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Home >> Signaling Pathways >> Apoptosis >> KEAP1-Nrf2

KEAP1-Nrf2

The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.

Products for  KEAP1-Nrf2

  1. Cat.No. Product Name Information
  2. GN10654 (+)-Corynoline (+)-Corynoline Chemical Structure
  3. GC31691 (+)-DHMEQ (+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ Chemical Structure
  4. GC65610 (R)-5-Hydroxy-1,7-diphenyl-3-heptanone (R)-5-Hydroxy-1,7-diphenyl-3-heptanone is a diarylheptanoid that can be found in Alpinia officinarum. (R)-5-Hydroxy-1,7-diphenyl-3-heptanone Chemical Structure
  5. GC12545 2-HBA indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway. 2-HBA Chemical Structure
  6. GC15355 2-Trifluoromethyl-2'-methoxychalcone Nrf2 activator 2-Trifluoromethyl-2'-methoxychalcone Chemical Structure
  7. GC33815 4-Hydroxyphenylacetic acid A phenolic acid with anti-inflammatory activity 4-Hydroxyphenylacetic acid Chemical Structure
  8. GC31648 4-Octyl Itaconate

    4-Octyl Itaconate?(4-OI) is a cell-permeable itaconate derivative. Itaconate and 4-Octyl Itaconate?had similar thiol reactivity, making 4-Octyl Itaconate?a suitable itaconate surrogate to study its biological function.

     4-Octyl Itaconate Chemical Structure
  9. GN10629 5,7-dihydroxychromone 5,7-dihydroxychromone Chemical Structure
  10. GC16120 AI-3 Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor AI-3 Chemical Structure
  11. GN10415 Astilbin Astilbin Chemical Structure
  12. GC15371 Bardoxolone An anti-inflammatory compound that activates Nrf2/ARE signaling Bardoxolone Chemical Structure
  13. GC11572 Bardoxolone methyl A synthetic triterpenoid with potent anticancer and antidiabetic activity Bardoxolone methyl Chemical Structure
  14. GC34070 Brusatol (NSC 172924) Brusatol (NSC 172924) (NSC172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol (NSC 172924) enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol (NSC 172924) can be developed into an adjuvant chemotherapeutic agent. Brusatol (NSC 172924) increases cellular apoptosis. Brusatol (NSC 172924) Chemical Structure
  15. GC61636 CBR-470-2 CBR-470-2, a glycine-substituted analog, can activate NRF2 signaling. CBR-470-2 Chemical Structure
  16. GC35629 CDDO-dhTFEA CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. CDDO-dhTFEA Chemical Structure
  17. GC35630 CDDO-EA CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator. CDDO-EA Chemical Structure
  18. GC32723 CDDO-Im (RTA-403) CDDO-Im (RTA-403) (RTA-403) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ. CDDO-Im (RTA-403) Chemical Structure
  19. GC16625 CDDO-TFEA Nrf2 activator CDDO-TFEA Chemical Structure
  20. GC14787 Curcumin A yellow pigment with diverse biological activities Curcumin Chemical Structure
  21. GC40226 Curcumin-d6 Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS. Curcumin-d6 Chemical Structure
  22. GN10318 Danshensu Danshensu Chemical Structure
  23. GC34010 Danshensu (Dan shen suan A)

    Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway.

