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Home >> Signaling Pathways >> Neuroscience >> COX

COX

COX (cyclooxygenase) is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane.

Products for  COX

  1. Cat.No. Product Name Information
  2. GC36828 Oxaprozin D4 Oxaprozin D4 (Wy-21743 D4) is the deuterium labeled Oxaprozin, which is a non-steroidal anti-inflammatory agent (NSAID). Oxaprozin D4 Chemical Structure
  3. GC69640 Oxaprozin-d4

    Oxaprozin-d4 is the deuterated form of Oxaprozin.

     Oxaprozin-d4 Chemical Structure
  4. GC49054 Oxaprozin-d5 An internal standard for the quantification of oxaprozin Oxaprozin-d5 Chemical Structure
  5. GC40651 Oxyphenbutazone Oxyphenbutazone is a metabolite of phenylbutazone. Oxyphenbutazone Chemical Structure
  6. GC32640 Pamicogrel (KBT3022) Pamicogrel (KBT3022) (KBT3022) is a cyclooxygenase (COX) inhibitor. Pamicogrel (KBT3022) Chemical Structure
  7. GC14849 Paradol A phenolic ketone with diverse biological activities Paradol Chemical Structure
  8. GC36852 Parecoxib Parecoxib (SC 69124) is a highly selective?and orally active COX-2 inhibitor, the prodrug of Valdecoxib. Parecoxib Chemical Structure
  9. GC17051 Parecoxib Sodium COX-2 inhibitor Parecoxib Sodium Chemical Structure
  10. GC60283 Pentagamavunon-1 Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 inhibits NF-κB activation. Pentagamavunon-1 Chemical Structure
  11. GC44597 Peonidin (chloride)

    Peonidin is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables.

     Peonidin (chloride) Chemical Structure
  12. GC15928 Phenacetin Non-opioid analgesic Phenacetin Chemical Structure
  13. GC66429 Phenacetin-d5 Phenacetin-d5 (Acetophenetidin-d5) is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats. Phenacetin-d5 Chemical Structure
  14. GC61180 Phenidone Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone Chemical Structure
  15. GC15008 Phenylbutazone non-steroidal anti-inflammatory agent Phenylbutazone Chemical Structure
  16. GC65108 Phenylbutazone(diphenyl-d10) Phenylbutazone(diphenyl-d10) Chemical Structure
  17. GC69699 Phenylbutazone-13C12

    Phenylbutazone-13C12 is a labeled form of Phenylbutazone with 13 carbon atoms. Phenylbutazone is an effective reducing co-factor for prostaglandin H synthase (PHS) and peroxidase enzymes. It is a hepatotoxin and a nonsteroidal anti-inflammatory drug (NSAID). Phenylbutazone induces the expression of muscleblind-like protein 1 (MBNL1), which has potential for research in ankylosing spondylitis.

