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Home >> Signaling Pathways >> Cell Cycle/Checkpoint >> Microtubule/Tubulin

Microtubule/Tubulin

Microtubule is the cylindrical and filamentous structure that required for cell shape, migration, cilia and flagella mobility etc. Tubulin is the major component of microtubules.

Products for  Microtubule/Tubulin

  1. Cat.No. Product Name Information
  2. GC41520 Lachnone A Lachnone A is a chromone fungal metabolite originally isolated from Lachnum. Lachnone A Chemical Structure
  3. GC41272 Lateropyrone Lateropyrone is a fungal metabolite produced by Fusarium species. Lateropyrone Chemical Structure
  4. GC50052 Laulimalide

    Microtubule stabilzing agent

     Laulimalide Chemical Structure
  5. GC50214 LCB 03-0110 dihydrochloride Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk LCB 03-0110 dihydrochloride Chemical Structure
  6. GC33175 Lexibulin dihydrochloride (CYT-997 dihydrochloride) Lexibulin dihydrochloride (CYT-997 dihydrochloride) (CYT-997 dihydrochloride) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Lexibulin dihydrochloride (CYT-997 dihydrochloride) induces cell apoptosis and induces mitochondrial ROS generation in GC cells. Lexibulin dihydrochloride (CYT-997 dihydrochloride) Chemical Structure
  7. GC61400 MAP4343 MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 Chemical Structure
  8. GC62205 Maytansine Maytansine is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations. Maytansine Chemical Structure
  9. GC32895 Maytansinol (Ansamitocin P-0) Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and induces microtubule disassembly in vitro. Maytansinol (Ansamitocin P-0) Chemical Structure
  10. GC36560 Mc-MMAD Mc-MMAD is a protective group (maleimidocaproyl)-conjugated MMAD. MMAD is a potent tubulin inhibitor. Mc-MMAD is a drug-linker conjugate for ADC. Mc-MMAD Chemical Structure
  11. GC36561 Mc-MMAE Mc-MMAE is a protective group (maleimidocaproyl)-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Mc-MMAE is a drug-linker conjugate for ADC. Mc-MMAE Chemical Structure
  12. GC34068 McMMAF (Maleimidocaproyl monomethylauristatin F) McMMAF (Maleimidocaproyl monomethylauristatin F) is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor. McMMAF (Maleimidocaproyl monomethylauristatin F) Chemical Structure
  13. GC17649 Mebendazole broad-spectrum anthelmintic that inhibits intestinal microtubule synthesis Mebendazole Chemical Structure
  14. GC19244 Mertansine Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine Chemical Structure
  15. GC36608 Microtubule inhibitor 1 Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity, with an IC50 value of 9-16 nM in cancer cells. Microtubule inhibitor 1 Chemical Structure
  16. GC65143 MKC-1 MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family. MKC-1 Chemical Structure
  17. GC15798 MMAD MMAD Chemical Structure
  18. GC63461 MMAE-d8

    MMAE-d8 (Monomethyl auristatin E-d8) is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.

     MMAE-d8 Chemical Structure
  19. GC10034 MMAF Anti-mitotic/anti-tubulin/antineoplastic agent MMAF Chemical Structure
  20. GC36633 MMAF Hydrochloride MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF Hydrochloride Chemical Structure
  21. GC38397 MMAF sodium MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium Chemical Structure
  22. GC63774 MMAF-d8 hydrochloride D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent. MMAF-d8 hydrochloride Chemical Structure
  23. GC17276 Monomethyl auristatin E

    A potent antimitotic compound

     Monomethyl auristatin E Chemical Structure
  24. GC15285 MPC 6827 hydrochloride MPC 6827 hydrochloride (MPC-6827 hydrochloride) is a blood brain barrier permeable microtubule-disrupting agent, with potent and broad-spectrum in vitro and in vivo cytotoxic activities. MPC 6827 hydrochloride (MPC-6827 hydrochloride) exhibits potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models. MPC 6827 hydrochloride (MPC 6827 hydrochloride) is a promising candidate for the treatment of multiple cancer types. MPC 6827 hydrochloride Chemical Structure
  25. GC41564 MPT0B014 An inhibitor of tubulin polymerization MPT0B014 Chemical Structure
  26. GC36652 MPT0B392 MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line. MPT0B392 Chemical Structure
  27. GC66457 MY-875 MY-875 is a competitive microtubulin polymerization inhibitor with an IC50 value of 0.92 μM. MY-875 inhibits microtubulin polymerization by targeting colchicine binding sites and activates the Hippo pathway. MY-875 induces apoptosis and has anticancer activity. MY-875 Chemical Structure
  28. GC69516 MY-943

    MY-943 is an effective tubulin polymerization and LSD1 inhibitor with anti-cancer activity. MY-943 induces G2/M phase arrest and cell apoptosis, and inhibits cell migration, making it suitable for gastric cancer research.

