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Home >> Signaling Pathways >> Cell Cycle/Checkpoint >> Microtubule/Tubulin

Microtubule/Tubulin

Microtubule is the cylindrical and filamentous structure that required for cell shape, migration, cilia and flagella mobility etc. Tubulin is the major component of microtubules.

Products for  Microtubule/Tubulin

  1. Cat.No. Product Name Information
  2. GC49736 10-acetyl Docetaxel

    PNU 101383, 10-acetyl Taxotere

     10-acetyl Docetaxel (10-Acetyl docetaxel) is an analog of Docetaxel, with anticancer activity. Docetaxel is a microtubule disassembly inhibitor, with antimitotic activity. 10-acetyl Docetaxel Chemical Structure
  3. GC12954 10-DAB (10-Deacetylbaccatin)

    NSC 251677

     An inhibitor of microtubule assembly 10-DAB (10-Deacetylbaccatin) Chemical Structure
  4. GC35044 10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features. 10-Deacetyl-7-xylosyl paclitaxel Chemical Structure
  5. GC35045 10-Oxo Docetaxel A docetaxel degradation product 10-Oxo Docetaxel Chemical Structure
  6. GC15084 2-Methoxyestradiol (2-MeOE2)

    2Hydroxyestradiol 2methyl ether, 2ME2, NSC 659853, Panzem

     2-Methoxyestradiol (2-MeOE2/2-Me) is an HIF-1α inhibitor. 2-Methoxyestradiol (2-MeOE2) Chemical Structure
  7. GC17271 4'-Demethylepipodophyllotoxin

    (-)-4′-Demethylepipodophyllotoxin

     An inhibitor of tubulin polymerization 4'-Demethylepipodophyllotoxin Chemical Structure
  8. GC63958 6α-Hydroxy Paclitaxel-d5 6α-Hydroxy Paclitaxel-d5 is the deuterium labeled 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion-transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer. 6α-Hydroxy Paclitaxel-d5 Chemical Structure
  9. GC35188 7-Epi-10-oxo-docetaxel 7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) is a impurity of docetaxel detected by high performance liquid chromatography (HPLC). 7-Epi-10-oxo-docetaxel Chemical Structure
  10. GC35189 7-Epi-docetaxel 7-Epi-10-oxo-docetaxel (Docetaxel Impurity C; 7-Epitaxotere) is a impurity of docetaxel. 7-Epi-docetaxel Chemical Structure
  11. GN10625 7-Epitaxol

    7-epi Taxol

     7-Epitaxol Chemical Structure
  12. GC42610 7-hydroxy Pestalotin

    LL-P880β

     7-hydroxy Pestalotin is a fungal metabolite originally isolated from Penicillium. 7-hydroxy Pestalotin Chemical Structure
  13. GC35197 7-xylosyltaxol A taxane with microtubule disruptor and anticancer activities 7-xylosyltaxol Chemical Structure
  14. GC15875 ABT-751 (E7010) ABT-751 (E7010)(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively. ABT-751 (E7010) Chemical Structure
  15. GC68614 AcLys-PABC-VC-Aur0101

    AcLys-PABC-VC-Aur0101 is part of an antibody-conjugated active molecule (anti-CXCR4 ADC). It is composed of Aur0101 (a type of auristatin microtubule inhibitor) and a degradable linker AcLys-PABC-VC.

     AcLys-PABC-VC-Aur0101 Chemical Structure
  16. GC64698 AM-5308 AM-5308 is a potent kinesin KIF18A inhibitor (WO2021211549A1, C13). AM-5308 Chemical Structure
  17. GC65578 Aminobenzenesulfonic auristatin E TFA Aminobenzenesulfonic auristatin E TFA is a drug-linker conjugate for ADC. Aminobenzenesulfonic auristatin E TFA has potent antitumor activity by using Auristatin E (a cytotoxic tubulin modifier), linked via the ADC linker Aminobenzenesulfonic. Aminobenzenesulfonic auristatin E TFA Chemical Structure
  18. GC33370 Amphethinile (Amphetinile)

