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nAChR

nAChRs (nicotinic acetylcholine receptors) are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. They are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the presynaptic and postsynaptic sides of theneuromuscular junction. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Like the other type of acetylcholine receptor-the muscarinic acetylcholine receptor (mAChR)-the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). Just as muscarinic receptors are named such because they are also activated by muscarine, nicotinic receptors can be opened not only by acetylcholine but also by nicotine —hence the name "nicotinic".

Targets for  nAChR

Products for  nAChR

  1. Cat.No. Product Name Information
  2. GC70179 α7 Nicotinic receptor agonist-1

    Alpha-7 Nicotinic receptor agonist-1 (Preparation 5) is an alpha-7 nAChR agonist. It can be used for research on psychiatric disorders such as schizophrenia, mania or bipolar disorder, and anxiety disorders, as well as intellectual disabilities such as Alzheimer's disease, learning deficits, cognitive impairments, attention deficits, memory loss, Lewy body dementia and attention deficit hyperactivity disorder.

    α7 Nicotinic receptor agonist-1  Chemical Structure
  3. GC14410 (±)-Epibatidine nicotinic agonist (±)-Epibatidine  Chemical Structure
  4. GC34959 (+)-Sparteine (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine  Chemical Structure
  5. GC31084 (-)-(S)-B-973B (-)-(S)-B-973B  Chemical Structure
  6. GC14157 (-)-Lobeline hydrochloride nicotinic receptor partial agonist (-)-Lobeline hydrochloride  Chemical Structure
  7. GC64735 (S)-(-)-Levamisole (S)-(-)-Levamisole (Levamisole), an anthelmintic agent with immunomodulatory properties. (S)-(-)-Levamisole  Chemical Structure
  8. GC69979 (S)-VQW-765

    (S)-VQW-765 ((S)-AQW-051) is a partial agonist of the α7 nicotinic acetylcholine receptor (nAChR) with oral activity, selectivity and efficacy. It has potential applications in cognitive impairments associated with neurological diseases such as Alzheimer's disease or schizophrenia.

    (S)-VQW-765  Chemical Structure
  9. GC11757 3-Bromocytisine α4β4, α4β2 and α7 nACh receptor agonist 3-Bromocytisine  Chemical Structure
  10. GC13542 Adiphenine HCl Adiphenine HCl is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC50s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine HCl  Chemical Structure
  11. GC30866 Anabasine ((S)-Anabasine) Anabasine ((S)-Anabasine) ((S)-Anabasine ((S)-Anabasine)) is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine ((S)-Anabasine)  Chemical Structure
  12. GC17695 Aniracetam Nootropic drug for senile dementia Aniracetam  Chemical Structure
  13. GC15667 Atracurium Besylate Neuromuscular blocking agent Atracurium Besylate  Chemical Structure
  14. GC14339 Benzethonium Chloride Potent inhibitor of nAChRs Benzethonium Chloride  Chemical Structure
  15. GC35538 BNC375 BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs with an EC50 of 1.9 μM. BNC375  Chemical Structure
  16. GC64064 Bradanicline Bradanicline is a highly selective α7 nicotinic acetylcholine receptor (nAChR) agonist (humanα7 nAChR: EC50=17 nM; Ki= 1.4 nM). Bradanicline  Chemical Structure
  17. GC16937 Carbamoylcholine chloride

    Cholinergic receptor agonist

    Carbamoylcholine chloride  Chemical Structure
  18. GC12119 CCMI Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR) CCMI  Chemical Structure
  19. GC16911 CGS 9343B CGS 9343B (CGS-9343B) is a potent, orally active and selective inhibitor of calmodulin. CGS 9343B  Chemical Structure
  20. GC43261 Cholesteryl Myristate Cholesteryl Myristate is a natural steroid present in traditional Chinese medicine. Cholesteryl Myristate binds to several ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel. Cholesteryl Myristate  Chemical Structure
  21. GC12226 Cisatracurium Besylate Neuromuscular-blocking drug Cisatracurium Besylate  Chemical Structure
  22. GC63868 COG 133 TFA COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide. COG 133 TFA  Chemical Structure
  23. GC31209 Cyclodrine hydrochloride Cyclodrine hydrochloride is a cholinergic (muscarinic, nicotinic) (mAChR and nAChR) receptor antagonist. Cyclodrine hydrochloride  Chemical Structure
  24. GC16255 Decamethonium Bromide Nicotinic AChR partial agonist Decamethonium Bromide  Chemical Structure
  25. GC12593 Desformylflustrabromine hydrochloride Positive allosteric modulator of nicotinic α4β2 receptors Desformylflustrabromine hydrochloride  Chemical Structure
  26. GC35858 Dianicline Dianicline is a α4β2 nicotinic acetylcholine receptor partial agonist, a class of drugs that includes varenicline and cytisine for smoking cessation. Dianicline  Chemical Structure
  27. GC32185 Dinotefuran (MTI-446) Dinotefuran (MTI-446) is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors. Dinotefuran (MTI-446)  Chemical Structure
  28. GC66073 Flupyradifurone Flupyradifurone is a systemic nAChR agonist that interferes with signal transduction in the central nervous system of sucking pests. Flupyradifurone can be used as a butenolide insecticide. Flupyradifurone  Chemical Structure
  29. GC64394 Flupyrimin Flupyrimin acts as an antagonist at the insect nicotinic acetylcholine receptor (nAChR). Flupyrimin  Chemical Structure
  30. GC10913 GTS 21 dihydrochloride nAChRs agonist, novel GTS 21 dihydrochloride  Chemical Structure
  31. GC15178 Hexamethonium Bromide Selective antagonist of neuronal-type nicotinic AChR Hexamethonium Bromide  Chemical Structure
  32. GC43877 Hydroxy Bupropion Buproprion is an inhibitor of the reuptake of dopamine and norepinephrine and is also an antagonist of neuronal acetylcholine nicotinic receptors. Hydroxy Bupropion  Chemical Structure
  33. GC63928 Iptakalim hydrochloride Iptakalim hydrochloride, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Iptakalim hydrochloride  Chemical Structure
  34. GC10329 Mecamylamine hydrochloride nicotinic acetylcholine receptor antagonist Mecamylamine hydrochloride  Chemical Structure
  35. GC10443 Meclofenoxate hydrochloride Drug for senile dementia and AD treatment Meclofenoxate hydrochloride  Chemical Structure
  36. GC13678 Methyllycaconitine citrate