     Phenylbutazone-13C12 Chemical Structure
  18. GC49128 Phenylbutazone-d9 An internal standard for the quantification of phenylbutazone Phenylbutazone-d9 Chemical Structure
  19. GC16790 Piroxicam Prostaglandin synthesis/Coxinhibitor Piroxicam Chemical Structure
  20. GC61193 Piroxicam D3 An internal standard for the quantification of piroxicam Piroxicam D3 Chemical Structure
  21. GN10395 Prim-O-glucosylcimifugin Prim-O-glucosylcimifugin Chemical Structure
  22. GC66258 Propacetamol Propacetamol is an analgesic agent. Propacetamol also is a precursor form of paracetamol. Propacetamol can be used in postoperative pain, acute trauma and gastrointestinal disorders. Propacetamol Chemical Structure
  23. GC33876 Propyphenazone (4-Isopropylantipyrine) Propyphenazone (4-Isopropylantipyrine) is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone (4-Isopropylantipyrine)-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors. Propyphenazone (4-Isopropylantipyrine) Chemical Structure
  24. GC14847 Psoralidin apoptosis inducer Psoralidin Chemical Structure
  25. GC17367 Rebamipide cholecystokinin type 1 (CCK1) receptor inhibitor Rebamipide Chemical Structure
  26. GC61234 Rebamipide D4 An internal standard for the quantification of rebamipide Rebamipide D4 Chemical Structure
  27. GC63398 Rebamipide mofetil Rebamipide mofetil is an orally active prodrug of Rebamipide (OPC12759). Rebamipide mofetil Chemical Structure
  28. GC61235 Regaloside B Regaloside B is a phenylpropanoid isolated from Lilium longiflorum. Regaloside B Chemical Structure
  29. GC61238 Rehmapicrogenin Rehmapicrogenin, isolated from the root of Rehmannia glutinosa, exhibits potent anti-inflammatory effect by inhibiting iNOS, COX-2 and IL-6. Rehmapicrogenin Chemical Structure
  30. GC38198 Revaprazan hydrochloride Revaprazan hydrochloride is a novel acid pump antagonist (APA). Revaprazan hydrochloride Chemical Structure
  31. GC12411 RHC 80267 diacylglycerol lipase inhibitor RHC 80267 Chemical Structure
  32. GC38151 Roburic acid Roburic acid Chemical Structure
  33. GC10516 Rofecoxib COX-2 inhibitor Rofecoxib Chemical Structure
  34. GC45823 Rofecoxib-d5 An internal standard for the quantification of rofecoxib Rofecoxib-d5 Chemical Structure
  35. GN10039 Rutaecarpine Rutaecarpine Chemical Structure
  36. GC31813 RWJ 63556 RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities. RWJ 63556 Chemical Structure
  37. GC30027 S-(+)-Marmesin ((+)-Marmesin) S-(+)-Marmesin ((+)-Marmesin) is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity. S-(+)-Marmesin ((+)-Marmesin) Chemical Structure
  38. GC31835 S-2474 S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (5-LO), with IC50s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory drug. S-2474 Chemical Structure
  39. GC16508 Salicylic acid COX inhibitor Salicylic acid Chemical Structure
  40. GC49480 Salicylic Acid-d4 Salicylic Acid-d4 is the deuterium labeled 2-Carboxyphenol. Salicylic Acid-d4 Chemical Structure
  41. GC64032 Salicylic acid-d6 Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) is a deuterium labeled Salicylic acid. Salicylic acid-d6 Chemical Structure
  42. GC49363 Salicyluric Acid A major metabolite of aspirin and salicylic acid Salicyluric Acid Chemical Structure
  43. GC10973 SC 236 COX-2 inhibitor SC 236 Chemical Structure
  44. GC15634 SC 560 COX-1-selective inhibitor SC 560 Chemical Structure
  45. GC17817 SC 58125 COX-2 inhibitor SC 58125 Chemical Structure
  46. GC31960 SC57666

    SC57666 is a selective COX2 inhibitor with an IC50 of 26 nM.

     SC57666 Chemical Structure
  47. GC31985 SC58451 SC58451 is a potent and selective Cox-2 inhibitor. SC58451 Chemical Structure
  48. GC12013 Sodium salicylate

    NF-κB inhibitor

     Sodium salicylate Chemical Structure
  49. GC60345 Sphondin Sphondin possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE2 release in A549 cells. Sphondin Chemical Structure
  50. GC64940 Sudoxicam Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class. Sudoxicam Chemical Structure
  51. GC16716 Sulindac Anti-inflammatory agent;COX inhibitor Sulindac Chemical Structure
  52. GC15059 Sulindac sulfide