    Amphetinile; CRC 82-07

     Amphethinile (Amphetinile) is an anti-tubulin agent. The affinity constant for the association (Ka) of Amphethinile (Amphetinile) with tubulin is 1.3 μM. Amphethinile (Amphetinile) Chemical Structure
  19. GC64273 AMXI-5001 AMXI-5001 is a potent, orally active, and dual parp1/2 and microtubule polymerization inhibitor. MXI-5001 exhibits selective antitumor cytotoxicity across a wide variety of human cancer cells with much lower IC50s than existing clinical PARP1/2 inhibitors. AMXI-5001 induces complete regression of established tumors, including exceedingly large tumors. AMXI-5001 Chemical Structure
  20. GC67900 AMXI-5001 hydrochloride AMXI-5001 hydrochloride Chemical Structure
  21. GC11947 Ansamitocin P-3

    Antibiotic C-15003P3, Maytansinol butyrate

     A microtubule depolymerizing agent Ansamitocin P-3 Chemical Structure
  22. GC66198 Anti-α-Tubulin Antibody, AF555 conjugate Anti-α-Tubulin Antibody, AF555 conjugate is a conjugate of mouse anti-α-tubulin monoclonal antibody and the red fluorescent dye Alexa Fluor 555. Anti-α-Tubulin Antibody, AF555 conjugate can be used for the detection of tubulin (Ex/Em: 554/567 nm). Anti-α-Tubulin Antibody, AF555 conjugate Chemical Structure
  23. GC68024 Antiproliferative agent-14 Antiproliferative agent-14 Chemical Structure
  24. GC35429 Auristatin E Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates. Auristatin E inhibits cell division by blocking the polymerisation of tubulin. Auristatin E Chemical Structure
  25. GC35430 Auristatin F Auristatin F is a potent cytotoxin. Auristatin F, a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC). Auristatin F Chemical Structure
  26. GC63663 Avanbulin

    BAL27862

     Avanbulin (BAL27862) is a potent, Colchicine site-binding, tubulin assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC50 of 1.4 μM. Avanbulin binds to tubulin with an apparent Kd value of 244 nM. Avanbulin can be used for the research of cancer and cell division. Avanbulin Chemical Structure
  27. GC60620 Batabulin Batabulin (T138067) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death. Batabulin Chemical Structure
  28. GC60621 Batabulin sodium

    T138067

     An inhibitor of tubulin polymerization Batabulin sodium Chemical Structure
  29. GC42942 bis-ANS (potassium salt)

    4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid

     bis-ANS (potassium salt) is a fluorescent probe of hydrophobic protein. bis-ANS (potassium salt) Chemical Structure
  30. GC34102 BNC105 BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. BNC105 Chemical Structure
  31. GC39483 BO-264 BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity. BO-264 Chemical Structure
  32. GC48901 BRD9876 An Eg5 inhibitor BRD9876 Chemical Structure
  33. GC33149 BTB-1

    NSC 156750, NSC 658180

     A reversible Kif18A inhibitor BTB-1 Chemical Structure
  34. GC11765 Cabazitaxel

    TXD 258, XRP 6258

     Microtubule associated inhibitor Cabazitaxel Chemical Structure
  35. GC65575 Cabazitaxel-d6 Cabazitaxel-d6 (XRP6258-d6) is the deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel-d6 Chemical Structure
  36. GC45395 Cabazitaxel-d9

    XRP6258-d9; RPR-116258A-d9; taxoid XRP6258-d9

     Cabazitaxel-d9 is deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel-d9 Chemical Structure
  37. GC74519 Cantuzumab ravtansine

