Home >> Signaling Pathways >> Apoptosis

Apoptosis

As one of the cellular death mechanisms, apoptosis, also known as programmed cell death, can be defined as the process of a proper death of any cell under certain or necessary conditions. Apoptosis is controlled by the interactions between several molecules and responsible for the elimination of unwanted cells from the body.

Many biochemical events and a series of morphological changes occur at the early stage and increasingly continue till the end of apoptosis process. Morphological event cascade including cytoplasmic filament aggregation, nuclear condensation, cellular fragmentation, and plasma membrane blebbing finally results in the formation of apoptotic bodies. Several biochemical changes such as protein modifications/degradations, DNA and chromatin deteriorations, and synthesis of cell surface markers form morphological process during apoptosis.

Apoptosis can be stimulated by two different pathways: (1) intrinsic pathway (or mitochondria pathway) that mainly occurs via release of cytochrome c from the mitochondria and (2) extrinsic pathway when Fas death receptor is activated by a signal coming from the outside of the cell.

Different gene families such as caspases, inhibitor of apoptosis proteins, B cell lymphoma (Bcl)-2 family, tumor necrosis factor (TNF) receptor gene superfamily, or p53 gene are involved and/or collaborate in the process of apoptosis.

Caspase family comprises conserved cysteine aspartic-specific proteases, and members of caspase family are considerably crucial in the regulation of apoptosis. There are 14 different caspases in mammals, and they are basically classified as the initiators including caspase-2, -8, -9, and -10; and the effectors including caspase-3, -6, -7, and -14; and also the cytokine activators including caspase-1, -4, -5, -11, -12, and -13. In vertebrates, caspase-dependent apoptosis occurs through two main interconnected pathways which are intrinsic and extrinsic pathways. The intrinsic or mitochondrial apoptosis pathway can be activated through various cellular stresses that lead to cytochrome c release from the mitochondria and the formation of the apoptosome, comprised of APAF1, cytochrome c, ATP, and caspase-9, resulting in the activation of caspase-9. Active caspase-9 then initiates apoptosis by cleaving and thereby activating executioner caspases. The extrinsic apoptosis pathway is activated through the binding of a ligand to a death receptor, which in turn leads, with the help of the adapter proteins (FADD/TRADD), to recruitment, dimerization, and activation of caspase-8 (or 10). Active caspase-8 (or 10) then either initiates apoptosis directly by cleaving and thereby activating executioner caspase (-3, -6, -7), or activates the intrinsic apoptotic pathway through cleavage of BID to induce efficient cell death. In a heat shock-induced death, caspase-2 induces apoptosis via cleavage of Bid.

Bcl-2 family members are divided into three subfamilies including (i) pro-survival subfamily members (Bcl-2, Bcl-xl, Bcl-W, MCL1, and BFL1/A1), (ii) BH3-only subfamily members (Bad, Bim, Noxa, and Puma9), and (iii) pro-apoptotic mediator subfamily members (Bax and Bak). Following activation of the intrinsic pathway by cellular stress, pro‑apoptotic BCL‑2 homology 3 (BH3)‑only proteins inhibit the anti‑apoptotic proteins Bcl‑2, Bcl-xl, Bcl‑W and MCL1. The subsequent activation and oligomerization of the Bak and Bax result in mitochondrial outer membrane permeabilization (MOMP). This results in the release of cytochrome c and SMAC from the mitochondria. Cytochrome c forms a complex with caspase-9 and APAF1, which leads to the activation of caspase-9. Caspase-9 then activates caspase-3 and caspase-7, resulting in cell death. Inhibition of this process by anti‑apoptotic Bcl‑2 proteins occurs via sequestration of pro‑apoptotic proteins through binding to their BH3 motifs.

