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Home >> Signaling Pathways >> Neuroscience

Neuroscience

Neuroscience

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).

Targets for  Neuroscience

Products for  Neuroscience

  1. Cat.No. Product Name Information
  2. GC15203 Acephate Anticholinesterase insecticide Acephate Chemical Structure
  3. GC45371 Acepromazine (maleate)   Acepromazine (maleate) Chemical Structure
  4. GC12917 Acetaminophen

    A COX inhibitor

     Acetaminophen Chemical Structure
  5. GC42693 Acetaminophen Glucuronide (sodium salt) Acetaminophen glucuronide is an inactive metabolite of the analgesic and antipyretic agent acetaminophen. Acetaminophen Glucuronide (sodium salt) Chemical Structure
  6. GC42694 Acetaminophen sulfate (potassium salt) Acetaminophen sulfate is a metabolite of acetaminophen. Acetaminophen sulfate (potassium salt) Chemical Structure
  7. GC64137 Acetaminophen-d3 Acetaminophen-d3 Chemical Structure
  8. GC46781 Acetaminophen-d4 A Certified Reference Material Acetaminophen-d4 Chemical Structure
  9. GC18262 Acetamiprid A neonicotinoid insecticide Acetamiprid Chemical Structure
  10. GC42703 Acetyl β-Endorphin (1-26) (human) (trifluoroacetate salt) Acetyl β-endorphin (1-26) is a neuropeptide found in rat hippocampus, brain stem, and pituitary. Acetyl β-Endorphin (1-26) (human) (trifluoroacetate salt) Chemical Structure
  11. GC42704 Acetyl β-Endorphin (human) (trifluoroacetate salt) Acetyl β-endorphin is an acetylated derivative of β-endorphin that binds to opioid receptors in rat caudal dorsomedial medulla (Ki = 490 nM) and mouse brain membrane preparations (IC50 = 109 nM). Acetyl β-Endorphin (human) (trifluoroacetate salt) Chemical Structure
  12. GC46789 Acetyl-L-carnitine-d3 (chloride) An internal standard for the quantification of L-acetylcarnitine Acetyl-L-carnitine-d3 (chloride) Chemical Structure
  13. GC40952 Acetylaszonalenin Acetylaszonalenin is a fungal metabolite that has been found in A. Acetylaszonalenin Chemical Structure
  14. GC14142 Acetylcholine Chloride Major transmitter at many nervous sites Acetylcholine Chloride Chemical Structure
  15. GC11786 Acetylcysteine

    Acetylcysteine is the N-acetyl derivative of CYSTEINE.

     Acetylcysteine Chemical Structure
  16. GC35236 Acetylshikonin Acetylshikonin, derived from the root of Lithospermum erythrorhizon, has anti-cancer and antiinflammation activity. Acetylshikonin Chemical Structure
  17. GC65618 AChE-IN-23 AChE-IN-23 (compound 3h) is an acetylcholinesterase (AChE) inhibitor with an IC50 value of 48.3 μM. AChE-IN-23 Chemical Structure
  18. GC65979 AChE-IN-27 AChE-IN-27 (compound 8c) is an AChE inhibitor (IC50=0.19 μM). AChE-IN-27 can be used in studies of neurological diseases such as alzheimer's disease, dementia, ataxia and myasthenia gravis. AChE-IN-27 Chemical Structure
  19. GC64390 AChE-IN-3 AChE-IN-3 shows moderate inhibitory activity against AChE and strong NO inhibitory activity with an EC50 of 0.57 μM. AChE-IN-3 Chemical Structure
  20. GC14096 Aclidinium Bromide LAMAs antagonist Aclidinium Bromide Chemical Structure
  21. GC62827 Acotiamide D6 Acotiamide D6 Chemical Structure
  22. GC38732 Acotiamide monohydrochloride trihydrate Acotiamide monohydrochloride trihydrate is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with IC50 of 1.79 μM. Acotiamide monohydrochloride trihydrate Chemical Structure
  23. GC12435 ACPT-I Agonist for group III mGlu receptors ACPT-I Chemical Structure
  24. GC31695 Acrivastine (BW825C) Acrivastine (BW825C) (BW825C) is a short acting histamine 1 receptor antagonist for the treatment of allergic rhinitis. Acrivastine (BW825C) Chemical Structure
  25. GC60563 Acrivastine D7 Acrivastine D7 (BW825C D7) is a deuterium labeled Acrivastine. Acrivastine D7 Chemical Structure
  26. GC40645 Actarit Actarit is an orally active immunomodulator that reduces symptoms in animal models and clinical trials of rheumatoid arthritis. Actarit Chemical Structure
  27. GC15141 ACV 1

