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Neuroscience

Neuroscience

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).

Targets for  Neuroscience

Products for  Neuroscience

  1. Cat.No. Product Name Information
  2. GC32655 5-HT2 antagonist 1 5-HT2 antagonist 1 is a potent antagonist of 5-HT2 receptor, with weak α1 adrenoceptor blocking activity. 5-HT2 antagonist 1  Chemical Structure
  3. GC32664 5-HT2A antagonist 1 5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727. 5-HT2A antagonist 1  Chemical Structure
  4. GC65568 5-HT2B antagonist-1 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1  Chemical Structure
  5. GC31263 5-HT3 antagonist 1 5-HT3 antagonist 1 is a potent and selective antagonist of serotonin 3 (5-HT3) receptor. 5-HT3 antagonist 1  Chemical Structure
  6. GC31247 5-HT3 antagonist 2 5-HT3 antagonist 2 is a 5-HT3 receptor antagonist. 5-HT3 antagonist 2  Chemical Structure
  7. GC65983 5-HT3 antagonist 5 5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice. 5-HT3 antagonist 5  Chemical Structure
  8. GC31227 5-HT3-In-1 5-HT3-In-1 is extracted from patent EP0748807A1, compound example 8. 5-HT3-In-1  Chemical Structure
  9. GC30314 5-HT4 antagonist 1 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6. 5-HT4 antagonist 1  Chemical Structure
  10. GC31144 5-HT7 agonist 1 5-HT7 agonist 1 is a selective 5-HT7 receptor agonist, with an IC50 of 222.93 nM, can be used for the 5-HT7 receptor related disease, such as CNS disorders. 5-HT7 agonist 1  Chemical Structure
  11. GC49655 5-hydroxy Buspirone A metabolite of buspirone 5-hydroxy Buspirone  Chemical Structure
  12. GC49119 5-hydroxy Flunixin A metabolite of flunixin 5-hydroxy Flunixin  Chemical Structure
  13. GC52172 5-hydroxy Indole-3-acetic Acid-d6 5-hydroxy Indole-3-acetic Acid-d6  Chemical Structure
  14. GC49315 5-hydroxy Indomethacin A metabolite of indomethacin 5-hydroxy Indomethacin  Chemical Structure
  15. GC52106 5-hydroxy Isatin An inhibitor of MAO-A 5-hydroxy Isatin  Chemical Structure
  16. GC42550 5-hydroxy-6-methoxy (S)-Duloxetine 5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine. 5-hydroxy-6-methoxy (S)-Duloxetine  Chemical Structure
  17. GC42553 5-hydroxy-Nω-methyl Tryptamine (oxalate)

    5-hydroxy-Nω-methyl Tryptamine is a metabolite of serotonin in humans that has also been found in plants.