One of the most important ways of triggering apoptosis is mediated through death receptors (DRs), which are classified in TNF superfamily. There exist six DRs: DR1 (also called TNFR1); DR2 (also called Fas); DR3, to which VEGI binds; DR4 and DR5, to which TRAIL binds; and DR6, no ligand has yet been identified that binds to DR6. The induction of apoptosis by TNF ligands is initiated by binding to their specific DRs, such as TNFα/TNFR1, FasL /Fas (CD95, DR2), TRAIL (Apo2L)/DR4 (TRAIL-R1) or DR5 (TRAIL-R2). When TNF-α binds to TNFR1, it recruits a protein called TNFR-associated death domain (TRADD) through its death domain (DD). TRADD then recruits a protein called Fas-associated protein with death domain (FADD), which then sequentially activates caspase-8 and caspase-3, and thus apoptosis. Alternatively, TNF-α can activate mitochondria to sequentially release ROS, cytochrome c, and Bax, leading to activation of caspase-9 and caspase-3 and thus apoptosis. Some of the miRNAs can inhibit apoptosis by targeting the death-receptor pathway including miR-21, miR-24, and miR-200c.

p53 has the ability to activate intrinsic and extrinsic pathways of apoptosis by inducing transcription of several proteins like Puma, Bid, Bax, TRAIL-R2, and CD95.

Some inhibitors of apoptosis proteins (IAPs) can inhibit apoptosis indirectly (such as cIAP1/BIRC2, cIAP2/BIRC3) or inhibit caspase directly, such as XIAP/BIRC4 (inhibits caspase-3, -7, -9), and Bruce/BIRC6 (inhibits caspase-3, -6, -7, -8, -9). 

Any alterations or abnormalities occurring in apoptotic processes contribute to development of human diseases and malignancies especially cancer.

References:
1.Yağmur Kiraz, Aysun Adan, Melis Kartal Yandim, et al. Major apoptotic mechanisms and genes involved in apoptosis[J]. Tumor Biology, 2016, 37(7):8471.
2.Aggarwal B B, Gupta S C, Kim J H. Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey.[J]. Blood, 2012, 119(3):651.
3.Ashkenazi A, Fairbrother W J, Leverson J D, et al. From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors[J]. Nature Reviews Drug Discovery, 2017.
4.McIlwain D R, Berger T, Mak T W. Caspase functions in cell death and disease[J]. Cold Spring Harbor perspectives in biology, 2013, 5(4): a008656.
5.Ola M S, Nawaz M, Ahsan H. Role of Bcl-2 family proteins and caspases in the regulation of apoptosis[J]. Molecular and cellular biochemistry, 2011, 351(1-2): 41-58.

What is Apoptosis? The Apoptotic Pathways and the Caspase Cascade

Targets for  Apoptosis

Products for  Apoptosis

  1. Cat.No. Product Name Information
  2. GC15355 2-Trifluoromethyl-2'-methoxychalcone Nrf2 activator 2-Trifluoromethyl-2'-methoxychalcone  Chemical Structure
  3. GN10800 20(S)-NotoginsenosideR2 20(S)-NotoginsenosideR2  Chemical Structure
  4. GC46528 25-hydroxy Cholesterol-d6 An internal standard for the quantification of 25hydroxy cholesterol 25-hydroxy Cholesterol-d6  Chemical Structure
  5. GC48482 28-Acetylbetulin A lupane triterpenoid with anti-inflammatory and anticancer activities 28-Acetylbetulin  Chemical Structure
  6. GC35112 3'-Hydroxypterostilbene 3'-Hydroxypterostilbene is a Pterostilbene analogue. 3'-Hydroxypterostilbene inhibits the growth of COLO 205, HCT-116 and HT-29 cells with IC50s of 9.0, 40.2 and 70.9 ?M, respectively. 3'-Hydroxypterostilbene significantly down-regulates PI3K/Akt and MAPKs signaling pathways and effectively inhibits the growth of human colon cancer cells by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene can be used for the research of cancer. 3'-Hydroxypterostilbene  Chemical Structure
  7. GC12791 3,3'-Diindolylmethane A phytochemical with antiradiation and chemopreventative effects 3,3'-Diindolylmethane  Chemical Structure
  8. GC42237 3,5-dimethyl PIT-1 PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. 3,5-dimethyl PIT-1  Chemical Structure
  9. GC64762 3,6-Dihydroxyflavone 3,6-Dihydroxyflavone is an anti-cancer agent. 3,6-Dihydroxyflavone dose- and time-dependently decreases cell viability and induces apoptosis by activating caspase cascade, cleaving poly (ADP-ribose) polymerase (PARP). 3,6-Dihydroxyflavone increases intracellular oxidative stress and lipid peroxidation. 3,6-Dihydroxyflavone  Chemical Structure
  10. GC46583 3-Amino-2,6-Piperidinedione An active metabolite of (±)-thalidomide 3-Amino-2,6-Piperidinedione  Chemical Structure
  11. GC49849 3-Aminosalicylic Acid A salicylic acid derivative 3-Aminosalicylic Acid  Chemical Structure
  12. GC35106 3-Dehydrotrametenolic acid 3-?Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-?Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-?Dehydrotrametenolic acid induces apoptosis and has anticancer activity. 3-Dehydrotrametenolic acid  Chemical Structure
  13. GC68537 3-IN-PP1

