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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Targets for  Cell Cycle/Checkpoint

Products for  Cell Cycle/Checkpoint

  1. Cat.No. Product Name Information
  2. GC19058 BAY1217389 BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM. BAY1217389  Chemical Structure
  3. GC49757 Bazedoxifene N-oxide An oxidative degradation product of bazedoxifene Bazedoxifene N-oxide  Chemical Structure
  4. GC46907 Bazedoxifene-d4 An internal standard for the quantification of bazedoxifene Bazedoxifene-d4  Chemical Structure
  5. GC32868 BDP5290

    BDP5290 is a potent inhibitor of ROCK and MRCK with IC50 values of 17nM, 230nM, 123nM and 100nM for MRCKβ, ROCK1, ROCK2, respectively .

    BDP5290  Chemical Structure
  6. GC49042 Benastatin A A bacterial metabolite with diverse biological activities Benastatin A  Chemical Structure
  7. GC49781 Benomyl A carbamate pesticide Benomyl  Chemical Structure
  8. GC49836 Benoxaprofen Benoxaprofen (LRCL 3794) is a potent and long-acting anti-inflammatory and antipyretic compound. Benoxaprofen  Chemical Structure
  9. GC61831 Benproperine phosphate Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate  Chemical Structure
  10. GC49387 Berberine-d6 (chloride) An internal standard for the quantification of berberine Berberine-d6 (chloride)  Chemical Structure
  11. GC17828 BI-847325 dual inhibitor of MEK and Aurora kinases BI-847325  Chemical Structure
  12. GC11224 BI6727(Volasertib) BI6727(Volasertib) (BI 6727) is an orally active, highly potent and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0.87 nM. BI6727(Volasertib) inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. BI6727(Volasertib) induces mitotic arrest and apoptosis. BI6727(Volasertib), a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models. BI6727(Volasertib)  Chemical Structure
  13. GC42933 Binucleine 2 Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), a kinase involved in cell division. Binucleine 2  Chemical Structure
  14. GC49724 BIO-1211 (trifluoroacetate salt) A peptide inhibitor of α4β1 integrin BIO-1211 (trifluoroacetate salt)  Chemical Structure
  15. GC42936 Biotin Tripeptide-1 Biotin tripeptide-1 is an extracellular matrix (ECM) peptide that has been conjugated to biotin. Biotin Tripeptide-1  Chemical Structure
  16. GC42942 bis-ANS (potassium salt) bis-ANS (potassium salt) is a fluorescent probe of hydrophobic protein. bis-ANS (potassium salt)  Chemical Structure
  17. GC40060 Blasticidin A Blasticidin A is a bacterial metabolite originally isolated from S. Blasticidin A  Chemical Structure
  18. GC11648 BML-277 Chk2 inhibitor,potent and highly selective BML-277  Chemical Structure
  19. GC18408 BML-278 BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 uM. BML-278  Chemical Structure
  20. GC12865 BMS265246 CDK1/2 inhibitor,potent and selective BMS265246  Chemical Structure
  21. GC68021 BMVC BMVC  Chemical Structure
  22. GC63977 BMVC2 BMVC2 (o-BMVC) is a bisubstitute carbazole derivative of BMVC. BMVC2 is a G-quadruplex (G4) stabilizer. BMVC2  Chemical Structure
  23. GC34102 BNC105 BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. BNC105  Chemical Structure
  24. GC46937 Boc-Glu-OBzl An amino acid-containing building block Boc-Glu-OBzl  Chemical Structure
  25. GC42959 BODIPY 493/503

    BODIPY 493/503, a lipophilic fluorescence dye, emits bright green fluorescence has been used extensively for lipid droplet labeling (Ex/Em: 493/503 nm).

    BODIPY 493/503  Chemical Structure
  26. GC42960 BODIPY 505/515

    BODIPY 505/515, a lipophilic fluorescence dye, emits fluorescence has been used extensively for lipid droplet labeling (Ex/Em: 505/515 nm).

