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Home >> Signaling Pathways >> Cell Cycle/Checkpoint >> Mps1

Mps1

MPS1 (monopolar spindle 1 kinase) is a crucial part of the spindle assembly checkpoint. It facilitates the formation of C-MAD2 (closed MAD2) conformer and the MCC (mitotic checkpoint complex) assembly, and involved in the tumor growth.

Products for  Mps1

  1. Cat.No. Product Name Information
  2. GC15283 AZ3146 Mps1 inhibitor,potent and selective AZ3146 Chemical Structure
  3. GC19058 BAY1217389 BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM. BAY1217389 Chemical Structure
  4. GC32846 BOS-172722 BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer. BOS-172722 Chemical Structure
  5. GC33213 CCT251455 CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 (MPS1) inhibitor with an IC50 of 3 nM. CCT251455 Chemical Structure
  6. GC34073 Empesertib (BAY 1161909) Empesertib (BAY 1161909) (BAY 1161909) is a potent Mps1 inhibitor, with an IC50 of < 1 nM. Empesertib (BAY 1161909) Chemical Structure
  7. GC10083 MPI-0479605 Mps1 inhibitor,selective and ATP competitive MPI-0479605 Chemical Structure
  8. GC11292 Mps1-IN-1

    Mps1 kinase inhibitor

     Mps1-IN-1 Chemical Structure
  9. GC50110 Mps1-IN-1 dihydrochloride Selective Mps1 kinase inhibitor Mps1-IN-1 dihydrochloride Chemical Structure
  10. GC15745 Mps1-IN-2 Mps1 kinase inhibitor Mps1-IN-2 Chemical Structure
  11. GC36651 Mps1-IN-3 Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC50 of 50 nM. Mps1-IN-3 Chemical Structure
  12. GC65339 Mps1-IN-3 hydrochloride Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model. Mps1-IN-3 hydrochloride Chemical Structure
  13. GC36752 NMS-P715 An Mps1/TTK inhibitor NMS-P715 Chemical Structure
  14. GC13727 TC Mps1 12 Mps1 inhibitor TC Mps1 12 Chemical Structure

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