    3-IN-PP1 is a protein kinase D (PKD) inhibitor. It has effective and broad PKD inhibitory activity against PKD1, PKD2, and PKD3 with IC50 values of 108, 94, and 108 nM respectively. Additionally, 3-IN-PP1 is a broad-spectrum anticancer agent that inhibits the growth of various tumor cells. It can be used in cancer research.

    3-IN-PP1  Chemical Structure
  14. GC17394 3-Nitropropionic acid 3-Nitropropionic acid (β-Nitropropionic acid) is an irreversible inhibitor of succinate dehydrogenase. 3-Nitropropionic acid  Chemical Structure
  15. GC35099 3-O-Acetyloleanolic acid 3-O-Acetyloleanolic acid (3AOA), an oleanolic acid derivative isolated from the seeds of Vigna sinensis K., induces in cancer and also exhibits anti-angiogenesis activity. 3-O-Acetyloleanolic acid  Chemical Structure
  16. GC60507 3-O-Methylgallic acid 3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) is an anthocyanin metabolite and has potent antioxidant capacity. 3-O-methylgallic acid inhibits Caco-2 cell proliferation with an IC50 value of 24.1 μM. 3-O-methylgallic acid also induces cell apoptosis and has anti-cancer effects. 3-O-Methylgallic acid  Chemical Structure
  17. GC32767 3BDO A butyrolactone derivative and autophagy inhibitor 3BDO  Chemical Structure
  18. GC45354 4β-Hydroxywithanolide E A withanolide with anti-inflammatory and anticancer activities 4β-Hydroxywithanolide E  Chemical Structure
  19. GC48437 4'-Acetyl Chrysomycin A A bacterial metabolite with antibacterial and anticancer activities 4'-Acetyl Chrysomycin A  Chemical Structure
  20. GC42346 4-bromo A23187

    4-bromo A23187 is a halogenated analog of the highly selective calcium ionophore A23187.

    4-bromo A23187  Chemical Structure
  21. GC42401 4-hydroperoxy Cyclophosphamide An activated analog of cyclophosphamide 4-hydroperoxy Cyclophosphamide  Chemical Structure
  22. GC30896 4-Hydroxybenzyl alcohol A phenol with diverse biological activities 4-Hydroxybenzyl alcohol  Chemical Structure
  23. GC33815 4-Hydroxyphenylacetic acid A phenolic acid with anti-inflammatory activity 4-Hydroxyphenylacetic acid  Chemical Structure
  24. GC35138 4-Methyldaphnetin 4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation. 4-Methyldaphnetin  Chemical Structure
  25. GC68231 4-Methylsalicylic acid 4-Methylsalicylic acid  Chemical Structure
  26. GC31648 4-Octyl Itaconate

    4-Octyl Itaconate?(4-OI) is a cell-permeable itaconate derivative. Itaconate and 4-Octyl Itaconate?had similar thiol reactivity, making 4-Octyl Itaconate?a suitable itaconate surrogate to study its biological function.