    Neuronal nicotinic receptor antagonist

     ACV 1 Chemical Structure
  28. GC31693 Adelmidrol Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol Chemical Structure
  29. GC13542 Adiphenine HCl Adiphenine HCl is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC50s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine HCl Chemical Structure
  30. GC49216 ADL 08-0011 (hydrochloride) An active metabolite of alvimopan ADL 08-0011 (hydrochloride) Chemical Structure
  31. GC35252 Adoprazine Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine Chemical Structure
  32. GC34230 Adrenomedullin (1-50), rat Adrenomedullin (1-50), rat is a 50 amino acid peptide, which induces a selective arterial vasodilation via activation of CGRP1 receptor. Adrenomedullin (1-50), rat Chemical Structure
  33. GC35256 Adrenomedullin (11-50), rat Adrenomedullin (11-50), rat is the C-terminal fragment (11-50) of rat adrenomedullin. Adrenomedullin (11-50), rat Chemical Structure
  34. GC35257 Adrenomedullin (16-31), human Adrenomedullin (16-31), human is amino acid residues 16-31 fragment of human adrenomedullin (hADM). Adrenomedullin (16-31), human Chemical Structure
  35. GC42741 Adrenomedullin (22-52) (human) (trifluoroacetate salt) Adrenomedullin (22-52) is a C-terminal fragment of adrenomedullin (1-52). Adrenomedullin (22-52) (human) (trifluoroacetate salt) Chemical Structure
  36. GC32615 Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin (human)) Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin (human)), an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat. Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin (human)) Chemical Structure
  37. GP10109 Adrenorphin Adrenorphin Chemical Structure
  38. GP10102 Adrenorphin, Free Acid Adrenorphin, Free Acid Chemical Structure
  39. GC66406 Aducanumab Aducanumab (BIIB037), a human monoclonal antibody selective for aggregated forms of amyloid beta (Aβ). Aducanumab shows brain penetration, and can be used for Alzheimer's disease (AD) research. Aducanumab Chemical Structure
  40. GC12460 ADX 10059 hydrochloride Negative allosteric modulator at mGlu5 ADX 10059 hydrochloride Chemical Structure
  41. GC10494 ADX-47273 mGluR5 receptor positive allosteric modulator, potent and selective ADX-47273 Chemical Structure
  42. GC52495 AF-353 (hydrochloride) A dual P2X3 and P2X2/3 receptor antagonist AF-353 (hydrochloride) Chemical Structure
  43. GC10219 AF-DX 116 AF-DX 116 (AF-DX 116) is a selective and competitive M2 muscarinic acetylcholine receptor antagonist, with IC50 values of 640 nM and 386 nM for rabbit peripheral lung and rat heart, respectively. AF-DX 116 Chemical Structure
  44. GC15510 AF-DX 384 M2/M4 selective antagonist AF-DX 384 Chemical Structure
  45. GC62829 Afizagabar Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar Chemical Structure
  46. GC30844 Afloqualone An Analytical Reference Standard Afloqualone Chemical Structure
  47. GC41371 AFMK Melatonin is a neurotransmitter widely distributed in eukaryotes and is closely linked to circadean rhythms in mammals including humans. AFMK Chemical Structure
