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Home >> Signaling Pathways >> Cell Cycle/Checkpoint >> G-quadruplex

G-quadruplex

G-quadruplexes are four-stranded DNA structures that generated from guanine-rich DNA. It is reported to be essential for transcriptional regulation, DNA replication and genome stability in mammalian genome.

Products for  G-quadruplex

  1. Cat.No. Product Name Information
  2. GC15389 360A 360A Chemical Structure
  3. GC10115 360A iodide 360A iodide Chemical Structure
  4. GC68021 BMVC BMVC Chemical Structure
  5. GC63977 BMVC2 BMVC2 (o-BMVC) is a bisubstitute carbazole derivative of BMVC. BMVC2 is a G-quadruplex (G4) stabilizer. BMVC2 Chemical Structure
  6. GC64591 MM41 MM41 is a potent stabilizer of human telomeric and gene promoter DNA quadruplexes. MM41 is potently against the MIA PaCa-2 pancreatic cancer cell line with IC50 value of <10 nM. MM41 Chemical Structure
  7. GC32743 Phen-DC3 Trifluoromethanesulfonate (Phen-DC3 Triflate) Phen-DC3 Trifluoromethanesulfonate (Phen-DC3 Triflate) is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively. Phen-DC3 Trifluoromethanesulfonate (Phen-DC3 Triflate) Chemical Structure
  8. GC15162 Pyridostatin

    Pyridostatin is a highly selective G-quadruplex-binding small molecule that was designed to target polymorphic G-quadruplex structures regardless of sequence variability.

     Pyridostatin Chemical Structure
  9. GC48016 Pyridostatin (trifluoroacetate salt) Pyridostatin (RR82) TFA is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin (trifluoroacetate salt) promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin (trifluoroacetate salt) targets the proto-oncogene Src. Pyridostatin (trifluoroacetate salt) reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells. Pyridostatin (trifluoroacetate salt) Chemical Structure
  10. GC37043 Pyridostatin hydrochloride Pyridostatin (RR82) hydrochloride is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin hydrochloride promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin hydrochloride targets the proto-oncogene Src. Pyridostatin hydrochloride reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells. Pyridostatin hydrochloride Chemical Structure
  11. GC65887 SOP1812 SOP1812 is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer. SOP1812 Chemical Structure
  12. GC12092 TMPyP4 tosylate A human telomerase inhibitor TMPyP4 tosylate Chemical Structure

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