    4-Octyl Itaconate  Chemical Structure
  27. GC49127 4-oxo Cyclophosphamide An inactive metabolite of cyclophosphamide 4-oxo Cyclophosphamide  Chemical Structure
  28. GC45352 4-oxo Withaferin A 4-oxo Withaferin A is the analogue of withaferin A. Withaferin A is a withanolide isolated from Withania somnifera. 4-oxo Withaferin A has the potential for the research of multiple myeloma. 4-oxo Withaferin A  Chemical Structure
  29. GC45353 4-oxo-27-TBDMS Withaferin A 4-oxo-27-TBDMS Withaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.4-oxo-27-TBDMS Withaferin A induces tumor cells apoptosis. 4-oxo-27-TBDMS Withaferin A is a anticancer agent. 4-oxo-27-TBDMS Withaferin A  Chemical Structure
  30. GC60525 4-Vinylphenol (10%w/w in propylene glycol)

    4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo.

    4-Vinylphenol (10%w/w in propylene glycol)  Chemical Structure
  31. GC10468 4EGI-1 Competitive eIF4E/eIF4G interaction inhibitor 4EGI-1  Chemical Structure
  32. GC35150 5,7,4'-Trimethoxyflavone 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner. 5,7,4'-Trimethoxyflavone  Chemical Structure
  33. GN10629 5,7-dihydroxychromone 5,7-dihydroxychromone  Chemical Structure
  34. GC63972 5,7-Dimethoxyflavanone 5,7-Dimethoxyflavanone shows potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. 5,7-Dimethoxyflavanone  Chemical Structure
  35. GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone An active metabolite of various polyphenols 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone  Chemical Structure
  36. GC35147 5-(N,N-Hexamethylene)-amiloride An amiloride derivative with diverse biological activities 5-(N,N-Hexamethylene)-amiloride  Chemical Structure
  37. GC45356 5-Aminolevulinic Acid (hydrochloride)   5-Aminolevulinic Acid (hydrochloride)  Chemical Structure
  38. GC46681 5-Bromouridine A brominated uridine analog 5-Bromouridine  Chemical Structure
  39. GC42545 5-Fluorouracil-13C,15N2 5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil-13C,15N2  Chemical Structure
  40. GC46705 5-Methoxycanthinone 5-Methoxycanthinone is an orally active inhibitor of Leishmania strains. 5-Methoxycanthinone  Chemical Structure
  41. GC42586 6α-hydroxy Paclitaxel 6α-hydroxy Paclitaxel is a primary metabolite of the anticancer compound paclitaxel, produced by the action of the cytochrome P450 isoform CYP2C8. 6α-hydroxy Paclitaxel  Chemical Structure
  42. GC45772 6(5H)-Phenanthridinone An inhibitor of PARP1 and 2 6(5H)-Phenanthridinone  Chemical Structure
  43. GN10093 6-gingerol 6-gingerol  Chemical Structure
  44. GC49429 6-keto Lithocholic Acid A metabolite of lithocholic acid 6-keto Lithocholic Acid  Chemical Structure
  45. GC35184 7,3',4'-Tri-O-methylluteolin 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin  Chemical Structure
  46. GC45673 7,8-Dihydroneopterin An antioxidant 7,8-Dihydroneopterin  Chemical Structure
  47. GC16853 7,8-Dihydroxyflavone Tyrosine kinase receptor B (TrkB) agonist 7,8-Dihydroxyflavone  Chemical Structure
  48. GC42616 7-oxo Staurosporine

    7-oxo Staurosporine is an antibiotic originally isolated from S.

