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Mps1

MPS1 (monopolar spindle 1 kinase) is a crucial part of the spindle assembly checkpoint. It facilitates the formation of C-MAD2 (closed MAD2) conformer and the MCC (mitotic checkpoint complex) assembly, and involved in the tumor growth.

Products for  Mps1

  1. Cat.No. Product Name Information
  2. GC15283 AZ3146

    AZ 3146; AZ-3146

    Mps1 inhibitor,potent and selective AZ3146  Chemical Structure
  3. GC19058 BAY1217389 BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM. BAY1217389  Chemical Structure
  4. GC32846 BOS-172722 BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer. BOS-172722  Chemical Structure
  5. GC33213 CCT251455 CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 (MPS1) inhibitor with an IC50 of 3 nM. CCT251455  Chemical Structure
  6. GC34073 Empesertib (BAY 1161909)

    BAY 1161909

    Empesertib (BAY 1161909) (BAY 1161909) is a potent Mps1 inhibitor, with an IC50 of < 1 nM. Empesertib (BAY 1161909)  Chemical Structure
  7. GC10083 MPI-0479605 Mps1 inhibitor,selective and ATP competitive MPI-0479605  Chemical Structure
  8. GC11292 Mps1-IN-1

    Monopolar Spindle 1 Kinase Inhibitor 1, Mps1 Kinase Inhibitor 1

    Mps1 kinase inhibitor

    Mps1-IN-1  Chemical Structure
  9. GC50110 Mps1-IN-1 dihydrochloride Selective Mps1 kinase inhibitor Mps1-IN-1 dihydrochloride  Chemical Structure
  10. GC15745 Mps1-IN-2 Mps1 kinase inhibitor Mps1-IN-2  Chemical Structure
  11. GC36651 Mps1-IN-3 Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC50 of 50 nM. Mps1-IN-3  Chemical Structure
  12. GC65339 Mps1-IN-3 hydrochloride Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model. Mps1-IN-3 hydrochloride  Chemical Structure
  13. GC36752 NMS-P715 An Mps1/TTK inhibitor NMS-P715  Chemical Structure
  14. GC13727 TC Mps1 12 Mps1 inhibitor TC Mps1 12  Chemical Structure

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