     MY-943 Chemical Structure
  29. GC15773 Myoseverin microtubule-binding molecule Myoseverin Chemical Structure
  30. GC18445 N-Deacetylcolchicine An inhibitor of microtubule polymerization N-Deacetylcolchicine Chemical Structure
  31. GC14075 Nocodazole A tubulin production inhibitor,anti-neoplastic agent Nocodazole Chemical Structure
  32. GC32551 Ombrabulin (AC-7700) Ombrabulin (AC-7700) (AVE8062) is a derivative of CA-4 phosphate, which is known to exhibit antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells. Ombrabulin (AC-7700) Chemical Structure
  33. GC34022 Ombrabulin hydrochloride (AVE8062) Ombrabulin hydrochloride (AVE8062) is a derivative of CA-4 phosphate, which is known to exhibit antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells. Ombrabulin hydrochloride (AVE8062) Chemical Structure
  34. GC64626 Oryzalin Oryzalin is a dinitroaniline herbicide, binding to plant tubulin and inhibits microtubule (MT) polymerization in vitro. Oryzalin Chemical Structure
  35. GC33163 OSIP-486823 (OSIP 486823) OSIP-486823 (OSIP 486823) is a novel microtubule-interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules. OSIP-486823 (OSIP 486823) Chemical Structure
  36. GC65897 OXi8007 OXi8007 is a water-soluble phosphate prodrug of OXi8006, a tubulin-binding compound. OXi8007 Chemical Structure
  37. GC12511 Paclitaxel (Taxol)