    7-oxo Staurosporine  Chemical Structure
  49. GC16037 7BIO caspase independent nonapoptotic cell death inducer 7BIO  Chemical Structure
  50. GC46741 8(E),10(E),12(Z)-Octadecatrienoic Acid A conjugated PUFA 8(E),10(E),12(Z)-Octadecatrienoic Acid  Chemical Structure
  51. GC42622 8-bromo-Cyclic AMP 8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase. 8-bromo-Cyclic AMP  Chemical Structure
  52. GC49275 8-Oxycoptisine 8-Oxycoptisine is a natural protoberberine alkaloid with anti-cancer activity. 8-Oxycoptisine  Chemical Structure
  53. GC17119 8-Prenylnaringenin estrogen receptor inhibitor 8-Prenylnaringenin  Chemical Structure
  54. GC41642 9(E),11(E),13(E)-Octadecatrienoic Acid 9(E),11(E),13(E)-Octadecatrienoic acid (β-ESA) is a conjugated polyunsaturated fatty acid that is found in plant seed oils and in mixtures of conjugated linolenic acids synthesized by the alkaline isomerization of linolenic acid. 9(E),11(E),13(E)-Octadecatrienoic Acid  Chemical Structure
  55. GC41643 9(Z),11(E),13(E)-Octadecatrienoic Acid 9(Z),11(E),13(E)-Octadecatrienoic Acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. 9(Z),11(E),13(E)-Octadecatrienoic Acid  Chemical Structure
  56. GC40785 9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester 9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. 9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester  Chemical Structure
  57. GC40710 9(Z),11(E),13(E)-Octadecatrienoic Acid methyl ester 9Z,11E,13E-octadecatrienoic acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. 9(Z),11(E),13(E)-Octadecatrienoic Acid methyl ester  Chemical Structure
  58. GC39152 9-ING-41 9-ING-41 is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic drugs. 9-ING-41  Chemical Structure
  59. GN10035 9-Methoxycamptothecin 9-Methoxycamptothecin  Chemical Structure
  60. GC45960 9c(i472) 9c(i472) is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 9c(i472)  Chemical Structure
  61. GC50465 A 410099.1 High affinity XIAP antagonist; active in vivo A 410099.1  Chemical Structure
  62. GC17512 A-1155463 BCL-XL inhibitor, potent and selective A-1155463  Chemical Structure
  63. GC16278 A-1210477 MCL-1 inhibitor A-1210477  Chemical Structure
  64. GC17513 A-1331852 BCL-XL inhibitor, potent and selective A-1331852  Chemical Structure
  65. GC60544 A-192621 A-192621 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. A-192621  Chemical Structure
  66. GC32981 A-385358 A-385358 is a selective inhibitor of Bcl-XL with Kis of 0.80 and 67 nM for Bcl-XL and Bcl-2, respectively. A-385358  Chemical Structure
  67. GC11200 A23187

    A23187, free acid is a Ca2+ ionophore

    A23187  Chemical Structure
  68. GC42659 A23187 (calcium magnesium salt)

    A23187 is a divalent cation ionophore.

    A23187 (calcium magnesium salt)  Chemical Structure
  69. GC35216 AAPK-25 AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM. AAPK-25  Chemical Structure
  70. GC13805 Abacavir Abacavir  Chemical Structure
  71. GC64674 ABBV-167 ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax. ABBV-167  Chemical Structure
  72. GC60548 ABT-100 ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity. ABT-100  Chemical Structure
  73. GC14069 ABT-199 A Bcl-2 inhibitor ABT-199  Chemical Structure
  74. GC12405 ABT-263 (Navitoclax)

    ABT-263 (Navitoclax) is a inhibitor of Bcl-xL, Bcl-2 and Bcl-w, with Ki ≤0.5 nM, ≤1 nM and ≤1 nM respectively[1].