    IMGN242; huC242-DM4

     Cantuzumab ravtansine (IMGN242; huC242-DM4), an ADC, is a humanized monoclonal antibody, huC242, covalently linked via a disulfide bond to DM4 (DM4 ). Cantuzumab ravtansine Chemical Structure
  38. GC40890 CAY10701 CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI50s = 22 and 38 nM, respectively). CAY10701 Chemical Structure
  39. GC33300 CCB02 CCB02 is a selective CPAP-tubulin interaction inhibitor, binding to tubulin and competing for the CPAP binding site of β-tubulin, with an IC50 of 689 nM, and shows potent anti-tumor activity. CCB02 shows no inhibition on the cell cycle- and centrosome-related kinases, or the phosphorylation status of Aurora A, Plk1, Plk2, CDK2, and CHK1. CCB02 Chemical Structure
  40. GN10780 Cephalomannine

    NSC 318735

     Cephalomannine Chemical Structure
  41. GC35654 Ceratamine A Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent. Ceratamine A exhibits cytotoxicity against human cancer cell lines. Ceratamine A Chemical Structure
  42. GC11905 Cevipabulin

    TTI-237

     Anti-microtubule agent Cevipabulin Chemical Structure
  43. GC35659 Cevipabulin fumarate

    TTI-237 fumarate

     Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound and inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line. Cevipabulin fumarate Chemical Structure
  44. GC15894 CK-636

    CK-0944636

     Arp2/3 complex inhibitor CK-636 Chemical Structure
  45. GC74600 Cofetuzumab pelidotin

    PF-06647020; ABBV-647; h6M24-vc0101

     Cofetuzumab pelidotin (PF-06647020) is a PTK7-targeting ADC comprising a humanized anti-PTK7 mAb joined to an auristatin microtubule inhibitor payload, auristatin-0101, by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin Chemical Structure
  46. GC40664 Colcemid

    Demecolcine, NSC 3096

     Colcemid is a cytoskeletal inhibitor that induces mitotic arrest in the G2/M phase or meiotic arrest in the vesicle rupture (GVBD) phase in mammalian cells or oocytes, respectively. Colcemid Chemical Structure
  47. GC13261 Colchicine Colchicine, an orally active alkaloid, disrupts cytoskeletal function by inhibiting the polymerization of β-tubulin into microtubules, with an IC50 of 3 nM. Colchicine Chemical Structure
  48. GC43300 Combretastatin A1

    CA1

     Combretastatin A1 is a cis-stilbene originally isolated from C. Combretastatin A1 Chemical Structure
  49. GC17631 Combretastatin A4

    CA4, Combretastatin A4, CRC 8709

     tubulin polymerization inhibitor Combretastatin A4 Chemical Structure
  50. GC43315 Corynecin IV Corynecin IV is a chloramphenicol-like bacterial metabolite originally isolated from Corynebacterium. Corynecin IV Chemical Structure
  51. GC40663 Corynecin V Corynecin V is a chloramphenicol-like bacterial metabolite originally isolated from Corynebacterium. Corynecin V Chemical Structure
  52. GC19112 Crolibulin

    EPC2407

     Crolibulin is a small molecule tubulin polymerization inhibitor. Crolibulin Chemical Structure
  53. GC40482 Curvulin Curvulin is a phytotoxin first isolated from several species of the mold Curvularia. Curvulin Chemical Structure
  54. GC11252 CW069 allosteric inhibitor of HSET, selective CW069 Chemical Structure
  55. GC35789 Cys-mcMMAD Cys-mcMMAD is a drug-linker conjugate for ADC. MMAD is a potent tubulin inhibitor. Cys-mcMMAD Chemical Structure
  56. GC68929 Cys-McMMAF

    "Cys-McMMAF" is the payload released by "AlMcMMAF", a humanized A1 antibody that targets 5T4 and is coupled to microtubule-disrupting MMAF via a maleimide linker. Cys-McMMAF has anti-tumor effects in two mouse models of cancer (H1975 and MDA-MB-361-DYT2).

