Arp2/3 Complex

The intact ARP2/3 complex is first purified from Acanthamoeba castellanii based on its affinity for the actin-binding protein profilin, and is shown to consist of a stable assembly of seven polypeptides. Two of the subunits are actin-related proteins of the ARP2 and ARP3 subfamilies, giving the complex its name.

The ARP2/3 complex possesses little biochemical activity on its own. However, when engaged by nucleation-promoting factor (NPF) proteins, it is activated to initiate the formation of a new (daughter) filament that emerges from an existing (mother) filament in a y-branch configuration with a regular 70° branch angle. This coupling of nucleation and branching by the ARP2/3 complex is referred to as autocatalytic branching or dendritic nucleation, and is central to its functions in vivo.

Polymerization of actin filaments directed by the Arp2/3 complex supports many types of cellular movements.

Targets for Arp2/3 Complex

Products for Arp2/3 Complex

Cat.No. Product Name Information
GC61831 Benproperine phosphate

ASA 158-5, BPP
Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor.
GC14060 CK 666 Arp2/3 complex inhibitor that inhibits actin polymerization
GC15076 CK 869

CK-0157869
actin-related protein 2/3 (Arp2/3) complex inhibitor
GC15894 CK-636

CK-0944636
Arp2/3 complex inhibitor
GC32890 Cytochalasin B (Phomin)

NSC 107658, Phomin
Cytochalasin B is a cyto-permeable mycotoxin, and it is isolated from an ascomycete fungus belonging to the Phoma genus.
GC13440 Cytochalasin D

NSC 209835

An inhibitor of actin polymerization, selective
GC43461 Dihydrocytochalasin B

DCB
Dihydrocytochalasin B (DCB) is a member of the cytochalasin mycotoxin family that inhibits actin assembly.
GC15671 Latrunculin A

NSC 613011

A reversible inhibitor of actin assembly