Other Apoptosis
Products for Other Apoptosis
- Cat.No. Product Name Information
- GC19054 Azoramide Azoramide is a small-molecule modulator of the unfolded protein response with antidiabetic activity.
- GC35458 Bacopaside II A triterpene glycoside
- GN10507 Baohuoside I
- GC11572 Bardoxolone methyl A synthetic triterpenoid with potent anticancer and antidiabetic activity
- GC17195 Bax inhibitor peptide V5 A Bax inhibitor
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GC10345
Bay 11-7085
NK-κB activation inhibitor
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GC13035
Bay 11-7821
A selective and irreversible NF-κB inhibitor
- GC16389 BAY 61-3606 A Syk inhibitor
- GC12136 BAY 61-3606 dihydrochloride
- GC16516 BCH BCH (BCH) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis.
- GC10744 Bendamustine HCl Bendamustine HCl (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine HCl activats DNA-damage stress response and apoptosis. Bendamustine HCl has potent alkylating, anticancer and antimetabolite properties.
- GC14930 Benzbromarone TMEM16A/B calcium-activated chloride channel (CaCC) blocker
- GN10520 Benzoylpaeoniflorin
- GC38683 Benzyl isothiocyanate Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity.
- GN10358 Berbamine hydrochloride
- GN10539 Bergenin
- GC10734 Beta-Lapachone Beta-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
- GC35504 Beta-Zearalanol Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells.
- GN10632 Betulin
- GC10480 Betulinic acid A plant triterpenoid similar to bile acids
- GC12074 BG45 Novel HDAC3-selective inhibitor
- GC17828 BI-847325 dual inhibitor of MEK and Aurora kinases
- GC11224 BI6727(Volasertib) BI6727(Volasertib) (BI 6727) is an orally active, highly potent and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0.87 nM. BI6727(Volasertib) inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. BI6727(Volasertib) induces mitotic arrest and apoptosis. BI6727(Volasertib), a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models.
- GC13636 BIBR 1532 Telomerase inhibitor,novel and selective
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GC14233
BIO-acetoxime
GSK-3α/β inhibitor
- GC12426 Birinapant (TL32711) An antagonist of cIAP1, cIAP2, and XIAP
- GN10037 Bisdemethoxycurcumin
- GC35530 BJE6-106 BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM).
- GC11931 BKM120 An inhibitor of class I PI3K isoforms
- GC12822 BML-210(CAY10433) BML-210(CAY10433) is a novel HDAC inhibitor, and its mechanism of action has not been characterized.
- GC11648 BML-277 Chk2 inhibitor,potent and highly selective
- GC13628 BMS-833923 An orally bioavailable Smo inhibitor
- GC16774 Boc-D-FMK An irreversible pan-caspase inhibitor
- GC33501 Bornyl acetate An acetate form of borneol
- GC11040 Borrelidin threonyl-tRNA synthetase (ThrRS) inhibitor
- GC17644 Bortezomib (PS-341) Bortezomib (PS-341), as a dipeptide boronic acid proteasome inhibitor with antitumor activity, can potently inhibiit 20S proteasome with Ki of 0.6 nM by targeting a threonine residue..
- GC11632 Brassinolide A plant growth regulator
- GN10802 Brazilin
- GC35554 Brevilin A A sesquiterpene lactone with anticancer activity
- GC35555 Britannin Britannin, isolated from Inula aucheriana, is a sesquiterpene lactone.
- GC35559 Bruceine D Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells.
- GC38467 BTdCPU BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
- GC34511 BTR-1 BTR-1 is an active anti-cancer agent, causes S phase arrest, and affects DNA replication in leukemic cells. BTR-1 activates apoptosis and induces cell death.
- GC11141 BTZO 1 migration inhibitory factor (MIF) binder
- GC13671 Busulfan DNA alkylating agent
- GC10944 Butein Protein kinase inhibitor
- GC16818 BX-912 PDK1 inhibitor,potent and ATP-competitive
- GC19095 C-DIM12 C-DIM12 is a synthetic Nurr1 activaor induces Nurr1 and DA gene expression in cell lines and primary neurons.
- GC12733 C646 C646, a potent and selective p300/CBP histone acetyltransferase inhibitor (Ki 400 nM), has been shown to have pleiotropic activity, including neuroprotective, anti-cancer and anti-epithelial-mesenchymal transition (anti-EMT) effects..
- GC33218 CA-5f A potent late-stage macroautophagy/autophagy inhibitor
- GC15779 Cabozantinib (XL184, BMS-907351) Cabozantinib (XL184, BMS-907351) is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib (XL184, BMS-907351) displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib (XL184, BMS-907351) shows antiangiogenic activity. Cabozantinib (XL184, BMS-907351) disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis.
- GC12531 Cabozantinib malate (XL184) Cabozantinib malate (XL184) (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
- GC10692 Caffeic Acid Phenethyl Ester NF-κB activation inhibitor
- GC15161 Calcium D-Panthotenate Calcium D-Panthotenate (Vitamin B5 calcium salt), a vitamin, can reduce the patulin content of the apple juice.
- GC30240 Calcium dobesilate Calcium dobesilate, a vasoprotective, is widely used in chronic venous disease, diabetic retinopathy and the symptoms of haemorrhoidal attack in many countries.
