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5-HT Receptor

5-HT receptor (5-hydroxytryptamine receptors) is a group of GPCRs (G protein-coupled receptors) and LGICs (ligand-gated ion channels) found in the central and peripheral nervous systems.

Products for  5-HT Receptor

  1. Cat.No. Product Name Information
  2. GC31014 Irindalone (Lu 21-098) Irindalone (Lu 21-098) is a novel serotonin 5-HT2 antagonist. Irindalone (Lu 21-098)  Chemical Structure
  3. GC11984 Isamoltane hemifumarate 5-HT1B antagonist Isamoltane hemifumarate  Chemical Structure
  4. GN10186 Isocorynoxeine Isocorynoxeine  Chemical Structure
  5. GC39076 Isopteropodine Isopteropodine is heteroyohimbine-type oxindole alkaloid components of Uncaria tomentosa (Willd. Isopteropodine  Chemical Structure
  6. GC38433 Jatrorrhizine Jatrorrhizine is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities. Jatrorrhizine  Chemical Structure
  7. GC43926 Jatrorrhizine (chloride) Jatrorrhizine is an alkaloid that has been found in the Chinese herb C. Jatrorrhizine (chloride)  Chemical Structure
  8. GC60957 Jatrorrhizine hydroxide Jatrorrhizine?hydroxide is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities. Jatrorrhizine hydroxide  Chemical Structure
  9. GC31251 JNJ-18038683 JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively. JNJ-18038683  Chemical Structure
  10. GC14563 Ketanserin

    specific 5-HT2A serotonin receptor antagonist

    Ketanserin  Chemical Structure
  11. GC43999 Ketanserin (tartrate) Ketanserin is a potent antagonist of the serotonin (5-HT) receptor that is selective for 5-HT2 (IC50 = 6.3 nM; Ki = 2.1 nM). Ketanserin (tartrate)  Chemical Structure
  12. GC60965 Keto Ziprasidone Keto Ziprasidone is an impurity of Ziprasidone. Keto Ziprasidone  Chemical Structure
  13. GC11308 L-703,664 succinate 5-HT1D receptor agonist L-703,664 succinate  Chemical Structure
  14. GC15121 Lasmiditan 5-HT1F receptor agonist Lasmiditan  Chemical Structure
  15. GC36428 Lasmiditan hydrochloride Lasmiditan hydrochloride  Chemical Structure
  16. GC25563 Lasmiditan succinate Lasmiditan succinate (COL-144, LY573144) is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (Ki=2.21 nM) without vasoconstrictor activity. Lasmiditan succinate  Chemical Structure
  17. GC17974 Latrepirdine dihydrochloride Latrepirdine is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine dihydrochloride  Chemical Structure
  18. GC25569 Lerisetron Lerisetron (F 0930, F 0930RS) is a 5-HT3 receptor antagonist with IC50 of 0.81μM. Lerisetron  Chemical Structure
  19. GC33721 Lesopitron dihydrochloride (E4424) Lesopitron dihydrochloride (E4424) is a full and selective 5-HT1A receptor agonist with IC50 of 125 nM in rat hippocampal membranes. Lesopitron dihydrochloride (E4424)  Chemical Structure
  20. GC30972 Lidanserin (ZK-33839) Lidanserin (ZK-33839) (ZK-33839) acts as a 5-HT2A and α1-adrenergic receptor antagonist. Lidanserin (ZK-33839)  Chemical Structure
  21. GC30352 Lintopride

    Lintopride is a 5HT4 antagonist with moderate 5HT3 antagonist properties.