    COX inhibitor

     Sulindac sulfide Chemical Structure
  53. GC11721 Sulindac sulfone Sulindac sulfone is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. Sulindac sulfone Chemical Structure
  54. GC31440 Syringaldehyde A polyphenol with diverse biological activities Syringaldehyde Chemical Structure
  55. GC39040 Taraxerol acetate Taraxerol acetate is a COX-1 and COX-2 inhibitor with IC50 values of 116.3 μM and 94.7 μM, respectively. Taraxerol acetate the has the anticancer potential and induces cell apoptosis. Taraxerol acetate Chemical Structure
  56. GC64025 Tazofelone Tazofelone (LY 213829) is a cyclooxygenase-II (COX-II) inhibitor. Tazofelone transform into sulfoxide and quinol metabolites is primarily mediated by CYP3A. Tazofelone can be used for the research of inflammatory bowel disease. Tazofelone Chemical Structure
  57. GC11853 Tenidap COX/5-LOX inhibitor Tenidap Chemical Structure
  58. GC10006 Tenoxicam antiinflammatory agent Tenoxicam Chemical Structure
  59. GC49386 Tepoxalin A dual inhibitor of COX and 5-LO Tepoxalin Chemical Structure
  60. GC61764 Teriflunomide impurity 3 Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC50 of 30 ?M. Teriflunomide impurity 3 Chemical Structure
  61. GC19353 TFAP TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC50 of 0.8 uM. TFAP Chemical Structure
  62. GC31826 Thioflosulide (L-745337) Thioflosulide (L-745337) (L-745337) is a selective cyclooxygenase-2 (COX2) inhibitor, with an IC50 of 2.3 nM, and shows anti-inflammatory activity. Thioflosulide (L-745337) Chemical Structure
  63. GC45579 Tiaprofenic Acid   Tiaprofenic Acid Chemical Structure
  64. GC31956 Tilmacoxib (JTE522) Tilmacoxib (JTE522) (JTE522) is a highly selective, time-dependent and irreversible human COX-2 inhibitor with an IC50 of 85 nM in an enzyme assay. Tilmacoxib (JTE522) Chemical Structure
  65. GC31965 Timegadine (SR1368) Timegadine (SR1368), a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets. Timegadine (SR1368) Chemical Structure
  66. GC15395 Tolfenamic Acid Non-steroidal anti-inflammatory drug Tolfenamic Acid Chemical Structure
  67. GC45965 Tolfenamic Acid-d4 An internal standard for the quantification of tolfenamic acid Tolfenamic Acid-d4 Chemical Structure
  68. GC61337 Tolmetin Tolmetin is an orally active and potent COX inhibitor with IC50s of 0.35 ?M and 0.82 ?M human COX-1 and COX-2, respectively. Tolmetin Chemical Structure
  69. GC16428 Tolmetin (sodium salt hydrate) Tolmetin (sodium salt hydrate) is an orally active and potent COX inhibitor with IC50s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin (sodium salt hydrate) Chemical Structure
  70. GC13300 Triflusal COX inhibitor Triflusal Chemical Structure
  71. GC13402 Tryptanthrin inhibitor of Cox-2 and 5-LO Tryptanthrin Chemical Structure
  72. GC14020 Valdecoxib COX-2 inhibitor Valdecoxib Chemical Structure
  73. GC48232 Valdecoxib-d3 An internal standard for the quantification of valdecoxib Valdecoxib-d3 Chemical Structure
  74. GC10335 Valeroyl Salicylate selective, irreversible inhibitor of cyclooxygenase-1 (COX-1) Valeroyl Salicylate Chemical Structure
  75. GC61371 Veratric acid Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant and anti-inflammatory activities. Veratric acid Chemical Structure
  76. GC33632 Veratric acid (3,4-Dimethoxybenzoic acid) Veratric acid (3,4-Dimethoxybenzoic acid) Chemical Structure
  77. GC12391 Xanthohumol VCP inhibitor Xanthohumol Chemical Structure
  78. GC13626 Zaltoprofen Cyclooxygenase (COX) inhibitor Zaltoprofen Chemical Structure
  79. GC11203 ZLJ-6 dual inhibitor of COX and 5-lipoxygenase (5-LO) ZLJ-6 Chemical Structure
  80. GC35012 [10]-Shogaol [10]-Shogaol is an antioxidant from Zingiber officinale for human skin cell growth and a migration enhancer. [10]-Shogaol inhibits COX-2 with an IC50 of 7.5 μM and has antiproliferation activity. [10]-Shogaol Chemical Structure
  81. GC35013 [8]-Shogaol [8]-Shogaol, one of the pungent phenolic compounds in ginger, exhibits anti-platelet activity (IC50=5 μM) and inhibits COX-2 (IC50=17.5 μM). [8]-Shogaol induces apoptosis in human leukemia cells. [8]-Shogaol Chemical Structure

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