    5-hydroxy-Nω-methyl Tryptamine (oxalate)  Chemical Structure
  18. GC11626 5-Iodo-A-85380 dihydrochloride α4β2 and α6β2 nicotinic acetylcholine receptors agonist 5-Iodo-A-85380 dihydrochloride  Chemical Structure
  19. GC14225 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative Precursor to ligand for the α4β2 nicotinic receptor 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative  Chemical Structure
  20. GC14940 5-Methoxytryptamine 5-Methoxytryptamine  Chemical Structure
  21. GC64182 5-Methoxytryptamine hydrochloride 5-Methoxytryptamine hydrochloride  Chemical Structure
  22. GC14604 5-Methylfurmethiodide muscarinic agonist 5-Methylfurmethiodide  Chemical Structure
  23. GC46706 5-Methyltetrahydrofolic Acid (hydrate) A biologically active form of folic acid 5-Methyltetrahydrofolic Acid (hydrate)  Chemical Structure
  24. GC17477 5-Nonyloxytryptamine oxalate 5-HT1B agonist 5-Nonyloxytryptamine oxalate  Chemical Structure
  25. GC41156 5-Octyl D-glutamate 5-Octyl D-glutamate, also known as 5-octyl ester D-glutamate, is a stable, cell-permeable molecule that generates free D-glutamate upon hydrolysis of the ester bond by cytoplasmic esterases. 5-Octyl D-glutamate  Chemical Structure
  26. GC41094 5-trans Latanoprost Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. 5-trans Latanoprost  Chemical Structure
  27. GC41228 5-trans Latanoprost (free acid) Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. 5-trans Latanoprost (free acid)  Chemical Structure
  28. GC49438 5-trans-17-phenyl trinor Prostaglandin F2α The 5-trans isomer of 17-phenyl trinor PGF 5-trans-17-phenyl trinor Prostaglandin F2α  Chemical Structure
  29. GC31296 5HT6-ligand-1 5HT6-ligand-1 is a potent 5-HT6 receptor ligand with a Ki of 1.43 nM. 5HT6-ligand-1  Chemical Structure
  30. GC18176 5α,6β-Dihydroxycholestanol 5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase. 5α,6β-Dihydroxycholestanol  Chemical Structure
  31. GC30943 6,2'-Dihydroxyflavone 6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor. 6,2'-Dihydroxyflavone  Chemical Structure
  32. GC46720 6,9-Dichloro-1,2,3,4-tetrahydroacridine A synthetic intermediate in the synthesis of AChE inhibitors 6,9-Dichloro-1,2,3,4-tetrahydroacridine  Chemical Structure
  33. GC11284 6-(4-Methoxyphenyl)-3-pyridazinamine GABAA receptor antagonist 6-(4-Methoxyphenyl)-3-pyridazinamine  Chemical Structure
  34. GC42572 6-Amino-8-trifluoromethylphenanthridine 6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine. 6-Amino-8-trifluoromethylphenanthridine  Chemical Structure
  35. GC40479 6-Aminophenanthridine 6-Aminophenanthridine is an antiprion agent. 6-Aminophenanthridine  Chemical Structure
  36. GC14000 6-fluoro-DL-Tryptophan 6-fluoro-DL-Tryptophan is a potent, competitive inhibitor of tryptophan hydroxylase. 6-fluoro-DL-Tryptophan  Chemical Structure
  37. GC42580 6-hydroxy Chlorzoxazone

    6-hydroxy Chlorzoxazone is a metabolite of chlorzoxazone.

    6-hydroxy Chlorzoxazone  Chemical Structure
  38. GC49183 6-hydroxy Etodolac A metabolite of etodolac 6-hydroxy Etodolac  Chemical Structure
  39. GC16267 6-Hydroxydopamine hydrobromide Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine. 6-Hydroxydopamine hydrobromide  Chemical Structure
  40. GC16153 6-methoxy Naphthalene Acetic Acid competitive, non-selective COX inhibitor 6-methoxy Naphthalene Acetic Acid  Chemical Structure
  41. GC31309 6-Methoxy-2-naphthoic acid (Naproxen impurity O) 6-Methoxy-2-naphthoic acid (Naproxen impurity O) is an NMDA receptor modulator extracted from patent WO 2012019106 A2. 6-Methoxy-2-naphthoic acid (Naproxen impurity O)  Chemical Structure
  42. GC30898 6-Methylflavone 6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. 6-Methylflavone  Chemical Structure
  43. GC42584 6-O-desmethyl Donepezil 6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil. 6-O-desmethyl Donepezil  Chemical Structure
  44. GC10781 7-Chlorokynurenic acid NMDA receptor glycine site antagonist 7-Chlorokynurenic acid  Chemical Structure
  45. GC11395 7-Chlorokynurenic acid sodium salt NMDA receptor antagonist acting at the glycine site 7-Chlorokynurenic acid sodium salt  Chemical Structure
  46. GC46242 7-dehydro Cholesterol-d7

    7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol

    7-dehydro Cholesterol-d7  Chemical Structure
  47. GC48649 7-hydroxy Chlorpromazine (hydrochloride) An active metabolite of chlorpromazine 7-hydroxy Chlorpromazine (hydrochloride)  Chemical Structure
  48. GC35192 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone 7-?Hydroxy-?3,?4-?dihydro-?2(1H)?-?quinolinone (3,4-Dihydro-7-hydroxy-2(1H)-quinolinone) is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B. 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone  Chemical Structure
  49. GC16574 7-Hydroxy-DPAT hydrobromide D3 dopamine receptor agonist 7-Hydroxy-DPAT hydrobromide  Chemical Structure
  50. GC40572 7-keto Cholesterol A bioactive sterol and a major oxysterol component of oxidized LDL 7-keto Cholesterol  Chemical Structure
  51. GC46241 7-keto Cholesterol-d7