    Lintopride  Chemical Structure
  22. GC11495 Lofepramine

    Serotonin and noradrenalin re-uptake inhibitor (SNRI)

    Lofepramine  Chemical Structure
  23. GC13081 Loxapine 5-HT receptor antagonist Loxapine  Chemical Structure
  24. GC10242 Loxapine Succinate

    Dopamine receptor antagonist

    Loxapine Succinate  Chemical Structure
  25. GC14195 LP 12 hydrochloride 5-HT7 receptor agonist LP 12 hydrochloride  Chemical Structure
  26. GC17044 LP 20 hydrochloride ligand of the 5-HT7 receptor LP 20 hydrochloride  Chemical Structure
  27. GC18112 LP 44 LP44 (hydrochloride) is a selective 5-HT7 agonist with Ki of 0.22 nM. LP 44  Chemical Structure
  28. GC30880 LP-211 An agonist of 5-HT7 receptors LP-211  Chemical Structure
  29. GC11962 Lu AE58054 Hydrochloride A 5-HT6 receptor antagonist Lu AE58054 Hydrochloride  Chemical Structure
  30. GC30797 lumateperone Tosylate (ITI-007) Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. lumateperone Tosylate (ITI-007)  Chemical Structure
  31. GC30926 Lurasidone (SM-13496) Lurasidone (SM-13496) (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496)  Chemical Structure
  32. GC17593 Lurasidone HCl Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone HCl  Chemical Structure
  33. GC13607 LY 215840 5-HT2/5-HT7 receptor antagonist LY 215840  Chemical Structure
  34. GC10674 LY 266097 hydrochloride 5-HT2B receptor antagonist LY 266097 hydrochloride  Chemical Structure
  35. GC10919 LY 272015 hydrochloride

    5-HT2B receptor antagonist

    LY 272015 hydrochloride  Chemical Structure
  36. GC12657 LY 334370 hydrochloride 5-HT1F receptor agonist LY 334370 hydrochloride  Chemical Structure
  37. GC17039 LY 344864 A 5-HT1F receptor antagonist LY 344864  Chemical Structure
  38. GC36501 LY 344864 hydrochloride LY 344864 hydrochloride is a selective, orally active 5-HT1F receptor agonist with a Ki of 6 nM. LY 344864 hydrochloride  Chemical Structure
  39. GC36502 LY 344864 racemate LY 344864 racemate is a 5-HT1F receptor agonist extracted from patent US 5708187 A. LY 344864 racemate  Chemical Structure
  40. GC36503 LY 344864 S-enantiomer LY 344864 S-enantiomer is the S-enantiomer of LY344864. LY 344864 S-enantiomer  Chemical Structure
  41. GC14738 LY 393558 Dual 5-HT1B/1D receptor antagonist LY 393558  Chemical Structure
  42. GC17138 LY310762 5-HT1D receptor antagonist LY310762  Chemical Structure
  43. GC36511 LY334370 LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM. LY334370  Chemical Structure
  44. GC15456 m-Chlorophenylbiguanide hydrochloride 5-HT3 receptor agonist m-Chlorophenylbiguanide hydrochloride  Chemical Structure
  45. GC36548 Masupirdine free base Masupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine free base  Chemical Structure
  46. GC38509 Masupirdine mesylate Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine mesylate  Chemical Structure
  47. GC10051 MDL 100907 MDL 100907 is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. MDL 100907  Chemical Structure
  48. GC11119 MDL 11,939 MDL 11,939 (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively). MDL 11,939  Chemical Structure
  49. GC14083 MDL 72222 MDL 72222 (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM. MDL 72222  Chemical Structure
  50. GC10985 MDL 72832 hydrochloride ligand for 5-HT1A receptor, potent and selective MDL 72832 hydrochloride  Chemical Structure
  51. GC14019 MDL 73005EF hydrochloride 5-HT1A receptor antagonist MDL 73005EF hydrochloride  Chemical Structure
  52. GC39496 Melitracen hydrochloride Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride  Chemical Structure
  53. GC11929 Melperone hydrochloride 5-HT2A/D2 receptor antagonist Melperone hydrochloride  Chemical Structure
  54. GC14516 Mesulergine hydrochloride 5-HT2A and 2C receptor antagonist Mesulergine hydrochloride  Chemical Structure
  55. GC10357 Metergoline 5-HT1/5-HT2 antagonist Metergoline  Chemical Structure
  56. GC17360 Methiothepin maleate