    BODIPY 505/515  Chemical Structure
  27. GC42961 BODIPY 558/568 C12

    BODIPY 558/568 C12 is a fatty acid-conjugated fluorescent probe for lipid droplets.

    BODIPY 558/568 C12  Chemical Structure
  28. GC14002 Bohemine CDK inhibitor Bohemine  Chemical Structure
  29. GC32846 BOS-172722 BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer. BOS-172722  Chemical Structure
  30. GC46943 Boscalid A broad-spectrum carboxamide fungicide Boscalid  Chemical Structure
  31. GC40009 Bostrycin Bostrycin is an anthraquinone originally isolated from B. Bostrycin  Chemical Structure
  32. GC46946 BPC 157 (acetate) A pentadecapeptide with diverse biological activities BPC 157 (acetate)  Chemical Structure
  33. GC42969 bpV(phen) (potassium hydrate) bpV(phen) (potassium hydrate), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) (potassium hydrate)  Chemical Structure
  34. GC62128 Bractoppin Bractoppin is a inhibitor of phosphopeptide recognition by the human BRCA1 tBRCT domain with IC50 of 74 nM. Bractoppin  Chemical Structure
  35. GC48901 BRD9876 An Eg5 inhibitor BRD9876  Chemical Structure
  36. GC49740 Brevetoxin 3 A neurotoxin Brevetoxin 3  Chemical Structure
  37. GC46949 Bromacil An herbicide Bromacil  Chemical Structure
  38. GC12001 BS-181 A selective Cdk7 inhibitor BS-181  Chemical Structure
  39. GC13690 BS-181 HCl BS-181 HCl is a highly selective CDK7 inhibitor with IC50 of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. BS-181 HCl  Chemical Structure
  40. GC33149 BTB-1 A reversible Kif18A inhibitor BTB-1  Chemical Structure
  41. GC46104 Butyric Acid-d7 An internal standard for the quantification of sodium butyrate Butyric Acid-d7  Chemical Structure
  42. GC42997 Butyrolactone I A secondary metabolite from A Butyrolactone I  Chemical Structure
  43. GC45394 Bz-IEGR-pNA (acetate)   Bz-IEGR-pNA (acetate)  Chemical Structure
  44. GC40708 C2 L-erythro Ceramide (d18:1/2:0) C2 L-erythro Ceramide is a bioactive sphingolipid and a cell-permeable analog of naturally occurring ceramides. C2 L-erythro Ceramide (d18:1/2:0)  Chemical Structure
  45. GC40709 C2 L-threo Ceramide (d18:1/2:0) C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. C2 L-threo Ceramide (d18:1/2:0)  Chemical Structure
  46. GC45616 C6 Urea Ceramide An inhibitor of neutral ceramidase C6 Urea Ceramide  Chemical Structure
  47. GC11765 Cabazitaxel Microtubule associated inhibitor Cabazitaxel  Chemical Structure
  48. GC65575 Cabazitaxel-d6 Cabazitaxel-d6 (XRP6258-d6) is the deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel-d6  Chemical Structure
  49. GC45395 Cabazitaxel-d9 Cabazitaxel-d9 is deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel-d9  Chemical Structure
  50. GC47018 Cacodylic Acid (sodium salt hydrate) A reagent used in electron microscopy techniques Cacodylic Acid (sodium salt hydrate)  Chemical Structure
  51. GC18315 Calpain Inhibitor VI Calpain inhibitor VI is an inhibitor of the calcium-dependent cysteine proteases u-calpain (calpain-1; IC50 = 7.5 nM) and m-calpain (calpain-2; IC50 = 78 nM). Calpain Inhibitor VI  Chemical Structure
  52. GC65935 CAM833 CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization. CAM833  Chemical Structure
  53. GC43135 Cambendazol Cambendazol is one of the most effective agents for the therapy of human strongyloidiasis and . Cambendazol  Chemical Structure
  54. GC43139 Capsanthin Capsanthin is a carotenoid that has been found in red paprika and has diverse biological activities. Capsanthin  Chemical Structure
  55. GC18449 Cardanol monoene Cardanol monoene is a phenol found in cashew nut shell liquid that reversibly inhibits tyrosinase with an IC50 value of 56 uM in vitro. Cardanol monoene  Chemical Structure
  56. GC47042 Carfilzomib-d8 An internal standard for the quantification of carfilzomib Carfilzomib-d8  Chemical Structure
  57. GC16692 Casin GTPase Cdc42 inhibitor Casin  Chemical Structure
  58. GC52389 Caveolin-1 (82-101) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) A synthetic peptide fragment of caveolin-1 Caveolin-1 (82-101) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)  Chemical Structure
  59. GC43150 CAY10406 CAY10406 is a trifluoromethyl analog of an isatin sulfonamide compound that selectively inhibits caspases 3 and 7. CAY10406  Chemical Structure
  60. GC43154 CAY10443 Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome. CAY10443  Chemical Structure
  61. GC40795 CAY10503 CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase. CAY10503  Chemical Structure
  62. GC41253 CAY10554 CAY10554 is a potent cyclin-dependent kinase 5 (Cdk5) inhibitor, with IC50s of 64 and 98 nM for Cdk5 and Cdk2, respectively. CAY10554  Chemical Structure
  63. GC41317 CAY10625 Survivin is a cellular protein implicated in cell survival by interacting with and inhibiting the apoptotic function of several proteins including Smac/DIABLO, caspase-3, and caspase-7. CAY10625  Chemical Structure
  64. GC40890 CAY10701 CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI50s = 22 and 38 nM, respectively). CAY10701  Chemical Structure
  65. GC43206 CAY10732