    A potent mitotic inhibitor

     Paclitaxel (Taxol) Chemical Structure
  38. GC49404 Paclitaxel C A taxoid and an inhibitor of microtubule depolymerization Paclitaxel C Chemical Structure
  39. GC45758 Paclitaxel octadecanedioate A prodrug form of paclitaxel Paclitaxel octadecanedioate Chemical Structure
  40. GC32134 Parbendazole (SKF 29044) Parbendazole (SKF 29044) is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530nM, and exhibits a broad-spectrum anthelmintic activity. Parbendazole (SKF 29044) Chemical Structure
  41. GC33002 PBOX 6 PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound, acts as a microtubule-depolymerizing agent and an apoptotic agent. PBOX 6 Chemical Structure
  42. GC30801 PE859 PE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively. PE859 Chemical Structure
  43. GC33136 PF-06380101 PF-06380101 (Aur0101), an auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue. PF-06380101 (Aur0101) shows excellent potencies in tumor cell proliferation assays and differential ADME properties when compared to other synthetic auristatin analogues that are used in the preparation of ADCs. PF-06380101 Chemical Structure
  44. GC63740 PF-06380101-d8 PF-06380101 d8 (Aur0101 d8) is a deuterium labeled PF-06380101. PF-06380101, an Auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue. PF-06380101-d8 Chemical Structure
  45. GC15514 Phomopsin A cyclic hexapeptide mycotoxin that binds β-tubulin Phomopsin A Chemical Structure
  46. GC48394 Phomopsinamine An inhibitor of microtubule polymerization Phomopsinamine Chemical Structure
  47. GC38456 Pironetin An inhibitor of microtubule assembly Pironetin Chemical Structure
  48. GC10235 Plinabulin (NPI-2358) Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells. Plinabulin (NPI-2358) binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells. Plinabulin (NPI-2358) Chemical Structure
  49. GC10521 Podophyllotoxin A lignan with diverse biological activities Podophyllotoxin Chemical Structure
  50. GC49077 Podophyllotoxin-d6 An internal standard for the quantification of podophyllotoxin and picropodophyllotoxin Podophyllotoxin-d6 Chemical Structure
  51. GC64705 Podophyllotoxone Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the tubulin polymerization. Podophyllotoxone Chemical Structure
  52. GC33169 Rosabulin (STA 5312) Rosabulin (STA 5312) (STA 5312) is a potent and orally active microtubule inhibitor that inhibits microtubule assembly. Rosabulin (STA 5312) has broad-spectrum anti-tumor activity. Rosabulin (STA 5312) Chemical Structure
  53. GC38945 S516 S516 (Compound 22) is an active metabolite of CKD-516 and a potent tubulin polymerization inhibitor with an IC50 of 4.29 μM. S516 has marked antitumor activity. S516 Chemical Structure
  54. GC66437 SB-216 SB-216 is a potent tubulin polymerization inhibitor. SB-216 shows strong antiproliferative potency in a panel of human cancer cell lines, including melanoma, lung cancer, and breast cancer. SB-216 can be used for cancer research. SB-216 Chemical Structure
  55. GC39798 Scoulerine Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of BACE1 (?-site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells. Scoulerine Chemical Structure
  56. GC32935 Soblidotin (Auristatin PE) Soblidotin (Auristatin PE) (Auristatin PE) is a novel synthetic Dolastatin 10 derivative and inhibitor of tubulin polymerization. Soblidotin (Auristatin PE) Chemical Structure
  57. GC64019 Sovilnesib Sovilnesib (AMG 650) is a kinesin-like protein KIF18A inhibitor (WO2020132648). Sovilnesib can be used for the research of cancer. Sovilnesib Chemical Structure
  58. GC44946 Sporidesmolide III Sporidesmolide III is a cyclodepsipeptide originally isolated from P. Sporidesmolide III Chemical Structure
  59. GC37678 SS28 SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin. SS28 Chemical Structure
  60. GC33074 SSE15206 SSE15206 is a microtubule polymerization inhibitor (GI50 = 197 nM in HCT116 cells) that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells. SSE15206 Chemical Structure
  61. GC45688 STX140 An estrogen sulfamate STX140 Chemical Structure
  62. GC48119 Suprafenacine An inhibitor of tubulin polymerization with anticancer activity Suprafenacine Chemical Structure
  63. GA23633 T-Peptide Highly neurotoxic cell-permeable analog of PHF6. Induces aggregation of Tau peptides. T-Peptide Chemical Structure
  64. GC37715 Taccalonolide A Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells. Taccalonolide A Chemical Structure
  65. GC37716 Taccalonolide AJ Taccalonolide AJ is a semi-synthesis compound with cellular microtubule stabilizing activity. Taccalonolide AJ exhibits high potency antiproliferative activity against cancer cells, with an IC50 of 4.2 nM for HeLa cells. Taccalonolide AJ Chemical Structure
  66. GC37717 Taccalonolide B Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM. Taccalonolide B Chemical Structure
  67. GC17559 TAI-1 Hec1 inhibitor, potent, first-in-class TAI-1 Chemical Structure
  68. GC32753 Taltobulin (HTI-286) Taltobulin (HTI-286) (HTI-286), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin (HTI-286) inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis. Taltobulin (HTI-286) Chemical Structure
  69. GC61314 Taltobulin hydrochloride Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin hydrochloride inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis. Taltobulin hydrochloride Chemical Structure
  70. GC34303 Taltobulin hydrochloride (HTI-286 hydrochloride) Taltobulin hydrochloride (HTI-286 hydrochloride) Chemical Structure
  71. GC34135 Taltobulin trifluoroacetate (HTI-286 trifluoroacetate) Taltobulin trifluoroacetate (HTI-286 trifluoroacetate) (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate (HTI-286 trifluoroacetate) inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis. Taltobulin trifluoroacetate (HTI-286 trifluoroacetate) Chemical Structure
  72. GC33178 Tasidotin hydrochloride (ILX651) Tasidotin hydrochloride (ILX651) is a peptide analog of the antimitotic depsipeptide dolastatin 15, as an inhibitor of microtubule assembly and microtubule dynamics. Tasidotin hydrochloride (ILX651) Chemical Structure
  73. GC63211 Tau tracer 2 Tau tracer 2 (Pl-2620) is a Tau tracer used for imaging Tau protein aggregates. Tau tracer 2 Chemical Structure
  74. GC45022 Tetranactin Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. Tetranactin Chemical Structure
  75. GC45039 Thiocolchicine Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 μM) and a derivative of colchicine. Thiocolchicine Chemical Structure
  76. GC68366 Thiocolchicine-d3 Thiocolchicine-d3 Chemical Structure
  77. GC32448 Thymosin beta 4 (Thymosin β4)

    Thymosin β4 is a major actin sequestering protein in cells and can interact with G-actin.

