5-HT Receptor
5-HT receptor (5-hydroxytryptamine receptors) is a group of GPCRs (G protein-coupled receptors) and LGICs (ligand-gated ion channels) found in the central and peripheral nervous systems.
Products for 5-HT Receptor
- Cat.No. Product Name Information
- GC31014 Irindalone (Lu 21-098) Irindalone (Lu 21-098) is a novel serotonin 5-HT2 antagonist.
- GC11984 Isamoltane hemifumarate 5-HT1B antagonist
- GN10186 Isocorynoxeine
- GC39076 Isopteropodine Isopteropodine is heteroyohimbine-type oxindole alkaloid components of Uncaria tomentosa (Willd.
- GC38433 Jatrorrhizine Jatrorrhizine is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities.
- GC43926 Jatrorrhizine (chloride) Jatrorrhizine is an alkaloid that has been found in the Chinese herb C.
- GC60957 Jatrorrhizine hydroxide Jatrorrhizine?hydroxide is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities.
- GC31251 JNJ-18038683 JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively.
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GC14563
Ketanserin
specific 5-HT2A serotonin receptor antagonist
- GC43999 Ketanserin (tartrate) Ketanserin is a potent antagonist of the serotonin (5-HT) receptor that is selective for 5-HT2 (IC50 = 6.3 nM; Ki = 2.1 nM).
- GC60965 Keto Ziprasidone Keto Ziprasidone is an impurity of Ziprasidone.
- GC11308 L-703,664 succinate 5-HT1D receptor agonist
- GC15121 Lasmiditan 5-HT1F receptor agonist
- GC36428 Lasmiditan hydrochloride
- GC25563 Lasmiditan succinate Lasmiditan succinate (COL-144, LY573144) is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (Ki=2.21 nM) without vasoconstrictor activity.
- GC17974 Latrepirdine dihydrochloride Latrepirdine is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors.
- GC25569 Lerisetron Lerisetron (F 0930, F 0930RS) is a 5-HT3 receptor antagonist with IC50 of 0.81μM.
- GC33721 Lesopitron dihydrochloride (E4424) Lesopitron dihydrochloride (E4424) is a full and selective 5-HT1A receptor agonist with IC50 of 125 nM in rat hippocampal membranes.
- GC30972 Lidanserin (ZK-33839) Lidanserin (ZK-33839) (ZK-33839) acts as a 5-HT2A and α1-adrenergic receptor antagonist.
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GC30352
Lintopride
Lintopride is a 5HT4 antagonist with moderate 5HT3 antagonist properties.
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GC11495
Lofepramine
Serotonin and noradrenalin re-uptake inhibitor (SNRI)
- GC13081 Loxapine 5-HT receptor antagonist
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GC10242
Loxapine Succinate
Dopamine receptor antagonist
- GC14195 LP 12 hydrochloride 5-HT7 receptor agonist
- GC17044 LP 20 hydrochloride ligand of the 5-HT7 receptor
- GC18112 LP 44 LP44 (hydrochloride) is a selective 5-HT7 agonist with Ki of 0.22 nM.
- GC30880 LP-211 An agonist of 5-HT7 receptors
- GC11962 Lu AE58054 Hydrochloride A 5-HT6 receptor antagonist
- GC30797 lumateperone Tosylate (ITI-007) Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator.
- GC30926 Lurasidone (SM-13496) Lurasidone (SM-13496) (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively.
- GC17593 Lurasidone HCl Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively.
- GC13607 LY 215840 5-HT2/5-HT7 receptor antagonist
- GC10674 LY 266097 hydrochloride 5-HT2B receptor antagonist
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GC10919
LY 272015 hydrochloride
5-HT2B receptor antagonist
- GC12657 LY 334370 hydrochloride 5-HT1F receptor agonist
- GC17039 LY 344864 A 5-HT1F receptor antagonist
- GC36501 LY 344864 hydrochloride LY 344864 hydrochloride is a selective, orally active 5-HT1F receptor agonist with a Ki of 6 nM.
- GC36502 LY 344864 racemate LY 344864 racemate is a 5-HT1F receptor agonist extracted from patent US 5708187 A.
- GC36503 LY 344864 S-enantiomer LY 344864 S-enantiomer is the S-enantiomer of LY344864.
- GC14738 LY 393558 Dual 5-HT1B/1D receptor antagonist
- GC17138 LY310762 5-HT1D receptor antagonist
- GC36511 LY334370 LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM.
- GC15456 m-Chlorophenylbiguanide hydrochloride 5-HT3 receptor agonist
- GC36548 Masupirdine free base Masupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor).
- GC38509 Masupirdine mesylate Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor).
- GC10051 MDL 100907 MDL 100907 is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors.
- GC11119 MDL 11,939 MDL 11,939 (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively).
- GC14083 MDL 72222 MDL 72222 (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM.
- GC10985 MDL 72832 hydrochloride ligand for 5-HT1A receptor, potent and selective
- GC14019 MDL 73005EF hydrochloride 5-HT1A receptor antagonist
- GC39496 Melitracen hydrochloride Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent.
- GC11929 Melperone hydrochloride 5-HT2A/D2 receptor antagonist
- GC14516 Mesulergine hydrochloride 5-HT2A and 2C receptor antagonist
- GC10357 Metergoline 5-HT1/5-HT2 antagonist
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GC17360
Methiothepin maleate
5-HT antagonist
- GC33674 Methiothepin mesylate (Metitepine mesylate) Methiothepin mesylate (Metitepine mesylate) is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C).