    ABT-263 (Navitoclax)  Chemical Structure
  75. GC49745 ABT-263-d8 ABT-263-d8 is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM. ABT-263-d8  Chemical Structure
  76. GC17234 ABT-737 An inhibitor of anti-apoptotic Bcl-2 proteins ABT-737  Chemical Structure
  77. GA20494 Ac-Asp-Glu-Val-Asp-pNA The cleavage of the chromogenic caspase-3 substrate Ac-DEVD-pNA can be monitored at 405 nm. Ac-Asp-Glu-Val-Asp-pNA  Chemical Structure
  78. GC17602 Ac-DEVD-AFC fluorogenic substrate for activated caspase-3 Ac-DEVD-AFC  Chemical Structure
  79. GC32695 Ac-DEVD-CHO Ac-DEVD-CHO is a specific Caspase-3 inhibitor with a Ki value of 230 pM. Ac-DEVD-CHO  Chemical Structure
  80. GC48470 Ac-DEVD-CHO (trifluoroacetate salt) A dual caspase3/caspase7 inhibitor Ac-DEVD-CHO (trifluoroacetate salt)  Chemical Structure
  81. GC10951 Ac-DEVD-CMK cell-permeable, and irreversible inhibitor of caspase Ac-DEVD-CMK  Chemical Structure
  82. GC42689 Ac-DNLD-AMC Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-DNLD-AMC  Chemical Structure
  83. GC65107 Ac-FEID-CMK TFA Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK TFA  Chemical Structure
  84. GC60558 Ac-FLTD-CMK Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK  Chemical Structure
  85. GC49704 Ac-FLTD-CMK (trifluoroacetate salt) An inhibitor of caspase-1, -4, -5, and -11 Ac-FLTD-CMK (trifluoroacetate salt)  Chemical Structure
  86. GC18226 Ac-LEHD-AMC (trifluoroacetate salt) Ac-LEHD-AMC (trifluoroacetate salt) is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm). Ac-LEHD-AMC (trifluoroacetate salt)  Chemical Structure
  87. GC40556 Ac-LETD-AFC Ac-LETD-AFC is a fluorogenic substrate that can be cleaved specifically by caspase-8. Ac-LETD-AFC  Chemical Structure
  88. GC13400 Ac-VDVAD-AFC Ac-VDVAD-AFC is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer. Ac-VDVAD-AFC  Chemical Structure
  89. GC52372 Ac-VDVAD-AFC (trifluoroacetate salt) A fluorogenic substrate for caspase-2 Ac-VDVAD-AFC (trifluoroacetate salt)  Chemical Structure
  90. GC48974 Ac-VEID-AMC (ammonium acetate salt) A caspase-6 fluorogenic substrate Ac-VEID-AMC (ammonium acetate salt)  Chemical Structure
  91. GC18021 Ac-YVAD-CHO Selective inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1) Ac-YVAD-CHO  Chemical Structure
  92. GC42721 Ac-YVAD-CMK

    Ac-YVAD-CMK is a selective irreversible inhibitor of caspase-1 (Ki=0.8nM), which can prevent the proinflammatory cytokine IL-1β activation. Ac-YVAD-CMK can reduce the inflammatory response and induce a long-lasting neuroprotective effect.

    Ac-YVAD-CMK  Chemical Structure
  93. GC35227 ACBI1 ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis. ACBI1  Chemical Structure
  94. GN10341 Acetate gossypol Acetate gossypol  Chemical Structure
  95. GC11786 Acetylcysteine

    Acetylcysteine is the N-acetyl derivative of CYSTEINE.

    Acetylcysteine  Chemical Structure
  96. GC17094 Acitretin

    Metabolite of etretinate

    Acitretin  Chemical Structure
  97. GC35242 Actein Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo. Actein  Chemical Structure
  98. GC16866 Actinomycin D

    A DNA-interacting transcription blocker with anti-cancer activity

    Actinomycin D  Chemical Structure
  99. GC16350 Actinonin

    Peptidomimetic antibiotic that inhibits aminopeptidases

    Actinonin  Chemical Structure
  100. GC16362 AD57 (hydrochloride) polypharmacological cancer therapeutic that inhibits RET. AD57 (hydrochloride)  Chemical Structure
  101. GC34214 Adalimumab (Anti-Human TNF-alpha, Human Antibody) Adalimumab (Anti-Human TNF-alpha, Human Antibody) is a human monoclonal IgG1 antibody targeting tumour necrosis factorα (TNF-α). Adalimumab (Anti-Human TNF-alpha, Human Antibody)  Chemical Structure

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