Home >> Signaling Pathways >> Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Targets for  Cell Cycle/Checkpoint

Products for  Cell Cycle/Checkpoint

  1. Cat.No. Product Name Information
  2. GC48470 Ac-DEVD-CHO (trifluoroacetate salt) A dual caspase3/caspase7 inhibitor Ac-DEVD-CHO (trifluoroacetate salt)  Chemical Structure
  3. GC42689 Ac-DNLD-AMC Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-DNLD-AMC  Chemical Structure
  4. GC49704 Ac-FLTD-CMK (trifluoroacetate salt) An inhibitor of caspase-1, -4, -5, and -11 Ac-FLTD-CMK (trifluoroacetate salt)  Chemical Structure
  5. GC18226 Ac-LEHD-AMC (trifluoroacetate salt) Ac-LEHD-AMC (trifluoroacetate salt) is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm). Ac-LEHD-AMC (trifluoroacetate salt)  Chemical Structure
  6. GC40556 Ac-LETD-AFC Ac-LETD-AFC is a fluorogenic substrate that can be cleaved specifically by caspase-8. Ac-LETD-AFC  Chemical Structure
  7. GC15171 Ac-LEVD-AFC A fluorogenic substrate for caspase-4 Ac-LEVD-AFC  Chemical Structure
  8. GC13400 Ac-VDVAD-AFC Ac-VDVAD-AFC is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer. Ac-VDVAD-AFC  Chemical Structure
  9. GC52372 Ac-VDVAD-AFC (trifluoroacetate salt) A fluorogenic substrate for caspase-2 Ac-VDVAD-AFC (trifluoroacetate salt)  Chemical Structure
  10. GC48974 Ac-VEID-AMC (ammonium acetate salt) A caspase-6 fluorogenic substrate Ac-VEID-AMC (ammonium acetate salt)  Chemical Structure
  11. GC18021 Ac-YVAD-CHO Selective inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1) Ac-YVAD-CHO  Chemical Structure
  12. GC42721 Ac-YVAD-CMK

    Ac-YVAD-CMK is a selective irreversible inhibitor of caspase-1 (Ki=0.8nM), which can prevent the proinflammatory cytokine IL-1β activation. Ac-YVAD-CMK can reduce the inflammatory response and induce a long-lasting neuroprotective effect.