    5-HT antagonist

    Methiothepin maleate  Chemical Structure
  57. GC33674 Methiothepin mesylate (Metitepine mesylate) Methiothepin mesylate (Metitepine mesylate) is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C). Methiothepin mesylate (Metitepine mesylate)  Chemical Structure
  58. GC14724 Methylergometrine maleate 5-HT1/5-HT2 receptor antagonist Methylergometrine maleate  Chemical Structure
  59. GC16470 Methysergide maleate Mixed 5-HT1/5-HT2 receptor antagonist Methysergide maleate  Chemical Structure
  60. GC30446 MHP 133 MHP 133 is a drug with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors. MHP 133  Chemical Structure
  61. GC11447 Mirtazapine 5-HT2, 5-HT3, histamine H1 receptor and α2-adrenoceptor antagonist Mirtazapine  Chemical Structure
  62. GC48855 Mirtazapine (CRM) A Certified Reference Material Mirtazapine (CRM)  Chemical Structure
  63. GC61067 Mirtazapine D3 A Certified Reference Material Mirtazapine D3  Chemical Structure
  64. GC17745 MK 212 hydrochloride MK-212 (CPP) monohydrochloride is a centrally acting 5-HT1C/5-HT2 agonist. MK 212 hydrochloride  Chemical Structure
  65. GC11787 ML 10302 hydrochloride 5-HT4 partial agonist ML 10302 hydrochloride  Chemical Structure
  66. GC14891 MM 77 dihydrochloride 5-HT1A receptor antagonist MM 77 dihydrochloride  Chemical Structure
  67. GC13428 Mosapride Selective 5HT4 agonist Mosapride  Chemical Structure
  68. GC17536 Mosapride Citrate 5-HT receptor agonist Mosapride Citrate  Chemical Structure
  69. GC13977 MS 245 oxalate 5-HT6 antagonist MS 245 oxalate  Chemical Structure
  70. GC44259 Myristicin Myristicin is an alkenylbenzene present in small amounts in the essential oil of nutmeg that is reported to act as a serotonin receptor antagonist, a weak monamine oxidase inhibitor, and to produce hallucinogenic effects. Myristicin  Chemical Structure
  71. GC16553 N-Desmethylclozapine 5-HT2C serotonin receptor antagonist N-Desmethylclozapine  Chemical Structure
  72. GC16399 N-Methylquipazine dimaleate 5-HT3 agonist N-Methylquipazine dimaleate  Chemical Structure
  73. GC16251 NAD 299 hydrochloride Selective, high affinity 5-HT1A receptor antagonist NAD 299 hydrochloride  Chemical Structure
  74. GC61108 Naftidrofuryl oxalate Naftidrofuryl oxalate  Chemical Structure
  75. GC32511 Naftidrofuryl oxalate (Nafronyl oxalate salt) Naftidrofuryl oxalate (Nafronyl oxalate salt)  Chemical Structure
  76. GC31057 Naluzotan (PRX 00023) Naluzotan (PRX 00023) is a novel, potent, and selective amidosulfonamide 5-HT1A agonist with IC50 and Ki of appr 20 nM and 5.1 nM, used for the treatment of anxiety and depression; Also a weak hERG K+ channel blocker, with IC50 of 3800 nM. Naluzotan (PRX 00023)  Chemical Structure
  77. GC15235 NAN-190 hydrobromide

    5-HT1A antagonist

    NAN-190 hydrobromide  Chemical Structure
  78. GC11959 Naratriptan Naratriptan is a selective 5-HT1 receptor subtype agonist and is a triptan drug that is used for the treatment of migraine headaches. Naratriptan  Chemical Structure
  79. GC36693 Naratriptan D3 Hydrochloride Naratriptan D3 Hydrochloride is the deuterium labeled Naratriptan, which is a selective 5-HT1 receptor subtype agonist. Naratriptan D3 Hydrochloride  Chemical Structure
  80. GC13298 NAS-181 NAS181 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS-181  Chemical Structure
  81. GC13135 NBOH-2C-CN hydrochloride 5-HT2A agonist NBOH-2C-CN hydrochloride  Chemical Structure
  82. GC69545 Nefazodone