  48. GC39248 Afoxolaner An isoxazoline insecticide and acaricide Afoxolaner Chemical Structure
  49. GC31259 Aftin-4 An inducer of Aβ42 Aftin-4 Chemical Structure
  50. GC62830 AG-024322 AG-024322 is a potent ATP-competitive pan-CDK inhibitor against cell cycle kinases CDK1, CDK2, and CDK4 with Ki values in the 1-3 nM range. AG-024322 displays broad-spectrum anti-tumor activity and clear target modulation?in vivo. AG-024322 induces cell apoptosis. AG-024322 Chemical Structure
  51. GC17981 Agomelatine MT1/MT2 / 5-HT2C agonist Agomelatine Chemical Structure
  52. GC35269 Agomelatine hydrochloride Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine hydrochloride Chemical Structure
  53. GC35270 Agomelatine L(+)-Tartaric acid Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine L(+)-Tartaric acid Chemical Structure
  54. GC46818 Agomelatine-d6 A melatonin receptor agonist and 5-HT2B and 5-HT2C antagonist Agomelatine-d6 Chemical Structure
  55. GP10076 Agouti-related Protein (AGRP) (25-82), human Agouti-related Protein (AGRP) (25-82), human Chemical Structure
  56. GC14146 AIDA AIDA (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. AIDA Chemical Structure
  57. GC35272 Ajmalicine A terpenoid indole alkaloid Ajmalicine Chemical Structure
  58. GC49639 Akuammine An indole alkaloid with analgesic activity Akuammine Chemical Structure
  59. GC11556 AL 34662 potent 5-HT2 receptor agonist AL 34662 Chemical Structure
  60. GC42760 AL 6598 Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. AL 6598 Chemical Structure
  61. GC42761 AL 8810 ethyl amide AL 8810 is an 11β-fluoro analog of prostaglandin F2α (PGF2α) which acts as a potent and selective antagonist at the FP receptor. AL 8810 ethyl amide Chemical Structure
  62. GC45378 Alaproclate (hydrochloride)   Alaproclate (hydrochloride) Chemical Structure
  63. GC31388 ALB-127158(a) ALB-127158(a) is a potent and selective melanin concentrating hormone 1 (MCH1) receptor antagonist. ALB-127158(a) Chemical Structure
  64. GC17517 Alcaftadine H1 histamine receptor antagonist Alcaftadine Chemical Structure
  65. GC46826 Alclofenac An NSAID Alclofenac Chemical Structure
  66. GC35279 Aldicarb sulfone Aldicarb sulfone(Temik sulfone) is a carbamate insecticide; is a cholinesterase inhibitor which prevents the breakdown of acetylcholine in the synapse. Aldicarb sulfone Chemical Structure
  67. GC65281 Aleplasinin Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin Chemical Structure
  68. GC35284 Alimemazine D6 Alimemazine D6 is deuterium labeled Alimemazine, which is an antihistamine. Alimemazine D6 Chemical Structure
  69. GC15546 Alizapride HCl Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist. Alizapride HCl Chemical Structure
  70. GC49070 Alizapride-13C-d3 (hydrochloride) An internal standard for the quantification of alizapride Alizapride-13C-d3 (hydrochloride) Chemical Structure
  71. GC40476 Allethrin Allethrin is a pyrethroid insecticide and modulator of voltage-gated sodium channels (NaV). Allethrin Chemical Structure
  72. GC14192 Allopregnanolone