    CAY10732 functions as a fluorescent agent designed to identify the presence of carbon monoxide.

    CAY10732  Chemical Structure
  66. GC45405 CAY10737   CAY10737  Chemical Structure
  67. GC52245 CAY10792 An anticancer agent CAY10792  Chemical Structure
  68. GC33300 CCB02 CCB02 is a selective CPAP-tubulin interaction inhibitor, binding to tubulin and competing for the CPAP binding site of β-tubulin, with an IC50 of 689 nM, and shows potent anti-tumor activity. CCB02 shows no inhibition on the cell cycle- and centrosome-related kinases, or the phosphorylation status of Aurora A, Plk1, Plk2, CDK2, and CHK1. CCB02  Chemical Structure
  69. GC14986 CCG-100602 Rho pathway inhibitor CCG-100602  Chemical Structure
  70. GC12795 CCG-1423 RhoA inhibitor CCG-1423  Chemical Structure
  71. GC38898 CCG-222740 CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis. CCG-222740  Chemical Structure
  72. GC33006 CCT020312 CCT020312 is a selective EIF2AK3/PERK activator. CCT020312  Chemical Structure
  73. GC18053 CCT241533 A selective Chk2 inhibitor CCT241533  Chemical Structure
  74. GC17105 CCT241533 hydrochloride A selective Chk2 inhibitor CCT241533 hydrochloride  Chemical Structure
  75. GC19092 CCT241736 CCT241736 is a potent and orally bioavailable dual FLT3 and Aurora kinase inhibitor, which inhibits Aurora kinases (Aurora-A Kd, 7.5 nM, IC50, 38 nM; Aurora-B Kd, 48 nM), FLT3 kinase (Kd, 6.2 nM), and FLT3 mutants including FLT3-ITD (Kd, 38 nM) and FLT3(D835Y) (Kd, 14 nM). CCT241736  Chemical Structure
  76. GC14772 CCT244747 Potent and selective CHK1 inhibitor CCT244747  Chemical Structure
  77. GC33213 CCT251455 CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 (MPS1) inhibitor with an IC50 of 3 nM. CCT251455  Chemical Structure
  78. GC18051 CCT251545 analogue, Compound 51

