COX
COX (cyclooxygenase) is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane.
Products for COX
- Cat.No. Product Name Information
- GC14499 Fenoprofen calcium hydrate nonsteroidal, anti-inflammatory antiarthritic agent
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GC40565
Feprazone
Feprazone is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor that is 10-fold selective for COX-2 over COX-1.
- GC12397 Firocoxib COX2 inhibitor
- GC11768 FK 3311 A COX-2 inhibitor
- GC31818 Flosulide (ZK 38997) Flosulide (ZK 38997) is a potent and selective COX-2 inhibitor, used for the treatment for inflammatory diseases.
-
GC13466
Flufenamic acid
TRPC activator
- GC48827 Flufenamic Acid-d4 An internal standard for the quantification of flufenamic acid
- GC13569 Flunixin Meglumin Flunixin Meglumin is a cyclooxygenase (COX) inhibitor with IC50 values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively.
- GC64495 Flurbiprofen axetil Flurbiprofen axetil is a non-selective cyclooxygenase (COX) inhibitor.
- GC68323 Flurbiprofen-d5
- GC39013 FPL 62064 FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively.
- GC16881 FR 122047 hydrochloride FR 122047 hydrochloride (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC50 of 28 nM.
- GC33893 FR-188582 FR-188582 is a highly selective inhibitor of cyclooxygenase (COX)-2, with an IC50 value of 17 nM.
- GC13132 FR122047 (hydrate) selective inhibitor of COX-1
- GN10388 Gallic acid
- GC61436 Gallic acid hydrate Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2).
- GN10220 Ginsenoside Rb3
- GN10549 Ginsenoside Rd
- GN10799 Ginsenoside Rg3
- GC31706 Ginsenoside Rg5 A ginsenoside with diverse biological activities
- GC41218 Guaiacol Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin.
- GC36200 GW-406381 A NSAID and COX-2 inhibitor
- GC38616 Hamaudol Hamaudol is a chromone isolated from Saposhnikovia divaricata.
- GC41396 Heneicosapentaenoic Acid Heneicosapentaenoic Acid (HPA) is a 21:5 ω-3 fatty acid present in trace amounts in the green alga B.
- GC34116 Hexahydrocurcumin Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities.
- GC64833 Humulone Humulone (α-Lupulic acid), a prenylated phloroglucinol derivative, is a potent cyclooxygenase-2 (COX-2) inhibitor.
- GC18010 Ibufenac COX-1 and -2 inhibitor
- GC17863 Ibuprofen inhibitor of cyclooxygenase 1 and cyclooxygenase 2
- GC60926 Ibuprofen impurity 1 Ibuprofen impurity 1 is an Ibuprofen impurity.
- GC65519 Ibuprofen Impurity F Ibuprofen Impurity F is an Ibuprofen impurity.
- GC16294 Ibuprofen Lysine Ibuprofen ((±)-Ibuprofen) L-lysine is a potent orally active, selective COX-1 inhibitor with an IC50 value of 13 μM.
- GC66211 Ibuprofen sodium Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers.
- GC17419 Iguratimod A DMARD and COX-2 inhibitor
- GC36305 Imrecoxib Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM.
- GC36314 Indobufen Indobufen is a platelet aggregation inhibitor.
-
GC17556
Indomethacin
Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively.
- GC49698 Indomethacin Acyl Glucuronide A metabolite of indomethacin
- GC12719 Indomethacin heptyl ester non-selective inhibitor of both COX-1 and COX-2
- GC14777 Indomethacin N-octyl amide potent but non-selective inhibitor of both COX-1 and COX-2
- GC60935 Indomethacin sodium hydrate Indomethacin (Indometacin) sodium hydrateis a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively.
- GC40227 Indomethacin-d4 Indomethacin-d4 is intended for use as an internal standard for the quantification of indomethacin by GC- or LC-MS.
- GC68423 Indomethacin-d4 Methyl Ester
- GC13042 Inotilone cyclooxygenase (COX) inhibitor
- GC33861 Inulicin (1-O-Acetylbritannilactone) Inulicin (1-O-Acetylbritannilactone) (1-O-Acetylbritannilactone) is an active compound that inhibits VEGF-mediated activation of Src and FAK.
- GC39134 Isofraxidin Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells.
- GC39534 Isoxicam Isoxicam is an orally active, long-acting, non-steroidal anti-inflammatory agent for the research of arthritis.
- GC41645 Jacaric Acid Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants.
- GN10645 Jaceosidin
- GC13339 Ketoprofen Dual COX1/2 inhibitor
- GC15179 Ketorolac non-selective COX inhibitor
- GC47528 Ketorolac (calcium salt) Ketorolac (RS37619) hemicalcium is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.