    Allopregnanolone, a 3alpha, 5alpha progesterone metabolite, acts as a potent allosteric modulator of the γ-aminobutyric acid type A (GABAA) receptor, exerts antidepressant and neuroprotective action.

     Allopregnanolone Chemical Structure
  73. GC61689 Alminoprofen Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. Alminoprofen Chemical Structure
  74. GC15153 Almotriptan Malate 5-HT1B/1D-receptor agonist Almotriptan Malate Chemical Structure
  75. GC31054 Alniditan (Alnitidan) Alniditan (Alnitidan) (Alnitidan) is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK293 cells, respectively. Alniditan (Alnitidan) Chemical Structure
  76. GC62417 Alniditan dihydrochloride Alniditan (Alnitidan) dihydrochloride is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK?293 cells, respectively. Alniditan dihydrochloride Chemical Structure
  77. GC64554 Aloenin Aloenin (Aloenin A) is a natural compound, which has potent peroxyl radical-scavenging activities and moderate inhibitory active on β-secretase (BACE). Aloenin Chemical Structure
  78. GC35299 Aloeresin D Aloeresin D is a chromone glycoside isolated from Aloe vera, inhibits β-Secretase (BACE1) activity, with an IC50 of 39 μM. Aloeresin D Chemical Structure
  79. GC63495 Alogabat Alogabat (example 8) is a GABAA α5 receptor positive allosteric modulators (PAMs) (extracted from patent WO2018104419A1). Alogabat Chemical Structure
  80. GC13654 Alosetron A 5-HT3 receptor antagonist Alosetron Chemical Structure
  81. GC35301 Alosetron ((Z)-2-butenedioate) Alosetron (GR 68755) (Z)-2-butenedioate is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron ((Z)-2-butenedioate) Chemical Structure
  82. GC35302 Alosetron (Hydrochloride(1:X)) Alosetron (GR 68755) Hydrochloride(1:X) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron (Hydrochloride(1:X)) Chemical Structure
  83. GC35303 Alosetron D3 Hydrochloride Alosetron D3 Hydrochloride (GR-68755C D3) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist. Alosetron D3 Hydrochloride Chemical Structure
  84. GC11166 Alosetron Hydrochloride A 5-HT3 receptor antagonist Alosetron Hydrochloride Chemical Structure
  85. GC64265 Alosetron-13C,d3 Alosetron-13C,d3 Chemical Structure
  86. GC30983 alpha-Asarone (α-Asarone) alpha-Asarone (α-Asarone) (α-Asarone) is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice. alpha-Asarone (α-Asarone) Chemical Structure
  87. GC13515 Alphaxalone activates and potentiates GABAA receptor-activated membrane current (IGABA) Alphaxalone Chemical Structure
  88. GC49199 Alpidem An anxiolytic agent Alpidem Chemical Structure
  89. GC32905 Alprenolol ((RS)-Alprenolol) Alprenolol ((RS)-Alprenolol) ((RS)-Alprenolol ((RS)-Alprenolol); dl-Alprenolol ((RS)-Alprenolol)) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol ((RS)-Alprenolol) is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent. Alprenolol ((RS)-Alprenolol) Chemical Structure
  90. GC14105 Alprenolol hydrochloride β-adrenoceptor and 5-HT1A receptor antagonist. Alprenolol hydrochloride Chemical Structure
  91. GC14030 Altanserin hydrochloride 5-HT2A receptor antagonist Altanserin hydrochloride Chemical Structure
  92. GC40024 Altenusin

    Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.

     Altenusin Chemical Structure
  93. GC30996 Alvameline (Lu 25-109) Alvameline (Lu 25-109) (Lu25-109) is a partial M1 agonist and M2/M3 antagonist. Alvameline (Lu 25-109) Chemical Structure
  94. GC10891 Alverine Citrate Drug used for functional gastrointestinal disorders Alverine Citrate Chemical Structure
  95. GC49262 Alytesin (trifluoroacetate salt) A neuropeptide with diverse biological activities Alytesin (trifluoroacetate salt) Chemical Structure
  96. GC62834 ALZ-801 ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. ALZ-801 Chemical Structure
  97. GC10105 Amantadine HCl Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine HCl Chemical Structure
  98. GC16974 Ambenonium dichloride Ambenonium (WIN 8077) chloride is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium dichloride Chemical Structure
  99. GC17184 Ambrisentan ETA-receptor antagonist Ambrisentan Chemical Structure
  100. GC31815 Ambutonium bromide (BL700) Ambutonium bromide (BL700) is an acetylcholine antagonist. Ambutonium bromide (BL700) Chemical Structure
  101. GC14740 Amfenac Sodium Monohydrate Amfenac Sodium Monohydrate is a COX-2 inhibitor. Amfenac Sodium Monohydrate Chemical Structure

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