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COX

COX (cyclooxygenase) is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane.

Products for  COX

  1. Cat.No. Product Name Information
  2. GC14499 Fenoprofen calcium hydrate nonsteroidal, anti-inflammatory antiarthritic agent Fenoprofen calcium hydrate  Chemical Structure
  3. GC40565 Feprazone

    Feprazone is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor that is 10-fold selective for COX-2 over COX-1.

    Feprazone  Chemical Structure
  4. GC12397 Firocoxib COX2 inhibitor Firocoxib  Chemical Structure
  5. GC11768 FK 3311 A COX-2 inhibitor FK 3311  Chemical Structure
  6. GC31818 Flosulide (ZK 38997) Flosulide (ZK 38997) is a potent and selective COX-2 inhibitor, used for the treatment for inflammatory diseases. Flosulide (ZK 38997)  Chemical Structure
  7. GC13466 Flufenamic acid

    TRPC activator

    Flufenamic acid  Chemical Structure
  8. GC48827 Flufenamic Acid-d4 An internal standard for the quantification of flufenamic acid Flufenamic Acid-d4  Chemical Structure
  9. GC13569 Flunixin Meglumin Flunixin Meglumin is a cyclooxygenase (COX) inhibitor with IC50 values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively. Flunixin Meglumin  Chemical Structure
  10. GC64495 Flurbiprofen axetil Flurbiprofen axetil is a non-selective cyclooxygenase (COX) inhibitor. Flurbiprofen axetil  Chemical Structure
  11. GC68323 Flurbiprofen-d5 Flurbiprofen-d5  Chemical Structure
  12. GC39013 FPL 62064 FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064  Chemical Structure
  13. GC16881 FR 122047 hydrochloride FR 122047 hydrochloride (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC50 of 28 nM. FR 122047 hydrochloride  Chemical Structure
  14. GC33893 FR-188582 FR-188582 is a highly selective inhibitor of cyclooxygenase (COX)-2, with an IC50 value of 17 nM. FR-188582  Chemical Structure
  15. GC13132 FR122047 (hydrate) selective inhibitor of COX-1 FR122047 (hydrate)  Chemical Structure
  16. GN10388 Gallic acid Gallic acid  Chemical Structure
  17. GC61436 Gallic acid hydrate Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2). Gallic acid hydrate  Chemical Structure
  18. GN10220 Ginsenoside Rb3 Ginsenoside Rb3  Chemical Structure
  19. GN10549 Ginsenoside Rd Ginsenoside Rd  Chemical Structure
  20. GN10799 Ginsenoside Rg3 Ginsenoside Rg3  Chemical Structure
  21. GC31706 Ginsenoside Rg5 A ginsenoside with diverse biological activities Ginsenoside Rg5  Chemical Structure
  22. GC41218 Guaiacol Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol  Chemical Structure
  23. GC36200 GW-406381 A NSAID and COX-2 inhibitor GW-406381  Chemical Structure
  24. GC38616 Hamaudol Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol  Chemical Structure
  25. GC41396 Heneicosapentaenoic Acid Heneicosapentaenoic Acid (HPA) is a 21:5 ω-3 fatty acid present in trace amounts in the green alga B. Heneicosapentaenoic Acid  Chemical Structure
  26. GC34116 Hexahydrocurcumin Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities. Hexahydrocurcumin  Chemical Structure
  27. GC64833 Humulone Humulone (α-Lupulic acid), a prenylated phloroglucinol derivative, is a potent cyclooxygenase-2 (COX-2) inhibitor. Humulone  Chemical Structure
  28. GC18010 Ibufenac COX-1 and -2 inhibitor Ibufenac  Chemical Structure
  29. GC17863 Ibuprofen inhibitor of cyclooxygenase 1 and cyclooxygenase 2 Ibuprofen  Chemical Structure
  30. GC60926 Ibuprofen impurity 1 Ibuprofen impurity 1 is an Ibuprofen impurity. Ibuprofen impurity 1  Chemical Structure
  31. GC65519 Ibuprofen Impurity F Ibuprofen Impurity F is an Ibuprofen impurity. Ibuprofen Impurity F  Chemical Structure
  32. GC16294 Ibuprofen Lysine Ibuprofen ((±)-Ibuprofen) L-lysine is a potent orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen Lysine  Chemical Structure
  33. GC66211 Ibuprofen sodium Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers. Ibuprofen sodium  Chemical Structure
  34. GC17419 Iguratimod A DMARD and COX-2 inhibitor Iguratimod  Chemical Structure
  35. GC36305 Imrecoxib Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib  Chemical Structure
  36. GC36314 Indobufen Indobufen is a platelet aggregation inhibitor. Indobufen  Chemical Structure
  37. GC17556 Indomethacin

    Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively.