- GC14724 Methylergometrine maleate 5-HT1/5-HT2 receptor antagonist
- GC16470 Methysergide maleate Mixed 5-HT1/5-HT2 receptor antagonist
- GC30446 MHP 133 MHP 133 is a drug with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.
- GC11447 Mirtazapine 5-HT2, 5-HT3, histamine H1 receptor and α2-adrenoceptor antagonist
- GC48855 Mirtazapine (CRM) A Certified Reference Material
- GC61067 Mirtazapine D3 A Certified Reference Material
- GC17745 MK 212 hydrochloride MK-212 (CPP) monohydrochloride is a centrally acting 5-HT1C/5-HT2 agonist.
- GC11787 ML 10302 hydrochloride 5-HT4 partial agonist
- GC14891 MM 77 dihydrochloride 5-HT1A receptor antagonist
- GC13428 Mosapride Selective 5HT4 agonist
- GC17536 Mosapride Citrate 5-HT receptor agonist
- GC13977 MS 245 oxalate 5-HT6 antagonist
- GC44259 Myristicin Myristicin is an alkenylbenzene present in small amounts in the essential oil of nutmeg that is reported to act as a serotonin receptor antagonist, a weak monamine oxidase inhibitor, and to produce hallucinogenic effects.
- GC16553 N-Desmethylclozapine 5-HT2C serotonin receptor antagonist
- GC16399 N-Methylquipazine dimaleate 5-HT3 agonist
- GC16251 NAD 299 hydrochloride Selective, high affinity 5-HT1A receptor antagonist
- GC61108 Naftidrofuryl oxalate
- GC32511 Naftidrofuryl oxalate (Nafronyl oxalate salt)
- GC31057 Naluzotan (PRX 00023) Naluzotan (PRX 00023) is a novel, potent, and selective amidosulfonamide 5-HT1A agonist with IC50 and Ki of appr 20 nM and 5.1 nM, used for the treatment of anxiety and depression; Also a weak hERG K+ channel blocker, with IC50 of 3800 nM.
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GC15235
NAN-190 hydrobromide
5-HT1A antagonist
- GC11959 Naratriptan Naratriptan is a selective 5-HT1 receptor subtype agonist and is a triptan drug that is used for the treatment of migraine headaches.
- GC36693 Naratriptan D3 Hydrochloride Naratriptan D3 Hydrochloride is the deuterium labeled Naratriptan, which is a selective 5-HT1 receptor subtype agonist.
- GC13298 NAS-181 NAS181 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM.
- GC13135 NBOH-2C-CN hydrochloride 5-HT2A agonist
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GC69545
Nefazodone
Nefazodone is an orally active phenylpiperazine antidepressant. It effectively and selectively blocks postsynaptic 5-HT2A receptors, moderately inhibits the reuptake of serotonin and noradrenaline. Nefazodone can also alleviate the adverse effects of stress response on the immune system in mice. Nefazodone has a high affinity for CYP3A4 isoenzymes, indicating a potential risk for active molecule-active molecule interactions.
- GC16324 Nefazodone hydrochloride 5-HT2A receptor antagonist
- GC30796 Nelotanserin (APD125) Nelotanserin (APD125) is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively.
- GC39277 Nemifitide diTFA Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action.
- GC31018 NEO 376 (SPI-376) NEO 376 (SPI-376) is a selective modulator of 5-HT1 receptor, GABA receptor and dopamine receptor, with anti-psychotic actively.
- GC32563 Nexopamil racemate Nexopamil racemate is the racemate of Nexopamil.
- GC63111 NLX-204 hydrochloride
- GC11989 Nortriptyline (hydrochloride) norepinephrine and serotonin transporters blocker
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GC15872
NPEC-caged-serotonin
5-HT receptor agonist
- GC12744 NPS ALX Compound 4a dihydrochloride NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM.
- GC31015 NRA-0160 NRA-0160 is a selective dopamine D4 receptor antagonist, with a Ki value of 0.48 nM and with negligible affinity for dopamine D2 receptor (Ki: >10000 nM), D3 receptor (Ki: 39 nM), rat 5-HT2A receptor (Ki: 180 nM) and rat α1 adrenoceptor (Ki: 237 nM).
- GN10607 Nuciferine
- GC31173 Ocaperidone (R79598) Ocaperidone (R79598) is an effective antipsychotic agent, acting as a potent 5-HT2 and dopamine D2 antagonist, and a 5-HT1A agonist, with Kis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT2, a1-adrenergic receptor, dopamine D2, histamine H1 and a2-adrenergic receptor, respectively, and a pEC50 and pKi of 7.60 and 8.08 for h5-HT1A.
- GC12495 Olanzapine Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM).
- GC61809 Olanzapine D3 Olanzapine D3 (LY170053-d3) is the deuterium labeled Olanzapine.
- GC16142 Ondansetron serotonin 5-HT3 receptor antagonist
- GC11814 Ondansetron HCl Ondansetron HCl (GR 38032 hydrochloride; SN 307 hydrochloride) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.
- GC11651 Ondansetron hydrochloride dihydrate 5-HT3 receptor antagonist
- GC61889 OPC-14523 hydrochloride OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM).
- GC15268 Org 12962 hydrochloride 5-HT2C receptor agonist