- GC60966 Ketorolac D5 An internal standard for the quantification of ketorolac
- GC16594 Ketorolac tromethamine salt Non-selective COX inhibitor
- GC60225 Licarin A Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells.
- GC38196 Licofelone A dual inhibitor of COX1/COX2 and 5LO
- GC16721 Licofelone COX-1, COX-2 and 5-LOX inhibitor
- GC13572 Lornoxicam COX-1/COX-2 inhibitor
- GC48639 Lornoxicam-d4 An internal standard for the quantification of lornoxicam
- GC14013 Losartan Carboxaldehyde Losartan Carboxaldehyde is an important intermediate aldehyde metabolite of Losartan.
- GC36482 Loxoprofen Loxoprofen is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties.
- GC60228 Loxoprofen sodium Loxoprofen sodium is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties.
- GC12941 Lumiracoxib Novel, selective COX-2 inhibitor
- GN10022 luteolin-6-C-glucoside
-
GC30610
LY 178002
LY 178002 is a potent inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2, with IC50 of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.
- GC38066 Mavacoxib Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID).
- GC11096 Mefenamic Acid Anti-inflammatory agent
- GC61038 Mefenamic acid D4 An internal standard for the quantification of mefenamic acid
- GC11762 Meloxicam (Mobic) Meloxicam (Mobic) is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 μM and 36.6 μM for COX-2 and COX-1, respectively.
- GC40065 Meloxicam-d3 Meloxicam-d3 is intended for use as an internal standard for the quantification of meloxicam by GC- or LC-MS.
- GC44167 Metamizole (sodium salt) Metamizole (sodium salt) is a non-opioid compound with excellent analgesic and antipyretic effects.
- GC31737 Metamizole sodium hydrate Metamizole sodium hydrate is a potent analgesic drug that has been demonstrated to inhibit cyclooxygenase (COX).
- GC31943 Methyl Salicylate (Wintergreen oil) Methyl Salicylate (Wintergreen oil) (Wintergreen oil) is a topical analgesic and anti-inflammatory agent.
- GC41634 Metyrosine Metyrosine is an inhibitor of tyrosine hydroxylase.
- GC17980 N-(2-phenylethyl)-Indomethacin amide inhibitor of COX-2
- GC15372 N-(3-hydroxyphenyl)-Arachidonoyl amide selective, irreversible inhibitor of COX-2
- GC15959 N-(3-pyridyl)-Indomethacin amide inhibitor of COX-2
- GC10611 N-(4-acetamidophenyl)-Indomethacin amide inhibitor of COX-2
- GC16440 N-acetyl-2-carboxy Benzenesulfonamide non-selective inhibitor of COX
- GC17306 N-tert-butyl-α-Phenylnitrone N-tert-butyl-α-Phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts.
- GC40686 N-trans-Feruloyltyramine N-trans-Feruloyltyramine is a phenolic amide originally isolated from S.
-
GC13422
Nabumetone
COX inhibitor
- GC47734 Nabumetone-d3 An internal standard for the quantification of nabumetone
- GC32026 Naproxen etemesil (LT-NS 001) Naproxen etemesil (LT-NS 001) is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed.
- GC17975 Naproxen Sodium cyclooxygenase inhibitor
- GC12684 NCX 4040 COX-2 expression inhibitor
- GC13896 NCX 466 cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor
- GN10429 Neochlorogenic acid
- GC13637 Nepafenac COX-1 and COX-2 inhibitor
- GC36721 Nepafenac D5 An internal standard for the quantification of nepafenac
- GC18084 Nimesulide Non-steroidal anti-inflammatory drug
- GC39583 Nimesulide D5 An internal standard for the quantification of nimesulide
- GC36747 Nitroaspirin Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins.
- GC34028 Nitroflurbiprofen (HCT 1206) Nitroflurbiprofen (HCT 1206) is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.
- GC44439 NO-Indomethacin NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor.
- GC12241 NS 398 COX-2 inhibitor and anti-inflammatory agent
- GC14999 O-Acetyl Salicylhydroxamic Acid irreversible, non-selective inhibitor of COX-1 and COX-2
- GC49316 O-Desmethyl-N-deschlorobenzoyl Indomethacin A metabolite of indomethacin
- GC63478 Ocarocoxib Ocarocoxib, a potent COX-?2 (cyclooxygenase-?2) inhibitor, is a non-steroidal anti-inflammatory for veterinary use.
- GC49098 Olsalazine-13C6 An internal standard for the quantification of olsalazine
- GC12114 Oxaprozin COX inhibitor