Chk
Chk (Csk homologous kinase)
Products for Chk
- Cat.No. Product Name Information
- GC10546 AZD7762 Checkpoint kinase inhibitor,ATP competitive
- GC11648 BML-277 Chk2 inhibitor,potent and highly selective
- GC18053 CCT241533 A selective Chk2 inhibitor
- GC17105 CCT241533 hydrochloride A selective Chk2 inhibitor
- GC14772 CCT244747 Potent and selective CHK1 inhibitor
- GC15739 CHIR-124 Chk1 inhibitor,novel and potent
- GC15741 LY2603618 LY2603618 (LY2603618) is a potent and selective inhibitor of Chk1 with an IC50 of 7 nM.
- GC15663 LY2606368 LY2606368 (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. LY2606368 inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). LY2606368 causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. LY2606368 shows potent anti-tumor activity.
- GC16374 MK-8776(SCH-900776) MK-8776(SCH-900776) (MK-8776) is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with an IC50 of 3 nM. MK-8776(SCH-900776) shows 50- and 500-fold selectivity over CDK2 and Chk2, respectively.
- GC13448 NSC 109555 ditosylate Chk2 inhibitor,ATP-competitive
- GC14234 PF-477736 Chk1 inhibitor
- GC11022 SB 218078 checkpoint kinase 1 (Chk1) inhibitor
- GC10793 TCS 2312 checkpoint kinase 1 (chk1) inhibitor