    Indomethacin  Chemical Structure
  38. GC49698 Indomethacin Acyl Glucuronide A metabolite of indomethacin Indomethacin Acyl Glucuronide  Chemical Structure
  39. GC12719 Indomethacin heptyl ester non-selective inhibitor of both COX-1 and COX-2 Indomethacin heptyl ester  Chemical Structure
  40. GC14777 Indomethacin N-octyl amide potent but non-selective inhibitor of both COX-1 and COX-2 Indomethacin N-octyl amide  Chemical Structure
  41. GC60935 Indomethacin sodium hydrate Indomethacin (Indometacin) sodium hydrateis a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium hydrate  Chemical Structure
  42. GC40227 Indomethacin-d4 Indomethacin-d4 is intended for use as an internal standard for the quantification of indomethacin by GC- or LC-MS. Indomethacin-d4  Chemical Structure
  43. GC68423 Indomethacin-d4 Methyl Ester Indomethacin-d4 Methyl Ester  Chemical Structure
  44. GC13042 Inotilone cyclooxygenase (COX) inhibitor Inotilone  Chemical Structure
  45. GC33861 Inulicin (1-O-Acetylbritannilactone) Inulicin (1-O-Acetylbritannilactone) (1-O-Acetylbritannilactone) is an active compound that inhibits VEGF-mediated activation of Src and FAK. Inulicin (1-O-Acetylbritannilactone)  Chemical Structure
  46. GC39134 Isofraxidin Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin  Chemical Structure
  47. GC39534 Isoxicam Isoxicam is an orally active, long-acting, non-steroidal anti-inflammatory agent for the research of arthritis. Isoxicam  Chemical Structure
  48. GC41645 Jacaric Acid Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Jacaric Acid  Chemical Structure
  49. GN10645 Jaceosidin Jaceosidin  Chemical Structure
  50. GC13339 Ketoprofen Dual COX1/2 inhibitor Ketoprofen  Chemical Structure
  51. GC15179 Ketorolac non-selective COX inhibitor Ketorolac  Chemical Structure
  52. GC47528 Ketorolac (calcium salt) Ketorolac (RS37619) hemicalcium is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac (calcium salt)  Chemical Structure
  53. GC60966 Ketorolac D5 An internal standard for the quantification of ketorolac Ketorolac D5  Chemical Structure
  54. GC16594 Ketorolac tromethamine salt Non-selective COX inhibitor Ketorolac tromethamine salt   Chemical Structure
  55. GC60225 Licarin A Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Licarin A  Chemical Structure
  56. GC38196 Licofelone A dual inhibitor of COX1/COX2 and 5LO Licofelone  Chemical Structure
  57. GC16721 Licofelone COX-1, COX-2 and 5-LOX inhibitor Licofelone  Chemical Structure
  58. GC13572 Lornoxicam COX-1/COX-2 inhibitor Lornoxicam  Chemical Structure
  59. GC48639 Lornoxicam-d4 An internal standard for the quantification of lornoxicam Lornoxicam-d4  Chemical Structure
  60. GC14013 Losartan Carboxaldehyde Losartan Carboxaldehyde is an important intermediate aldehyde metabolite of Losartan. Losartan Carboxaldehyde  Chemical Structure
  61. GC36482 Loxoprofen Loxoprofen is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen  Chemical Structure
  62. GC60228 Loxoprofen sodium Loxoprofen sodium is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium  Chemical Structure
  63. GC12941 Lumiracoxib Novel, selective COX-2 inhibitor Lumiracoxib  Chemical Structure
  64. GN10022 luteolin-6-C-glucoside luteolin-6-C-glucoside  Chemical Structure
  65. GC30610 LY 178002

    LY 178002 is a potent inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2, with IC50 of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.

