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Home >> Signaling Pathways >> Apoptosis >> TNF-α

TNF-α

Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.

Products for  TNF-α

  1. Cat.No. Product Name Information
  2. GC63231 TNF-α-IN-2 TNF-α-IN-2 is a potent and orally active inhibitor of tumor necrosis factor alpha (TNFα), with an IC50 of 25 nM in the HTRF assay. TNF-α-IN-2 Chemical Structure
  3. GC68385 TNF-α-IN-6 TNF-α-IN-6 Chemical Structure
  4. GC31905 TNF-α-IN-1 TNF-α-IN-1 is a TNF-α inhibitor extracted from patent US20030096841A1, compound example I-7. TNF-α-IN-1 Chemical Structure
  5. GC38868 TRAF-STOP inhibitor 6877002 TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1. TRAF-STOP inhibitor 6877002 Chemical Structure
  6. GC48195 trans-trismethoxy Resveratrol-d4 An internal standard for the quantification of trans-trismethoxy resveratrol trans-trismethoxy Resveratrol-d4 Chemical Structure
  7. GC48202 Treprostinil (diethanolamine salt) Treprostinil (UT-15C) diethanolamine is a potent EP2, DP1 and IP agonist with Ki values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FP, respectively. Treprostinil (diethanolamine salt) Chemical Structure
  8. GC66460 UCB-5307 UCB-5307 is a potent TNF signaling inhibitor with a KD of 9 nM for human TNFα. UCB-5307 can penetrate the preformed hTNF/hTNFR1 complex. UCB-5307 Chemical Structure
  9. GC62346 UCB-9260 UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer. UCB-9260 Chemical Structure
  10. GC61533 UTL-5g UTL-5g (GBL-5g), an anti-inflammatory TNF-α inhibitor, has chemoprotective and liver radioprotective effects. UTL-5g Chemical Structure
  11. GC70104 Utomilumab

    Utomilumab (PF 05082566) is a humanized IgG2 mAb agonist that targets the T cell co-stimulatory receptor 4-1BB/CD137. Utomilumab can be used in research for relapsed/refractory follicular lymphoma (FL) and other CD20+ non-Hodgkin's lymphomas (NHL).

     Utomilumab Chemical Structure
  12. GC64839 Varlilumab Varlilumab (CDX-1127) is a first-in-class human IgG1 anti-CD27 monoclonal antibody. Varlilumab has an anti-tumor activity. Varlilumab Chemical Structure

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