Apoptosis Inducers
Apoptosis, a programmed cell death to eliminate damaged or abnormal cells, is a highly organized physiological process characterized by condensation of nuclear heterochromatin, cell shrinkage and loss of positional organization of organelles in the cytoplasm. Apoptosis inducers are a collection of compounds that are capable of inducing apoptosis in cells. Apoptosis has been extensively studied in numerous researches, where induction of apoptosis has been associated with a variety of events, including activation of p53 gene, transcription factor NF-κB or caspases. Apoptosis inducers have the potential to be incorporated into the management and therapy or prevention of cancer for their ability to induce apoptosis in cancer cells.
Products for Apoptosis Inducers
- Cat.No. Product Name Information
- GC16375 (±)-Jasmonic Acid methyl ester (±)-Jasmonic Acid methyl ester is an endogenous metabolite.
- GC11988 15-acetoxy Scirpenol mycotoxin that induce apoptotic cell death
- GC12258 2,3-DCPE hydrochloride
- GC15084 2-Methoxyestradiol (2-MeOE2) 2-Methoxyestradiol (2-MeOE2/2-Me) is a HIF-1α inhibitor that inhibits HIF-1α accumulation and HIF transcriptional activity. 2-Methoxyestradiol can trigger p53-induced apoptosis and has potential antitumor activity..
- GC12791 3,3'-Diindolylmethane A phytochemical with antiradiation and chemopreventative effects
- GC16037 7BIO caspase independent nonapoptotic cell death inducer
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GC16866
Actinomycin D
A DNA-interacting transcription blocker with anti-cancer activity
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GC12961
Apicidin
A cell-permeable HDAC inhibitor
- GC15878 Atractyloside Dipotassium Salt Inhibitor of ADP/ATP translocases
- GC12053 BAM7 A direct activator of Bax
- GC10744 Bendamustine HCl Bendamustine HCl (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine HCl activats DNA-damage stress response and apoptosis. Bendamustine HCl has potent alkylating, anticancer and antimetabolite properties.
- GC10480 Betulinic acid A plant triterpenoid similar to bile acids
- GC11632 Brassinolide A plant growth regulator
- GC14065 Capsaicin A terpene alkaloid with diverse biological activities
- GC11710 CFM 4 CFM 4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM 4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM 4 also suppresses growth of drug-resistant human breast cancer cells.
- GC17969 CHM 1 An inhibitor of tubulin polymerization
- GC16661 Citrinin A mycotoxin inducing apoptosis
- GC16116 Costunolide A natural sesquiterpene lactone
- GC14787 Curcumin A yellow pigment with diverse biological activities
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GC17198
Cycloheximide
Cycloheximide is an antibiotic that inhibits protein synthesis at the translation level, acting exclusively on cytoplasmic (80s) ribosomes of eukaryotes.
- GC15484 Deguelin A potent antiproliferative rotenoid compound
- GC10661 Destruxin B insecticidal and phytotoxic activity;induces apoptosis
- GC11834 Epibrassinolide Potential apoptosis inducer;steroidal plant growth stimulant
- GC14791 F16 potential antitumor agent
- GC12139 Gambogic Acid A xanthonoid with anticancer activity
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GN10421
Kaempferol
A dietary flavonoid
- GC17874 Matrine An alkaloid with diverse biological activities
- GC14312 Meisoindigo Apoptosis inducer;potential agent for AML
- GC13034 ML-291 ML-291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML-291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML-291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden.
- GC14050 MPI-0441138 inducer of apoptosis and growth inhibition
- GC14860 Oncrasin 1 An anticancer agent
- GC10282 Piperlongumine An alkaloid with anticancer and antioxidant activities
- GC10315 Plumbagin A natural naphthoquinone
- GC15035 PM00104 Potent antimyeloma agent
- GC14847 Psoralidin apoptosis inducer
- GC12857 R1530 A multi-kinase inhibitor
- GC15036 Raltegravir potassium salt Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection.
- GC16055 SMIP004
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GC17131
Streptozocin
A diabetogenic agent which targets beta cells
- GC18044 Trabectedin An alkaloid with anticancer activity
- GC12649 TW-37 An inhibitor of the Bcl-2 family proteins