    Methyllycaconitine citrate (MLA), a norditerpenoid alkaloid isolated from the seeds of Delphinium brownie.

    Methyllycaconitine citrate  Chemical Structure
  37. GC34079 Monepantel (AAD1566) Monepantel (AAD1566) is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits. Monepantel (AAD1566)  Chemical Structure
  38. GC33741 Nelonicline (ABT-126) Nelonicline (ABT-126) (ABT-126) is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain (Ki=12.3 nM). Nelonicline (ABT-126)  Chemical Structure
  39. GC13064 NS 1738

    positive allosteric modulator of α7 nicotinic acetylcholine receptor

    NS 1738  Chemical Structure
  40. GC11773 Pancuronium dibromide AChR antagonist Pancuronium dibromide  Chemical Structure
  41. GC38938 Pipecuronium bromide Pipecuronium bromide is a potent long-acting nondepolarizing steroidal neuromuscular blocking agent (NMBA), and a bisquaternary ammonium compound. Pipecuronium bromide  Chemical Structure
  42. GC12952 PNU 282987 α7 nAChR agonist PNU 282987  Chemical Structure
  43. GC11643 PNU-120596 α7 nAChR modulator,positive allosteric PNU-120596  Chemical Structure
  44. GC36942 PNU-282987 S enantiomer free base PNU-282987 S enantiomer free base is the S-enantiomer of PNU-282987 free base. PNU-282987 S enantiomer free base  Chemical Structure
  45. GC36952 Pozanicline Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM. Pozanicline  Chemical Structure
  46. GC38940 Pozanicline dihydrochloride Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites. Pozanicline dihydrochloride  Chemical Structure
  47. GC37543 Rivanicline Rivanicline (RJR-2403; (E)-Metanicotine) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 36000 nM). Rivanicline  Chemical Structure
  48. GC37544 Rivanicline hemioxalate Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 3.6 μM). Rivanicline hemioxalate  Chemical Structure
  49. GC31313 S16961 (S169611) S16961 (S169611) is a nicotinic receptor agonist. S16961 (S169611)  Chemical Structure
  50. GC12959 SIB 1553A hydrochloride SIB 1553A hydrochloride is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB 1553A hydrochloride  Chemical Structure
  51. GC37662 Sofiniclin Sofiniclin (ABT 894), an agonist of nicotinic acetylcholine receptor (nAChR), is used as a potential non-stimulant research for attention-deficit/hyperactivity disorder (ADHD). Sofiniclin  Chemical Structure
  52. GC19351 Tebanicline hydrochloride Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. Tebanicline hydrochloride  Chemical Structure
  53. GC70059 Tribendimidine

    Tribendimidine is a broad-spectrum anthelmintic drug with oral activity, which has particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotine acetylcholine receptor (nAChR) agonist.

    Tribendimidine  Chemical Structure
  54. GC12762 Varenicline α4β2 nAChRs antagonist Varenicline  Chemical Structure
  55. GC16143 Varenicline Hydrochloride α4β2 nicotinic receptor agonist Varenicline Hydrochloride  Chemical Structure
  56. GC10948 Varenicline Tartrate Subtype-selective agonist of α4β2 nicotinic receptors,orally active Varenicline Tartrate  Chemical Structure
  57. GC11210 Vecuronium Bromide Nonpolarizing neuromuscular relaxant Vecuronium Bromide  Chemical Structure
  58. GC70130 VQW-765

    VQW-765 (AQW-051) is a selective, orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist with a pKD value of 7.56 for recombinant human α7-nAChR. VQW-765 exhibits anxiolytic effects in vivo and can be used for research on anxiety disorders and acute anxiety.

    VQW-765  Chemical Structure
  59. GC30807 ZSET1446 (ST-101) ZSET1446 (ST-101) is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models. ZSET1446 (ST-101)  Chemical Structure

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