Home >> Signaling Pathways >> Cell Cycle/Checkpoint >> Cyclin-Dependent Kinases

Cyclin-Dependent Kinases

Cyclin-dependent kinases is a group of serine/threonine kinases. It is activated by binding to cyclin and participates in the regulation of cell cycle.

Products for  Cyclin-Dependent Kinases

  1. Cat.No. Product Name Information
  2. GC16429 (R)-DRF053 dihydrochloride cdk/CK1 inhibitor,potent and ATP-competitive (R)-DRF053 dihydrochloride  Chemical Structure
  3. GC15841 Alsterpaullone CDKs and GSK3β inhibitor Alsterpaullone  Chemical Structure
  4. GC14974 AMG 925 FLT3/CDK4 inhibitor,potent and selective AMG 925  Chemical Structure
  5. GC11410 Aminopurvalanol A cyclin-dependent kinase inhibitor Aminopurvalanol A  Chemical Structure
  6. GC13649 Arcyriaflavin A cdk4/cyclin D1 inhibitor Arcyriaflavin A  Chemical Structure
  7. GC15870 AT7519 Multi-CDK inhibitor AT7519  Chemical Structure
  8. GC13998 AT7519 Hydrochloride A Cdk inhibitor AT7519 Hydrochloride  Chemical Structure
  9. GC15597 AT7519 trifluoroacetate AT7519 trifluoroacetate  Chemical Structure
  10. GC12438 AZD-5438 Potent CDK1/2/9 inhibitor AZD-5438  Chemical Structure
  11. GC12826 AZD-5597

    Potent CDK inhibitor

    AZD-5597  Chemical Structure
  12. GC12865 BMS265246 CDK1/2 inhibitor,potent and selective BMS265246  Chemical Structure
  13. GC14002 Bohemine CDK inhibitor Bohemine  Chemical Structure
  14. GC12001 BS-181 A selective Cdk7 inhibitor BS-181  Chemical Structure
  15. GC13690 BS-181 HCl BS-181 HCl is a highly selective CDK7 inhibitor with IC50 of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. BS-181 HCl  Chemical Structure
  16. GC18051 CCT251545 analogue, Compound 51

    Potent, Selective, orally bioavailable CDK 8/19 Inhibitor

    CCT251545 analogue, Compound 51  Chemical Structure
  17. GC12425 CDK inhibitor II CDK inhibitor II  Chemical Structure
  18. GC14294 Cdk1/2 Inhibitor III Cdk1/2 Inhibitor III is a potent CDK1 and CDK2 inhibitor with IC50s of 0.6 nM and 0.5 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. Cdk1/2 Inhibitor III is also a potent CDC2-like kinase 1 (CLK1) and CLK3 inhibitor with IC50s of 8.9 nM and 29.2 nM, respectively. Cdk1/2 Inhibitor III  Chemical Structure
  19. GC11785 CDK4 inhibitor

    CDK4/Cyclin D1 inhibitor

    CDK4 inhibitor  Chemical Structure
  20. GC11564 Cdk4/6 Inhibitor IV GP-82996 (CINK4) is a pharmacological inhibitor of CDK4/6. GP-82996 has IC50s of 1.5, 5.6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, respectively. GP-82996 induces the apoptosis of cancer cells U2OS. GP-82996 can be used in the research of cancer. Cdk4/6 Inhibitor IV  Chemical Structure
  21. GC15914 CDK7-IN-1 potent and selective CDK7 inhibitor CDK7-IN-1  Chemical Structure
  22. GC12871 CDK9 inhibitor CDK9 inhibitor  Chemical Structure
  23. GC17359 CDK9 inhibitor 2 CDK9 inhibitor 2  Chemical Structure
  24. GC50175 CGP 74514 dihydrochloride Potent cdk1 inhibitor CGP 74514 dihydrochloride  Chemical Structure
  25. GC14650 CGP60474 A CDK inhibitor CGP60474  Chemical Structure
  26. GC18028 CVT-313 A Cdk2 inhibitor CVT-313  Chemical Structure
  27. GC11835 Deferasirox

