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p53

The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.

  1. Cat.No. Product Name Information
  2. GC33356 AM-8735
  3. GC15828 AMG232 p53-MDM2 inhibitor, novel
  4. GC35367 APG-115
  5. GC18136 BH3I-1 Bcl-2 or Bcl-XL inhibitor
  6. GC14634 CBL0137 curaxin that activates p53 and inhibits NF-κB
  7. GC15394 CBL0137 (hydrochloride)

    curaxin that activates p53 and inhibits NF-κB

  8. GC15225 COTI-2 activates mutant forms of p53
  9. GC15840 CP 31398 dihydrochloride p53 stabilizer
  10. GC32911 CTX1
  11. GC10896 Cyclic Pifithrin-α hydrobromide P53 inhibitor
  12. GC33384 DPBQ
  13. GC15258 GN25 p53-Snail binding Inhibitor
  14. GC10650 HLI 373 Hdm2 ubiquitin ligase (E3) inhibitor
  15. GC14755 Inauhzin SIRT1 inhibitor
  16. GC12117 JNJ-26854165 (Serdemetan)

    P53 activator, blocking Mdm2-p53 interaction

  17. GC32919 Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride)
  18. GC38812 MD-224
  19. GC16296 MI-773 MDM2 inhibitor
  20. GC11547 MI-773 (SAR405838) orally available MDM2 antagonist
  21. GC32881 Milademetan (DS-3032)

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