    7-keto Cholesterol is a bioactive sterol and a major oxysterol component of oxidized LDL

    7-keto Cholesterol-d7  Chemical Structure
  52. GC48880 7-Methoxyflavone A flavone with diverse biological activities 7-Methoxyflavone  Chemical Structure
  53. GC15338 8,11,14-Eicosatriynoic Acid A Cox, 12-LO, and 5-LO inhibitor 8,11,14-Eicosatriynoic Acid  Chemical Structure
  54. GC40587 8,12-iso-iPF2α-VI 8,12-iso-iPF2α-VI is an isoprostane produced by non-enzymatic, free radical-induced peroxidative damage to membrane lipids. 8,12-iso-iPF2α-VI  Chemical Structure
  55. GC49017 8-hydroxy Amoxapine A metabolite of amoxapine 8-hydroxy Amoxapine  Chemical Structure
  56. GC42626 8-hydroxy Efavirenz 8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz. 8-hydroxy Efavirenz  Chemical Structure
  57. GC18654 8-hydroxy Loxapine 8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. 8-hydroxy Loxapine  Chemical Structure
  58. GC49544 8-hydroxy Mirtazapine A metabolite of mirtazapine 8-hydroxy Mirtazapine  Chemical Structure
  59. GC14966 8-Hydroxy-DPAT hydrobromide 5-HT1A agonist 8-Hydroxy-DPAT hydrobromide  Chemical Structure
  60. GC12427 8-Hydroxy-PIPAT oxalate 5-HT1A receptor agonist 8-Hydroxy-PIPAT oxalate  Chemical Structure
  61. GC40759 8-methyl Nonanoic Acid

    Capsaicin, the chemical that imparts the spicy-hot quality of chili peppers, is produced by the fruits of plants belonging to the Capsicum family.

    8-methyl Nonanoic Acid  Chemical Structure
  62. GC30888 8-OH-DPAT (8-Hydroxy-DPAT) 8-OH-DPAT (8-Hydroxy-DPAT) is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT (8-Hydroxy-DPAT) weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5). 8-OH-DPAT (8-Hydroxy-DPAT)  Chemical Structure
  63. GC46753 9(S),12(S),13(S)-TriHOME An oxylipin 9(S),12(S),13(S)-TriHOME  Chemical Structure
  64. GC42640 9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic Acid 9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic acid is an ω-3 very long-chain polyunsaturated fatty acid. 9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic Acid  Chemical Structure
  65. GC14302 9,12-Octadecadiynoic Acid 9,12-Octadecadiynoic Acid (9a,12a-Octadecadiynoic acid) is a plant lipoxygenase inhibitor. 9,12-Octadecadiynoic Acid  Chemical Structure
  66. GC13537 A 331440 dihydrochloride H3 receptor antagonist,non-imidazole,high affinity A 331440 dihydrochloride  Chemical Structure
  67. GC14610 A 412997 dihydrochloride Selective D4 agonist A 412997 dihydrochloride  Chemical Structure
  68. GC12739 A 484954 A eukaryotic elongation factor-2 (eEF-2) kinase inhibitor A 484954  Chemical Structure
  69. GC17805 A 582941 A 582941 is a potent, selective and brain-penetrant partial agonist of α7 nAChR, with Kis of 10.8 and 16.7 nM in rat brain membranes and human frontal cortex, respectively. A 582941  Chemical Structure
  70. GC15498 A 68930 hydrochloride Agonist of D1-like dopamine receptor,potent and selective A 68930 hydrochloride  Chemical Structure
  71. GC11183 A 77636 hydrochloride Agonist of D1-like dopamine receptor,potent and selective A 77636 hydrochloride  Chemical Structure
  72. GC15434 A 839977 P2X7 antagonist,potent and selective A 839977  Chemical Structure
  73. GC16068 A 841720 mGluR1 antagonist, non-competitive A 841720  Chemical Structure
  74. GC15333 A 844606 α7 nAChR partial agonist A 844606  Chemical Structure
  75. GC11121 A 943931 dihydrochloride Antagonist of histamine H4 receptor,potent and selective A 943931 dihydrochloride  Chemical Structure
  76. GC17743 A 987306 H4 receptor antagonist,potent and selective A 987306  Chemical Structure
  77. GC63502 Aβ/tau aggregation-IN-1 Aβ/tau aggregation-IN-1 is a potent Aβ1-42 β-sheets formation and tau aggregation inhibitor. Aβ/tau aggregation-IN-1  Chemical Structure
  78. GC60037 A-3 hydrochloride A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride  Chemical Structure
  79. GC19499 A-381393