     Danshensu (Dan shen suan A) Chemical Structure
  24. GC64971 DDO-7263 DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2-ARE activator. DDO-7263 Chemical Structure
  25. GC61419 Dibenzoylmethane Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane Chemical Structure
  26. GC16590 Dimethyl Fumarate nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator Dimethyl Fumarate Chemical Structure
  27. GC62936 Dimethyl fumarate D6 Dimethyl fumarate D6 is a deuterium labeled Dimethyl fumarate. Dimethyl fumarate D6 Chemical Structure
  28. GC25351 Dimethyl itaconate Dimethyl itaconate can reprogram neurotoxic to neuroprotective primary astrocytes through the regulation of LPS-induced Nod-like receptor protein 3 (NLRP3) inflammasome and nuclear factor 2/heme oxygenase-1 (NRF2/HO-1) pathways. Dimethyl itaconate Chemical Structure
  29. GN10531 Dimethylfraxetin Dimethylfraxetin Chemical Structure
  30. GN10470 Eriodictyol Eriodictyol Chemical Structure
  31. GC62957 Eriodictyol-7-O-glucoside Eriodictyol-7-O-glucoside (Eriodictyol 7-O-β-D-glucoside), a flavonoid, is a potent free radical scavenger. Eriodictyol-7-O-glucoside Chemical Structure
  32. GC15605 Ezetimibe Cholesterol transport inhibitor Ezetimibe Chemical Structure
  33. GC60159 Ezetimibe ketone Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe ketone Chemical Structure
  34. GC66354 Ezetimibe-d4-1 Ezetimibe-d4 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe-d4-1 Chemical Structure
  35. GN10741 Garcinone D Garcinone D Chemical Structure
  36. GN10038 Ginsenoside Rh3 Ginsenoside Rh3 Chemical Structure
  37. GC33092 Hesperin An isothiocyanate with diverse biological activities Hesperin Chemical Structure
  38. GC11302 Hinokitiol A tropolone with diverse biological activities Hinokitiol Chemical Structure
  39. GC66004 K67 K67 specifically inhibits the interaction between Keap1 and S349-phosphorylated p62. K67 prevents p-p62 from blocking the binding of Keap1 and Nrf2. K67 effectively inhibits the proliferation of HCC cultures with high cellular S351-phosphorylated p62 by restoring the ubiquitination and degradation of Nrf2 driven by Keap1. K67 Chemical Structure
  40. GC36390 Keap1-Nrf2-IN-1 Keap1-Nrf2-IN-1 is a Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor erythroid 2-related factor 2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1-Nrf2-IN-1 Chemical Structure
  41. GC31321 KI696 KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 Chemical Structure
  42. GC34642 KI696 isomer KI696 isomer is the less active isomer of KI696. KI696 isomer Chemical Structure
  43. GC44006 Kinsenoside Kinsenoside is a glycoside originally isolated from A. Kinsenoside Chemical Structure
  44. GN10491 Mangiferin Mangiferin Chemical Structure
  45. GC31783 Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) Chemical Structure
  46. GC38819 ML334 An inhibitor of the Nrf2-Keap1 protein-protein interaction ML334 Chemical Structure
  47. GC19254 ML385 ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor. ML385 Chemical Structure
  48. GC13058 NK 252 Nrf2 activator NK 252 Chemical Structure
  49. GC69590 Nrf2 activator-2

    Nrf2 activator-2 (compound O15) is a derivative of sulforaphane, an effective Nrf2 activator with an EC50 of 2.9 μM in 293 T cells. Nrf2 activator-2 effectively inhibits the interaction between Keap1 and Nrf2, thereby showing an activating effect on Nrf2. Nrf2 activator-2 significantly reduces the level of ubiquitinated Nrf2 in cells.

     Nrf2 activator-2 Chemical Structure
  50. GC66054 Nrf2 activator-4 Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 μM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model. Nrf2 activator-4 Chemical Structure
  51. GC36773 Nrf2-IN-1 Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML). Nrf2-IN-1 Chemical Structure
  52. GC12821 Oltipraz Nrf2 activator;An antischistosomal agent Oltipraz Chemical Structure
  53. GC13693 Omaveloxolone (RTA-408) Omaveloxolone (RTA-408) (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO). Omaveloxolone (RTA-408) Chemical Structure
  54. GC15457 Pyridoxine A 4-methanol form of vitamin B6 Pyridoxine Chemical Structure
  55. GC17393 Pyridoxine HCl Pyridoxine HCl (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine HCl Chemical Structure
  56. GC50242 RA 839

    Nrf2 activator; inhibits Nrf2/Keap1 interaction

     RA 839 Chemical Structure
  57. GC63933 S-Allylmercaptocysteine S-allylmercaptocysteine, an organic sulfur compound extracted from garlic, has anti-inflammatory and anti-oxidative effects for various pulmonary diseases. S-Allylmercaptocysteine Chemical Structure
  58. GC14016 Sulforaphane

    Sulforaphane (SFN) known as [1-isothiocyanato-4-(methylsulfinyl)butane].

     Sulforaphane Chemical Structure
  59. GC14352 TAT 14 Nrf2 activator TAT 14 Chemical Structure
  60. GC34057 TBHQ (tert-Butylhydroquinone) TBHQ (tert-Butylhydroquinone) (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2. TBHQ (tert-Butylhydroquinone) (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma. TBHQ (tert-Butylhydroquinone) Chemical Structure
  61. GC61338 Toralactone Toralactone, isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism. Toralactone Chemical Structure

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