     Cys-McMMAF Chemical Structure
  57. GC11383 CYT997 (Lexibulin)

    Lexibulin

     CYT997 (Lexibulin) (CYT-997) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. CYT997 (Lexibulin) induces cell apoptosis and induces mitochondrial ROS generation in GC cells. CYT997 (Lexibulin) Chemical Structure
  58. GC12384 D-64131

    D 64131;D64131

     An inhibitor of tubulin polymerization D-64131 Chemical Structure
  59. GC35797 D8-MMAD D8-MMAD Chemical Structure
  60. GC35798 D8-MMAF

    Monomethylauristatin F D8

     D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride. MMAF Hydrochloride, a potent tubulin polymerization inhibitor, is used as a antitumor agent and a cytotoxic component of antibody-drug conjugates (ADCs). D8-MMAF Chemical Structure
  61. GC35799 D8-MMAF hydrochloride D8-MMAF hydrochloride Chemical Structure
  62. GC74061 DBM-C5-VC-PAB-MMAE DBM-C5-VC-PAB-MMAE (Compound 3a) is a Drug-Linker conjugate for ADC. DBM-C5-VC-PAB-MMAE Chemical Structure
  63. GC39486 DCLK1-IN-1 DCLK1-IN-1 is a highly selective inhibitor of DCLK1 and DCLK2 with IC50 values of 9.5nM and 31nM respectively in the KINOMEscan binding assay, and IC50 values of 57nM and 103nM respectively in the ATP kinase assay. DCLK1-IN-1 Chemical Structure
  64. GN10426 Deacetyltaxol

    10-DAP, 10-Deacetyltaxol

     Deacetyltaxol Chemical Structure
  65. GC41304 Deoxybrevianamide E Deoxybrevianamide E is an alkaloid fungal metabolite that has been found in Aspergillus. Deoxybrevianamide E Chemical Structure
  66. GC38564 Deoxypodophyllotoxin

    Anthricin, (-)-Deoxypodophyllotoxin, 4-Deoxypodophyllotoxin, DPT, RD4-6266

     Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from rhizomes of Sinopodophullumhexandrum (Berberidaceae). Deoxypodophyllotoxin Chemical Structure
  67. GC43469 Diminutol

    NG72

     Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis. Diminutol Chemical Structure
  68. GC60143 DM3

    Maytansinoid DM3

     DM3 (Maytansinoid DM3) is a maytansine analog bearing disulfide or thiol groups and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs). DM3 Chemical Structure
  69. GC38355 DM3-SMe DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM. DM3-SMe Chemical Structure
  70. GC32810 DM4 DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate. DM4 Chemical Structure
  71. GC38468 DM4-SMe DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM. DM4-SMe Chemical Structure
  72. GC38460 DM4-SPDP DM4-SPDP is a drug-linker conjugate composed of a potent antitubulin agent DM4 and a linker SMCC to make antibody drug conjugate. SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. DM4-SPDP Chemical Structure
  73. GC16684 Docetaxel Docetaxel is a taxane class of anti-mitotic chemotherapeutic agents with an IC50 of 0.2 µM. Docetaxel Chemical Structure
  74. GC48968 Docetaxel (hydrate)

    DTX, NSC 628503, RP 56976, Taxotel

    An analog of taxol with antitumor properties

     Docetaxel (hydrate) Chemical Structure
  75. GC12550 Docetaxel Trihydrate Docetaxel Trihydrate Chemical Structure
  76. GC16273 Dolastatin 10

    DLS 10; NSC 376128

     Antitumor agent Dolastatin 10 Chemical Structure
  77. GC10557 Dolastatin 10 trifluoroacetate Antitumor agent Dolastatin 10 trifluoroacetate Chemical Structure
  78. GA21397 Dolastatin 15