    Potent, Selective, orally bioavailable CDK 8/19 Inhibitor

    CCT251545 analogue, Compound 51  Chemical Structure
  79. GC48982 CD532 An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction CD532  Chemical Structure
  80. GC12425 CDK inhibitor II CDK inhibitor II  Chemical Structure
  81. GC43217 CDK/CRK Inhibitor CDK/CRK inhibitor is an inhibitor of cyclin-dependent kinases (CDK) and CDK-related kinases (CRK) with IC50 values ranging from 9-839 nM in vitro. CDK/CRK Inhibitor  Chemical Structure
  82. GC14294 Cdk1/2 Inhibitor III Cdk1/2 Inhibitor III is a potent CDK1 and CDK2 inhibitor with IC50s of 0.6 nM and 0.5 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. Cdk1/2 Inhibitor III is also a potent CDC2-like kinase 1 (CLK1) and CLK3 inhibitor with IC50s of 8.9 nM and 29.2 nM, respectively. Cdk1/2 Inhibitor III  Chemical Structure
  83. GC43219 Cdk2 Inhibitor II The cyclin-dependent kinase 2 (Cdk2) works with cyclins A or E to regulate S phase and G2-M transition during the cell cycle. Cdk2 Inhibitor II  Chemical Structure
  84. GC11785 CDK4 inhibitor

    CDK4/Cyclin D1 inhibitor

    CDK4 inhibitor  Chemical Structure
  85. GC11564 Cdk4/6 Inhibitor IV GP-82996 (CINK4) is a pharmacological inhibitor of CDK4/6. GP-82996 has IC50s of 1.5, 5.6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, respectively. GP-82996 induces the apoptosis of cancer cells U2OS. GP-82996 can be used in the research of cancer. Cdk4/6 Inhibitor IV  Chemical Structure
  86. GC15914 CDK7-IN-1 potent and selective CDK7 inhibitor CDK7-IN-1  Chemical Structure
  87. GC12871 CDK9 inhibitor CDK9 inhibitor  Chemical Structure
  88. GC17359 CDK9 inhibitor 2 CDK9 inhibitor 2  Chemical Structure
  89. GC35651 Cenisertib Cenisertib (AS-703569) is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia. Cenisertib  Chemical Structure
  90. GC32688 Centrinone (LCR-263) Centrinone (LCR-263) (LCR-263) is a selective and reversible inhibitor of polo-like kinase 4 (PLK4) with a Ki of 0.16 nM. Centrinone (LCR-263)  Chemical Structure
  91. GC32751 Centrinone-B (LCR-323) Centrinone-B (LCR-323) (LCR-323) is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM. Centrinone-B (LCR-323)  Chemical Structure
  92. GN10780 Cephalomannine Cephalomannine  Chemical Structure
  93. GC52489 Ceramide (hydroxy) (bovine spinal cord) A sphingolipid Ceramide (hydroxy) (bovine spinal cord)  Chemical Structure
  94. GC52485 Ceramide (non-hydroxy) (bovine spinal cord) A sphingolipid Ceramide (non-hydroxy) (bovine spinal cord)  Chemical Structure
  95. GC52486 Ceramide Phosphoethanolamine (bovine) A sphingolipid Ceramide Phosphoethanolamine (bovine)  Chemical Structure
  96. GC43229 Ceramide Phosphoethanolamines (bovine) Ceramide phosphoethanolamine (CPE) is an analog of sphingomyelin that contains ethanolamine rather than choline as the head group. Ceramide Phosphoethanolamines (bovine)  Chemical Structure
  97. GC47073 Ceramides (hydroxy) A mixture of hydroxy fatty acid-containing ceramides Ceramides (hydroxy)  Chemical Structure
  98. GC43230 Ceramides (non-hydroxy) Ceramides are generated from sphingomyelin through activation of sphingomyelinases or through the de novo synthesis pathway, which requires the coordinated action of serine palmitoyl transferase and ceramide synthase. Ceramides (non-hydroxy)  Chemical Structure
  99. GC35654 Ceratamine A Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent. Ceratamine A exhibits cytotoxicity against human cancer cell lines. Ceratamine A  Chemical Structure
  100. GC60688 Cereblon modulator 1 Cereblon modulator 1 (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Cereblon modulator 1  Chemical Structure
  101. GC47074 Cerebroside C A fungal metabolite Cerebroside C  Chemical Structure

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