    Ac-YVAD-CMK  Chemical Structure
  13. GC10244 Ac2-12 inhibitor of leukocyte extravasation Ac2-12  Chemical Structure
  14. GC15598 Ac2-26 inhibitor of leukocyte extravasation Ac2-26  Chemical Structure
  15. GC46786 Acetyl Hexapeptide-3 (acetate) A synthetic hexapeptide Acetyl Hexapeptide-3 (acetate)  Chemical Structure
  16. GC42701 Acetyl Tetrapeptide-3 Acetyl tetrapeptide-3 is a biomimetic peptide. Acetyl Tetrapeptide-3  Chemical Structure
  17. GC49699 Acetyl Tetrapeptide-9 (acetate) A synthetic signal peptide Acetyl Tetrapeptide-9 (acetate)  Chemical Structure
  18. GC46790 Acibenzolar-S-methyl A fungicide inducer of systemic acquired resistance Acibenzolar-S-methyl  Chemical Structure
  19. GC49804 Acridine An azaarene Acridine  Chemical Structure
  20. GC41242 Acridine Orange Acridine Orange is a cell-permeable fluorescent dye that stains organisms (bacteria, parasites, viruses, etc. Acridine Orange  Chemical Structure
  21. GC46810 Aflatoxin B1-13C17 An internal standard for the quantification of aflatoxin B1 Aflatoxin B1-13C17  Chemical Structure
  22. GC46811 Aflatoxin B2-13C17 An internal standard for the quantification of aflatoxin B2 Aflatoxin B2-13C17  Chemical Structure
  23. GC16475 Afuresertib pan-AKT inhibitor Afuresertib  Chemical Structure
  24. GC42747 Afuresertib (hydrochloride) Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively. Afuresertib (hydrochloride)  Chemical Structure
  25. GC35262 Afzelin A polyphenolic glycoside flavone with diverse biological activities Afzelin  Chemical Structure
  26. GC46825 Alachlor An herbicide Alachlor  Chemical Structure
  27. GC49773 Albendazole sulfone-d3 An internal standard for the quantification of albendazole sulfone Albendazole sulfone-d3  Chemical Structure
  28. GC48848 Albendazole-d7 An internal standard for the quantification of albendazole Albendazole-d7  Chemical Structure
  29. GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid all-trans-13,14-Dihydroretinol  Chemical Structure
  30. GC18539 all-trans-4-hydroxy Retinoic Acid all-trans-4-hydroxy Retinoic acid is a metabolite of all-trans retinoic acid formed by the cytochrome P450 (CYP) isoforms CYP26A1, B1, and C1. all-trans-4-hydroxy Retinoic Acid  Chemical Structure
  31. GC40476 Allethrin Allethrin is a pyrethroid insecticide and modulator of voltage-gated sodium channels (NaV). Allethrin  Chemical Structure
  32. GC45379 Alloxan (hydrate)   Alloxan (hydrate)  Chemical Structure
  33. GC18386 Aloisine RP106 Aloisine is an inhibitor of Cdk1/cyclin B, Cdk5/p25, and GSK3 (IC50s = 0.70, 1.5, and 0.92 uM, respectively). Aloisine RP106  Chemical Structure
  34. GC15841 Alsterpaullone CDKs and GSK3β inhibitor Alsterpaullone  Chemical Structure
  35. GC18437 Alternariol monomethyl ether Alternariol monomethyl ether, isolated from the roots of Anthocleista djalonensis (Loganiaceae), is an important taxonomic marker of the plant species. Alternariol monomethyl ether  Chemical Structure
  36. GC64698 AM-5308 AM-5308 is a potent kinesin KIF18A inhibitor (WO2021211549A1, C13). AM-5308  Chemical Structure
  37. GC14974 AMG 925 FLT3/CDK4 inhibitor,potent and selective AMG 925  Chemical Structure
  38. GC39156 AMG PERK 44 AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC50 of 6 nM. AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC50=7300 nM) and B-Raf (IC50 >1000 nM), respectively. AMG PERK 44 induces autophagy. AMG PERK 44  Chemical Structure
  39. GC45809 AMG-Tie2-1 A Tie2 and VEGFR2 inhibitor AMG-Tie2-1  Chemical Structure
  40. GC65578 Aminobenzenesulfonic auristatin E TFA Aminobenzenesulfonic auristatin E TFA is a drug-linker conjugate for ADC. Aminobenzenesulfonic auristatin E TFA has potent antitumor activity by using Auristatin E (a cytotoxic tubulin modifier), linked via the ADC linker Aminobenzenesulfonic. Aminobenzenesulfonic auristatin E TFA  Chemical Structure
  41. GC42788 Aminopeptidase N Inhibitor Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). Aminopeptidase N Inhibitor  Chemical Structure
  42. GC11410 Aminopurvalanol A cyclin-dependent kinase inhibitor Aminopurvalanol A  Chemical Structure
  43. GC18274 Amiprofos-methyl Amiprofos-methyl (APM) is a phosphoric amide herbicide. Amiprofos-methyl  Chemical Structure
  44. GC33370 Amphethinile (Amphetinile) Amphethinile (Amphetinile) is an anti-tubulin agent. The affinity constant for the association (Ka) of Amphethinile (Amphetinile) with tubulin is 1.3 μM. Amphethinile (Amphetinile)  Chemical Structure
  45. GC16391 Amuvatinib (MP-470, HPK 56) A multi-targeted RTK inhibitor Amuvatinib (MP-470, HPK 56)  Chemical Structure
  46. GC33362 Amuvatinib hydrochloride (MP470 hydrochloride) Amuvatinib hydrochloride (MP470 hydrochloride) (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib hydrochloride (MP470 hydrochloride) (MP470 hydrochloride) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair. Antineoplastic activity. Amuvatinib hydrochloride (MP470 hydrochloride)  Chemical Structure
  47. GC64273 AMXI-5001 AMXI-5001 is a potent, orally active, and dual parp1/2 and microtubule polymerization inhibitor. MXI-5001 exhibits selective antitumor cytotoxicity across a wide variety of human cancer cells with much lower IC50s than existing clinical PARP1/2 inhibitors. AMXI-5001 induces complete regression of established tumors, including exceedingly large tumors. AMXI-5001  Chemical Structure
  48. GC67900 AMXI-5001 hydrochloride AMXI-5001 hydrochloride  Chemical Structure
  49. GC49419 Aniline-d5 An internal standard for the quantification of aniline Aniline-d5  Chemical Structure
  50. GC11947 Ansamitocin P-3 A microtubule depolymerizing agent Ansamitocin P-3  Chemical Structure
  51. GC25075 Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM. Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222)  Chemical Structure
  52. GC66198 Anti-α-Tubulin Antibody, AF555 conjugate Anti-α-Tubulin Antibody, AF555 conjugate is a conjugate of mouse anti-α-tubulin monoclonal antibody and the red fluorescent dye Alexa Fluor 555. Anti-α-Tubulin Antibody, AF555 conjugate can be used for the detection of tubulin (Ex/Em: 554/567 nm). Anti-α-Tubulin Antibody, AF555 conjugate  Chemical Structure
  53. GC68024 Antiproliferative agent-14 Antiproliferative agent-14  Chemical Structure
  54. GC46867 Apremilast-d5 An internal standard for the quantification of apremilast Apremilast-d5  Chemical Structure
  55. GC32692 APTO-253 (LOR-253) APTO-253 (LOR-253) (LOR-253) is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 (LOR-253)  Chemical Structure
  56. GC34300 AR-13324 analog mesylate AR-13324 analog mesylate  Chemical Structure
  57. GC19034 AR-13324 mesylate