    NSC 617668

     Dolastatin 15 originally isolated from the sea hare Dolabella auricularia belongs to a family of antimitotic and antineoplastic depsipeptides inducing apoptosis in various malignant cell types. It was shown to inhibit the growth of the P388 lymphocytic leukemia cell line efficiently, with an ED?? value of 2.4 ng/mL. Dolastatin 15 Chemical Structure
  79. GC73441 EAPB 02303 EAPB 02303 is a microtubule-disrupting agent and inhibitor. EAPB 02303 Chemical Structure
  80. GC16827 ELR510444 Novel microtubule disruptor ELR510444 Chemical Structure
  81. GC33125 Entasobulin Entasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity. Entasobulin Chemical Structure
  82. GC11202 Epothilone A

    Epo A

     Microtubule stabilizing macrolide Epothilone A Chemical Structure
  83. GC17240 Epothilone B (EPO906, Patupilone)

    Epo B

     Epothilone B (EPO906, Patupilone) is a microtubule stabilizer with a Ki of 0.71μM. Epothilone B (EPO906, Patupilone) Chemical Structure
  84. GC17440 Epothilone D

    Desoxyepothilone B, NSC 73147

     A microtubule-stabilizing agent Epothilone D Chemical Structure
  85. GC72977 Epothilone F Epothilone F is a Microtubule/Tubulin-stabilizing agent with anti-tumor activity. Epothilone F Chemical Structure
  86. GC74126 ER-076349 ER-076349 is an inhibitor of tubulin polymerization, induces G2-M cell cycle arrest, and disrupts mitotic spindles. ER-076349 Chemical Structure
  87. GC14354 Eribulin synthetic analogue of halichondrin B Eribulin Chemical Structure
  88. GC12483 Eribulin mesylate synthetic analogue of halichondrin B Eribulin mesylate Chemical Structure
  89. GC63845 Eribulin-d3 mesylate Eribulin-d3 mesylate is a deuterium labeled Eribulin mesylate. Eribulin mesylate is a microtubule targeting agent that is used for the research of cancer. Eribulin-d3 mesylate Chemical Structure
  90. GC67333 Estramustine Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts. Estramustine Chemical Structure
  91. GC32816 Estramustine phosphate sodium

    Ro 21-8837/001

     A derivative of estradiol that destabilizes microtubules Estramustine phosphate sodium Chemical Structure
  92. GC73543 FC-116 FC-11 is a Tubulin inhibitor that effectively inhibits tumor growth in mice. FC-116 Chemical Structure
  93. GC12319 Ferulenol antimycobacterial activity and stimulates tubulin polymerization Ferulenol Chemical Structure
  94. GC13210 Flubendazole

    NSC 313680, R-17889, R-17899

     Autophagy activator Flubendazole Chemical Structure
  95. GC16727 Flutax 1 A fluorescent taxol derivative used for direct imaging of the microtubule cytoskeleton Flutax 1 Chemical Structure
  96. GC50397 Flutax 2 Green fluorescent taxol derivative; binds microtubules Flutax 2 Chemical Structure
  97. GC66242 Flutax-2 (5/6-mixture) Flutax-2 (5/6-mixture) is an active fluorescent derivative of Taxol. Flutax-2 (5/6-mixture) binds to polymerized α,β-tubulin dimers. Flutax-2 (5/6-mixture) is able to stabilize microtubules of intact T. gallinae and T. foetus trophozoites. Flutax-2 (5/6-mixture) Chemical Structure
  98. GC63596 Fmoc-MMAE Fmoc-MMAE is a protective group-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Fmoc-MMAE can be used in the synthesis of ADC. Fmoc-MMAE Chemical Structure
  99. GC12308 Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium

    CA4P, Combrestatin A4, CRC 8709

     Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium is the Combretastatin A4 prodrug that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis. Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium Chemical Structure
  100. GC74279 Ganoderic acid T-Q

    Ganodermic acid T-Q

     Ganoderic acid T-Q (Ganodermic acid T-Q) (compound 1) is a natural product that can be found in ganoderma lucidum. Ganoderic acid T-Q Chemical Structure
  101. GC73080 Glembatumumab vedotin

    CDX-011; CR011-vcMMAE

     Glembatumumab vedotin (CDX-011) is an ADC comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB and conjugated to the cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin Chemical Structure

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