Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

Home >> Signaling Pathways >> Apoptosis >> Apoptosis Inducers

Apoptosis Inducers

Apoptosis, a programmed cell death to eliminate damaged or abnormal cells, is a highly organized physiological process characterized by condensation of nuclear heterochromatin, cell shrinkage and loss of positional organization of organelles in the cytoplasm. Apoptosis inducers are a collection of compounds that are capable of inducing apoptosis in cells. Apoptosis has been extensively studied in numerous researches, where induction of apoptosis has been associated with a variety of events, including activation of p53 gene, transcription factor NF-κB or caspases. Apoptosis inducers have the potential to be incorporated into the management and therapy or prevention of cancer for their ability to induce apoptosis in cancer cells.

Products for  Apoptosis Inducers

  1. Cat.No. Product Name Information
  2. GC16375 (±)-Jasmonic Acid methyl ester

    (±)-Methyl Jasmonate

     (±)-Jasmonic Acid methyl ester is an endogenous metabolite. (±)-Jasmonic Acid methyl ester Chemical Structure
  3. GC11988 15-acetoxy Scirpenol

    4-Deacetylanguidin,NSC 267030

     mycotoxin that induce apoptotic cell death 15-acetoxy Scirpenol Chemical Structure
  4. GC12258 2,3-DCPE hydrochloride 2,3-DCPE hydrochloride Chemical Structure
  5. GC15084 2-Methoxyestradiol (2-MeOE2)

    2Hydroxyestradiol 2methyl ether, 2ME2, NSC 659853, Panzem

     2-Methoxyestradiol (2-MeOE2/2-Me) is an HIF-1α inhibitor. 2-Methoxyestradiol (2-MeOE2) Chemical Structure
  6. GC12791 3,3'-Diindolylmethane

    DIM

     A phytochemical with antiradiation and chemopreventative effects 3,3'-Diindolylmethane Chemical Structure
  7. GC16037 7BIO

    7-Bromoindirubin-3’-oxime

     caspase independent nonapoptotic cell death inducer 7BIO Chemical Structure
  8. GC16866 Actinomycin D

    Cosmegen, Dactinomycin, Meractinomycin, NCI C04682, NSC 3053, Oncostatin K

     Actinomycin D (dactinomycin) is a natural chromopeptide isolated from Streptomyces species, and has one heterocyclic chromophore and two cyclic pentapeptide lactone rings. [1] Actinomycin D Chemical Structure
  9. GC12961 Apicidin

    OSI 2040

    A cell-permeable HDAC inhibitor

     Apicidin Chemical Structure
  10. GC15878 Atractyloside Dipotassium Salt Inhibitor of ADP/ATP translocases Atractyloside Dipotassium Salt Chemical Structure
  11. GC12053 BAM7

    BAM 7;BAM-7

     A direct activator of Bax BAM7 Chemical Structure
  12. GC10744 Bendamustine HCl

    SDX-105

     Bendamustine HCl (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine HCl activats DNA-damage stress response and apoptosis. Bendamustine HCl has potent alkylating, anticancer and antimetabolite properties. Bendamustine HCl Chemical Structure
  13. GC10480 Betulinic acid

    Lupatic Acid, NSC 113090

     Betulinic acid is a natural pentacyclic triterpenoid compound and an inhibitor of eukaryotic topoisomerase I with an IC50 value of 5 μM. Betulinic acid Chemical Structure
  14. GC11632 Brassinolide A plant growth regulator Brassinolide Chemical Structure
  15. GC14065 Capsaicin Capsaicin is a highly selective agonist for the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), a ligand-gated, nonselective cation channel, preferentially expressed on small-diameter sensory neurons. Capsaicin Chemical Structure
  16. GC11710 CFM 4 CFM 4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM 4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM 4 also suppresses growth of drug-resistant human breast cancer cells. CFM 4 Chemical Structure
  17. GC17969 CHM 1

    NSC 656158

     An inhibitor of tubulin polymerization CHM 1 Chemical Structure
  18. GC16661 Citrinin

