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Neurokinin Receptor

There are three main classes of neurokinin receptors: NK1R (the substance P preferring receptor), NK2R, and NK3R. These tachykinin receptors belong to the class I (rhodopsin-like) G-protein coupled receptor (GPCR) family. The various tachykinins have different binding affinities to the neurokinin receptors: NK1R, NK2R, and NK3R. These neurokinin receptors are in the superfamily of transmembrane G-protein coupled receptors (GPCR) and contain seven transmembrane loops. Neurokinin-1 receptor interacts with the Gαq-protein and induces activation of phospholipase C followed by production of inositol triphosphate (IP3) leading to elevation of intracellular calcium as a second messenger. Further, cyclic AMP (cAMP) is stimulated by NK1R coupled to the Gαs-protein. The neurokinin receptors are expressed on many cell types and tissues.

Products for  Neurokinin Receptor

  1. Cat.No. Product Name Information
  2. GC15200 Aprepitant Substance P (SP) inhibitor
  3. GC33724 Befetupitant (Ro67-5930)
  4. GC30104 Fezolinetant (ESN-364)
  5. GC16246 Fosaprepitant Neurokinin-1 antagonist
  6. GC10659 Fosaprepitant dimeglumine salt Neurokinin-1 antagonist
  7. GC16408 GR 159897 neurokinin NK2 receptor antagonist,orally active
  8. GC18080 GR 73632 Potent and selective tachykinin NK1 receptor agonist
  9. GC13239 Hemokinin 1 (mouse)

    agonist at the tachykinin NK1 receptor

  10. GC31199 Ibodutant (MEN 15596)
  11. GC31145 Kassinin
  12. GC18128 L-732,138 tachykinin NK1 receptor antagonist
  13. GC36543 Maropitant
  14. GC17547 MEN 10376 NK2 receptor antagonist
  15. GC36582 Men 10376 TFA
  16. GC31300 MEN11467
  17. GC34408 Monohydroxy Netupitant D6
  18. GC17596 Netupitant neurokinin 1 (NK1) receptor antagonist
  19. GC34418 Netupitant D6 (CID-6451149 D6)
  20. GC33559 Netupitant metabolite Monohydroxy Netupitant (Monohydroxy Netupitant)
  21. GC11738 Neurokinin A (porcine) Endogenous tachykinin peptide

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