    AR-13324 is a potent inhibitor of ROCK I and ROCK II that has been shown to induce morphologic changes in cultured human and porcine TM cells at low concentration.

    AR-13324 mesylate  Chemical Structure
  58. GC45385 Ara-G   Ara-G  Chemical Structure
  59. GC46878 Aranciamycin A fungal metabolite with diverse biological activities Aranciamycin  Chemical Structure
  60. GC13649 Arcyriaflavin A cdk4/cyclin D1 inhibitor Arcyriaflavin A  Chemical Structure
  61. GC52474 Arg-Gly-Asp (trifluoroacetate salt) A synthetic peptide corresponding to an integrin cell adhesion sequence Arg-Gly-Asp (trifluoroacetate salt)  Chemical Structure
  62. GC52332 Arimoclomol A co-inducer of heat shock proteins Arimoclomol  Chemical Structure
  63. GC16472 ARQ 621

    Eg5 inhibitor

    ARQ 621  Chemical Structure
  64. GC11656 ARRY 520 trifluoroacetate A potent Eg5 inhibitor ARRY 520 trifluoroacetate  Chemical Structure
  65. GC13282 ARRY-520 R enantiomer ARRY-520 R enantiomer  Chemical Structure
  66. GC46882 Artemisinin-d3 An internal standard for the quantification of artemisinin Artemisinin-d3  Chemical Structure
  67. GC11754 AS 1892802 ROCK inhibitor,potent and ATP-competitive AS 1892802  Chemical Structure
  68. GC17712 AT13148 Multi-AGC kinase inhibitor,ATP-competitive AT13148  Chemical Structure
  69. GC15870 AT7519 Multi-CDK inhibitor AT7519  Chemical Structure
  70. GC13998 AT7519 Hydrochloride A Cdk inhibitor AT7519 Hydrochloride  Chemical Structure
  71. GC15597 AT7519 trifluoroacetate AT7519 trifluoroacetate  Chemical Structure
  72. GC65327 ATM Inhibitor-5 ATM Inhibitor-5 [formula (1)] is a potent inhibitor of serine/threonine protein kinase ATM (extracted from patent WO2022058351A1). ATM Inhibitor-5  Chemical Structure
  73. GC65514 ATR inhibitor 1 ATR inhibitor 1 is a ATR inhibitor extracted from patent WO2015187451A1, compound I-l, has a Ki value below 1 ?Μ. ATR inhibitor 1  Chemical Structure
  74. GC68707 ATR-IN-4

    ATR-IN-4 is an effective ATR inhibitor. ATR-IN-4 inhibits the growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460, with IC50 values of 130.9 nM and 41.33 nM, respectively (excerpted from patent CN112142744A, compound 13).

