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Apoptosis Inducers

Apoptosis, a programmed cell death to eliminate damaged or abnormal cells, is a highly organized physiological process characterized by condensation of nuclear heterochromatin, cell shrinkage and loss of positional organization of organelles in the cytoplasm. Apoptosis inducers are a collection of compounds that are capable of inducing apoptosis in cells. Apoptosis has been extensively studied in numerous researches, where induction of apoptosis has been associated with a variety of events, including activation of p53 gene, transcription factor NF-κB or caspases. Apoptosis inducers have the potential to be incorporated into the management and therapy or prevention of cancer for their ability to induce apoptosis in cancer cells.

Products for  Apoptosis Inducers

  1. Cat.No. Product Name Information
  2. GC16375 (±)-Jasmonic Acid methyl ester (±)-Jasmonic Acid methyl ester is an endogenous metabolite. (±)-Jasmonic Acid methyl ester  Chemical Structure
  3. GC11988 15-acetoxy Scirpenol mycotoxin that induce apoptotic cell death 15-acetoxy Scirpenol  Chemical Structure
  4. GC12258 2,3-DCPE hydrochloride 2,3-DCPE hydrochloride  Chemical Structure
  5. GC15084 2-Methoxyestradiol (2-MeOE2) 2-Methoxyestradiol (2-MeOE2/2-Me) is a HIF-1α inhibitor that inhibits HIF-1α accumulation and HIF transcriptional activity. 2-Methoxyestradiol can trigger p53-induced apoptosis and has potential antitumor activity.. 2-Methoxyestradiol (2-MeOE2)  Chemical Structure
  6. GC12791 3,3'-Diindolylmethane A phytochemical with antiradiation and chemopreventative effects 3,3'-Diindolylmethane  Chemical Structure
  7. GC16037 7BIO caspase independent nonapoptotic cell death inducer 7BIO  Chemical Structure
  8. GC16866 Actinomycin D

    A DNA-interacting transcription blocker with anti-cancer activity

    Actinomycin D  Chemical Structure
  9. GC12961 Apicidin

    A cell-permeable HDAC inhibitor

    Apicidin  Chemical Structure
  10. GC15878 Atractyloside Dipotassium Salt Inhibitor of ADP/ATP translocases Atractyloside Dipotassium Salt  Chemical Structure
  11. GC12053 BAM7 A direct activator of Bax BAM7  Chemical Structure
  12. GC10744 Bendamustine HCl Bendamustine HCl (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine HCl activats DNA-damage stress response and apoptosis. Bendamustine HCl has potent alkylating, anticancer and antimetabolite properties. Bendamustine HCl  Chemical Structure
  13. GC10480 Betulinic acid A plant triterpenoid similar to bile acids Betulinic acid  Chemical Structure
  14. GC11632 Brassinolide A plant growth regulator Brassinolide  Chemical Structure
  15. GC14065 Capsaicin A terpene alkaloid with diverse biological activities Capsaicin  Chemical Structure
  16. GC11710 CFM 4 CFM 4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM 4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM 4 also suppresses growth of drug-resistant human breast cancer cells. CFM 4  Chemical Structure
  17. GC17969 CHM 1 An inhibitor of tubulin polymerization CHM 1  Chemical Structure
  18. GC16661 Citrinin A mycotoxin inducing apoptosis Citrinin  Chemical Structure
  19. GC16116 Costunolide A natural sesquiterpene lactone Costunolide  Chemical Structure
  20. GC14787 Curcumin A yellow pigment with diverse biological activities Curcumin  Chemical Structure
  21. GC17198 Cycloheximide

    Cycloheximide is an antibiotic that inhibits protein synthesis at the translation level, acting exclusively on cytoplasmic (80s) ribosomes of eukaryotes.

    Cycloheximide  Chemical Structure
  22. GC15484 Deguelin A potent antiproliferative rotenoid compound Deguelin  Chemical Structure
  23. GC10661 Destruxin B insecticidal and phytotoxic activity;induces apoptosis Destruxin B  Chemical Structure
  24. GC11834 Epibrassinolide Potential apoptosis inducer;steroidal plant growth stimulant Epibrassinolide  Chemical Structure
  25. GC14791 F16 potential antitumor agent F16  Chemical Structure
  26. GC12139 Gambogic Acid A xanthonoid with anticancer activity Gambogic Acid  Chemical Structure
  27. GN10421 Kaempferol

    A dietary flavonoid

    Kaempferol  Chemical Structure
  28. GC17874 Matrine An alkaloid with diverse biological activities Matrine  Chemical Structure
  29. GC14312 Meisoindigo Apoptosis inducer;potential agent for AML Meisoindigo  Chemical Structure
  30. GC13034 ML-291 ML-291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML-291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML-291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden. ML-291  Chemical Structure
  31. GC14050 MPI-0441138 inducer of apoptosis and growth inhibition MPI-0441138  Chemical Structure
  32. GC14860 Oncrasin 1 An anticancer agent Oncrasin 1  Chemical Structure
  33. GC10282 Piperlongumine An alkaloid with anticancer and antioxidant activities Piperlongumine  Chemical Structure
  34. GC10315 Plumbagin A natural naphthoquinone Plumbagin  Chemical Structure
  35. GC15035 PM00104 Potent antimyeloma agent PM00104  Chemical Structure
  36. GC14847 Psoralidin apoptosis inducer Psoralidin  Chemical Structure
  37. GC12857 R1530 A multi-kinase inhibitor R1530  Chemical Structure
  38. GC15036 Raltegravir potassium salt Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection. Raltegravir potassium salt  Chemical Structure
  39. GC16055 SMIP004 SMIP004  Chemical Structure
  40. GC17131 Streptozocin

    A diabetogenic agent which targets beta cells

    Streptozocin  Chemical Structure
  41. GC18044 Trabectedin An alkaloid with anticancer activity Trabectedin  Chemical Structure
  42. GC12649 TW-37 An inhibitor of the Bcl-2 family proteins TW-37  Chemical Structure

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