    Oral iron chelator

    Deferasirox  Chemical Structure
  28. GC17648 Dinaciclib(SCH727965) Dinaciclib(SCH727965) (SCH 727965) is a potent inhibitor of CDK, with IC50s of 1 nM, 1 nM, 3 nM, and 4 nM for CDK2, CDK5, CDK1, and CDK9, respectively. Dinaciclib(SCH727965)  Chemical Structure
  29. GC16063 Flavopiridol An inhibitor of cyclin-dependent kinases Flavopiridol  Chemical Structure
  30. GC16425 Flavopiridol hydrochloride CDK inhibitor, potent and selective Flavopiridol hydrochloride  Chemical Structure
  31. GC16545 GX-674 Nav1.7 antagonist GX-674  Chemical Structure
  32. GC15215 Iso-Olomoucine inactive stereoisomer of the Cdk5 inhibitor olomoucine Iso-Olomoucine  Chemical Structure
  33. GC14230 K03861 K03861 (K03861) is a type II CDK2 inhibitor with Kd of 8.2 nM. K03861 (K03861) inhibits CDK2 activity by competing with binding of activating cyclins. K03861  Chemical Structure
  34. GC14182 Kenpaullone CDK1/cyclin B and GSK-3β inhibitor Kenpaullone  Chemical Structure
  35. GC17067 LDC000067 CDK9 inhibitor, novel and highly specific LDC000067  Chemical Structure
  36. GC10842 LEE011 LEE011 (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. LEE011  Chemical Structure
  37. GC15922 LEE011 hydrochloride LEE011 hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. LEE011 hydrochloride  Chemical Structure
  38. GC15377 LEE011 succinate LEE011 succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. LEE011 succinate  Chemical Structure
  39. GC16822 LY2835219 LY2835219 (LY2835219 methanesulfonate) is a selective CDK4/6 inhibitor with IC50s of 2 nM and 10 nM for CDK4 and CDK6, respectively. LY2835219  Chemical Structure
  40. GC11823 LY2835219 free base A dual inhibitor of Cdk4 and Cdk6 LY2835219 free base  Chemical Structure
  41. GC11971 LY2857785 CDK9 inhibitor LY2857785  Chemical Structure
  42. GC14162 ML167 Clk4 inhibitor,highly selective ML167  Chemical Structure
  43. GC12886 NSC 625987 Cyclin-dependent kinase (cdk) 4 inhibitor NSC 625987  Chemical Structure
  44. GC11634 NSC 693868 CDKs and GSK-3 inhibitor NSC 693868  Chemical Structure
  45. GC15963 Nu 6027 ATR/CDK inhibitor, potent and selective Nu 6027  Chemical Structure
  46. GC16959 NVP-LCQ195 NVP-LCQ195  Chemical Structure
  47. GC16520 Olomoucine cdk inhibitor Olomoucine  Chemical Structure
  48. GC15607 ON123300 multi-targeted kinase inhibitor,inhibits CDK4, Ark5, PDGFRβ, FGFR1, RET, and Fyn ON123300  Chemical Structure
  49. GC15421 Palbociclib (PD0332991) Isethionate Palbociclib (PD 0332991) isethionate is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib (PD0332991) Isethionate has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma. Palbociclib (PD0332991) Isethionate  Chemical Structure
  50. GC15173 PD 0332991 (Palbociclib) PD 0332991 (Palbociclib) (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. PD 0332991 (Palbociclib) has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma. PD 0332991 (Palbociclib)  Chemical Structure
  51. GC17935 PD 0332991 (Palbociclib) HCl Palbociclib (PD 0332991) monohydrochloride is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. PD 0332991 (Palbociclib) HCl has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma. PD 0332991 (Palbociclib) HCl  Chemical Structure
  52. GC11944 PF 4800567 hydrochloride casein kinase 1ε inhibitor PF 4800567 hydrochloride  Chemical Structure
  53. GC15588 PHA-848125 PHA-848125 (PHA-848125) is a potent, ATP-competitive and dual inhibitor of CDK and Tropomyosin receptor kinase (TRK), with IC50s of 45, 150, 160, 363, 398 nM and 53 nM for cyclin A/CDK2, cyclin H/CDK7, cyclin D1/CDK4, cyclin E/CDK2, cyclin B/CDK1 and TRKA, respectively. PHA-848125  Chemical Structure
  54. GC14707 Purvalanol A potent, and cell-permeable CDK inhibitor Purvalanol A  Chemical Structure
  55. GC16268 Purvalanol B CDK1/CDK2/CDK4 inhibitor Purvalanol B  Chemical Structure
  56. GC17400 R547 CDK1/2/4 inhibitor,ATP-competitive R547  Chemical Structure
  57. GC12348 Ro 3306 An ATP-competitive, potent CDK1 inhibitor Ro 3306  Chemical Structure
  58. GC11401 Roscovitine (Seliciclib,CYC202) Roscovitine (Seliciclib,CYC202) (Roscovitine) is an orally bioavailable and selective CDKs inhibitor with IC50s of 0.2 μM, 0.65 μM, and 0.7 μM for CDK5, Cdc2, and CDK2, respectively. Roscovitine (Seliciclib,CYC202)  Chemical Structure
  59. GC17150 Ryuvidine SETD8 protein lysine methyltransferase (PKMT) inhibitor Ryuvidine  Chemical Structure
  60. GC12064 SB1317 A multi-kinase inhibitor SB1317  Chemical Structure
  61. GC17792 SCH900776 S-isomer SCH900776 S-isomer  Chemical Structure
  62. GC11396 SNS-032 (BMS-387032) SNS-032 (BMS-387032) (BMS-387032) is a potent and selective inhibitor ofCDK2, CDK7, and CDK9 withIC50sof 38 nM, 62 nM and 4 nM, respectively. SNS-032 (BMS-387032) has antitumor effect. SNS-032 (BMS-387032)  Chemical Structure
  63. GC15571 SU 9516 A pro-apoptotic Cdk2/cyclin A inhibitor SU 9516  Chemical Structure
  64. GC10840 THZ1 Covalent CDK7 inhibitor,potent and selective THZ1  Chemical Structure
  65. GC12642 THZ1 Hydrochloride CDK7 inhibitor THZ1 Hydrochloride  Chemical Structure
  66. GC13511 THZ2 CDK7 inhibitor THZ2  Chemical Structure
  67. GC16420 THZ531 CDK12 and CDK13 covalent inhibitor THZ531  Chemical Structure
  68. GC16413 TMCB

    CK2 and ERK8 inhibitor

    TMCB  Chemical Structure
  69. GC16000 WHI-P180 EGFR/Janus Kinase 3 inhibitor WHI-P180  Chemical Structure
  70. GC13100 [Ala92]-p16 (84-103) inhibitor of cyclin-dependent kinase-4 (cdk4)/cyclin D1 [Ala92]-p16 (84-103)  Chemical Structure

69 Item(s)

per page

Set Descending Direction