    ATR-IN-4  Chemical Structure
  75. GC46892 ATRA-BA Hybrid A prodrug form of all-trans retinoic acid and butyric acid ATRA-BA Hybrid  Chemical Structure
  76. GC46895 Aurintricarboxylic Acid (ammonium salt) A protein synthesis inhibitor with diverse biological activities Aurintricarboxylic Acid (ammonium salt)  Chemical Structure
  77. GC35429 Auristatin E Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates. Auristatin E inhibits cell division by blocking the polymerisation of tubulin. Auristatin E  Chemical Structure
  78. GC35430 Auristatin F Auristatin F is a potent cytotoxin. Auristatin F, a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC). Auristatin F  Chemical Structure
  79. GC33379 Aurora B inhibitor 1 Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor extracted from patent WO2007059299A1, compound 1-3, has a Ki value of <0.010 uM. Aurora B inhibitor 1  Chemical Structure
  80. GC38441 Aurora Kinase Inhibitor 3 A potent inhibitor of Aurora A kinase Aurora Kinase Inhibitor 3  Chemical Structure
  81. GC67899 Aurora kinase inhibitor-8 Aurora kinase inhibitor-8  Chemical Structure
  82. GC63663 Avanbulin Avanbulin (BAL27862) is a potent, Colchicine site-binding, tubulin assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC50 of 1.4 μM. Avanbulin binds to tubulin with an apparent Kd value of 244 nM. Avanbulin can be used for the research of cancer and cell division. Avanbulin  Chemical Structure
  83. GC50370 AZ 13705339 Highly potent PAK1 and PAK2 inhibitor AZ 13705339  Chemical Structure
  84. GC66036 AZ13705339 hemihydrate AZ13705339 hemihydrate is a highly potent and selective PAK1 inhibitor with IC50s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 hemihydrate has binding affinities to PAK1 and PAK2, with Kds of 0.28 nM and 0.32 nM, respectively. AZ13705339 hemihydrate can be used in the research of cancers. AZ13705339 hemihydrate  Chemical Structure
  85. GC15283 AZ3146 Mps1 inhibitor,potent and selective AZ3146  Chemical Structure
  86. GC19047 AZ32 AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 uM for ATM in cell. AZ32  Chemical Structure
  87. GC18956 AZ82

    AZ82 is a small molecule inhibitor of KIFC1/HSET, a kinesin-14 family protein that is important for assembling bipolar spindles in cancer cells containing supernumerary centrosomes.

    AZ82  Chemical Structure
  88. GC35442 Azaindole 1 Azaindole 1 (Azaindole 1; TC-S 7001) is an orally active and ATP-competitive ROCK inhibitor with IC50s of 0.6 and 1.1nM for human ROCK-1 and ROCK-2, respectively. Azaindole 1  Chemical Structure
  89. GC48971 AZD 1152 (hydrochloride) A prodrug for a potent Aurora B inhibitor AZD 1152 (hydrochloride)  Chemical Structure
  90. GC12438 AZD-5438 Potent CDK1/2/9 inhibitor AZD-5438  Chemical Structure
  91. GC12826 AZD-5597

    Potent CDK inhibitor

    AZD-5597  Chemical Structure
  92. GC64938 AZD-7648 AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity. AZD-7648  Chemical Structure
  93. GC11593 AZD0156 ATM kinase inhibitor AZD0156  Chemical Structure
  94. GC19468 AZD1390

    AZD1390 is a potent and selective ATM inhibitor

    AZD1390  Chemical Structure
  95. GC16941 AZD6738 AZD6738 (AZD6738) is an orally active and bioavailable inhibitor of ATR kinase with an IC50 of 1 nM. AZD6738  Chemical Structure
  96. GC10546 AZD7762 Checkpoint kinase inhibitor,ATP competitive AZD7762  Chemical Structure
  97. GC60620 Batabulin Batabulin (T138067) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death. Batabulin  Chemical Structure
  98. GC60621 Batabulin sodium An inhibitor of tubulin polymerization Batabulin sodium  Chemical Structure
  99. GC42897 BAY 61-3606 (hydrochloride) BAY 61-3606 is a cell-permeable, reversible inhibitor of spleen tyrosine kinase (Syk; Ki = 7.5 nM; IC50 = 10 nM). BAY 61-3606 (hydrochloride)  Chemical Structure
  100. GC33420 BAY-1895344 BAY-1895344 (BAY-1895344) is a potent, orally active and selective ATR inhibitor with an IC50 of 7 nM. BAY-1895344 has anti-tumor activity. BAY-1895344 can be used for the research of solid tumors and lymphomas. BAY-1895344  Chemical Structure
  101. GC34374 BAY-1895344 hydrochloride An ATR inhibitor BAY-1895344 hydrochloride  Chemical Structure

Items 101 to 200 of 1035 total

per page
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Set Descending Direction