    A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist

    A-381393  Chemical Structure
  80. GC31214 A-437203 (Lu201640) A-437203 (Lu201640) is a selective D3 receptor antagonist with Ki of 71, 1.6, and 6220 nM for D2, D3, and D4 receptors, respectively. A-437203 (Lu201640)  Chemical Structure
  81. GC11842 A-740003 A selective P2X7 antagonist A-740003  Chemical Structure
  82. GC15014 A-867744 A positive allosteric modulator of α7 nAChRs A-867744  Chemical Structure
  83. GC10641 AA 29504 GABAA receptor modulator AA 29504  Chemical Structure
  84. GC31055 Abaperidone Abaperidone is a potent antagonist of 5-HT2A?receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM. Abaperidone  Chemical Structure
  85. GC42674 ABD459 ABD459 is a neutral antagonist of the central cannabinoid 1 (CB1) receptor (Ki = 8.6 nM). ABD459  Chemical Structure
  86. GC11795 ABT 724 trihydrochloride Dopamine D4 receptor agonist,potent and selective ABT 724 trihydrochloride  Chemical Structure
  87. GC35222 ABT-239 ABT-239 is a novel, highly efficacious, non-imidazole?class of H3R antagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist. ABT-239  Chemical Structure
  88. GC33552 ABT-670 ABT-670 is a selective, oral bioavailable agonist of dopamine D4 receptor, with EC50 of 89 nM, 160 nM, and 93 nM for human?D4, ferret?D4, and rat?D4, respectively. ABT-670  Chemical Structure
  89. GP10121 Ac-Endothelin-1 (16-21), human Ac-Endothelin-1 (16-21), human  Chemical Structure
  90. GC42721 Ac-YVAD-CMK

    Ac-YVAD-CMK is a selective irreversible inhibitor of caspase-1 (Ki=0.8nM), which can prevent the proinflammatory cytokine IL-1β activation. Ac-YVAD-CMK can reduce the inflammatory response and induce a long-lasting neuroprotective effect.

    Ac-YVAD-CMK  Chemical Structure
  91. GC49263 Ac2-26 (human) (ammonium salt) An annexin A1-mimetic peptide Ac2-26 (human) (ammonium salt)  Chemical Structure
  92. GC30859 AC260584 AC260584 is an M1 muscarinic receptor allosteric agonist with a pEC50 of 7.6. AC260584  Chemical Structure
  93. GC14916 Acamprosate calcium An NMDA modulator Acamprosate calcium  Chemical Structure
  94. GC46778 Acamprosate-d3 (calcium salt) An internal standard for the quantification of acamprosate Acamprosate-d3 (calcium salt)  Chemical Structure
  95. GC17079 ACDPP hydrochloride mGlu5 receptor antagonist ACDPP hydrochloride  Chemical Structure
  96. GC64332 Aceclidine Aceclidine is a modulator of M3 muscarinic acetylcholine receptor. Aceclidine  Chemical Structure
  97. GC12787 Aceclidine (hydrochloride) agonist of muscarinic receptors Aceclidine (hydrochloride)  Chemical Structure
  98. GC15902 Aceclofenac non-steroidal anti-inflammatory drug Aceclofenac  Chemical Structure
  99. GC42691 Aceclofenac ethyl ester A potential impurity found in commercial preparations of aceclofenac Aceclofenac ethyl ester  Chemical Structure
  100. GC42692 Aceclofenac methyl ester A potential impurity in commercial preparations of aceclofenac Aceclofenac methyl ester  Chemical Structure
  101. GC10454 Acemetacin COX inhibitor Acemetacin  Chemical Structure

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