ADC Linker
Antibody-drug conjugates (ADCs) consist of a desirable monoclonal antibody, an active cytotoxic drug and an appropriate linker. An appropriate linker between the antibody and the cytotoxic drug provides a specific bridge, and thus helps the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately releases the cytotoxic drug at tumor sites. In addition to conjugation, the linkers maintain ADCs’ stability during the preparation and storage stages of the ADCs and during the systemic circulation period.
The ADCs currently undergoing clinical evaluation contain linkers are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell. Noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule, which will retain the linker and the amino acid by which it was attached to the antibody.
The selection of linker is target dependent, based on the knowledge of the internalization and degradation of the antibody-target antigen complex, and a preclinical in vitro and in vivo activity comparison of conjugates. Moreover, the choice of a linker is also influenced by which cytotoxin is used, as each molecule has different chemical constraints, and frequently the drug structure lends itself to a specific linker.
Targets for ADC Linker
Products for ADC Linker
- Cat.No. Product Name Information
- GC38459 Propargyl-C2-NHS ester Propargyl-C2-NHS ester is a nonclaevable linker for antibody-drug-conjugation (ADC).
- GC66846 Propargyl-C8-amido-PEG2-NHS ester Propargyl-C8-amido-PEG2-NHS ester is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38075 Propargyl-O-C1-amido-PEG2-C2-NHS ester Propargyl-O-C1-amido-PEG2-C2-NHS ester is a nonclaevable 2-unit PEG linker for antibody-drug-conjugation (ADC).
- GC38020 Propargyl-O-C1-amido-PEG4-C2-NHS ester Propargyl-O-C1-amido-PEG4-C2-NHS ester is a nonclaevable 4-unit PEG linker for antibody-drug-conjugation (ADC).
- GC64251 Propargyl-PEG1-NHS ester Propargyl-PEG1-NHS ester is a nonclaevable 1-unit PEG linker for antibody-drug-conjugation (ADC).
- GC66761 Propargyl-PEG1-SS-alcohol Propargyl-PEG1-SS-alcohol is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66633 Propargyl-PEG1-SS-PEG1-acid Propargyl-PEG1-SS-PEG1-acid is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67130 Propargyl-PEG1-SS-PEG1-C2-Boc Propargyl-PEG1-SS-PEG1-C2-Boc is a Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG1-SS-PEG1-C2-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67582 Propargyl-PEG1-SS-PEG1-PFP ester Propargyl-PEG1-SS-PEG1-PFP ester is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66938 Propargyl-PEG1-SS-PEG1-propargyl Propargyl-PEG1-SS-PEG1-propargyl is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC61551 Propargyl-PEG2-acid Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- GC61207 Propargyl-PEG2-amine Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
- GC65807 Propargyl-PEG2-NHBoc Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
- GC65485 Propargyl-PEG3-acid Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne.
- GC66729 Propargyl-PEG3-NHS ester Propargyl-PEG3-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG3-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC62245 Propargyl-PEG4-Br Propargyl-PEG4-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Br is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC65836 Propargyl-PEG4-CH2CH2-Boc Propargyl-PEG4-CH2CH2-Boc is a non-cleavable ADC linker that can be used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG4-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
- GC67451 Propargyl-PEG4-thiol Propargyl-PEG4-thiol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-thiol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC64151 Propargyl-PEG5-acid Propargyl-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-acid can used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- GC64322 Propargyl-PEG5-amine Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
- GC63835 Propargyl-PEG5-NHS ester Propargyl-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC65653 Propargyl-PEG6-acid Propargyl-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66611 Propargyl-PEG6-NHS ester Propargyl-PEG6-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC65809 Propargyl-PEG7-acid Propargyl-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG7-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67156 Propargyl-PEG7-NHS ester Propargyl-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66303 Propargyl-PEG8-acid Propargyl-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The ADCs can be used in bacterial infections caused by Gram-negative bacteria.
- GC67153 Propargyl-PEG8-bromide Propargyl-PEG8-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-bromide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66709 Propargyl-PEG8-NH2 Propargyl-PEG8-NH2 (compound 3b) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-NH2 is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66707 Propargyl-PEG8-NHS ester Propargyl-PEG8-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67320 Propargyl-PEG9-bromide Propargyl-PEG9-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG9-bromide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66218 Propargyl-Tos Propargyl-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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GC69783
Py-MAA-Val-Cit-PAB-MMAE
Py-MAA-Val-Cit-PAB-MMAE (AAJ8D6-PY-Val-Cit-MMAE) is an ADC linker used to synthesize Zapadcine-3a (ADC). Zapadcine-3a has broad-spectrum anti-tumor activity. It targets TRAILR2 and is engulfed by tumor cell lysosomes, releasing small molecule compounds to specifically kill TRAILR2-positive tumors. Zapadcine-3a efficiently eliminates tumor cells and cures tumors.