    NSC 186

     Citrinin is a mycotoxin with multiple biological activities produced by several fungal strains of the genera Penicillium, Aspergillus, and Monascus. Citrinin Chemical Structure
  19. GC16116 Costunolide

    Costus lactone, Melampolide, NSC 106404

     A natural sesquiterpene lactone Costunolide Chemical Structure
  20. GC14787 Curcumin

    Indian Saffron, Turmeric yellow

     A yellow pigment with diverse biological activities Curcumin Chemical Structure
  21. GC17198 Cycloheximide

    Naramycin A; Actidione; 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide

     Cycloheximide is an antibiotic that inhibits protein synthesis at the translation level, acting exclusively on cytoplasmic (80s) ribosomes of eukaryotes. Cycloheximide Chemical Structure
  22. GC15484 Deguelin

    (-)cisDeguelin

     A potent antiproliferative rotenoid compound Deguelin Chemical Structure
  23. GC10661 Destruxin B

    SB 242536,NSC 236580

     insecticidal and phytotoxic activity;induces apoptosis Destruxin B Chemical Structure
  24. GC11834 Epibrassinolide

    EBL, 24-Epibrassinolide

     Potential apoptosis inducer;steroidal plant growth stimulant Epibrassinolide Chemical Structure
  25. GC14791 F16 potential antitumor agent F16 Chemical Structure
  26. GC12139 Gambogic Acid

    GA, β-Guttiferin

     Gambogic Acid A cell-permeable caspase activator and apoptosis inducer commonly used in studies of breast, lung, and liver cancers. Gambogic Acid Chemical Structure
  27. GN10421 Kaempferol

    Nimbecetin, NSC 407289, NSC 656277, Pelargidenon, Rhamnolutein, Swartziol, Trifolitin

     Kaempferol is a flavonoid that acts as an inverse agonist of ERRα and ERRγ and possesses antioxidant, anti-inflammatory and antitumor activities. Kaempferol Chemical Structure
  28. GC17874 Matrine

    NSC 146051, NSC 318810

     Matrine is an alkaloid found in Sophora japonica plants that acts as a kappa opioid receptor and µ-receptor agonist. Matrine Chemical Structure
  29. GC14312 Meisoindigo

    Methylisoindigotin

     Apoptosis inducer;potential agent for AML Meisoindigo Chemical Structure
  30. GC13034 ML-291 ML-291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML-291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML-291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden. ML-291 Chemical Structure
  31. GC14050 MPI-0441138

    EP128265

     inducer of apoptosis and growth inhibition MPI-0441138 Chemical Structure
  32. GC14860 Oncrasin 1 An anticancer agent Oncrasin 1 Chemical Structure
  33. GC10282 Piperlongumine

    Piplartine

     Piperlongumine is a natural alkaloid compound extracted from Piper longum L., which has multiple pharmacological activities, including anti-tumor, lipid metabolism regulation, anti-platelet aggregation and analgesic activities. Piperlongumine Chemical Structure
  34. GC10315 Plumbagin

    NSC 236613, NSC 688284

     A natural naphthoquinone Plumbagin Chemical Structure
  35. GC15035 PM00104 Potent antimyeloma agent PM00104 Chemical Structure
  36. GC14847 Psoralidin apoptosis inducer Psoralidin Chemical Structure
  37. GC12857 R1530 A multi-kinase inhibitor R1530 Chemical Structure
  38. GC15036 Raltegravir potassium salt

    MK-0518

     Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection. Raltegravir potassium salt Chemical Structure
  39. GC16055 SMIP004 SMIP004 Chemical Structure
  40. GC17131 Streptozocin

    Estreptozocin, NSC 37917, NSC 85998, Streptozocin, STZ, U 9889

     Streptozocin, a potent DNA-methylating antibiotic, is a naturally occurring nitrosoamide used for extensively to produce diabetes in experimental models. Streptozocin Chemical Structure
  41. GC18044 Trabectedin

    Ecteinascidin 743, ET-743, NSC 648766

     An alkaloid with anticancer activity Trabectedin Chemical Structure
  42. GC12649 TW-37 An inhibitor of the Bcl-2 family proteins TW-37 Chemical Structure

41 Item(s)

per page

Set Descending Direction