Cyclin-Dependent Kinases
Cyclin-dependent kinases is a group of serine/threonine kinases. It is activated by binding to cyclin and participates in the regulation of cell cycle.
Products for Cyclin-Dependent Kinases
- Cat.No. Product Name Information
- GC16429 (R)-DRF053 dihydrochloride cdk/CK1 inhibitor,potent and ATP-competitive
- GC15841 Alsterpaullone CDKs and GSK3β inhibitor
- GC14974 AMG 925 FLT3/CDK4 inhibitor,potent and selective
- GC11410 Aminopurvalanol A cyclin-dependent kinase inhibitor
- GC13649 Arcyriaflavin A cdk4/cyclin D1 inhibitor
- GC15870 AT7519 Multi-CDK inhibitor
- GC13998 AT7519 Hydrochloride A Cdk inhibitor
- GC15597 AT7519 trifluoroacetate
- GC12438 AZD-5438 Potent CDK1/2/9 inhibitor
-
GC12826
AZD-5597
Potent CDK inhibitor
- GC12865 BMS265246 CDK1/2 inhibitor,potent and selective
- GC14002 Bohemine CDK inhibitor
- GC12001 BS-181 A selective Cdk7 inhibitor
- GC13690 BS-181 HCl BS-181 HCl is a highly selective CDK7 inhibitor with IC50 of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9.
-
GC18051
CCT251545 analogue, Compound 51
Potent, Selective, orally bioavailable CDK 8/19 Inhibitor
- GC12425 CDK inhibitor II
- GC14294 Cdk1/2 Inhibitor III Cdk1/2 Inhibitor III is a potent CDK1 and CDK2 inhibitor with IC50s of 0.6 nM and 0.5 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. Cdk1/2 Inhibitor III is also a potent CDC2-like kinase 1 (CLK1) and CLK3 inhibitor with IC50s of 8.9 nM and 29.2 nM, respectively.
-
GC11785
CDK4 inhibitor
CDK4/Cyclin D1 inhibitor
- GC11564 Cdk4/6 Inhibitor IV GP-82996 (CINK4) is a pharmacological inhibitor of CDK4/6. GP-82996 has IC50s of 1.5, 5.6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, respectively. GP-82996 induces the apoptosis of cancer cells U2OS. GP-82996 can be used in the research of cancer.
- GC15914 CDK7-IN-1 potent and selective CDK7 inhibitor
- GC12871 CDK9 inhibitor
- GC17359 CDK9 inhibitor 2
- GC50175 CGP 74514 dihydrochloride Potent cdk1 inhibitor
- GC14650 CGP60474 A CDK inhibitor
- GC18028 CVT-313 A Cdk2 inhibitor
-
GC11835
Deferasirox
Oral iron chelator
- GC17648 Dinaciclib(SCH727965) Dinaciclib(SCH727965) (SCH 727965) is a potent inhibitor of CDK, with IC50s of 1 nM, 1 nM, 3 nM, and 4 nM for CDK2, CDK5, CDK1, and CDK9, respectively.
- GC16063 Flavopiridol An inhibitor of cyclin-dependent kinases
- GC16425 Flavopiridol hydrochloride CDK inhibitor, potent and selective
- GC16545 GX-674 Nav1.7 antagonist
- GC15215 Iso-Olomoucine inactive stereoisomer of the Cdk5 inhibitor olomoucine
- GC14230 K03861 K03861 (K03861) is a type II CDK2 inhibitor with Kd of 8.2 nM. K03861 (K03861) inhibits CDK2 activity by competing with binding of activating cyclins.
- GC14182 Kenpaullone CDK1/cyclin B and GSK-3β inhibitor
- GC17067 LDC000067 CDK9 inhibitor, novel and highly specific
- GC10842 LEE011 LEE011 (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
- GC15922 LEE011 hydrochloride LEE011 hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
- GC15377 LEE011 succinate LEE011 succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
- GC16822 LY2835219 LY2835219 (LY2835219 methanesulfonate) is a selective CDK4/6 inhibitor with IC50s of 2 nM and 10 nM for CDK4 and CDK6, respectively.
- GC11823 LY2835219 free base A dual inhibitor of Cdk4 and Cdk6
- GC11971 LY2857785 CDK9 inhibitor
- GC14162 ML167 Clk4 inhibitor,highly selective
- GC12886 NSC 625987 Cyclin-dependent kinase (cdk) 4 inhibitor
- GC11634 NSC 693868 CDKs and GSK-3 inhibitor
- GC15963 Nu 6027 ATR/CDK inhibitor, potent and selective
- GC16959 NVP-LCQ195
- GC16520 Olomoucine cdk inhibitor
- GC15607 ON123300 multi-targeted kinase inhibitor,inhibits CDK4, Ark5, PDGFRβ, FGFR1, RET, and Fyn
- GC15421 Palbociclib (PD0332991) Isethionate Palbociclib (PD 0332991) isethionate is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib (PD0332991) Isethionate has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma.
- GC15173 PD 0332991 (Palbociclib) PD 0332991 (Palbociclib) (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. PD 0332991 (Palbociclib) has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma.
- GC17935 PD 0332991 (Palbociclib) HCl Palbociclib (PD 0332991) monohydrochloride is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. PD 0332991 (Palbociclib) HCl has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma.
- GC11944 PF 4800567 hydrochloride casein kinase 1ε inhibitor
- GC15588 PHA-848125 PHA-848125 (PHA-848125) is a potent, ATP-competitive and dual inhibitor of CDK and Tropomyosin receptor kinase (TRK), with IC50s of 45, 150, 160, 363, 398 nM and 53 nM for cyclin A/CDK2, cyclin H/CDK7, cyclin D1/CDK4, cyclin E/CDK2, cyclin B/CDK1 and TRKA, respectively.
- GC14707 Purvalanol A potent, and cell-permeable CDK inhibitor
- GC16268 Purvalanol B CDK1/CDK2/CDK4 inhibitor
- GC17400 R547 CDK1/2/4 inhibitor,ATP-competitive
- GC12348 Ro 3306 An ATP-competitive, potent CDK1 inhibitor
- GC11401 Roscovitine (Seliciclib,CYC202) Roscovitine (Seliciclib,CYC202) (Roscovitine) is an orally bioavailable and selective CDKs inhibitor with IC50s of 0.2 μM, 0.65 μM, and 0.7 μM for CDK5, Cdc2, and CDK2, respectively.
- GC17150 Ryuvidine SETD8 protein lysine methyltransferase (PKMT) inhibitor
- GC12064 SB1317 A multi-kinase inhibitor
- GC17792 SCH900776 S-isomer
- GC11396 SNS-032 (BMS-387032) SNS-032 (BMS-387032) (BMS-387032) is a potent and selective inhibitor ofCDK2, CDK7, and CDK9 withIC50sof 38 nM, 62 nM and 4 nM, respectively. SNS-032 (BMS-387032) has antitumor effect.
- GC15571 SU 9516 A pro-apoptotic Cdk2/cyclin A inhibitor
- GC10840 THZ1 Covalent CDK7 inhibitor,potent and selective
- GC12642 THZ1 Hydrochloride CDK7 inhibitor
- GC13511 THZ2 CDK7 inhibitor
- GC16420 THZ531 CDK12 and CDK13 covalent inhibitor
-
GC16413
TMCB
CK2 and ERK8 inhibitor
- GC16000 WHI-P180 EGFR/Janus Kinase 3 inhibitor
- GC13100 [Ala92]-p16 (84-103) inhibitor of cyclin-dependent kinase-4 (cdk4)/cyclin D1