- GC61257 S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) and refers to the Alkyl-Chain composition. S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is the linker portions of the molecules employed for mAb attachment purposes.
- GC66171 SIA Crosslinker SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38695 SMCC SMCC is a protein crosslinker. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses.
- GC39441 SMPT SMPT is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38549 SNPB SNPB is a cleavable linker that is used for making antibody-drug conjugate (ADC).
- GC66834 SNPB-sulfo-Me SNPB-sulfo-Me is a cleavable linker that is used for making antibody-drug conjugate (ADC).
- GC30150 SPDB SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs).
- GC38017 SPDB-sulfo SPDB-sulfo is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs) .
- GC38342 SPDH SPDH is a cleavable ADC linker used for diagnosis and treatment of cancer or B cell proliferative diseas.
- GC38598 SPDMB SPDMB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs).
- GC38334 SPDMV SPDMV is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs).
- GC38019 SPDMV-sulfo SPDMV-sulfo is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs).
- GC30018 SPDP (SPDP Crosslinker) SPDP (SPDP Crosslinker) (SPDP (SPDP Crosslinker) Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs).
- GC38336 SPDV SPDV is a cleavable ADC linker used for diagnosis and treatment of cancer or B cell proliferative diseas.
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GC69936
Spermine(N3BBB)
Spermine (N3BBB) is a click chemistry reagent containing an azide group, which can be used for various biochemical research purposes.
- GC38333 SPP SPP is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate.
- GC38239 Succinic anhydride Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.
- GC64609 Sulfo-LC-SPDP Sulfo-LC-SPDP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
- GC66617 Sulfo-SIAB Sulfo-SIAB is a nonclaevable monovalent bilinker.
- GC67483 Sulfo-SIAB sodium Sulfo-SIAB sodium is a nonclaevable monovalent bilinker.
- GC30045 Sulfo-SMCC sodium Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
- GC67187 Sulfo-SMPB sodium Sulfo-SMPB sodium is a non-cleavable, heterobifunctional chemical cross-linking reagent which contains N-hydroxysuccinimide (NHS) ester and maleimide groups, allowing covalent conjugation of amine- and sulfhydryl-containing molecules.
- GC66618 Sulfo-SNPB Sulfo-SNPB is a cleavable linker that is used for making antibody-drug conjugate (ADC).
- GC39447 sulfo-SPDB sulfo-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66540 Sulfo-SPDP-C6-NHS sodium Sulfo-SPDP-C6-NHS sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38603 Sulfo-SPP Sulfo-SPP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
- GC64164 tans-4-Hydroxy-D-proline hydrochloride tans-4-Hydroxy-D-proline hydrochloride is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PR
- GC64180 tans-4-Hydroxy-D-proline methyl ester hydrochloride tans-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs.
- GC67491 TCO-PEG12-NHS ester TCO-PEG12-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG12-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66850 TCO-PEG4-DBCO TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67602 TCO-PEG4-NHS ester TCO-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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GC69999
TCO-SS-amine
TCO-SS-amine is a cleavable ADC linker that can be used to synthesize antibody-drug conjugates (ADCs).
- GC66232 Tetraethylene glycol monotosylate Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetraethylene glycol monotosylate also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.
- GC39727 Tetrazine-PEG4-amine hydrochloride Tetrazine-PEG4-amine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC61328 Tetrazine-PEG4-SS-NHS Tetrazine-PEG4-SS-NHS is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66185 Tetrazine-PEG6-amine hydrochloride Tetrazine-PEG6-amine (hydrochloride) is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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GC70019
Tetrazine-PEG7-amine hydrochloride
Tetrazine-PEG7-amine hydrochloride is a degradable (cleavable) ADC linker containing 7 units of PEG, which can be used to synthesize antibody conjugated active molecules (ADCs).
- GC66993 THP-SS-alcohol THP-SS-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66950 THP-SS-PEG1-Boc THP-SS-PEG1-Boc is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66984 THP-SS-PEG1-Tos THP-SS-PEG1-Tos is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67166 Tr-PEG3-OH Tr-PEG3-OH is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67168 Tr-PEG5-OH Tr-PEG5-OH is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tr-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
- GC67173 Tr-PEG6-OH Tr-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66814 Tr-PEG8-OH Tr-PEG8-OH is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tr-PEG8-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
- GC38462 trans-Sulfo-SMCC trans-Sulfo-SMCC is a non-cleavable and membrane permeable ADC crosslinker.
- GC62545 Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
- GC32722 Val-cit-PAB-OH Val-cit-PAB-OH is a cleavable ADC linker.
- GC37911 Vipivotide tetraxetan Linker Vipivotide tetraxetan Linker (PSMA-617 Linker) is a nonclaevable peptide linker for synthesis of Vipivotide tetraxetan (PSMA-617).