    Nefazodone is an orally active phenylpiperazine antidepressant. It effectively and selectively blocks postsynaptic 5-HT2A receptors, moderately inhibits the reuptake of serotonin and noradrenaline. Nefazodone can also alleviate the adverse effects of stress response on the immune system in mice. Nefazodone has a high affinity for CYP3A4 isoenzymes, indicating a potential risk for active molecule-active molecule interactions.

    Nefazodone  Chemical Structure
  83. GC16324 Nefazodone hydrochloride 5-HT2A receptor antagonist Nefazodone hydrochloride  Chemical Structure
  84. GC30796 Nelotanserin (APD125) Nelotanserin (APD125) is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively. Nelotanserin (APD125)  Chemical Structure
  85. GC39277 Nemifitide diTFA Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide diTFA  Chemical Structure
  86. GC31018 NEO 376 (SPI-376) NEO 376 (SPI-376) is a selective modulator of 5-HT1 receptor, GABA receptor and dopamine receptor, with anti-psychotic actively. NEO 376 (SPI-376)  Chemical Structure
  87. GC32563 Nexopamil racemate Nexopamil racemate is the racemate of Nexopamil. Nexopamil racemate  Chemical Structure
  88. GC63111 NLX-204 hydrochloride NLX-204 hydrochloride  Chemical Structure
  89. GC11989 Nortriptyline (hydrochloride) norepinephrine and serotonin transporters blocker Nortriptyline (hydrochloride)  Chemical Structure
  90. GC15872 NPEC-caged-serotonin

    5-HT receptor agonist

    NPEC-caged-serotonin  Chemical Structure
  91. GC12744 NPS ALX Compound 4a dihydrochloride NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM. NPS ALX Compound 4a dihydrochloride  Chemical Structure
  92. GC31015 NRA-0160 NRA-0160 is a selective dopamine D4 receptor antagonist, with a Ki value of 0.48 nM and with negligible affinity for dopamine D2 receptor (Ki: >10000 nM), D3 receptor (Ki: 39 nM), rat 5-HT2A receptor (Ki: 180 nM) and rat α1 adrenoceptor (Ki: 237 nM). NRA-0160  Chemical Structure
  93. GN10607 Nuciferine Nuciferine  Chemical Structure
  94. GC31173 Ocaperidone (R79598) Ocaperidone (R79598) is an effective antipsychotic agent, acting as a potent 5-HT2 and dopamine D2 antagonist, and a 5-HT1A agonist, with Kis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT2, a1-adrenergic receptor, dopamine D2, histamine H1 and a2-adrenergic receptor, respectively, and a pEC50 and pKi of 7.60 and 8.08 for h5-HT1A. Ocaperidone (R79598)  Chemical Structure
  95. GC12495 Olanzapine Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine  Chemical Structure
  96. GC61809 Olanzapine D3 Olanzapine D3 (LY170053-d3) is the deuterium labeled Olanzapine. Olanzapine D3  Chemical Structure
  97. GC16142 Ondansetron serotonin 5-HT3 receptor antagonist Ondansetron  Chemical Structure
  98. GC11814 Ondansetron HCl Ondansetron HCl (GR 38032 hydrochloride; SN 307 hydrochloride) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy. Ondansetron HCl  Chemical Structure
  99. GC11651 Ondansetron hydrochloride dihydrate 5-HT3 receptor antagonist Ondansetron hydrochloride dihydrate  Chemical Structure
  100. GC61889 OPC-14523 hydrochloride OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM). OPC-14523 hydrochloride  Chemical Structure
  101. GC15268 Org 12962 hydrochloride 5-HT2C receptor agonist Org 12962 hydrochloride  Chemical Structure

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