     Thymosin beta 4 (Thymosin β4) Chemical Structure
  78. GC34109 Tirbanibulin Mesylate (KX2-391 (Mesylate)) Tirbanibulin Mesylate (KX2-391 (Mesylate)) (KX2-391 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Tirbanibulin Mesylate (KX2-391 (Mesylate)) Chemical Structure
  79. GC18763 TN-16 TN-16 is an inhibitor of microtubule polymerization (IC50 = 0.4-1.7 uM). TN-16 Chemical Structure
  80. GC10537 Triclabendazole Microtubule associated inhibitor Triclabendazole Chemical Structure
  81. GC33291 Tubulin inhibitor 1 Tubulin inhibitor 1 is a tubulin inhibitor, inhibits tubulin polymerization. Tubulin inhibitor 1 shows potent anti-tumor activity, casues cellular mitotic arrest in the G2/M phase, and induces cellular apoptosis. Tubulin inhibitor 1 Chemical Structure
  82. GC70076 Tubulin inhibitor 11

    Tubulin inhibitor 11 is an effective orally active inhibitor of microtubules, which targets the colchicine binding site on tubulin. It inhibits microtubule polymerization, promotes mitotic arrest and induces apoptosis in cells.

     Tubulin inhibitor 11 Chemical Structure
  83. GC39558 Tubulin inhibitor 6 An inhibitor of tubulin polymerization and a PP2A activator Tubulin inhibitor 6 Chemical Structure
  84. GC37835 Tubulysin Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule drug conjugate (SMDC) delivery system. Tubulysin Chemical Structure
  85. GC33155 Tubulysin A (TubA) Tubulysin A (TubA)(TubA) is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays; anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysin A (TubA) Chemical Structure
  86. GC37836 Tubulysin B Tubulysin B Chemical Structure
  87. GC37837 Tubulysin C Tubulysin C is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin C is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Tubulysin C Chemical Structure
  88. GC37838 Tubulysin D Tubulysin D is one of the most potent derivatives among the tubulysins isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin D is a novel tetrapeptide that displays potent antitumor activity and leads to cell cycle arrest and apoptosis by inhibiting tubulin polymerization with an IC50 of 1.7 μM. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin D Chemical Structure
  89. GC37839 Tubulysin E Tubulysin E is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin E is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Tubulysin E Chemical Structure
  90. GC37840 Tubulysin F Tubulysin F is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin F is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Tubulysin F Chemical Structure
  91. GC37841 Tubulysin G Tubulysin G is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin G is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Tubulysin G Chemical Structure
  92. GC37842 Tubulysin H Tubulysin H is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin H is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Tubulysin H Chemical Structure
  93. GC37843 Tubulysin I Tubulysin I is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin I is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Tubulysin I Chemical Structure
  94. GC37844 Tubulysin M Tubulysin M is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin M is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Tubulysin M Chemical Structure
  95. GC50056 UA 62784 Inhibits microtubule polymerization UA 62784 Chemical Structure
  96. GC33269 Valecobulin (CKD-516) Valecobulin (CKD-516) (CKD516) is a valine prodrug of (S516) and a vascular disrupting agent (VDA). Valecobulin (CKD-516) is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. Valecobulin (CKD-516) Chemical Structure
  97. GC39177 Valecobulin hydrochloride Valecobulin hydrochloride (CKD-516 hydrochloride) is a valine prodrug of S516 and a vascular disrupting agent (VDA). Valecobulin hydrochloride is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. Valecobulin hydrochloride Chemical Structure
  98. GC38480 Vat-Cit-PAB-Monomethyl Dolastatin 10 Vat-Cit-PAB-Monomethyl Dolastatin 10 is a drug-linker conjugate for ADC with potent antitumor activity by using Monomethyl Dolastatin 10 (a potent tubulin inhibitor), linked via the ADC linker Vat-Cit-PAB. Vat-Cit-PAB-Monomethyl Dolastatin 10 Chemical Structure
  99. GC37890 Vc-MMAD Vc-MMAD consists the ADCs linker (Val-Cit) and potent tubulin inhibitor (MMAD). Vc-MMAD is a drug-linker conjugate for ADC. Vc-MMAD Chemical Structure
  100. GC37891 VcMMAE VcMMAE (mc-vc-PAB-MMAE) is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). VcMMAE Chemical Structure
  101. GC37899 VERU-111 VERU-111 (ABI-231) is a potent and orally active α and β tubulin inhibitor, which displays strong antiproliferative activity, with an average IC50 of 5.2 nM against panels of melanoma and prostate cancer cell lines. VERU-111 (ABI-231) suppresses tumor growth and metastatic phenotypes of cervical cancer cells via targeting HPV E6 and E7, and has potential for the treatment of prostate cancer. VERU-111 Chemical Structure

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