drug conjugates (ADCs).

    TCO-SS-amine  Chemical Structure
  66. GC66232 Tetraethylene glycol monotosylate Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetraethylene glycol monotosylate also can be used as a PROTAC linker that can be used in the synthesis of PROTACs. Tetraethylene glycol monotosylate  Chemical Structure
  67. GC39727 Tetrazine-PEG4-amine hydrochloride Tetrazine-PEG4-amine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetrazine-PEG4-amine hydrochloride  Chemical Structure
  68. GC61328 Tetrazine-PEG4-SS-NHS Tetrazine-PEG4-SS-NHS is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetrazine-PEG4-SS-NHS  Chemical Structure
  69. GC66185 Tetrazine-PEG6-amine hydrochloride Tetrazine-PEG6-amine (hydrochloride) is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetrazine-PEG6-amine hydrochloride  Chemical Structure
  70. GC70019 Tetrazine-PEG7-amine hydrochloride

    Tetrazine-PEG7-amine hydrochloride is a degradable (cleavable) ADC linker containing 7 units of PEG, which can be used to synthesize antibody conjugated active molecules (ADCs).

    Tetrazine-PEG7-amine hydrochloride  Chemical Structure
  71. GC66993 THP-SS-alcohol THP-SS-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). THP-SS-alcohol  Chemical Structure
  72. GC66950 THP-SS-PEG1-Boc THP-SS-PEG1-Boc is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). THP-SS-PEG1-Boc  Chemical Structure
  73. GC66984 THP-SS-PEG1-Tos THP-SS-PEG1-Tos is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). THP-SS-PEG1-Tos  Chemical Structure
  74. GC67166 Tr-PEG3-OH Tr-PEG3-OH is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tr-PEG3-OH  Chemical Structure
  75. GC67168 Tr-PEG5-OH Tr-PEG5-OH is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tr-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tr-PEG5-OH  Chemical Structure
  76. GC67173 Tr-PEG6-OH Tr-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tr-PEG6-OH  Chemical Structure
  77. GC66814 Tr-PEG8-OH Tr-PEG8-OH is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tr-PEG8-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tr-PEG8-OH  Chemical Structure
  78. GC38462 trans-Sulfo-SMCC trans-Sulfo-SMCC is a non-cleavable and membrane permeable ADC crosslinker. trans-Sulfo-SMCC  Chemical Structure
  79. GC62545 Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine  Chemical Structure
  80. GC32722 Val-cit-PAB-OH Val-cit-PAB-OH is a cleavable ADC linker. Val-cit-PAB-OH  Chemical Structure
  81. GC37911 Vipivotide tetraxetan Linker Vipivotide tetraxetan Linker (PSMA-617 Linker) is a nonclaevable peptide linker for synthesis of Vipivotide tetraxetan (PSMA-617). Vipivotide tetraxetan Linker  Chemical Structure

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