- GC19086 Calicheamicin Calicheamicin is a cytotoxic agent that causes double-strand DNA breaks.
- GC10342 Calpeptin A calpain inhibitor
- GN10667 Calycosin
- GC35598 Camellianin A Camellianin A, the main flavonoid in A. nitida leaves, displays anticancer activity and angiotensin converting enzyme (ACE)-inhibitory activity. Camellianin A inhibits the proliferation of the human Hep G2 and MCF-7 cell lines and induces the significant increase of the G0/G1 cell population.
- GC12318 Candesartan Cilexetil Prodrug of the angiotensin II receptor 1 (AT1) antagonist candesartan
- GC15866 Capecitabine DNA, RNA and protein synthesis inhibitor
- GC17918 Capsazepine A TRPV1 antagonist
- GC18069 Cardamonin Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM.
- GC15089 Carfilzomib (PR-171) A proteasome inhibitor
- GN10733 Carnosic acid
- GC35612 Carvacrol Carvacrol is a monoterpenoid phenol isolated from Thymus mongolicus Ronn.
- GC32841 Catechin ((+)-Catechin) Catechin ((+)-Catechin) ((+)-Catechin ((+)-Catechin)) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
- GN10543 caudatin
- GC13648 CC-223 CC-223 (CC-223) is a potent, selective, and orally bioavailable inhibitor of mTOR kinase, with an IC50 value for mTOR kinase of 16 nM. CC-223 inhibits both mTORC1 and mTORC2.
- GC39169 CC-92480 CC-92480 (CC-92480), a cereblon E3 ubiquitin ligase modulating drug (CELMoD), acts as a molecular glue. CC-92480 shows high affinity to cereblon, resulting in potent antimyeloma activity.
- GC19088 CC122 CC122 (CC 122) is an orally active cereblon modulator.
- GC12891 CCT007093 PPM1D inhibitor
- GC14566 CCT137690 An inhibitor of Aurora kinases and FLT3
- GC35636 CDK9-IN-7 CDK9-IN-7 (compound 21e) is a selective, highly potent, and orally active CDK9/cyclin T inhibitor (IC50=11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM). CDK9-IN-7 shows antitumor activity without obvious toxicity. CDK9-IN-7 induces NSCLC cell apoptosis, arrests the cell cycle in the G2 phase, and suppresses the stemness properties of NSCLC.
- GC19096 CDKI-73 CDKI-73 is a potent CDK9 inhibitor with Ki of 4 nM; shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).
- GC15083 Celastrol A triterpenoid antioxidant
- GN10113 Cepharanthine
- GC11543 Cesium chloride
- GC35668 CG-200745 CG-200745 (CG-200745) is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG-200745 inhibits deacetylation of histone H3 and tubulin. CG-200745 induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. CG-200745 enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine and 5-Fluorouracil (5-FU; ). CG-200745 induces apoptosis and has anti-tumour effects.
- GC10666 CGP 57380 MNK1 inhibitor, specific and selective
- GC43234 Chaetoglobosin A Chaetoglobosin A is a mycotoxic cytochalasin that was first isolated from the marine-derived endophytic fungus C.
- GN10463 Chelerythrine
- GC13065 Chelerythrine Chloride Potent inhibitor of PKC and Bcl-xL
- GC40878 Chelidonine Chelidonine is a benzophenanthridine alkaloid that has been isolated from C.
- GC15739 CHIR-124 Chk1 inhibitor,novel and potent
- GC35682 CHMFL-ABL/KIT-155 CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s of 46 nM and 75 nM, respectively), and it also presents significant inhibitory activities to BLK (IC50=81 nM), CSF1R (IC50=227 nM), DDR1 (IC50=116 nM), DDR2 (IC50=325 nM), LCK (IC50=12 nM) and PDGFRβ (IC50=80 nM) kinases. CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155) arrests cell cycle progression and induces apoptosis.
- GC13408 CI994 (Tacedinaline) An inhibitor of HDAC1, -2, and -3
- GC19436 CID-5721353 CID5721353 is an inhibitor of BCL6 with an IC50 value of 212 μM, which corresponds to a Ki of 147 μM.
- GC32997 Cinchonine ((8R,9S)-Cinchonine) Cinchonine ((8R,9S)-Cinchonine) is a natural compound present in Cinchona bark. Cinchonine ((8R,9S)-Cinchonine) activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells.
- GN10189 Cinobufagin
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GC17491
CITCO
Constitutive androstane receptor (CAR) agonist
- GC31186 Citicoline sodium salt Citicoline sodium salt salt is an intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes and also exerts neuroprotective effects.
- GC41514 Citreoviridin Citreoviridin is a mycotoxin isolated from several Penicillium species that has been shown to inhibit the mitochondrial ATP synthetase system.
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GC14203
Citric acid
Commonly used laboratory reagent
- GC10509 Cladribine Apoptosis inducer in CLL cells
- GC15219 Clofarabine Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase
- GC10813 Clofibric Acid PPAR agonist
- GC32587 Clofilium tosylate Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3.
- GC10033 Cobimetinib A potent, orally available MEK1 inhibitor
- GN10123 Columbianadin