    LY 178002  Chemical Structure
  66. GC38066 Mavacoxib Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib  Chemical Structure
  67. GC11096 Mefenamic Acid Anti-inflammatory agent Mefenamic Acid  Chemical Structure
  68. GC61038 Mefenamic acid D4 An internal standard for the quantification of mefenamic acid Mefenamic acid D4  Chemical Structure
  69. GC11762 Meloxicam (Mobic) Meloxicam (Mobic) is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 μM and 36.6 μM for COX-2 and COX-1, respectively. Meloxicam (Mobic)  Chemical Structure
  70. GC40065 Meloxicam-d3 Meloxicam-d3 is intended for use as an internal standard for the quantification of meloxicam by GC- or LC-MS. Meloxicam-d3  Chemical Structure
  71. GC44167 Metamizole (sodium salt) Metamizole (sodium salt) is a non-opioid compound with excellent analgesic and antipyretic effects. Metamizole (sodium salt)  Chemical Structure
  72. GC31737 Metamizole sodium hydrate Metamizole sodium hydrate is a potent analgesic drug that has been demonstrated to inhibit cyclooxygenase (COX). Metamizole sodium hydrate  Chemical Structure
  73. GC31943 Methyl Salicylate (Wintergreen oil) Methyl Salicylate (Wintergreen oil) (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Methyl Salicylate (Wintergreen oil)  Chemical Structure
  74. GC41634 Metyrosine Metyrosine is an inhibitor of tyrosine hydroxylase. Metyrosine  Chemical Structure
  75. GC17980 N-(2-phenylethyl)-Indomethacin amide inhibitor of COX-2 N-(2-phenylethyl)-Indomethacin amide  Chemical Structure
  76. GC15372 N-(3-hydroxyphenyl)-Arachidonoyl amide selective, irreversible inhibitor of COX-2 N-(3-hydroxyphenyl)-Arachidonoyl amide  Chemical Structure
  77. GC15959 N-(3-pyridyl)-Indomethacin amide inhibitor of COX-2 N-(3-pyridyl)-Indomethacin amide  Chemical Structure
  78. GC10611 N-(4-acetamidophenyl)-Indomethacin amide inhibitor of COX-2 N-(4-acetamidophenyl)-Indomethacin amide  Chemical Structure
  79. GC16440 N-acetyl-2-carboxy Benzenesulfonamide non-selective inhibitor of COX N-acetyl-2-carboxy Benzenesulfonamide  Chemical Structure
  80. GC17306 N-tert-butyl-α-Phenylnitrone N-tert-butyl-α-Phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-butyl-α-Phenylnitrone  Chemical Structure
  81. GC40686 N-trans-Feruloyltyramine N-trans-Feruloyltyramine is a phenolic amide originally isolated from S. N-trans-Feruloyltyramine  Chemical Structure
  82. GC13422 Nabumetone

    COX inhibitor

    Nabumetone  Chemical Structure
  83. GC47734 Nabumetone-d3 An internal standard for the quantification of nabumetone Nabumetone-d3  Chemical Structure
  84. GC32026 Naproxen etemesil (LT-NS 001) Naproxen etemesil (LT-NS 001) is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen etemesil (LT-NS 001)  Chemical Structure
  85. GC17975 Naproxen Sodium cyclooxygenase inhibitor Naproxen Sodium  Chemical Structure
  86. GC12684 NCX 4040 COX-2 expression inhibitor NCX 4040  Chemical Structure
  87. GC13896 NCX 466 cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor NCX 466  Chemical Structure
  88. GN10429 Neochlorogenic acid Neochlorogenic acid  Chemical Structure
  89. GC13637 Nepafenac COX-1 and COX-2 inhibitor Nepafenac  Chemical Structure
  90. GC36721 Nepafenac D5 An internal standard for the quantification of nepafenac Nepafenac D5  Chemical Structure
  91. GC18084 Nimesulide Non-steroidal anti-inflammatory drug Nimesulide  Chemical Structure
  92. GC39583 Nimesulide D5 An internal standard for the quantification of nimesulide Nimesulide D5  Chemical Structure
  93. GC36747 Nitroaspirin Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins. Nitroaspirin  Chemical Structure
  94. GC34028 Nitroflurbiprofen (HCT 1206) Nitroflurbiprofen (HCT 1206) is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats. Nitroflurbiprofen (HCT 1206)  Chemical Structure
  95. GC44439 NO-Indomethacin NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. NO-Indomethacin  Chemical Structure
  96. GC12241 NS 398 COX-2 inhibitor and anti-inflammatory agent NS 398  Chemical Structure
  97. GC14999 O-Acetyl Salicylhydroxamic Acid irreversible, non-selective inhibitor of COX-1 and COX-2 O-Acetyl Salicylhydroxamic Acid  Chemical Structure
  98. GC49316 O-Desmethyl-N-deschlorobenzoyl Indomethacin A metabolite of indomethacin O-Desmethyl-N-deschlorobenzoyl Indomethacin  Chemical Structure
  99. GC63478 Ocarocoxib Ocarocoxib, a potent COX-?2 (cyclooxygenase-?2) inhibitor, is a non-steroidal anti-inflammatory for veterinary use. Ocarocoxib  Chemical Structure
  100. GC49098 Olsalazine-13C6 An internal standard for the quantification of olsalazine Olsalazine-13C6  Chemical Structure
  101. GC12114 Oxaprozin COX inhibitor Oxaprozin  Chemical Structure

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